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ExploreInternational audience; Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including accumulation of abnormal proteins...
dementia alzheimer csf markers sequence disease cognitive latent time clinical progression Read moreIntroduction Alzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. Blood is frequently used as a source for biomarkers; however, its complexity prevents pro...
alzheimer metabolites biomarker serum nuclear magnetic resonance single molecule array panel involved ad Read moreHere, using cryo-EM, authors reveal that amyloid-β and tau are identical in Alzheimer disease and Down syndrome. This has implications for assessing whether adults with Down syndrome could be included...
filaments amyloid-β disease alzheimer syndrome ad tau ds Read moreAIMS: To evaluate the potential superiority of donanemab vs. aducanumab on the percentage of participants with amyloid plaque clearance (≤24.1 Centiloids [CL]) at 6 months in patients with early sympt...
disease symptomatic alzheimer tau plaque intermediate arms event months 001 amyloid aducanumab 0 ± ad donanemab doses] q4w iv baseline clearance participants cl Read moreThe activation of the Wnt signaling pathway is implicated in a neuroprotective mechanism against the Alzheimer disease. When this pathway is blocked, it activates GSK3 beta, leading to tau hyperphosph...
binding potential molecular alzheimer disease dkk1 compounds lrp6 Read moreBackground Working memory capacity impairment is an early sign of Alzheimer's disease, but the underlying mechanisms remain unclear. Clarifying how working memory capacity is affected will help us bet...
alzheimer's disease working memory capacity 5xfad mice fos excitatory neuron results wild-type neurons activation disease alzheimer capacity memory cortex excitatory 5xfad prelimbic Read moreAlzheimer's disease prognosis is critical for early Mild Cognitive Impairment patients for timely treatment to improve the patient's quality of life. Whilst existing prognosis techniques demonstrate...
disease model data alzheimer prognosis based hgib Read moreINTRODUCTION: For many patients and caregivers, a major goal of disease-modifying treatments (DMT) for Alzheimer disease (AD) dementia is to extend independence in instrumental and basic activities of...
ad dementia disease alzheimer treatments time clinical extend cdr months Read moreAlzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have sh...
model generalizability dataset disease classification alzheimer Read moreThis study presents an innovative method for Alzheimer's disease diagnosis using 3D MRI designed to enhance the explainability of model decisions. Our approach adopts a soft attention mechanism, ena...
alzheimer disease ad 0 mri Read moreCHRFAM7A is a human-specific gene that encodes the nicotinic acetylcholine receptor (nAChR) subunit dupα7. This gene originated after a fusion between a partial duplication of the CHRNA...
cultures levels significant exposure ma aβ-induced cerveau exposition exprimant aß sous-unité au subunit alzheimer α7-nachr human role disease interneurons neuronal ins chrfam7a aβ gene maladie gène Read moreIL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells...
alzheimer Read moreInternational audience; The exact neuropathological mechanism by which dementia process unfolds is under intense scrutiny. The disease affects about 38 million people worldwide, 70% of w...
functional alzheimer connectivity Read moreAlthough pathogenic variants in PSEN1 leading to autosomal‐dominant Alzheimer disease (ADAD) are highly penetrant, substantial interindividual variability in the rates of cognitive decline and biomark...
nc alzheimer carriers disease interindividual adad pathogenic psen1 tm cy variant Read moreInternational audience; Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including accumulation of abnormal proteins...
dementia alzheimer csf markers sequence disease cognitive latent time clinical progression Read moreInternational audience; The exact neuropathological mechanism by which dementia process unfolds is under intense scrutiny. The disease affects about 38 million people worldwide, 70% of w...
functional alzheimer connectivity Read moreBackground Luffa cylindrica (L.) is an annual climbing plant that produces fibrous fruit and can also be used as a vegetable in northern parts of India. Various studies have been carried out on the pl...
lc–ms alzheimer’s disease in silico amyloid beta docking fruit various perlolyrine disease alzheimer promising activity lc–ms analysis cylindrica luffa Read moreAlzheimer's Disease (AD) is primarily an irreversible neurodegenerative disorder affecting millions of individuals today. The prognosis of the disease solely depends on treating symptoms as they ari...
structural disease alzheimer Read moreInternational audience; Age, sex and APOE-ε4 genotype have been identified as the strongest predictors of the risk of developing Alzheimer's Disease (AD). This work models the pathologic...
disease genotype alzheimer sex Read moreSporadic Alzheimer’s disease (AD) is a complex neurological disorder characterized by many risk loci with potential associations with different traits and diseases. AD, characterized by a progressive ...
alzheimer gene expression genetic correlation neural network alzheimer’s disease models ad network neural traits Read moreNearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent “neurologica...
diseases alzheimer parkinson drugs protein Read moreLarge-scale brain networks undergo widespread changes with older age and in neurodegenerative diseases such as Alzheimer's disease (AD). Research in young adults (YA) suggest that the underlying funct...
emn correlated architecture alzheimer organization brain fc tau networks ad network memory rest adults Read moreLarge-scale brain networks undergo widespread changes with older age and in neurodegenerative diseases such as Alzheimer's disease (AD). Research in young adults (YA) suggest that the underlying funct...
emn correlated architecture alzheimer organization brain fc tau networks ad network memory rest adults Read moreAlzheimer's disease (AD) is a progressive and irreversible brain disorder that unfolds over the course of 30 years. Therefore, it is critical to capture the disease progression in an early stage suc...
alzheimer learning disease ad risk Read moreBackground Evidence on the relative risk of death across all stages of Alzheimer’s disease (AD) is lacking but greatly needed for the evaluation of new interventions. We used data from the Uniform Dat...
mortality alzheimer mild cognitive impairment prodromal ad predementia comorbidity institution study stage relative severity alzheimer’s participants mortality dementia death risk Read moreBackground Amyotrophic lateral sclerosis (ALS) is characterized by a rapid disease course, with disease severity being associated with declining health-related quality of life (HRQoL) in persons livin...
amyotrophic lateral sclerosis quality of life patient-reported outcomes disease progression real-world evidence disease stages als clinical outcomes cals Read moreBackground Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue, expa...
