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ExplorarINTRODUCTION Despite increasing evidence of a role of rare genetic variation in the risk of Alzheimer's disease (AD), limited attention has been paid to its contribution to AD-related biomarker tra...
traits biomarker novel variation rare whole-exome disease alzheimer Leer másAlzheimer's Disease is an incurable cognitive condition that affects thousands of people globally. While some diagnostic methods exist for Alzheimer's Disease, many of these methods cannot detect Al...
science disease anns alzheimer Leer másAlthough pathogenic variants in PSEN1 leading to autosomal‐dominant Alzheimer disease (ADAD) are highly penetrant, substantial interindividual variability in the rates of cognitive decline and biomark...
nc alzheimer carriers disease interindividual adad pathogenic psen1 tm cy variant Leer másMotivation: Electronic Health Records (EHR) represent a comprehensive resource of a patient's medical history. EHR are essential for utilizing advanced technologies such as deep learning (DL), enabl...
attention rnn alzheimer propose clinical performance ehr dl visits Leer másAlzheimer's Disease is a devastating neurological disorder that is increasingly affecting the elderly population. Early and accurate detection of Alzheimer's is crucial for providing effective treat...
mri detection alzheimer disease Leer másAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Early detection of AD is crucial for effective intervention and treatment. In...
spontaneous alzheimer language disease pause method information speech detection ad Leer másAlthough pathogenic variants in PSEN1 leading to autosomal‐dominant Alzheimer disease (ADAD) are highly penetrant, substantial interindividual variability in the rates of cognitive decline and biomark...
nc alzheimer carriers disease interindividual adad pathogenic psen1 tm cy variant Leer másThe global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease (AD) and associated socioeconomic burdens. Abnormal metabolism of amyloid‐β (Aβ) has been...
research aβ neuroprotective disease neurodegeneration alzheimer ad Leer másAlzheimer's disease (AD) is a multi-facet pathology, that can be monitored through a variety of data types. This thesis aims to leverage multimodal longitudinal data, especially imaging...
time variety fournir clinical provide biomarqueurs biomarkers fil temps données data variété au grande ma ad progression disease alzheimer maladie Leer másAlzheimer's Disease is an incurable cognitive condition that affects thousands of people globally. While some diagnostic methods exist for Alzheimer's Disease, many of these methods cannot detect Al...
science disease anns alzheimer Leer másINTRODUCTION: For many patients and caregivers, a major goal of disease-modifying treatments (DMT) for Alzheimer disease (AD) dementia is to extend independence in instrumental and basic activities of...
ad dementia disease alzheimer treatments time clinical extend cdr months Leer másBackground A positive effect of the effect of a 3-month oral spermidine intake on memory performance has already been demonstrated. The continuation of this study aimed to examine whether there could ...
alzheimer nutrition biogen amines memory perfomance cerad-plus memory results performance positive effect Leer másObjective Research the dose–response relationship between overall and certain types of exercise and cognitive function in older adults with Alzheimer's disease and dementia. Design Systemic and Bayesi...
old adults alzheimer dementia exercise dose–response rcts network meta-analysis sd disease ae optimal cri effective cognitive exercise 0 95% mets-min/week dose smds Leer másInsoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer’s ...
alzheimer tau seeding spreading microglia propagation oligomeric compared seeding tau Leer másAlzheimer's disease (AD) is a leading neurodegenerative condition and the primary cause of dementia, characterized by progressive cognitive decline and memory loss. Its progression, marked by shrink...
weight ad scheme flexi-fuzz-lssvm approach samples flexi-fuzz noise diagnosis alzheimer proposed models imbalance class Leer másCHRFAM7A is a human-specific gene that encodes the nicotinic acetylcholine receptor (nAChR) subunit dupα7. This gene originated after a fusion between a partial duplication of the CHRNA...
cultures levels significant exposure ma aβ-induced cerveau exposition exprimant aß sous-unité au subunit alzheimer α7-nachr human role disease interneurons neuronal ins chrfam7a aβ gene maladie gène Leer másAlzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory and cognitive decline, affecting millions worldwide. Diagnosing AD is challenging due to its heterogeneou...
gnns computer science neuroimaging cognitive brain alzheimer ad layer Leer másAlzheimer's disease (AD) is a progressive neurodegenerative disorder with increasing prevalence among the aging population, necessitating early and accurate diagnosis for effective disease managemen...
science 3d computer 2d results alzheimer disease diagnosis Leer másAlzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have sh...
model generalizability dataset disease classification alzheimer Leer másAmyloid β protein (Aβ) and tau, the two main proteins implicated in causing Alzheimer's disease (AD), are posited to trigger synaptic dysfunction long before significant synaptic loss occurs in vulner...
dysfunction forms plasticity alzheimer patient amyloid ad ltp brain aβ protein synaptic Leer másAlzheimer's Disease is a progressive neurological disorder that is one of the most common forms of dementia. It leads to a decline in memory, reasoning ability, and behavior, especially in older peo...
disease alzheimer Leer másInternational audience; The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the identification of many diseases. This article aimed to ...
alzheimer diseases biomarker parkinson molecularly imprinted polymers disease biomarkers Leer másMotivation: Electronic Health Records (EHR) represent a comprehensive resource of a patient's medical history. EHR are essential for utilizing advanced technologies such as deep learning (DL), enabl...
attention rnn alzheimer propose clinical performance ehr dl visits Leer másIntroduction Alzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of life. Clinic...
aducanumab alzheimer’s disease β-amyloid cholinesterase inhibitors dementia cognitive dysfunction early-onset alzheimer’s disease inflammation late-onset alzheimer’s disease n-methyl-d-aspartate neurodegeneration neurofibrillary tangles memory neurocognitive disorders senile plaques tau proteins alzheimer Leer másINTRODUCTION: Previous studies have applied normative modeling on a single neuroimaging modality to investigate Alzheimer Disease (AD) heterogeneity. We employed a deep learning-based multimodal nor...
ad individual-level modeling alzheimer abnormality normative disease atn Leer másBackground Actigraphy has been proposed as a measure for tracking functional decline and disease progression in patients with Motor Neuron Disease (MND). There is, however, little evidence to show tha...
accelerometry amyotrophic lateral sclerosis longitudinal cohort study motor neuron disease vs wrist- n = compared measures 0 actigraphy patients mnd functional disease Leer másTDP-43 is an aggregation-prone protein which accumulates in the hallmark pathological inclusions of amyotrophic lateral sclerosis (ALS). However, the analysis of deeply phenotyped human post-mortem sa...
tdp-43 loss-of-function neuropathology cryptic splicing rna aptamer amyotrophic lateral sclerosis cognition als demonstrate events tdp-43 loss-of-function cryptic manifestation stmn-2 Leer másBackground This study aimed at providing diagnostic properties and normative cut-offs for the Italian ECAS Carer Interview (ECAS-CI). Materials N = 292 non-demented ALS patients and N = 107 healthy ...
edinburgh cognitive and behavioura... amyotrophic lateral sclerosis frontotemporal degeneration behavioural symptom psychometrics ecas fbi sc ecas-ci nos Leer másBackground Amyotrophic lateral sclerosis (ALS) is an irreversible degenerative disease. Placebo-controlled randomized trials are currently the main trial design to assess the clinical efficacy of drug...
