Document detail
ID

oai:pubmedcentral.nih.gov:1013...

Topic
Review
Author
Tiucă, Robert Aurelian Tiucă, Oana Mirela Pașcanu, Ionela Maria
Langue
en
Editor

MDPI

Category

Biomedicines

Year

2023

listing date

11/29/2023

Keywords
common genetic thyroid cancer
Metrics

Abstract

Thyroid cancer is the most common endocrine malignancy, with an increasing trend in the past decades.

It has a variety of different histological subtypes, the most frequent one being differentiated thyroid cancer, which refers to papillary carcinoma, the most common histological type, followed by follicular carcinoma.

Associations between genetic polymorphisms and thyroid cancer have been investigated over the years and are an intriguing topic for the scientific world.

To date, the results of associations of single nucleotide polymorphisms, the most common genetic variations in the genome, with thyroid cancer have been inconsistent, but many promising results could potentially influence future research toward developing new targeted therapies and new prognostic biomarkers, thus consolidating a more personalized management for these patients.

This review focuses on emphasizing the existing literature data regarding genetic polymorphisms investigated for their potential association with differentiated thyroid cancer and highlights the opportunity of using genetic variations as biomarkers of diagnosis and prognosis for thyroid cancer patients.

Tiucă, Robert Aurelian,Tiucă, Oana Mirela,Pașcanu, Ionela Maria, 2023, The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update, MDPI

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