stroke traumatic brain injury sudden cardiac arrest concussion modeling migraine ischemia na/k pump huntington disease alzheimer disease amyotrophic lateral sclerosis ketamine penumbra persistent vegetative state dendritic beading brain swelling spreading brain damage release injury sd excitotoxicity glutamate Read moreBackground Fasciculation is an important sign for the diagnosis of amyotrophic lateral sclerosis (ALS). Our study aimed to analyze the difference in fasciculation detected with muscle ultrasonography ...
amyotrophic lateral sclerosis fasciculation ultrasonography peripheral neuropathy diagnosis als non-als mus muscle patients fasciculation Read moreBackground Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways h...
amyotrophic lateral sclerosis -repeat e... pre-clinical models transcriptome genome-wide mechanisms of neuropro... srsf1-dependent rna nuclear export... disease-modifying gene expression ... voltage-gated potassium ion channe... genome-wide export motor pathological human patient-derived therapeutic neuroprotective nuclear transcripts rna neurons Read moreAims Neuroinflammation might be involved in the degeneration and progression of Amyotrophic Lateral Sclerosis (ALS). Here, we studied the role of the circulating lymphocytes in ALS, in particular the ...
amyotrophic lateral sclerosis circulating blood lymphocytes nk lymphocytes disease progression biomarker circulating analysis increased bulbar gender role lateral nk levels patients sclerosis cells blood lymphocytes disease Read moreAmyotrophic lateral sclerosis (ALS) is a rare, incurable, and fatal neurodegenerative disease with median survival time from onset to death ranging from 20 to 48 months. Breaking bad news about ALS di...
breaking bad news amyotrophic lateral sclerosis diagnosis communication bad breaking news als Read moreAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axo...
cytoskeleton neurofilament mitochondria amyotrophic lateral sclerosis neurodegeneration axonal transport gut microbiome neurons mitochondrial cytoskeletal Read moreBackground This study was an introduction to the Swedish ALSrisc Study and explored the association of lifestyle and medical conditions, with risk and progression of amyotrophic lateral sclerosis (ALS...
amyotrophic lateral sclerosis motor neuron disease neuroepidemiology case-control study smoking study diabetes patients 90 associated 95%ci 0 bmi death diagnosis als lower hr Read moreBackground Law 219/2017 was approved in Italy in December 2017, after a years-long debate on the autonomy of healthcare choices. This Law, for the first time in Italian legislation, guarantees the pat...
amyotrophic lateral sclerosis law 219/2017 mechanical ventilation withdrawal end-of-life care palliative care advance care planning survey patients services care health als italy withdrawal italian law Read moreDysfunction and degeneration of synapses is a common feature of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene is the...
c9orf72 amyotrophic lateral sclerosis frontotemporal dementia synapsin synapse reduced c9als/ftd hippocampal haploinsufficiency als/ftd excitatory interaction synapsin Read moreBackground Patients with amyotrophic lateral sclerosis present perioperative challenges for clinical anesthesiologists for anesthesia-associated complications. Case presentation A 54-year-old Han woma...
amyotrophic lateral sclerosis sacral plexus block dexmedetomidine case report plexus block real-time ultrasound-guided sacral lateral sclerosis amyotrophic Read moreIntroduction Even if electromyography (EMG) is routinely used to confirm the diagnosis of amyotrophic lateral sclerosis (ALS), few studies have analysed the correlation between electrophysiological pa...
amyotrophic lateral sclerosis motor neuron disease electromyography clinical neurophysiology respectively parameters progression p = scores als Read moreObjective Half of ALS patients are cognitively and/or behaviourally impaired. As cognition/behaviour and cerebral glucose metabolism can be correlated by means of ^18F-Fluorodeoxyglucose positron emis...
amyotrophic lateral sclerosis cerebral glucose metabolism fdg-pet cognition grey matter volume cognitively patients results behaviourally cerebral als metabolism impaired alsni alsci alscbi glucose Read moreObjective There is increasing evidence that amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting large-scale brain networks. However, it is still unclear which stru...
amyotrophic lateral sclerosis white matter dti network connectomics machine learning psychoradiology = 0 healthy using motor = 2 structural disease als patients baseline rate Read moreBackground Motor neuron diseases (MND), with amyotrophic lateral sclerosis constituting most cases, are rare conditions of unknown etiology. There have been reports of an increase in incidence during ...
motor neuron disease amyotrophic lateral sclerosis incidence epidemiology age data rate mnd sweden incidence Read moreBackground Magnetic resonance imaging (MRI) of the brain and cervical spinal cord is often performed in diagnostic evaluation of suspected motor neuron disease/amyotrophic lateral sclerosis (MND/ALS)....
motor neuron disease amyotrophic lateral sclerosis mri neurodegenerative disease using precentral ci [95% -scores analysis brain corticospinal 0 mri tract Read moreBackground Observational studies have suggested a close but controversial relationship between blood pressure (BP) and amyotrophic lateral sclerosis (ALS). It remains unclear whether this association ...
amyotrophic lateral sclerosis blood pressure calcium channel blocker mendelian randomization 95% approach study ci = 0 factor pressure blood Read moreAmyotrophic lateral sclerosis (ALS) is an age-related neurodegenerative disease characterized by selective loss of motor neurons in the brainstem and spinal cord. Several genetic factors have been ass...
amyotrophic lateral sclerosis copy number variant customized acgh diagnostics cnvs load disease cnvs load als Read moreBackground Neuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS) indicates that neurodegeneration may spread corticofugally. Methods We conducted an observational study to define the...
amyotrophic lateral sclerosis cortical spreading spreading patterns tdp-43 spreading bulbar limb onset als pattern reported clinical patients Read moreBackground Swallowing dysfunction is related to major cause of adverse events and an indicator of shorter survival among patients with neuromuscular disorders (NMD). It is critical to assess the swall...
tongue thickness tongue pressure amyotrophic lateral sclerosis myotonic dystrophy type 1 duchenne muscular dystrophy patients als mean mtp tt dm1 tongue Read moreThe pathological hallmark of the majority of amyotrophic lateral sclerosis (ALS) cases is the mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43), an RNA-binding protein. Several st...
amyotrophic lateral sclerosis mirna pirna piwi protein tdp-43 protein piwil1 rna als Read moreAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons, leading to paralysis and eventually death. Symptomatic treatments such as i...
amyotrophic lateral sclerosis motor neurons autophagy stem cells gene editing progression therapies als Read moreBackground Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metaboli...