amyotrophic lateral sclerosis disease course placebo model-based meta-analysis (mbma) lateral time sclerosis duration drug amyotrophic development trials course clinical os als Leer másBackground Flail arm syndrome is a restricted phenotype of motor neuron disease that is characterized by progressive, predominantly proximal weakness and atrophy of the upper limbs. Objective The stud...
amyotrophic lateral sclerosis diffusion tensor imaging flail arm syndrome magnetic resonance imaging motor neuron disease dti tract-of-interest-based according pattern study white matter analysis patients als Leer másBackground Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-asso...
spinal cord motor neuron transcription factor amyotrophic lateral sclerosis synthetic mrna mci-186 neurotrophic factor differentiation neuroprotective efficacy mns ipscs disease treatment mimns gdnf effect neurotoxicity signaling neurotrophic edaravone als Leer másBiallelic pathogenic repeat expansions in RFC1 were recently identified as molecular origin of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) as well as of one of the most commo...
repeat analysis oxford nanopore sequencing amyotrophic lateral sclerosis rfc1 mnd motor neuron disease additional clinical repeat mnd expansions rfc1 Leer másBackground The characterisation of presymptomatic disease-burden patterns in asymptomatic mutation carriers has a dual academic and clinical relevance. The understanding of disease propagation mechani...
presymptomatic asymptomatic amyotrophic lateral sclerosis frontotemporal dementia magnetic resonance imaging (mri) biomarker pharmaceutical trials repeat study hexanucleotide changes analyses morphometric presymptomatic cortical subcortical grey matter Leer másBackground The ALS Functional Rating Scale in its revised version (ALSFRS-R) is a disease-specific severity score that reflects motor impairment and functional deterioration in people with amyotrophic...
amyotrophic lateral sclerosis alsfrs-r patient reported outcomes digital medicine annotated functional options clinical als alsfrs-r-se version adapted Leer másAmyotrophic lateral sclerosis (ALS) is the most common subtype of motor neuron disease (MND). The current gold-standard measure of progression is the ALS Functional Rating Scale—Revised (ALS-FRS(R)), ...
amyotrophic lateral sclerosis motor neuron disease devices sensors clinical trials technology function evaluate mnd included motor progression studies Leer másAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of both upper and lower motor neurons. A defining histopathological feature in ap...
amyotrophic lateral sclerosis als motor neuron disease non-motor symptoms patients clinical neurons non-motor symptoms als Leer másAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the brain and spinal cord motor neurons. On 25 April 2023, the drug tofersen, an antisense oligonucleotide, received ...
amyotrophic lateral sclerosis selenium selenium compounds sod1 tofersen gene sod1 administration drug disease selenium tofersen Leer másTDP-43 proteinopathy is a salient neuropathologic feature in a subset of frontotemporal lobar degeneration (FTLD-TDP), in amyotrophic lateral sclerosis (ALS-TDP), and in limbic-predominant age-related...
tdp-43 limbic predominant age-related tdp... frontotemporal lobar degeneration amyotrophic lateral sclerosis hippocampal sclerosis of aging dementia alzheimer’s disease national alzheimer’s coordinating ... alzheimer’s ftld-tdp atrophy available neuropathologic odds pathology tdp-43 data als/ftld-tdp late-nc participants Leer másA central event in the pathogenesis of motor neuron disease (MND) is the loss of neuromuscular junctions (NMJs), yet the mechanisms that lead to this event in MND remain to be fully elucidated. Mainte...
amyotrophic lateral sclerosis als neuromuscular junction musk agrin motor neurons acetylcholine receptors patients muscle mnd Leer másBackground Law 219/2017 was approved in Italy in December 2017, after a years-long debate on the autonomy of healthcare choices. This Law, for the first time in Italian legislation, guarantees the pat...
amyotrophic lateral sclerosis law 219/2017 mechanical ventilation withdrawal end-of-life care palliative care advance care planning survey patients services care health als italy withdrawal italian law Leer másBackground This study evaluated a novel control method for patients unable to independently control powered wheelchairs. Patients with amyotrophic lateral sclerosis often require a wheelchair but stru...
amyotrophic lateral sclerosis electromyography muscle activation wheelchair temporalis muscles impression amyotrophic sclerosis change lateral control study wheelchair patients Leer másBackground Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with not only motor symptoms but also extra-motor features including cognitive impairment. The most common cognitive profile ob...
amyotrophic lateral sclerosis cognitive impairment ecas survival longitudinal decline motor function als time patients Leer másThe pathological hallmark of the majority of amyotrophic lateral sclerosis (ALS) cases is the mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43), an RNA-binding protein. Several st...
amyotrophic lateral sclerosis mirna pirna piwi protein tdp-43 protein piwil1 rna als Leer másBehavioral disorders, with an average prevalence of 30–60% are important non-motor symptoms in amyotrophic lateral sclerosis (ALS) that have a negative impact on prognosis, management and quality of l...
amyotrophic lateral sclerosis behavioral disorders apathy anxiety epidemiology neuroimaging functional connectivity biomarkers treatment options disorders current brain symptoms behavioral als Leer másBackground Amyotrophic lateral sclerosis (ALS) is the most common, fatal adult neuromuscular disease. It is a multi-system disorder characterized primarily by motor manifestations, but there is establ...
amyotrophic lateral sclerosis als ecas cognitive alsftd behavioral cognitive 0 arabic ecas egyptian patients Leer másBackground Amyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of motor neurons (MNs), leading to paralysis, respiratory failure and death within 2–5 years of diagnosis. The exa...
neurodegeneration amyotrophic lateral sclerosis mutation... pluripotent stem cells secretome neuroprotective mice model death ipscs ipsc-cm hipscs mutation cm Leer másObjective Half of ALS patients are cognitively and/or behaviourally impaired. As cognition/behaviour and cerebral glucose metabolism can be correlated by means of ^18F-Fluorodeoxyglucose positron emis...
amyotrophic lateral sclerosis cerebral glucose metabolism fdg-pet cognition grey matter volume cognitively patients results behaviourally cerebral als metabolism impaired alsni alsci alscbi glucose Leer másBackground To date, the role of blood lipid levels and their association with the onset and prognosis of ALS is controversial. We explored these associations in a large, population-based case–control ...
amyotrophic lateral sclerosis hypermetabolism cholesterol triglycerides hdl levels ldl hr triglycerides ci 95% associated als Leer másBackground This study evaluated a novel control method for patients unable to independently control powered wheelchairs. Patients with amyotrophic lateral sclerosis often require a wheelchair but stru...
amyotrophic lateral sclerosis electromyography muscle activation wheelchair temporalis muscles impression amyotrophic sclerosis change lateral control study wheelchair patients Leer másBackground Epidemiological studies have reported an association between amyotrophic lateral sclerosis (ALS) and different autoimmune disorders. This study aims to explore the causal relationship betwe...
mendelian randomization amyotrophic lateral sclerosis autoimmune disorders causal relationship studies european reverse snps risk gwas relationship als autoimmune disorders analyses effects study Leer másBACKGROUND: Anal cancer disproportionately affects men who have sex with men (MSM) living with HIV. High-resolution anoscopy (HRA) is an in-clinic procedure to detect precancerous anal lesions and can...
cancer sampling =0 0 race lower hra participants anal home clinic hiv attendance arm versus Leer másBackground Frequent emergency department (FED) visits by cancer patients represent a significant burden to the health system. This study identified determinants of FED in recently hospitalized cancer ...
