detalle del documento
IDENTIFICACIÓN
oai:pubmedcentral.nih.gov:1031...
Tema
Original ArticleAutor
Li, Xue Zou, Shimin Tu, Xiaomeng Hao, Shishuai Jiang, Tian Chen, Jie-GuangLangue
enEditor
Springer Nature Singapore
Categoría
Neuroscience Bulletin
Año
2023
fecha de cotización
3/7/2024
Palabras clave
rgcs n-cadherin ndds foxp4Resumen
Heterozygous loss-of-function variants of FOXP4 are associated with neurodevelopmental disorders (NDDs) that exhibit delayed speech development, intellectual disability, and congenital abnormalities.
The etiology of NDDs is unclear.
Here we found that FOXP4 and N-cadherin are expressed in the nuclei and apical end-feet of radial glial cells (RGCs), respectively, in the mouse neocortex during early gestation.
Knockdown or dominant-negative inhibition of Foxp4 abolishes the apical condensation of N-cadherin in RGCs and the integrity of neuroepithelium in the ventricular zone (VZ).
Inhibition of Foxp4 leads to impeded radial migration of cortical neurons and ectopic neurogenesis from the proliferating VZ.
The ectopic differentiation and deficient migration disappear when N-cadherin is over-expressed in RGCs.
The data indicate that Foxp4 is essential for N-cadherin-based adherens junctions, the loss of which leads to periventricular heterotopias.
We hypothesize that FOXP4 variant-associated NDDs may be caused by disruption of the adherens junctions and malformation of the cerebral cortex.
Li, Xue,Zou, Shimin,Tu, Xiaomeng,Hao, Shishuai,Jiang, Tian,Chen, Jie-Guang, 2023, Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells, Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice, Springer Nature Singapore
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