raav2 agranular insula orbitofrontal cortex lateral hypothalamus hypermetabolism amyotrophic lateral sclerosis lateral patients cortex mouse disruption murine hypothalamic projections als Read moreTranscribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for detecting RNA foci, fluorescence in situ hyb...
amyotrophic lateral sclerosis fragile x fxtas repeat-associated non-aug (ran) tr... rna gelation rna foci stress granules g3bp hybridization r-hcr patient Read moreAmyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in which many processes are detected including (neuro)inflammation. Many drugs have been tested for ALS in clinical trial...
amyotrophic lateral sclerosis biomarker inflammation cytokines inflammation als Read morePurpose We examined longitudinal trends and factors associated with insomnia over 3 years in a cohort of young breast cancer patients. Methods Women with stage I–III breast cancer at ≤ 45 years were r...
sleep insomnia breast cancer premenopausal quality of life survivorship 0001 women flashes hot depressive associated symptoms breast < 0 cancer Read moreAim In addition to significant improvements in sensitivity and image quality, the recent introduction of long axial field-of-view (LAFOV) PET/CT scanners has enabled dynamic whole-body imaging for the...
prostate cancer lafov pet/ct whole-body pet/ct dynamic pet [f]psma-1007 kinetic modeling significantly shorter time pet-2 pet-10 differences low-dose static whole-body [^18f]psma-1007 pet/ct lafov patients cancer prostate tumor analysis lesions dynamic ci 95% Read moreBACKGROUND: In ageing societies such as the United States, evaluating the incidence and survival rates of cancer in older adults is essential. This study aimed to analyse the incidence and survival ra...
united cancer incidence individuals 55 years survival Read moreClustered miRNAs consist of two or more miRNAs transcribed together and may coordinately regulate gene expression. Differential expression of clustered miRNAs is found to be controlled by crosstalk of...
dna methylation cancer informatics integrated data analysis epigenomics analysis cpg methylation clustered expression cancer cmirc mirnas Read moreBACKGROUND: We aimed to address the shortage of evidence regarding the safety of the local resection approach by comparing long-term oncological outcomes between patients managed by local resection an...
analysis ncrt cancer rectal patients resection hr = 0 0 95% ci radical local Read moreBACKGROUND: Prognosis is crucial for personalized treatment and surveillance suggestion of the resected non-small-cell lung cancer (NSCLC) patients in stage I-III. Although the tumor-node-metastasis (...
images risk cancer lung ct set treatment foundation patients genotype study egfr system stage ipes hospital prognosis nsclc 0 Read moreOBJECTIVE: We developed a new scale—the Social Adjustment Scale for Youth Cancer Survivors—and examined its psychometric properties. METHODS: In the scale's development stage, preliminary items were c...
properties validity interviews psychometric scale youth social adjustment cancer survivors items Read moreMammary cancer is one of the most common neoplasms of dogs, primarily bitches. While studies have been carried out identifying differing risk of mammary neoplasia in different dog breeds, few studies ...
canine mammary adenoma carcinoma complex mixed cancer studies neoplasia single disease significantly neoplastic associations dog mammary breed multiple odds lesions diagnosis Read moreBackground Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in...
cervical cancer circular rna circmast1 n4-acetylcytidine nat10 yap progression circrnas role tumor cervical cancer assay circmast1 Read morePurpose This study evaluated the risk of metachronous colorectal cancer (CRC) after resection of index (first) rectal cancer in patients with Lynch syndrome (LS). Methods Clinicopathological data of p...
lynch syndrome rectal cancer colorectal cancer metachronous colorectal cancer = 0 9% risk index study colon ls resection cancer metachronous crc Read moreBackground The prevalence of smoking among cervical cancer survivors is high and evidence-based smoking cessation interventions are critically needed. This paper describes the study design, methods, a...
cervical cancer cervical intraepithelial neoplasia... cervical dysplasia cancer smoking smoking cessation tobacco cessation digital history st personally tailored designed individuals efficacy clinical smoking months maps treatment trial Read moreThe International Nuclear Workers Study (INWORKS) contributes knowledge on the dose-response association between predominantly low dose, low dose rate occupational exposures to penetrating forms of io...
cancer epidemiology longitudinal studies dose-response mortality studies effect solid inworks hire modification mortality analyses temporal cancer Read moreObjectives This study constructed a nomogram based on grayscale ultrasound features and real-time shear wave elastography (SWE) parameters to predict thyroid cancer. Methods Clinical data of 217 thyro...
thyroid nodule grayscale ultrasound characteristi... real-time shear wave elastography risk prediction model based analyzed variables parameters independent factors thyroid nomogram prediction model features ultrasound grayscale risk nodules ci 95% swe real-time cancer Read moreBACKGROUND: The early detection and diagnosis of cancer to reduce avoidable mortality and morbidity is a challenging task in primary health care. There is a growing evidence base on how to enable earl...
researchers suggestions cancer research diagnosis primary Read moreBackground The prognosis for recurrence cases of hormone receptor-positive HER2-negative breast cancer remains poor, and treatment strategies that emphasize quality of life have often been chosen, wit...
breast cancer cdk4/6 inhibitors complete remission immune systems immunosenescent t cell recurrence cells recurrence immune cancer breast Read morePurpose Individualized medicine has become increasingly important in bladder cancer treatment, whereas useful biomarkers for prognostic prediction are still lacking. The current study, therefore, cons...
pyroptosis lncrna lmmune bladder cancer regression patients cancer analysis bladder immune Read moreDrug resistance in cancer is associated with overexpression of the multidrug resistance (MDR1) gene, leading to the failure of cancer chemotherapy treatment. Therefore, the establishment of an effecti...