emergency department visits cancer cohort study frequent users system 40 70 frequent health fed ahr 95% ci cancer patients 0 10–2 Leer másBACKGROUNDS/AIMS: This is a retrospective analysis of whether the 8th edition American Joint Committee on Cancer (AJCC) was a significant improvement over the 7th AJCC distal extrahepatic cholangiocar...
iia cancer survival stage ajcc Leer másBackground Studies on the epidemiological characteristics, treatment strategies and prognosis of nasal and paranasal sinus cancer are still relatively limited. Methods This study analyzed the age-adju...
nasal cavity and paranasal sinus c... epidemiology prognosis machine learning chemotherapy gradient 2012 models boosting cancer 0 paranasal nasal sinus chemotherapy study Leer másBackground In this study, we combined adjuvant chemotherapy after radical gastric cancer resection with tumor-specific total nutrient therapy to analyze how it affects the nutritional state and immune...
gastric cancer postoperative chemotherapy tumor-specific total nutrients enteral nutrition immunity 36 resection indicators 007 function immune vs 0 ± patients nutritional tumor-specific 28 cancer gastric radical control 001 chemotherapy experimental total g/l adjuvant Leer másLung cancer remains the first cause of cancer-related death despite many therapeutic innovations, including immune checkpoint inhibitors (ICI). ICI are now well used in daily practice a...
liquid circulating cancer lung immune Leer másProtein synthesis via translation is a central process involving several essential proteins called translation factors. Although traditionally described as cellular “housekeepers,” multiple studies ha...
cancer eef1a1 eef1a2 pi3k akt elongation translation tissues eef1a1 factor oncogenic eef1a2 expression Leer másMounting evidence demonstrates that long noncoding RNAs (lncRNAs) have critical roles in the initiation and progression of cancer. Here, we report that small nucleolar RNA host gene 3 (SNHG3) is a key...
progression assay rna expression cancer breast Leer másClonal hematopoiesis (CH) driven by mutations in the DNA damage response (DDR) pathway is frequent in patients with cancer and is associated with a higher risk of therapy-related myeloid neoplasms (t-...
cancer mutations hsp90i clones patients clonal treatment Leer másThe development of breast cancer has been mainly reported in women who have reached the post-menopausal stage; therefore, it is the primary factor responsible for death amongst postmenopausal women. H...
nipple aspirate fluid (naf) breast cancer biomarkers liquid biopsy fluid tumors naf breast cancer women Leer másProtein lysine methyltransferase SET and MYND domain-containing 3 (SMYD3) is aberrantly expressed in various cancer settings. The mechanisms that SMYD3 activates the expression of critical pro-tumoral...
emp1 cancer gc expression cells Leer másBACKGROUND: Inositol 1,4,5-trisphosphate receptor (IP3R), a critical calcium ion (Ca2+) regulator, plays a vital role in breast cancer (BC) metabolism. Dysregulated IP3R in BC cells can drive abnormal...
mcf-7 ip3r lines cancer cells mda-mb-231 bc gene silencing ip3r3 cell activity Leer másThe management of metastatic cancer is complicated by chemotherapy resistance. This manuscript provides a comprehensive academic review of strategies to overcome chemotherapy resistance in metastatic ...
discussed provides drug mechanisms overcome therapies comprehensive metastatic cancer review Leer másBackground Depression and anxiety symptoms are two common psychological disturbances in cervical cancer patients. We tested whether sense of coherence (SOC) mediates the association of perceived socia...
cervical cancer sense of coherence perceived social support depressive and anxiety symptoms mediating role social association support sense coherence perceived cervical patients cancer depressive symptoms depression soc scale = − 0 01 < 0 Leer másWe report herein a case of malignant peripheral nerve sheath tumor (MPNST), an extremely rare, esophageal malignancy. A 67-year-old, female patient presented with a nodular lesion in the cervical esop...
malignant peripheral nerve sheath ... esophagus post-irradiation development cancer lesion occur mpnst Leer másBackground Nordic countries excel in cancer care, but studies on uptake, costs, or managed entry agreements of cancer medicines have not been conducted recently. The aim of this study was to examine t...
cancer medicines distribution costs uptake managed entry agreements availability nordic countries survey orally administered cancer medicin... sweden community finland varied availability via countries managed nordic medicines care iceland administered orally uptake cancer entry outpatient products Leer másBackground Radiomics provided opportunities to quantify the tumor phenotype non-invasively. This study extracted contrast-enhanced computed tomography (CECT) radiomic signatures and evaluated clinical...
non-small-cell lung cancer bone metastasis radiomics risk factor predict cohort model cect cancer prediction 0 metastasis radiomics clinical Leer másPurpose Visitor restriction policies to prevent the spread of COVID-19 among patients and clinicians were widespread during the pandemic, resulting in the exclusion of caregivers at key points of canc...
covid-19 perioperative period qualitative methods upper gastrointestinal cancer decision-making caregivers patients restrictions challenges visitor care caregivers cancer Leer másBackground Preoperative assessment of the histological type of ovarian cancer is essential to determine the appropriate treatment strategy. Tumor location may be helpful in this regard. The purpose of...
ovary carcinoma magnetic resonance imaging location cccs attachment angles mri cancers serous hgscs < 0 cancer position endometriosis-associated measured ovarian uterus carcinomas posteriorly positioned significantly Leer másBackground The evolutionarily conserved protein FBXO9 acts as a substrate receptor for the SKP1-cullin-1-RBX1 ubiquitin ligase and is implicated in cancer, exhibiting either tumor-suppressive or oncog...
fbxo9 ubiquitination v-atpase assembly migration cancer stemness metastasis tumor resulting using assays cancer lung v-atpase assembly metastasis fbxo9 Leer másBackground Minimal-accessed (robotic and endoscopic) breast cancer surgery is increasingly performed due to better cosmetic results and acceptable oncological outcomes. This study aims to demonstrate ...
endoscopic-assisted breast surgery... single-port 3-dimensional (3d) end... nipple-sparing mastectomy (nsm) breast-conserving surgery (bcs) breast cancer endoscopic gynecomastia surgery robotic nipple-sparing mastectomy ... cancer patient-reported nac mean s-p 3d e-bcs procedures endoscopic-assisted cosmetic 6% results eabs satisfaction breast patients e-nsm Leer másBACKGROUND: Cervical cancer stands as one of the most prevalent cancer types among women, despite its preventable nature through early screening and vaccination strategies. The link between being over...
screening cervical women factors cancer ccs 95% Leer másAutomatic identification of clinical trials for which a patient is eligible is complicated by the fact that trial eligibility is stated in natural language. A potential solution to this problem is t...
cancer language eligibility clinical criteria Leer másProstate cancer (Pca) continues to be a leading cause of cancer-related mortality in men, and the limitations in precision of traditional diagnostic methods such as the Digital Rectal Exam (DRE), Pr...
staging deep cancer Leer másBACKGROUND: Cervical cancer stands as one of the most prevalent cancer types among women, despite its preventable nature through early screening and vaccination strategies. The link between being over...
screening cervical women factors cancer ccs 95% Leer másExternal disturbances exciting a mechanical resonator can be exploited to gain information on the environment. Many of these interactions manifest as momentum kicks, such as the recoil of residual g...
