detalle del documento
IDENTIFICACIÓN
oai:HAL:hal-03955598v1
Tema
long non-coding RNA LncRNAs phytoc... long non-coding RNA LncRNAs phytochemical cancer metastasis therapy [CHIM]Chemical Sciences [SDV]Life Sciences [q-bio]Autor
Rajabi, Sadegh Rajani, Huda, Fatima Mohammadkhani, Niloufar Ramírez-Coronel, Andrés, Alexis Maleki, Mahsa Maresca, Marc Hajimehdipoor, HomaLangue
enEditor
HAL CCSD;MDPI
Categoría
CNRS - Centre national de la recherche scientifique
Año
2023
fecha de cotización
29/9/2023
Palabras clave
phytochemicals phytochemical lncrnas non-coding metastasis cancerResumen
Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s).
According to estimations, metastasis results in over 90% of cancer-associated death around the globe.
Long non-coding RNAs (LncRNAs) are a group of regulatory RNA molecules more than 200 base pairs in length.
The main regulatory activity of these molecules is the modulation of gene expression.
They have been reported to affect different stages of cancer development including proliferation, apoptosis, migration, invasion, and metastasis.
An increasing number of medical data reports indicate the probable function of LncRNAs in the metastatic spread of different cancers.
Phytochemical compounds, as the bioactive agents of plants, show several health benefits with a variety of biological activities.
Several phytochemicals have been demonstrated to target LncRNAs to defeat cancer.
This review article briefly describes the metastasis steps, summarizes data on some well-established LncRNAs with a role in metastasis, and identifies the phytochemicals with an ability to suppress cancer metastasis by targeting LncRNAs.
Rajabi, Sadegh,Rajani, Huda, Fatima,Mohammadkhani, Niloufar,Ramírez-Coronel, Andrés, Alexis,Maleki, Mahsa,Maresca, Marc,Hajimehdipoor, Homa, 2023, Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis, HAL CCSD;MDPI
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