Détail du document
Identifiant
oai:www.zora.uzh.ch:191903
Sujet
Institute of Intensive Care Medici... Institute of Pathology and Molecul... Clinic for Cardiology Clinic for Infectious Diseases 610 Medicine & health COVIDAuteur
Burkhard‐Koren, Nina Maria Haberecker, Martina Maccio, Umberto Ruschitzka, Frank Schuepbach, Reto A Zinkernagel, Annelies S https://orcid.org/0000-0003-4700-1118 Hardmeier, Thomas Varga, Zsuzsanna https://orcid.org/0000-0002-2855-983X Moch, Holger https://orcid.org/0000-0002-7986-2839Langue
engEditeur
Wiley Open Access
Catégorie
Subjects = 04 Faculty of Medicine
Année
2021
Date de référencement
12/10/2023
Mots clés
macrothrombi comparison covid‐19 autopsies influenza pulmonary patientsRésumé
Similar to the influenza A pandemic in 1918/1919, the new Coronavirus disease 2019 (COVID‐19) has spread globally.
The causes of death in COVID‐19 are frequently compared to a seasonal influenza outbreak.
Complete COVID‐19 autopsy studies were almost non‐existent in the first months of the outbreak and are still rare with respect to the number of deaths.
It has been recently reported that capillary microthrombi are significantly more prevalent in patients with COVID‐19 than in patients with influenza A. To date, the contribution of macrothrombi, i.e. visible thrombi in pulmonary arteries, to the death of patients with influenza A in comparison to COVID‐19 remains unaddressed.
Here, we report autopsy findings in 411 patients who died from the ‘Spanish’ influenza A pandemic between May 1918 and April 1919 at the University Hospital Zurich, Switzerland.
We compare these results with influenza A autopsies from 2009 to 2020, other influenza A autopsy series and all COVID‐19 autopsies published to date.
No descriptions of any macroscopic thromboembolic events were mentioned in influenza A autopsy reports.
In 75 published COVID‐19 autopsies, pulmonary artery thrombosis/embolism was reported in 36%.
The direct comparison of macroscopic autopsy findings suggests a significantly greater degree of grossly visible pulmonary macrothrombi in patients with COVID‐19 in comparison to influenza A autopsies even though most patients received empiric thromboprophylaxis.
This is consistent with the concept of a SARS‐related de novo coagulopathy with generalised in situ clot formation, which could explain the high incidence of pulmonary thrombosis/embolism with or without underlying deep vein thrombosis and in the absence of a history of venous thromboembolic events.
Burkhard‐Koren, Nina Maria,Haberecker, Martina,Maccio, Umberto,Ruschitzka, Frank,Schuepbach, Reto A,Zinkernagel, Annelies S, https://orcid.org/0000-0003-4700-1118,Hardmeier, Thomas,Varga, Zsuzsanna, https://orcid.org/0000-0002-2855-983X,Moch, Holger, https://orcid.org/0000-0002-7986-2839, 2021, Higher prevalence of pulmonary macrothrombi in SARS-CoV-2 than in influenza A: autopsy results from 'Spanish flu' 1918/1919 in Switzerland to Coronavirus disease 2019, Wiley Open Access