sensing momentum kicks resonator Leer másBandit algorithms have garnered significant attention due to their practical applications in real-world scenarios. However, beyond simple settings such as multi-arm or linear bandits, optimal algori...
pure exploration optimal Leer másIn the face of increasing demand for zero-touch networks to automate network management and operations, two pivotal concepts have emerged: "Learn to Slice" (L2S) and "Slice to Learn" (S2L). L2S invo...
learning s2l ai l2s network learn slice services Leer másSparse autoencoders (SAEs) are a promising approach to extracting features from neural networks, enabling model interpretability as well as causal interventions on model internals. SAEs generate spa...
token solve constraint matches tokens sparse choice features saes Leer másThe unpredictability of random numbers is fundamental to both digital security and applications that fairly distribute resources. However, existing random number generators have limitations-the gene...
generation generators unpredictable protocol traceable random randomness quantum Leer másEstimating causal quantities from observational data is crucial for understanding the safety and effectiveness of medical treatments. However, to make reliable inferences, medical practitioners requ...
understanding au-learner causal effect cdte Leer másIn this paper, we investigate the existence of parameterized algorithms running in subexponential time for two fundamental cycle-hitting problems: Feedback Vertex Set (FVS) and Triangle Hitting (TH)...
graphs Leer másWe introduce SPOT, an object-centric imitation learning framework. The key idea is to capture each task by an object-centric representation, specifically the SE(3) object pose trajectory relative to...
task demonstrations object-centric object pose Leer másCombating money laundering has become increasingly complex with the rise of cybercrime and digitalization of financial transactions. Graph-based machine learning techniques have emerged as promising...
financial learning graph-based machine laundering data Leer másIn this paper, we derive a priori error estimates for variational inequalities of the first kind in an abstract framework. This is done by combining the first Strang Lemma and the Falk Theorem. The ...
estimates variational error Leer másAs cancer cases continue to rise, with a 2023 study from Zhejiang and Harvard predicting a 31 percent increase in cases and a 21 percent increase in deaths by 2030, the need to find more effective t...
vaccines using percent personalized cancer Leer másSparsity is a central aspect of interpretability in machine learning. Typically, sparsity is measured in terms of the size of a model globally, such as the number of variables it uses. However, this...
learning machine explanations sparsity Leer másFederated learning is a distributed machine learning paradigm designed to protect data privacy. However, data heterogeneity across various clients results in catastrophic forgetting, where the model...
local historical global federated knowledge learning model computer Leer másNeural Radiance Fields (NeRF) have revolutionized the field of 3D visual representation by enabling highly realistic and detailed scene reconstructions from a sparse set of images. NeRF uses a volum...
computer science nerf Leer másRecent advances in prototypical learning have shown remarkable potential to provide useful decision interpretations associating activation maps and predictions with class-specific training prototype...
multiple prototypes prototypical learning diagnosis diseases multi-label cipl Leer másRecent advances in large language models (LLMs) show the potential of using LLMs as evaluators for assessing the quality of text generations from LLMs. However, applying LLM evaluators naively to co...
estimation methods llm evaluators Leer másWe present a novel AI-based ideation assistant and evaluate it in a user study with a group of innovators. The key contribution of our work is twofold: we propose a method of idea exploration in a c...
generations exploration Leer másRecurrent neural networks are a successful neural architecture for many time-dependent problems, including time series analysis, forecasting, and modeling of dynamical systems. Training such network...
using approach forecasting training neural Leer másRecent advances in Large Language Models (LLMs) have helped facilitate exciting progress for robotic planning in real, open-world environments. 3D scene graphs (3DSGs) offer a promising environment ...
llm-based robot planning embodiedrag Leer másQuantum Neural Networks (QNNs) combine quantum computing and neural networks, leveraging quantum properties such as superposition and entanglement to improve machine learning models. These quantum c...
quantum learning machine testing qnn neural networks qnns Leer másMotivated by the need to remove discrimination in certain applications, we develop a meta-algorithm that can convert any efficient implementation of an instance of Hedge (or equivalently, an algorit...
algorithm Leer másGraphs play a central role in modeling complex relationships in data, yet most graph learning methods falter when faced with cold-start nodes--new nodes lacking initial connections--due to their rel...
methods learning Leer másIn recent years, the rapid development of large language models (LLMs) has brought new vitality into various domains, generating substantial social and economic benefits. However, jailbreaking, a fo...
prompts sij jailbreak models Leer másLarge language models (LLMs) have revolutionized numerous applications, yet their deployment remains challenged by memory constraints on local devices. While scaling laws have enhanced LLM capabilit...
language weight bitstack memory compression science computer Leer másIn this paper, we propose a new class of splitting methods to solve the stochastic Langevin equation, which can simultaneously preserve the ergodicity and exponential integrability of the original e...
preserve stochastic equation ergodicity methods Leer másLong COVID continues to challenge public health by affecting a considerable number of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
health computer science advanced 0 research covid media social Leer másWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másLong COVID continues to challenge public health by affecting a considerable number of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
health computer science advanced 0 research covid media social Leer másChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másLong COVID continues to challenge public health by affecting a considerable number of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
health computer science advanced 0 research covid media social Leer másLong COVID continues to challenge public health by affecting a considerable number of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
health computer science advanced 0 research covid media social Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másBackground Despite the decreased incidence of the human immunodeficiency virus (HIV) in Tanzania, the number of adolescents living with HIV is increasing. This study aimed to describe factors independ...
adolescents antiretroviral therapy determinants dolutegravir viral load suppression tanzania suppressed hr ci 95% hiv virally study dtg-based living art adolescents regimen load Leer másBACKGROUND: Pregnant women and children living with HIV in Kenya achieve viral suppression (VS) at lower rates than other adults. While many factors contribute to these low rates, the acquisition and ...
art children providers kenya resistance drug testing hiv drm Leer másInternational audience; Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (A...
pyfu amongst hiv [2 bmi-related cancer trends cancers incidence Leer másBackground Vitamin E supplementation in many adult populations has been found to reduce the impact of oxidative stress from chronic diseases which include HIV infection. With paucity of data among the...
human immunodeficiency virus vitamin e highly active antiretroviral thera... = 0 serum levels hiv children Leer másBackground Since the HIV epidemic in the 1980s, CMV retinitis has been mainly reported in this context. CMV retinitis in persons living with HIV is usually observed when CD4 + cells are below 50 cells...
cmv retinitis recurrence lymphocyte count cd4 + lymphocytes immunoglobulins cytomegalovirus immunosuppression solid organ transplant infectious uveitis counts clinical manifestations cmv disease hiv immune markers patients Leer másOBJECTIVE: Zambia has embarked on improving the diagnostic capacity by setting up high throughput and accurate machines in the testing process and introduction of dried blood spot (DBS) as a sample ty...
hiv positive diagnosis performance blood dried spot sample Leer másBACKGROUND: Current HIV prophylactic vaccines evaluate HIV Env as purified proteins. CD40.HIVRI.Env is an innovative antigen delivery targeting gp140 Env from HIV Clade C 96ZM651 to CD40-expressing an...
0 randomized anrs w48 vaccine hiv w26 hivri + Leer másINTRODUCTION: Pre-exposure prophylaxis (PrEP) is an effective, yet underutilized tool for HIV prevention. We sought to understand practice patterns and opportunities for prescribing PrEP across two la...
