Détail du document
Identifiant
doi:10.1007/s00415-023-11753-8...
Auteur
Maier, Patrizia M. Iggena, Deetje Meyer, Thomas Finke, Carsten Ploner, Christoph J.Langue
enEditeur
Springer
Catégorie
Medicine & Public Health
Année
2023
Date de référencement
10/05/2023
Mots clés
navigation spatial memory hippocampus amyotrophic lateral sclerosis motor neuron disease spatial test controls memory-guided navigation als mean non-demented memoryRésumé
Background Previous studies have yielded inconsistent results about hippocampal involvement in non-demented patients with amyotrophic lateral sclerosis (ALS).
We hypothesized that testing of memory-guided spatial navigation i.e., a highly hippocampus-dependent behaviour, might reveal behavioural correlates of hippocampal dysfunction in non-demented ALS patients.
Methods We conducted a prospective study of spatial cognition in 43 non-demented ALS outpatients (11f, 32 m, mean age 60.0 years, mean disease duration 27.0 months, mean ALSFRS-R score 40.0) and 43 healthy controls (14f, 29 m, mean age 57.0 years).
Participants were tested with a virtual memory-guided navigation task derived from animal research (“starmaze”) that has previously been used in studies of hippocampal function.
Participants were further tested with neuropsychological tests of visuospatial memory (SPART, 10/36 Spatial Recall Test), fluency (5PT, five-point test) and orientation (PTSOT, Perspective Taking/Spatial Orientation Test).
Results Patients successfully learned and navigated the starmaze from memory, both in conditions that forced memory of landmarks (success: patients 50.7%, controls 47.7%, p = 0.786) and memory of path sequences (success: patients 96.5%, controls 94.0%, p = 0.937).
Measures of navigational efficacy (latency, path error and navigational uncertainty) did not differ between groups ( p ≥ 0.546).
Likewise, SPART, 5PT and PTSOT scores did not differ between groups ( p ≥ 0.238).
Conclusions This study found no behavioural correlate for hippocampal dysfunction in non-demented ALS patients.
These findings support the view that the individual cognitive phenotype of ALS may relate to distinct disease subtypes rather than being a variable expression of the same underlying condition.
Maier, Patrizia M.,Iggena, Deetje,Meyer, Thomas,Finke, Carsten,Ploner, Christoph J., 2023, Memory-guided navigation in amyotrophic lateral sclerosis, Springer