× cancer biosensor dna Read moreBackground Establishing the existence of health inequalities remains a high research and policy agenda item in the United Kingdom. We describe ethnic and socio-economic differences in paediatric cance...
disparities time socio-economic cancer deprivation ethnic survival Read moreBackground In cancer genomic medicine, finding driver mutations involved in cancer development and tumor growth is crucial. Machine-learning methods to predict driver missense mutations have been deve...
driver mutation prediction cancer missense mutation graph neural network molecular interaction mutations networks missense cancer network variants net-dmpred graph Read moreOvarian cancer is one of the common tumors of the female reproductive organs. It has a high mortality rate, is highly heterogeneous, and early detection and primary prevention are very complex. Autoph...
cancer mirnas expression cellular cells ovarian Read moreBACKGROUND: Hepatitis B virus X protein (XTP1) is overexpressed in tumor tissues and regulates cancer progression. However, the molecular mechanism of XTP1 in gastric cancer (GC) is poorly understood....
assessed progression cancer knockdown potential development analysis xtp1 cell assay gc cdk6 migration apoptosis Read moreBackground This study aimed to assess the health-related quality of life (HRQOL) (physical, functional, emotional, social, spiritual) and psychological (anxiety and depression) well-being and their as...
metastatic cancer palliative care quality of life bangladesh physical bangladesh reported spiritual scale metastatic scores cancer patients Read morePurpose Cisplatin resistance is the major obstacle in the clinical treatment of ovarian cancer patients. Molecular mechanisms of cisplatin resistance are multifaceted. Gold(I)-compounds, i.e. N -heter...
cisplatin chemoresistance erk-signaling gold(i)-nhc-complex ovarian cancer thioredoxin reductase a2780cis ovarian cancer auranofin nhc-au -compounds mc3 balance cell redox cisplatin resistance Read morePurpose Within families affected by parental cancer, open communication impacts the well-being of parents and their children; however, limited research exists on communication patterns in these famili...
parental cancer minor children family intervention family-scout qualitative research template analysis health services research study parental parents cancer families patterns interviews communication Read moreAndrogens, or male sex hormones, bind to androgen receptors within prostate cells and can cause growth of prostate cancer. The treatment of prostate cancer often includes drugs that bind to androgen r...
= 0 receptors study results studies treatment treatments brain cbf versus receptor inhibitors significant regions androgen cancer effects blood flow prostate enzalutamide Read moreSIEM systems are prevalent and play a critical role in a variety of analyst workflows in Security Operation Centers. However, modern SIEMs face a big challenge: they still cannot relieve analysts fr...
security Read moreThis work deals with a novel Gaussian filter-based pressure correction technique with a super compact higher order finite difference scheme for solving unsteady three-dimensional (3D) incompressible...
3d fluid numerical gaussian grid scheme accuracy time pressure level Read moreThis paper introduces GET-Zero, a model architecture and training procedure for learning an embodiment-aware control policy that can immediately adapt to new hardware changes without retraining. To ...
transformer get-zero model embodiment Read moreDeep Ultraviolet (DUV) Photolithography is currently used to fabricate mass-scale integrated circuits (ICs). Its high throughput and resolution could benefit large-scale RF MEMS production for the t...
resonators Read moreThe increasing popularity of online services has made Internet Traffic Classification a critical field of study. However, the rapid development of internet protocols and encryption limits usable dat...
datasets techniques encrypted traffic classification data internet augmentation Read moreWe present an approach to the coupling of mixed-dimensional continua by employing the mathematically enriched linear Cosserat micropolar model. The kinematical reduction of the model to lower dimens...
reinforced Read moreThe Cox Proportional Hazards (CPH) model has long been the preferred survival model for its explainability. However, to increase its predictive power beyond its linear log-risk, it was extended to u...
proportional cox nam-based survival hazards senn networks neural model Read moreWith the rapid advancement of stereo vision technologies, stereo image compression has emerged as a crucial field that continues to draw significant attention. Previous approaches have primarily emp...
science computer bidirectional image compression Read moreWith the rapid development of location based services, multimodal spatio-temporal (ST) data including trajectories, transportation modes, traffic flow and social check-ins are being collected for de...
learning mobility based features scenarios smart transportation multimodal st Read moreWhile a lucrative and growing field, low levels of gender and racial diversity in CS remain prevalent. Education and workforce support programs with the intention to promote underrepresented student...
program science inform impact participants computer capital cs students persistence programs Read moreMemory management is necessary with the increasing number of multi-connected AI devices and data bandwidth issues. For this purpose, high-speed multi-port memory is used. The traditional multi-port ...
memory proposed multi-port Read moreControl of off-road vehicles is challenging due to the complex dynamic interactions with the terrain. Accurate modeling of these interactions is important to optimize driving performance, but the re...
model Read moreCross-domain recommendation has attracted substantial interest in industrial apps such as Meituan, which serves multiple business domains via knowledge transfer and meets the diverse interests of us...
industrial framework recommendation domains Read moreLarge language models (LLMs) have garnered increasing attention owing to their powerful logical reasoning capabilities. Generally, larger LLMs (L-LLMs) that require paid interfaces exhibit significa...
logical reasoning logic distillation ld s-llms planning decision-making capabilities Read moreWe introduce NOVIC, an innovative real-time uNconstrained Open Vocabulary Image Classifier that uses an autoregressive transformer to generatively output classification labels as language. Leveragin...
labels science text vocabulary image object computer Read moreThis study assesses landslide vulnerability in the Chittagong Hill Tracts (CHT), specifically focusing on Bandarban district in Southeast Bangladesh. By employing a multidisciplinary approach, thirt...
susceptibility Read moreSome blockchain networks employ a distributed consensus algorithm featuring Byzantine fault tolerance. Notably, certain public chains, such as Cosmos and Tezos, which operate on a proof-of-stake mec...
byzantine data consensus blockchains blockchain distribution time block Read moreAn effective paradigm of multi-modal learning (MML) is to learn unified representations among modalities. From a causal perspective, constraining the consistency between different modalities can min...
learn learning modalities $c^3$ causal Read morePanoramic cycling videos can record 360{\deg} views around the cyclists. Thus, it is essential to conduct automatic road user analysis on them using computer vision models to provide data for studie...
videos computer data models Read moreWhile hallucinations of large language models (LLMs) prevail as a major challenge, existing evaluation benchmarks on factuality do not cover the diverse domains of knowledge that the real-world user...
factuality real-world hallucinations entities llms Read moreWe study the average edit distance between two random strings. More precisely, we adapt a technique introduced by Lueker in the context of the average longest common subsequence of two random string...
edit distance improve average Read moreThere is increased interest in the interplay between text and visuals in the field of data visualization. However, this attention has predominantly been on the use of text in standalone visualizatio...
visualization practices interactive data text dashboard Read moreGraph Neural Networks (GNNs) have achieved notable success in the analysis of non-Euclidean data across a wide range of domains. However, their applicability is constrained by the dependence on the ...