[1 obgyn sex women hiv institutions infectious disease prescribing opportunities aor institution 0 3% ed persons encounters prep [0 vs Leer másBackground It is evident that public health education interventions to promote the use of condoms against HIV infections in Ghana have yielded modest results. However, existing studies in the field of...
risk preference risk-averse risk-lover condom use hiv/aids ghana education hiv/aids public condom predicted abstain sex individual preference behaviour health hiv individuals preferences condoms Leer másBackground Behavioral economic (BE) biases have been studied in the context of numerous health conditions, yet are understudied in the field of HIV prevention. This aim of this study was to quantify t...
behavioral economics young adults baltimore african-american hiv prevention qualitative homelessness mixed methods sex prevention study methods biases hiv Leer másBackground Binge drinking, inequitable gender norms and sexual risk behaviour are closely interlinked. This study aims to model the potential effect of alcohol counselling interventions (in men and wo...
hiv/aids structural intervention alcohol gender norms mathematical modelling south africa sexual transmission intervention incidence behaviour risk effects period 0 model gender-transformative 2% hiv africa south drinking counselling Leer másBACKGROUND: In Malawi, female sex workers (FSW) have high HIV incidence and regular testing is suggested. HIV self-testing (HIVST) is a safe and acceptable alternative to standard testing services. Th...
recruited malawi distributors relationship test regret distribution evidence hiv 0 hivst social harms associated peer Leer másIntroduction West African men who have sex with men (MSM) remain at substantial risk of contracting HIV. Pre-exposure prophylaxis (PrEP) can be an effective game-changer in reducing the...
african study participants proposed stigmatization msm hiv west communities Leer másBACKGROUND: Antiretroviral therapy-linked metabolic abnormalities have become a growing concern among people living with HIV. There is limited data regarding the effects of dolutegravir-based treatmen...
13 dyslipidemia increase lipoprotein high-density blood lipid serum glucose profiles efavirenz-based levels ci 95% patients aor hiv people study living dolutegravir-based therapy Leer másBackground Population-level research evaluating HIV-related stigma among countries with varied national HIV prevalence is scarce. To better understand HIV-related stigma and mitigate its potential neg...
stigma hiv prevalence phia people living with hiv africa 80 countries people lower associated compared stigma living hiv 90%ci = regions 0 or = 0 middle odds plwh hiv-related prevalence Leer másINTRODUCTION: In sub-Saharan Africa, migrants are more likely to be HIV seropositive and viremic than non-migrants. However, little is known about HIV prevalence and viremia in non-migrants living in ...
living 0 survey hiv household non-migrants non-migrant non-migrating migrant households spouses migration Leer másObjectives To make clear the roles of social interaction and social support in HIV infection among elderly men who visit female sex workers (FSW). Methods We conducted a case-control study: 106 newly ...
social support hiv elderly men client of female sex workers case-control study material interaction hrhe protective partner life experiences social fsw sexual controls hiv visiting Leer másMetabolic-dysfunction-associated fatty liver disease (MAFLD) is a comorbidity that generally increases in people living with HIV (PLWH). This condition is usually accompanied by persistent inflammatio...
telomere aging length hiv quantification methylation Leer másBackground Tuberculosis (TB), a leading cause of infectious death, is curable when patients complete a course of multi-drug treatment. Because entry into the TB treatment cascade usually relies on sym...
tuberculosis asymptomatic subclinical tb linkage cascade of care telephonic individuals survey hiv data register subclinical treatment community-based status completed started tb Leer másBackground Consultations for sexually transmitted infection (STI) provide an opportunity to offer HIV testing to both patients and their partners. This study describes the organisation of HIV self-tes...
self-testing screening hiv hiv testing offer hiv self-testing sexually transmitted infections-st... côte d’ivoire clinic barriers study partners task-shifting services professionals sti hivst consultations health organisation offered testing hiv Leer másBackground Persons with HIV (PWH) can now achieve a near-normal life expectancy due to antiretroviral therapy (ART). Despite widespread availability of ART in the United States (US), many of the count...
hiv/aids sexual minority community health worker mhealth art adherence study mhealth community health suppression improve art pwh adherence viral hiv Leer másBackground Although many behavioral interventions are adapted, little is known about the reasons for adaptations and the process and outcomes influencing adaptations. To address this gap, we explored ...
hiv adolescent young adult adaptation implementation science sub-saharan africa bootcamp process service teams services hiv youth hivst adaptations intervention modifications Leer másInternational audience; HIV-1 Tat is a key viral protein that stimulates several steps of viral gene expression. Tat is especially required for the transcription of viral genes. Neverthe...
capsid enables cyclophilin production tat-cypa-ca encapsidated tripartite hiv-1 viral transcription hiv virions tat required protein complex Leer másBackground Uptake of HIV pre-exposure prophylaxis (PrEP) remains low among transgender people as compared to other subgroups, despite high rates of HIV acquisition. In California, Latinx people compri...
transgender health prep hiv services peer navigation trans women peer support services healthcare equity health disparities project navigation phe transgender conducted hiv prep healthcare Leer másPeople with HIV (PWH) are at an elevated risk of developing severe COVID-19 outcomes because of compromised immunity and more comorbidities. However, existing literature suggests a lower rate of COVID...
hiv covid-19 testing population-based electronic health records march pwh hiv covid-19 Leer másBenign acute childhood myositis (BACM) is a self-limited childhood illness, and viral infections mainly cause it. Clinical and laboratory alterations usually normalize rapidly; generally, the only med...
benign myositis children pediatrics myalgia gait complaint influenza associated pediatric 1% sars-cov-2 influenza median iqr 3% acute • patients laboratory bacm clinical virus admitted Leer másBackground Healthcare workers are sometimes required to complete a declination form if they choose not to accept the influenza vaccine. We analysed the declination data with the goal of identifying ba...
vaccination influenza declination forms attitudes risk perception workers healthcare lack perception staff data vaccine influenza declination risk reasons Leer másInternational audience; Naturally occurring pentacyclic triterpenes, such as betulinic acid (BA) and its derivatives, exhibit various pharmaceutical activities and have been the subject ...
entry conjugate influenza virus Leer másInfluenza virus is a persistent threat to human health; indeed, the deadliest modern pandemic was in 1918 when an H1N1 virus killed an estimated 50 million people globally. The intent of this work is ...
virus covariation evidence motifs local influenza Leer másBackground Vaccination is a powerful tool in the fight against seasonal influenza, among underserved, middle-age and older, Latinx adults. Yet, vaccine hesitancy and inconsistent uptake in this popula...
influenza vaccination provider recommendation latinx hispanic older adults explore survey -value=0 provider receiving correlates influenza uptake underserved latinx Leer másInfluenza poses a significant threat to public health, particularly among the elderly, young children, and people with underlying dis-eases. The manifestation of severe conditions, such as pneumonia...
host viruses computer science protein data influenza sequences Leer másInfluenza neuraminidase is an important drug target. Glycans are present on neuraminidase and are generally considered to inhibit antibody binding via their glycan shield. In this work, we studied the...
glycan primary ligand binding site influenza neuraminidase Leer másBackground Data on ventilator associated pneumonia (VAP) in COVID-19 and influenza patients admitted to intensive care units (ICU) are scarce. This study aimed to estimate day-60 mortality related to ...
