Document detail
ID
doi:10.1007/s10072-023-07074-3...
Author
Aiello, Edoardo Nicolò Solca, Federica Torre, Silvia Gentile, Francesco Scheveger, Francesco Olivero, Marco Colombo, Eleonora Maranzano, Alessio Manzoni, Martina Morelli, Claudia Doretti, Alberto Verde, Federico Silani, Vincenzo Ticozzi, Nicola Poletti, BarbaraLangue
enEditor
Springer
Category
Medicine & Public Health
Year
2023
listing date
10/4/2023
Keywords
amyotrophic lateral sclerosis activities of daily living neuropsychology functional independence frontotemporal degeneration scores behavioural fi iadl ecas-language non-demented = 0 features als patientsAbstract
Background The present study aimed at determining whether, net of motor confounders, neuropsychological features affect functional independence (FI) in activities of daily living (ADLs) in non-demented amyotrophic lateral sclerosis (ALS) patients.
Methods N = 88 ALS patients without frontotemporal dementia were assessed for FI—Katz’s Basic ADL Scale (BADL) and Lawton-Brody’s Instrumental ADL Scale (IADL)—, cognition—Edinburgh Cognitive and Behavioural ALS Screen (ECAS)—and behaviour—Beaumont Behavioural Inventory and Dimensional Apathy Scale.
The association between cognitive and behavioural measures and BADL/IADL scores was assessed by covarying for demographics, anxiety and depression levels, disease duration and motor confounders—i.e. ALS Functional Rating Scale-Revised (ALSFRS-R) scores, progression rate and both King’s and Milano-Torino stages.
Results Higher scores on the ECAS-Language were associated with higher IADL scores ( p = 0.005), whilst higher apathetic features—as measured by the Dimensional Apathy Scale (DAS)—were inversely related to the BADL ( p = 0.003).
Whilst IADL scores were related to all ECAS-Language tasks, the DAS-Initiation was the only subscale associated with BADL scores.
Patients with abnormal ECAS-Language ( p = 0.023) and DAS ( p = 0.008) scores were more functionally dependent than those without.
Discussion Among non-motor features, language changes and apathetic features detrimentally affect FI in non-demented ALS patients.
Aiello, Edoardo Nicolò,Solca, Federica,Torre, Silvia,Gentile, Francesco,Scheveger, Francesco,Olivero, Marco,Colombo, Eleonora,Maranzano, Alessio,Manzoni, Martina,Morelli, Claudia,Doretti, Alberto,Verde, Federico,Silani, Vincenzo,Ticozzi, Nicola,Poletti, Barbara, 2023, Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients, Springer
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