neural features node graph Read moreImplicit neural fields have made remarkable progress in reconstructing 3D surfaces from multiple images; however, they encounter challenges when it comes to separating individual objects within a sc...
segmentation objects method introduce Read moreUnderstanding user interests is crucial for Click-Through Rate (CTR) prediction tasks. In sequential recommendation, pre-training from user historical behaviors through self-supervised learning can ...
user tasks ctr pre-trained models Read moreBackground Public transportation plays a major role in the transmission of SARS-CoV2, the virus that causes COVID-19, due to the confined spaces in vehicles. It is therefore very crucial to apply COVI...
covid-19 public transportation public transport operators covid-19 preventive measures study risk eastern uganda epidemic aware included interviews participants awareness perceptions public transportation covid-19 perceived covid passengers barriers operators challenges 19 preventive transmission transport measures Read moreBackground Public transportation plays a major role in the transmission of SARS-CoV2, the virus that causes COVID-19, due to the confined spaces in vehicles. It is therefore very crucial to apply COVI...
covid-19 public transportation public transport operators covid-19 preventive measures study risk eastern uganda epidemic aware included interviews participants awareness perceptions public transportation covid-19 perceived covid passengers barriers operators challenges 19 preventive transmission transport measures Read moreBACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...
36 reduce week covid covid-19 outcome placebo amubarvimab/romlusevimab Read moreBACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...
36 reduce week covid covid-19 outcome placebo amubarvimab/romlusevimab Read moreObjective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...
physical rehabilitation early mobilization critical illness occupational therapy physical therapy covid outcomes care < 0 am-pac covid-19 physical hospital 001 Read moreBackground Public transportation plays a major role in the transmission of SARS-CoV2, the virus that causes COVID-19, due to the confined spaces in vehicles. It is therefore very crucial to apply COVI...
covid-19 public transportation public transport operators covid-19 preventive measures study risk eastern uganda epidemic aware included interviews participants awareness perceptions public transportation covid-19 perceived covid passengers barriers operators challenges 19 preventive transmission transport measures Read moreObjective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...
physical rehabilitation early mobilization critical illness occupational therapy physical therapy covid outcomes care < 0 am-pac covid-19 physical hospital 001 Read moreThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Read moreBackground Public transportation plays a major role in the transmission of SARS-CoV2, the virus that causes COVID-19, due to the confined spaces in vehicles. It is therefore very crucial to apply COVI...
covid-19 public transportation public transport operators covid-19 preventive measures study risk eastern uganda epidemic aware included interviews participants awareness perceptions public transportation covid-19 perceived covid passengers barriers operators challenges 19 preventive transmission transport measures Read moreBACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...
36 reduce week covid covid-19 outcome placebo amubarvimab/romlusevimab Read moreAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Read moreThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Read moreThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Read moreBackground Public transportation plays a major role in the transmission of SARS-CoV2, the virus that causes COVID-19, due to the confined spaces in vehicles. It is therefore very crucial to apply COVI...
covid-19 public transportation public transport operators covid-19 preventive measures study risk eastern uganda epidemic aware included interviews participants awareness perceptions public transportation covid-19 perceived covid passengers barriers operators challenges 19 preventive transmission transport measures Read moreBACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...
36 reduce week covid covid-19 outcome placebo amubarvimab/romlusevimab Read moreBackground Public transportation plays a major role in the transmission of SARS-CoV2, the virus that causes COVID-19, due to the confined spaces in vehicles. It is therefore very crucial to apply COVI...
covid-19 public transportation public transport operators covid-19 preventive measures study risk eastern uganda epidemic aware included interviews participants awareness perceptions public transportation covid-19 perceived covid passengers barriers operators challenges 19 preventive transmission transport measures Read moreLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Read moreAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Read moreAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Read moreObjective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...
physical rehabilitation early mobilization critical illness occupational therapy physical therapy covid outcomes care < 0 am-pac covid-19 physical hospital 001 Read moreLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Read moreAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Read moreThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Read moreAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Read moreLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Read moreHPTN 083 demonstrated that injectable cabotegravir (CAB) was superior to oral tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) for HIV prevention in cisgender men and transgender women who have s...
083 tdf-ftc insti administration hptn arm hiv testing resistance Read moreBackground Depression is the most common psychiatric disorder in HIV/AIDs patients, and its prevalence is three times higher in HIV/AIDs patients. Globally, over 35 million people were living with HIV...
hiv aids prevalence factors associated depression art somalia adult living banadir odds treatment hospital adherence mogadishu unit somalia art hiv/aids patients depression Read moreBACKGROUND: Children under age five years, particularly those living with HIV (CLHIV), are at risk for rapid progression of tuberculosis (TB). We aimed to describe TB clinical presentations, diagnosti...
shorter time services associated enrolled [0 [1 0 aor p = 0 hiv diagnosis tb children clhiv Read moreBackground While triple anti-retroviral therapy (ART) has improved HIV-infected children surviving into adolescence and adulthood, these children remain vulnerable to HIV-related psychological disturb...
children and adolescents living wi... emotional and behavioural difficul... art teen club malawi study aor single parent prosocial conduct hyperactivity 95% ci descriptive behavioural children hiv stage art challenges results teen clubs adolescents clinical Read moreBackground Scholars recommend providing migrants living with HIV (MLWH) with free treatment, rapidly, once linked to care to optimize their HIV-related experiences and health outcomes. Quantitative ev...
migrants hiv patient-reported outcomes care experience multidisciplinary satisfaction free region birth patient-reported experiences care hiv experience perceived measure treatment differed significantly scores Read moreBackground People who inject drugs (PWID) in Europe are at an increased risk of HIV/AIDS, chronic viral hepatitis B (HBV) and C (HCV), and tuberculosis (TB). We aimed to complement the evidence base o...
good practice pwid care continuum hcv hiv europe implemented drugs practice interventions european cascade evidence pwid mogps settings care Read moreBACKGROUND: Structural interventions are endorsed to enhance biomedical and behavioural HIV prevention programmes for adolescents. Aiming to inform future interventions, we evaluated longitudinal asso...