= 0 48 h imv 95% ahr = 1 [ci risk patients influenza covid-19 < 0 vap 01 associated ventilated mortality Leer másPrior to 2017, chicken production in South Africa had only ever been affected by an endemic strain of H6N2 low pathogenic avian influenza (LPAI), but since 2017, an outbreak of Goose/Guangdong clade 2...
avian influenza virus h6n2 h5n1 genome sequencing reassortment clade province h5n2 h5n1 4b commercial avian influenza h6n2 virus Leer másInfluenza poses a severe threat to global health. Despite the whole inactivated virus (WIV)‐based nasal vaccine being a promising strategy for influenza protection, the mucosal barrier is still a bott...
mucosal influenza protection nasal wiv Leer másBackground Respiratory infections such as influenza account for significant global mortality each year. Generating lipid profiles is a novel and emerging research approach that may provide new insight...
lipidomics viral infection sputum influenza bayesian regression 18 human clusters 0_19 16 respiratory infections 0_18 species sputum 0 viral infection cluster lipid Leer másBACKGROUND: Adult hematopoietic cell transplant (HCT) recipients are at high risk for influenza-related morbidity and mortality and have suboptimal influenza vaccine immune responses compared to healt...
recipients vaccine transplant agmr hct vaccination adults influenza ci adult compared 95% hd-tiv Leer másBackground To date, few cases of TSS caused by coagulase negative (CoN) staphylococci have been reported in the literature. Recent data show that CoN staphylococci are capable of secreting a number of...
case report staphylococcus epidermidis toxic shock syndrome influenza superinfection day infection influenza diffuse patient induced tss clinical Leer másBACKGROUND: Few studies have directly compared the risk and magnitude of post-acute sequelae following COVID-19 and influenza, and most of these studies were conducted before emergence of the Omicron....
hospitalizations deaths study ed visits influenza risk hr 95% ci patients compared vs Leer másBACKGROUND: Cardiovascular diseases (CVDs) are consistently ranked among the leading causes of death among older adults in Ireland. COVID-19 and influenza infection are associated with cardiovascular ...
covid-19 adults quarter cvd 2020 data cardiovascular rates excess ireland mortality influenza ia 0 Leer másBACKGROUND: Quantitative evidence on the impact of meteorological factors on influenza transmissibility across different virus types/subtypes is scarce, and no previous studies have reported the effec...
h1n1 non-linear pdm09 5 °c h3n2 types/subtypes association ambient variability transmissibility meteorological increased factors influenza humidity absolute Leer másSeasonal influenza is usually considered an acute respiratory infection with a full recovery within a week. In addition to the traditional outcomes, there is now evidence of indirect effects in terms ...
disease burden vaccination benefits efficacy and safety randomization vulnerable populations study design seasonal evidence influenza Leer másIntroduction Respiratory tract infections (RTIs) stand out as the most frequent causes leading to visits to the emergency department and hospitalizations. This study aims to assess the types and preva...
covid-19 respiratory pathogens rsv influenza sars-cov-2 infections study respiratory Leer másSeasonal influenza is usually considered an acute respiratory infection with a full recovery within a week. In addition to the traditional outcomes, there is now evidence of indirect effects in terms ...
disease burden vaccination benefits efficacy and safety randomization vulnerable populations study design seasonal evidence influenza Leer másBACKGROUND: Pertussis and seasonal influenza are responsible for significant maternal, neonatal, and infant morbidity and mortality, but vaccine coverage rates (VCR) for both pertussis (administered a...
uk identified countries components pregnancy spain united pertussis seasonal influenza tdap Leer másAvian-origin H3N2 canine influenza virus (CIV) is one of the most prevalent influenza virus subtypes in dogs worldwide. Previous studies have shown that during the evolution of H3N2 CIV in dogs, its a...
canine influenza virus genetic characteristics receptor binding property virulence in mice virus civs dogs influenza h3n2 Leer másAll data generated or analyzed during this study are included in this published article and its Additional files.;International audience; The global spread of avian influenza A viruses i...
evaluated epidemiological estimated [sdv evaluation according vaccination systematic strategies review influenza avian transmission models Leer másForecasting influenza in a timely manner aids health organizations and policymakers in adequate preparation and decision making. However, effective influenza forecasting still remains a challenge de...
influenza model pandemic historical forecasting Leer másBackground Healthcare workers are sometimes required to complete a declination form if they choose not to accept the influenza vaccine. We analysed the declination data with the goal of identifying ba...
vaccination influenza declination forms attitudes risk perception workers healthcare lack perception staff data vaccine influenza declination risk reasons Leer másBACKGROUND: The annual reappearance of respiratory viruses has been recognized for decades. The onset of the COVID-19 pandemic altered typical respiratory virus transmission patterns. COVID-19 mitigat...
burden influenza illness viruses cohort hive rate circulation virus specimens participants compared respiratory study covid-19 pandemic period Leer másBackground Accurate identification of bacterial communities is crucial for research applications, diagnostics, and clinical interventions. Although 16S ribosomal RNA (rRNA) gene sequencing is a widely...
bacterial dna 16s rrna gene-based sequencing v1–v9 region nanopore sequencing minion taxonomic 0 microbial standard results full-length pearson employed correlation rrna gene 16s sequencing Leer másBackground Sepsis can cause immune dysregulation and multiple organ failure in patients and eventually lead to death. The gut microbiota has demonstrated its precise therapeutic potential in the treat...
sepsis gut microbiota mortality intensive care outcome prediction specimens changes microbiota abundance gut Leer másBackground Lignin is an intricate phenolic polymer found in plant cell walls that has tremendous potential for being converted into value-added products with the possibility of significantly increasin...
lignin degradation cazymes aorb19 lc–uv whole genome analyses lignocellulosic waste products production analysis based strain degradation potential lignin u/l genes aorb19 Leer másListeria monocytogenes is an important foodborne pathogen that incorporated into many serious infections in human especially immunocompromised individuals, pregnant women, the elderly, and newborns. T...
antibiotic resistance foodborne pathogens public health hazards virulence genes antibiotic isolates 67% monocytogenes poultry Leer másBackground Mangrove sediment microbes are increasingly attracting scientific attention due to their demonstrated capacity for diverse bioremediation activities, encompassing a wide range of environmen...
metagenomic analysis 16s rrna mangrove sediment organohalides bioremediation community organohalide sediment picrust diverse ohr reductive mangrove sediments Leer másBackground The current understanding of acquired chromosomal colistin resistance mechanisms in Enterobacterales primarily involves the disruption of the upstream PmrAB and PhoPQ two-component system (...
colistin resistance chromosome phop mgrb pmrb parental understanding mics clinical regulatory enterobacterales compared genes study pmra pmrb resistance coli phopq tsarec02 tsarec03 colistin Leer másBackground Antibiotic-associated diarrhea (AAD) refers to symptoms of diarrhea that cannot be explained by other causes after the use of antibiotics. AAD is thought to be caused by a disruption of int...
antibiotic-associated diarrhea fecal microbiota transplantation dysbiosis efficacy treatment transplantation patients intestinal aad microbiota Leer másPeutz–Jeghers Syndromeis a rare autosomal dominant genetic disease characterized by gastrointestinal hamartomatous polyps and skin and mucous membrane pigmentation. The pathogenesis of PJS remains unc...
