Document detail
ID
oai:HAL:hal-02573204v1
Topic
Aging Alzheimer's disease Amyloid Biomarker Cerebrospinal fluid Inflammation Mild cognitive impairment Multicenter Parkinson's disease Tau [SDV]Life Sciences [q-bio] [SDV.MHEP]Life Sciences [q-bio]/Hu...Author
Brosseron, Frederic Kolbe, Carl-Christian Santarelli, Francesco Carvalho, Stéphanie Antonell, Anna Castro-Gomez, Sergio Tacik, Pawel Namasivayam, Aishwarya, Alex Mangone, Graziella Schneider, Reinhard Latz, Eicke Wüllner, Ullrich Svenningsson, Per Sánchez-Valle, Raquel Molinuevo, José Luis Corvol, Jean-Christophe Heneka, Michael, T.Langue
enEditor
HAL CCSD;Wiley
Category
CNRS - Centre national de la recherche scientifique
Year
2020
listing date
12/15/2023
Keywords
levels biomarker csf parkinson alzheimer diseaseAbstract
International audience; INTRODUCTION:Multiple immunity biomarkers have been suggested as tracers of neuroinflammation in neurodegeneration.
This study aimed to verify findings in cerebrospinal fluid (CSF) samples of Alzheimer's disease (AD) and Parkinson's disease (PD) subjects from the network of the European, Innovative Medicines Initiative-funded project AETIONOMY.METHODS:A total of 227 samples from the studies/centres AETIONOMY, ICEBERG, and IDIBAPS were used to analyse 21 selected immunity biomarkers in CSF.
Results were compared to data of an independent cohort of 399 subjects previously published.RESULTS:Immunity markers were predominantly and reproducibly associated with pathological levels of tau isoforms, but also with amyloid levels, aging, sex, APOE genotype, and center-specific factors.DISCUSSION:Immunity biomarker levels in CSF reflect molecular and cellular pathology rather than diagnosis in neurodegenerative disorders.
Assay standardization and stratification for age and other covariates could improve the power of such markers in clinical applications or intervention studies targeting immune responses in neurodegeneration.
Brosseron, Frederic,Kolbe, Carl-Christian,Santarelli, Francesco,Carvalho, Stéphanie,Antonell, Anna,Castro-Gomez, Sergio,Tacik, Pawel,Namasivayam, Aishwarya, Alex,Mangone, Graziella,Schneider, Reinhard,Latz, Eicke,Wüllner, Ullrich,Svenningsson, Per,Sánchez-Valle, Raquel,Molinuevo, José Luis,Corvol, Jean-Christophe,Heneka, Michael, T., 2020, Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study, HAL CCSD;Wiley
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