five south structural adolescents multiple adolescent 91 factors probability associated pr = 0 lower sex hiv 95%ci = 0 risk behaviours maximum scores mean age-disparate supervision caregiver protective interventions transactional caregiving food sexual Read moreOBJECTIVES: We examined the impact of COVID-19-related restrictions on sexual behaviours, STI and HIV testing and testing need among men who have sex with men (MSM) in the UK. METHODS: We used social ...
p1 surveys increased recent 0% low p3 msm unmet hiv sex p2 p<0 aor vs reporting testing 001 sti Read moreBackground Neuromyelitis optica spectrum disorder (NMOSD) are autoimmune inflammatory disorders of the CNS in which patients have severe relapses of optic neuritis and myelitis. Aquaporin-4 antibody (...
neuromyelitis optica spectrum diso... familial nmosd nmosd genetics nmosd sub-saharan africa familial nmosd sub-saharan africa.... doses familial oral studies nmosd hiv Read moreWomen’s ability to control their fertility and have the number of children they want when they want them is an internationally recognized human right. This right has been the driving force behind fami...
family planning women living with hiv counseling low and middle income countries women’s behaviors review services hiv Read moreIntroduction Amid the global health crisis, HIV/TB co-infection presents significant challenges, amplifying the burden on patients and healthcare systems alike. Metabolomics offers an innovative windo...
tb hiv co-infection metabolomics urine gc-ms metabolomics co-infection hiv/tb metabolic Read moreBACKGROUND: Human Immunodeficiency Virus (HIV) infection remains a public health concern in many countries. The increased life expectancy in the post-Antiretroviral Therapy (ART) era has led to an inc...
study association cardiovascular hiv 0 medications antiretroviral factors associated p-value participants increased 95%ci hiv-related health risk aor Read moreBackground While there is no cure for HIV, adherence to antiretroviral therapy can extend the lifespan and improve the quality of life of people with HIV. Despite the global reduction of HIV infection...
medication adherence people with hiv (pwh) antiretroviral therapy (art) mobile health (mhealth) spanish speakers latinos medication republic dominican populations hiv people study trial mhealth Read moreBackground The gains from successful antiretroviral therapy (ART) roll-out could be compromised by the increasing burden of non-communicable diseases, particularly cardiovascular diseases among people...
hypertension prevalence art-naïve plwh hiv nigeria diseases burden art plwh study 95%ci hypertension – Read moreThe HIV treatment landscape in low- and middle-income countries (LMICs) is rapidly evolving, exemplified by the expansion of differentiated service delivery (DSD) during the coronavirus disease (COVID...
long-acting antiretrovirals hiv treatment hiv service delivery hiv product attributes end user preferences long-acting populations studies hiv research service plhiv product delivery Read moreIntroduction Since 2019, for the first time, a two-drug regimen with dolutegravir/lamivudine (DTG/3TC) has been recommended for HIV treatment as initial and subsequent therapy in the international gui...
antiretroviral therapy dolutegravir effectiveness hiv integrase strand transfer inhibito... lamivudine post-marketing surveillance safety 2-drug regimen surveillance post-marketing art-experienced adrs dtg/3tc safety evaluated effectiveness patients Read moreThe latent reservoir of HIV persists for decades in people living with HIV (PWH) on antiretroviral therapy (ART). To determine if persistence arises from the natural dynamics of memory CD4+ T cells ha...
persistence cells natural cd4+ dynamics proviruses hiv Read moreBackground The rapid start of antiretroviral therapy (RSA) model initiates antiretroviral therapy (ART) as soon as possible after a new or preliminary diagnosis of HIV, in advance of HIV-1 RNA and oth...
hiv art rapid start art community-based health care hiv viral load suppression time therapy accepted days b/f/taf virologic community-based participants suppression hiv study rsa antiretroviral Read moreBackground Retention in care and HIV viral load suppression remains sub-optimal among HIV positive adolescents in many settings including TASO Uganda, despite the implementation of interventions such ...
hiv adolescents otz viral load retention soroti centers mbale hiv taso model Read moreINTRODUCTION: Availability of anti-retroviral treatment has changed HIV in to a manageable chronic disease, making effective self-management essential. However, only a few studies in low- and middle-i...
factors hiv service effective care patients self-management Read moreIndetectable = Intransmisible (I = I) comunica que las personas que viven con VIH (PVVIH) y reciben tratamiento antirretroviral (TAR) no transmitirán el VIH a sus parejas sexuales. En este estudio, de...
latin america u = u sexual and gender minorities hiv incluyó desconocido riesgo educación brasil méxico estado perú risk using education gender conscientes unknown hiv u = u pvvih plhiv vih awareness status los tar concienciación eran hiv-negative mexico brazil peru art i = i las el con lower Read morePurpose This study aimed to examine the impact of the COVID-19 lockdown on social determinants of health (SDOH) among Blacks with HIV and a comorbid diagnosis of hypertension or type 2 diabetes mellit...
covid-19 african american lockdown social determinants of health health disparities blacks minorities racial ethnic lockdown sdoh pre-lockdown hiv Read moreObjectives. To assess changes in minor consent laws for sexually transmitted infection (STI) and HIV testing, treatment, and prevention services in all 50 US states and the District of Columbia from 1...
confidentiality minor testing minors treatment sti hiv laws services prevention Read moreBackground Persons with opioid use disorders who inject drugs (PWID) in the United States (US) face multiple and intertwining health risks. These include interference with consistent access, linkage, ...
hptn moud including integra 26 weeks 094 prep navigation peer care access trial health mobile prevention unit treatment hiv Read moreBackground Several studies have shown different effects of telehealth interventions on adherence to Antiretroviral therapy (ART) among people living with HIV. This study conducted a meta-analysis of R...
digital health hiv acquired immunodeficiency syndrome... adherence antiretroviral therapy (art) telemedicine meta-analysis using rcts pooled intervention ci 95% telehealth art hiv adherence patients Read moreAll H5N8 genome sequences of HA segment are available in the GISAID database (https://www.gisaid.org). The prior values and distributions of the model parameters are described in SI Appendix Table S2....
pathogenic highly available influenza avian sequences birds transmission hpaiv epidemic farms Read moreBacillus Calmette-Guerin (BCG) and the cell wall skeleton (CWS) derived from BCG are known to enhance nonspecific immune activation and anti-cancer immunity; however, their roles as a vaccine adjuvant...