gut microbiota peutz–jeghers syndrome short chain fatty acids benign polyps serine/threonine kinase 11 negatively correlated patients gut microbiota acid Leer másFungal infections in humans range in severity from superficial, cutaneous manifestations to deep-seated, invasive infection, particularly in immunocompromised patients. The mycology laboratory must be...
mycology fungi yeast culture maldi-tof histopathology nucleic acid detection pcr serology antigen detection antimicrobial susceptibility testi... fungal provide Leer másBackground The safety of milk production in terms of foodborne infections is a worldwide issue, particularly in developing countries where production is often unhygienic. A cross-sectional study was c...
hygiene staphylococcus aureus antimicrobial resistance raw milk meta ethiopia hygiene raw cow mastitis 95%ci smallholder dairy 8% study susceptibility milk assess aureus Leer másBackground We aimed to compare the performance of carbapenemase classification in carbapenem-resistant Klebsiella pneumoniae (CRKP) obtained using the BD Phoenix CPO Detect panel (CPO panel) and Cephe...
carbapenem-resistant bd phoenix cpo xpert carba-r assay detect identified 55 performance carbapenemase xpert 100% carba-r class isolates panel Leer másBackground Candida albicans is the most common fungus that causes vaginal candidiasis in immunocompetent women and catastrophic infections in immunocompromised patients. The treatment of such infectio...
drug repurposing vaginal candidiasis fluconazole resistant ... fusidic acid efflux pumps mice combined potential inhibitory treatment isolates pump concentration efflux activity combination vaginal azoles model albicans fusidic resistance Leer másBackground The rising prevalence of extended-spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae (ESβL-PE) in street foods poses a significant risk to human health due to its epidem...
extended-spectrum β-lactamase street-vended food foods respectively food extended-spectrum spp street Leer másPurpose Co-culturing is a widely used method to improve bioethanol production from biomass enriched in fermentable sugars. This study aims to produce bioethanol from sugarcane molasses by simultaneous...
co-fermentation optimization bioethanol sugarcane molasses ethanol yield stress tolerance statistical optimization g^−1 h^−1 conditions using respectively 5 g production productivity ethanol isolate yield bioethanol molasses anomalus l^−1 0 co-fermentation Leer másObjective Staphylococcus aureus ( S. aureus) , especially Methicillin resistant S. aureus (MRSA), has been disseminated across communities and hospitals, associated with severe infections and organ fa...
ha-mrsa ca-mrsa drug resistance prevalence genotyping nosocomial infection medical affiliated wenzhou isolates 2018 university clinical strains aureus 105 hospital Leer másBackground Diarrhoea is a public health problem, especially in developing countries where it is the second leading cause of child mortality. In Low Income Countries like in Mali, self-medication and i...
diarrhoea esbl community health strains health community study cotrimoxazole diarrhoea 176 coli 554 mali antibiotics resistant 8% resistance salmonella Leer másBackground Hundreds of millions of tons coal fly ash are produced annually to support economic development and industrial production. However, directly applying coal fly ash to agricultural production...
coal fly ash soil amendment soil microbial community land productivity enhancement humic acid study g1 ash coal fly Leer másBackground Saline lakes are home to various archaea that play special and crucial roles in the global biogeochemical cycle. The Qinghai-Tibet Plateau hosts a large number of lakes with diverse salinit...
archaea diversity ecological functions plateau saline lakes network analysis lakes qinghai-tibet roles plateau archaeal saline archaea salinity Leer másIntroduction : Lactic acid bacteria (LAB) are a cluster of microbes distributed in a variety of environments and have potential probiotic activity to improve human well-being. This study was aimed at ...
derashe konso lactic acid bacteria probiotic starter culture study fermented isolated pseudomesenteroides potential weissella paramesenteroides cheka probiotic leuconostoc isolates lab Leer másBackground Coprophagy plays a vital role in maintaining growth and development in many small herbivores. Here, we constructed a coprophagy model by dividing rabbits into three groups, namely, control ...
caecotrophy growth performance microbiome scfas rabbits correlated coprophagy growth rabbits prevention abundance performance cp Leer másBackground HIV-infected persons demonstrate notable disturbances in their intestinal microbiota; however, the impact of intestinal microbiota on HIV susceptibility in men who have sex with men (MSM), ...
hiv intestinal microbiota art msm diversity rhi non-msm controls healthy hiv uninfected infection art intestinal msm Leer másHypocreomycetidae is a highly diverse group with species from various habitats. This subclass has been reported as pathogenic, endophytic, parasitic, saprobic, fungicolous, lichenicolous, algicolous, ...
ancestral character analysis divergence time estimates molecular clock analysis morphology phylogeny freshwater fungi species morphological nectriaceae placed marine fungi taxa time analysis phylogenetic terrestrial freshwater hypocreomycetidae Leer másInfectious diseases that spread through the bloodstream, known as bloodstream infections (BSIs), are a major global health problem. Positive outcomes for patients with sepsis are typically the result ...
electronic nose (e-nose) bactec vitek 2 bactec diagnosis bloodstream pneumonia coli using bsis e-nose analysis Leer másA Special-purpose Committee on Fungal Names with the Same Epithet was established at the XIX International Botanical Congress (IBC) in Shenzhen, China in 2017, with a mandate to report to the 12th Int...
pleomorphic fungi one fungus one name 1f-1n committee names congress special-purpose international fungi Leer másBackground The traditional Sichuan Sun-dried vinegar (SSV) with unique flavor and taste is believed to be generated by the solid-state fermentation craft. However, how microorganisms and their metabol...
sichuan sun-dried vinegar microbial community fermentation metabolites correlation analysis schwanniomyces ranging flavor process microorganisms stages zygosaccharomyces metabolites correlation ssv Leer másBACKGROUND: Alzheimer’s disease (AD) and age-related macular degeneration (AMD) share similar pathological features, suggesting common genetic aetiologies between the two. Investigating gene associati...
gene diagnostic based analysis amd ad apoe apoc1 identified genes pleiotropy Leer másBACKGROUND: Spontaneous intracranial hypotension is an important cause of treatable secondary headaches. Evidence on the efficacy of epidural blood patching and surgery for spontaneous intracranial hy...
surgery using epidural data blood patching efficacy Leer másRATIONAL: Several tools exist to assess comorbidities in neurological disorders, the most widely used being the Charlson Comorbidity Index (CCI), but it has several limitations. The Comorbidity and Ge...
questionnaire burden disorders symptom cghq cci scores eq-5d-5l neurological comorbidities comorbidity correlated Leer másMultiple sclerosis (MS) is a global health concern affecting around 2.6 million people. It is characterised by neural inflammation, myelin breakdown and cognitive decline. Cognitive impairment, especi...
health training exercise ms cognitive Leer másBACKGROUND: Sialidosis is a rare disorder caused by mutations in the NEU1 gene located on chromosome 6p21.3, constituting a group of autosomal recessive diseases. Enzyme activity analysis, electron mi...
spots report disease cherry-red genetic testing Leer másRespiration protocols have been developed to manipulate mental states, including their use for therapeutic purposes. In this systematic review, we discuss evidence that respiration may play a fundamen...
mental Leer másBACKGROUND: The glycinergic system plays an important inhibitory role in the mouse central nervous system, where glycine controls the excitability of spinal itch- and pain-mediating neurons. Impairmen...
alpha brainstem analysis glra3 glycine expression Leer másBACKGROUND: Multiple sclerosis is a demyelinating chronic neurologic disease that can lead to disability and thus to deterioration of quality of life. Psychological parameters such as ego defense mech...
quality style psychological life 5% sclerosis health mental 0 defense Leer másBACKGROUND: Essential tremor (ET) is a movement disorder that affects 4%–5% of adults >65 years. For patients with medically refractory ET, neurosurgical interventions such as deep brain stimulation (...
introduction treatment database trends dbs patients demographics mrgfus Leer másThe medial preoptic area (mPOA) regulates the probability and intensity of singing behavior in birds. Polzin and colleagues examined the molecular changes in the mPOA that were associated with gregari...