bcg vaccine protective responses adjuvant immune influenza Read moreBackground The burden of influenza morbidity and mortality in nursing homes (NH) is high. Vaccination of residents and professionals working in NH is the main prevention strategy. Despite recommendati...
vaccination influenza nursing homes healthcare workers vaccine coverage 0] 1–1 using nationwide increase nh vaccination [1 nursing professionals coverage information hcw influenza Read moreINTRODUCTION: Influenza virus infection is associated with high morbidity and mortality, and so additional therapeutic strategies to reduce the burden for healthcare systems are needed. Statins, by vi...
statin studies meta-analysis 0 95% ci statins influenza patients virus mortality Read moreBackground We aimed to investigate the clinical characteristics of severe influenza virus-associated pneumonia complicated with bacterial infection in children. Methods We retrospectively analysed dat...
bacteria children infection influenza virus pneumonia significant children statistically bacteria 05 < 0 clinical complicated observation infection influenza severe pneumonia virus-associated Read moreUptake of influenza vaccine among pregnant women remains low. We investigated whether unvaccinated pregnant women were clustered geographically and determined factors associated with failure to vaccin...
associated influenza clusters odds factors 95% pregnant or = 1 ci unvaccinated Read moreBackground: Procalcitonin (PCT) and C-Reactive protein (CRP) are well-established sepsis biomarkers. The association of baseline PCT levels and mortality in pneumonia remains unclear, and we still do ...
severe influenza patients bc compared mortality pvp biomarkers 0 pneumonia [0 crp versus levels Read moreBackground The impact of coronavirus diseases 2019 (COVID-19) related non-pharmaceutical interventions (NPIs) on influenza activity in the presence of other known seasonal driving factors is unclear, ...
influenza-like illness non-pharmaceutical intervention covid-19 sars-cov-2 influenza china factors 95% 2020–2021 respectively seasonal driving presence interventions ili counts weekly ci impact study npis covid-19 sar Read moreBACKGROUND: Cardiovascular diseases (CVDs) are consistently ranked among the leading causes of death among older adults in Ireland. COVID-19 and influenza infection are associated with cardiovascular ...
covid-19 adults quarter cvd 2020 data cardiovascular rates excess ireland mortality influenza ia 0 Read moreBACKGROUND: The Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD (PAIVED) is a multicenter study assessing influenza vaccine effectiveness in active duty service members, retirees, a...
2019-20 2018-19 vaccine seasons 6% 2020-21 pandemic covid-19 reporting participants ili paived influenza Read moreBACKGROUND: Influenza viruses are dangerous pathogens. Seventy-Seven genomes of recently emerged genotype 4 reassortant Eurasian avian-like H1N1 virus (G4-EA-H1N1) are currently available. We investig...
influenza genome pqs g4-ea-h1n1 genomes Read moreBackground Influenza A virus (IAV) remains an important global public health threat with limited epidemiological information available from low-and-middle-income countries. The major objective of this...
influenza active surveillance influenza like illness (ili) severe acute respiratory illness (... pandemic seasonal influenza influenza observed surveillance ili positive Read moreThe 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first...
influenza genomic 1918 iav Read moreBACKGROUND: Influenza vaccine hesitancy rates are increasing in the United States, even as influenza infection accounts for significant pediatric morbidity and mortality. Disinformation and controvers...
regression 01 ppcc vaccinations visits rates 0 vaccination 2021-22 seasons pediatric social season clinic vaccine [0 patients pandemic influenza Read moreBACKGROUND: It is well known that influenza and other respiratory viruses are wintertime-seasonal in temperate regions. However, respiratory disease seasonality in the tropics remains elusive. In this...
disease collected ili annual nonannual influenza respiratory Read moreWhile often believed to be a passive agent that merely exploits its host's metabolism, influenza virus has recently been shown to actively move across glycan-coated surfaces. This form of enzymatica...
influenza Read moreBACKGROUND: Respiratory virome is an integral part of the human microbiome and its characterization may contribute to a better understanding of the changes that arise in the disease and, consequently,...
syncytial results presence n = 1 samples acute influenza metapneumovirus wori rhinovirus study virus n = 2 human viruses lower patients n = 3 Read moreInternational audience; Objective: To evaluate vaccination coverage and reasons for non-vaccination in patients with primary Sjögren's syndrome (pSS). Method: A total of 111 patients ful...
3% low vaccine 0 coverage patients 95% pss ci influenza Read moreSIMPLE SUMMARY: Ten years have passed since the beginning of the H1N1pdm09 flu pandemic. No sooner had humanity recovered from its consequences than a new attack came—the COVID-19 pandemic. What happe...
respiratory covid-19 rhinoviruses influenza viruses Read moreBACKGROUND: Many pregnant women and parents have concerns about vaccines. This analysis examined the impact of MomsTalkShots, an individually tailored educational application, on vaccine attitudes of ...
women 55% baseline intervention confidence educational tailored vs 95%ci perceived influenza increased infant attitudes pregnant knowledge vaccine maternal Read moreManaging sanitary crises linked to avian influenza viruses has become a crucial challenge for the long-term sustainability of the European poultry sector. In the last decade, Europe has...
voies sector région routes foyers region live resulting afin outbreaks patterns exchange canards duck élevages influenza france farms hpai – densité 2016 épizootie density epizootic avons réduction sud-ouest vivants southwest iahp farm virus propagation reduction avian aviaire transmission 2017 mouvements Read moreOBJECTIVE: The 2022 Australian winter was the first time that COVID-19, influenza and respiratory syncytial virus (RSV) were circulating in the population together, after two winters of physical dista...
testing-based sentinel results incidence programme surveillance covid-19 influenza participants Read moreInternational audience; In 2016/2017, H5N8 highly pathogenic avian influenza (HPAI) virus of the Goose/Guangdong lineage spread from Asia to Europe, causing the biggest and most widespre...
hpai epidemic duck tropism enterotropism highly intestinal avian respiratory influenza virus pathogenic species h5n8 viruses Read moreInternational audience; AbstractLow-pathogenicity avian influenza H9N2 remains an endemic disease worldwide despite continuous vaccination, indicating the need for an improved vaccine st...
administered adjuvants antigen-specific inactivated influenza avian cell h9n2 subtilis spores Read moreBackground At the time of the SARS-CoV-2 emergence, asthma patients were initially considered vulnerable because respiratory viruses, especially influenza, are associated with asthma exacerbations, in...
asthma covid-19 influenza prognosis clinical data warehouses 95% hospitalized 2017–2018 2018–2019 ci factors risk asthma influenza covid-19 Read moreBackground The urinary tract harbors unique microbial communities that play important roles in urogenital health and disease. Dogs naturally suffer from several of the same urological disorders as hum...
urinary microbiota canine urine collection technique cystocentesis midstream voiding p = results composition diversity study urinary samples microbiota canine cystocentesis Read moreBackground Pediatric chronic intestinal pseudo-obstruction (PIPO) is a rare disease characterized by symptoms and radiological signs suggestive of intestinal obstruction, in the absence of lumen-occlu...
chronic intestinal pseudo-obstruct... gut microbiota serotonin pathway peristalsis dysbiosis controls gut 5-ht pipo mam patients intestinal results serotonin microbiota Read moreBackground Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with di...
human papillomavirus cervical screening cervicovaginal microbiota metabolomics microbiota results cervicovaginal acid Read moreBackground Aspergillus species cause a variety of serious clinical conditions with increasing trend in antifungal resistance. The present study aimed at evaluating hospital epidemiology and antifungal...
spp. prevalence incidence species distribution antifungal compounds mic epidemiological cut-off values clsi or = 0 species risk january compared [0 0 hospital seasonality aspergillus ci 95% = 0 antifungal niger isolates susceptibility or = 2 clinical [1 Read moreThe mycobiome, comprising fungi inhabiting plants, potentially plays a crucial role in tree health and survival amidst environmental stressors like climate change and pathogenic fungi. Understanding t...
plant-host relationship drought stress genotypic variation microbes fungal community environmental conditions ecosystems water composition root spruce norway phloem forest fungi Read moreDiaporthe is an important plant pathogenic genus, which also occurs as endophytes and saprobes. Many Diaporthe species that are morphologically similar proved to be genetically distinct. The current u...
coalescence-based models gcpsr ptp/mptp species/species-complexes species boundaries taxonomy boundaries species genus Read moreBackground Hemotropic Mycoplasma species (hemoplasmas) cause hemolytic anemia in cats worldwide and are recognized as emerging zoonotic pathogens. There is no comprehensive study on the prevalence and...
emerging pathogens hemotropic mycoplasmas pcr zoonoses hemotropic mhf iran study prevalence cmhm cats species mycoplasma Read moreBackground Carbapenems represent the first line treatment of serious infections caused by drug-resistant Klebsiella pneumoniae . Carbapenem-resistant K. pneumoniae (CRKP) is one of the urgent threats ...
carbapenem-resistant coumarin qrt-pcr checkerboard assay molecular docking binding inhibitory carbapenemases expression molecular assay isolates crkp pneumoniae coumarin carbapenemase Read moreBackground Non-reducing polyketide synthases (NR-PKSs) account for a major share of natural product diversity produced by both Asco- and Basidiomycota. The present evolutionary diversification into el...
biosynthesis enzyme engineering orsellinic acid polyketide synthase sat domain polyketide clade domains sat-domainless domain Read moreThe ecosystem of the earth is fascinating and intricate. The interactions that occur in the soil affect its characteristics as a substrate for development and activity of soil microorganisms and plant...
amf mycorrhiza helper bacteria rhizobacteria rhizosphere inter-organismal cross-talk hyphosphere rhizosphere plant soil interactions microorganisms fungi amf Read moreBackground The production of succinic acid (SA) from biomass has attracted worldwide interest. Saccharomyces cerevisiae is preferred for SA production due to its strong tolerance to low pH conditions,...
succinic acid genetic background comparative transcriptomic analysi... response mechanism acid production folding study tolerance whereas cerevisiae strains sa genes protein significantly Read moreBackground Primary nephrotic syndrome (PNS) is a common glomerular disease in children. Clostridium butyricum ( C. butyricum), a probiotic producing butyric acid, exerts effective in regulating inflam...
pns inflammation th17/tregs gut microbiota urinary microbiota treatment pns gut-kidney axis urine butyricum Read moreBackground Fenofibrate is a compound with diverse biological properties that can be utilized to lower blood lipids. Understanding the impact of the gut microbiota in hyperlipidemia is vital for contro...
intestinal flora hyperlipidemic hamsters fenofibrate metagenomics microbiota pathways hfd treated bacteroides genes hamsters lipid gut Read moreThe chalara-like anamorphs of Leotiomycetes are phialidic hyphomycetes with cylindrical collarettes and deeply seated sporulating loci, and hyaline, aseptate or septate, cylindrical conidia. They are ...
leotiomycetes chalara-like fungi anamorphs diversity taxonomy phylogeny china tapesina nagrajchalara bloxamia bioscypha didonia phaeoscypha accepted phialides anamorphs conidial genus str genera species diao wu chalara-like chalara Read moreBackground Antimicrobial resistant infections continue to be a leading global public health crisis. Mobile genetic elements, such as plasmids, have been shown to play a major role in the dissemination...
short-read whole genome sequencing... carbapenem resistance esbls plasmids sequence health antimicrobial identified plasmid-borne bla carbapenem plasmids coli resistant Read moreBackground Migratory birds exhibit heterogeneity in foraging strategies during wintering to cope with environmental and migratory pressures, and gut bacteria respond to changes in host diet. However, ...
black-necked crane diet gut fungi wintering period wintering late winter black-necked period cranes significantly fungi diet composition food gut Read moreBackground Haemophilus influenzae ( Hi ) is an emerging cause of early onset neonatal sepsis, but mechanisms of transmission are not well understood. We aimed to determine the prevalence of vaginal ca...
perinatal pathogen vertical transmission neonatal infection vaginal microbiome haemophilus hpd carriage hi demographic positive presence vaginal Read moreBackground Small peptides play a crucial role in plant growth and adaptation to the environment. Exogenous small peptides are often applied together with surfactants as foliar fertilizers, but the imp...
(l.) o. ... phyllosphere small peptides surfactants rhamnolipid microorganisms diversity community plant Read moreBackground The increasing incidence and prevalence of carbapenem-resistant Enterobacter cloacae complex (CREC) poses great challenges to infection prevention and disease treatment. However, much remai...
complex carbapenemase ndm-5 ndm-1 st171 st418 bla 8% hospital 05 gene sts crec isolates st418 st171 Read more