Leer másFatigue is the subjective sensation of weariness, increased sense of effort, or exhaustion and is pervasive in neurologic illnesses. Despite its prevalence, we have a limited understanding of the neur...
motor mvc correlated role cerebellum reduced excitability control perception cbi Leer másThe current project was funded by the Global Engagement Seed Grant from the International Brain Research Organisation (IBRO) as part of the IBRO-led Global Engagement Initiative. The project was focus...
report current engagement neuroscience public project Leer másBACKGROUND AND OBJECTIVE: Retinal vascular density (VD) measured using optical coherence tomography with angiography (OCTA) has been suggested as a potential marker of intracerebral vascular changes i...
patients retinal vd Leer másBackground There are increasing reports of cases of Guillain-Barré syndrome (GBS), as an adverse event of an immune checkpoint inhibitor (ICI) but postmarket data on the incidence of this remains scar...
data event reports reporting study avelumab faers checkpoint associated adverse ror Leer másDexterous object manipulation depends critically on information about forces normal and tangential to the fingerpads, and also on torque associated with object orientation at grip surfaces. We investi...
encode normal monkey direction human fingerpads tactile afferent sa-ii torque Leer másMitochondria exert powerful control over cellular physiology, contributing to ion homeostasis, energy production, and metabolite biosynthesis. The trafficking and function of these organelles are part...
mfn2 cycle particularly control sv fusion axons network axonal function qc 2+ ca presynaptic Leer másBrachial plexus avulsion (BPA) is a combined injury involving the central and peripheral nervous systems. Patients with BPA often experience severe neuropathic pain (NP) in the affected limb. NP is in...
drgs system edema bpa nervous sympathetic pain mice peripheral bdnf Leer másTraumatic brain injury (TBI) is one of the leading causes of death and disability worldwide, and destruction of the cerebrovascular system is a major factor in the cascade of secondary injuries caused...
cerebral tbi tfus flow blood Leer másBACKGROUND: In Australia, tixagevimab/cilgavimab 150 mg/150 mg was a government-funded pre-exposure prophylaxis for COVID-19 people with multiple sclerosis (pwMS) and other neuroimmunological conditio...
pwnic eligible pwms assess received covid-19 tixagevimab/cilgavimab uptake Leer másBACKGROUND AND PURPOSE: IV thrombolysis with alteplase before mechanical thrombectomy for emergent large-vessel-occlusion stroke is associated with access-site bleeding complications. However, the inc...
patients 2% thrombectomy mechanical stroke versus large-vessel-occlusion femoral complications access-site alteplase tenecteplase Leer másBACKGROUND: Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for motor complications in Parkinson’s disease (PD). However, its effects on neuropsychiatric symptoms ...
ci pd 95% p<0 001 acute neuropsychiatric stn-dbs effects conditions Leer másBACKGROUND AND PURPOSE: Vein of Galen malformation is a rare congenital cerebrovascular malformation. In affected patients, increased cerebral venous pressure constitutes an important etiologic factor...
detect sagittal veins profiles damage examinations ultrasound superior component sinus venous cerebral malformation retrograde flow Leer másOBJECTIVE: Given the rapid shift to in-home teleneuropsychology models, more research is needed to investigate the equivalence of non-facilitator models of teleneuropsychology delivery for people with...
people measures yod anxiety teleneuropsychology Leer másAccording to a classical view of face perception (Bruce and Young, 1986; Haxby et al., 2000), face identity and facial expression recognition are performed by separate neural substrates (ventral and l...
rdms facial regions dcnns recognition brain tested expression trained view recognize lateral intracranial neural Leer másCSF-venous fistulas are an increasingly recognized type of CSF leak that can be particularly challenging to detect, even with recently improved imaging techniques. Currently, most institutions use dec...
imaging photon-counting myelography Leer másBACKGROUND: GBA mutations are the commonest genetic risk factor for Parkinson's disease (PD) and also impact disease progression. OBJECTIVE: The objective of this study was to define a biochemical pro...
α‐synuclein parkinson disease biochemical levels non‐mutated mononuclear cells pd peripheral blood Leer másNeuron subtype dysfunction is a key contributor to neurologic disease circuits, but identifying associated gene regulatory pathways is complicated by the molecular complexity of the brain. For example...
parkinson dopamine molecular brain subtypes neural hypoxia-inducible depletion circuit pv + neuron factor type-specific disease neurons Leer másParkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like th...
computer datscan machine parkinson disease Leer másSubject: In this article, convolutional networks of one, two, and three dimensions are compared with respect to their ability to distinguish between the drawing tests produced by Parkinson's disease...
cnn parkinson disease convolutional two- one- three-dimensional models Leer másInternational audience; BackgroundHyposmia and isolated REM sleep behavior disorder are well-established features of prodromal Parkinson's disease (PD).ObjectivesThe objective of the pre...
disease parkinson taste Leer másEditorial on the Research Topic Neuroprotection and disease modification in Parkinson's disease: Volume II Parkinson's disease (PD) is the second prevailing neurodegenerative disease wo...
symptoms mptp progression enteric dutasteride al mouse model strategies disease pd parkinson Leer másPump-guided intrajejunal levodopa administration is one of the indispensable forms of therapy in advanced Parkinson's syndrome, along with deep brain stimulation and subcutaneous apomorphine injection...
idopathic parkinson syndrome jet-peg levodopa hybrid-peg levodopa parkinson internal application Leer másBackground: The aim of this systematic review was (1) to identify the brain regions involved in anxiety in Parkinson's disease (PD) based on neuroimaging studies and (2) to interpret th...
striatum fc circuits amygdala studies parkinson disease anxiety reduced pd cortico‐striato‐thalamocortical cortex limbic fear Leer másBACKGROUND: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. OBJEC...
gwass international prostate prs cancer pd 0 parkinson [0 disease associated cancers consortium ovarian genetic association Leer másParkinson's disease is a common neurological disease, entailing a multitude of motor deficiency symptoms. In this project, we developed a device with an uploaded edge machine learning algorithm that...
parkinson Leer másThe hypokinetic motor symptoms of Parkinson's disease (PD) are closely linked with a decreased motor cortical output as a consequence of elevated basal ganglia inhibition. However, whether and how the...
midbrain loss parkinson adaptations impaired parkinsonism dopaminergic ptns decreased pyramidal m1 cortical motor neurons Leer másParkinson's disease (PD) is a progressive neurodegenerative disorder that impacts motor functions and speech characteristics This study focuses on differentiating individuals with Parkinson's diseas...
speech healthy accuracy features parkinson machine learning classification Leer másAdvanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device‐aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG),...
disease nonmotor articles dyskinesia time lcig parkinson advanced Leer másParkinson disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain. The majority of early onset forms of Parkinson disease are a result of ...
parkinson disease Leer másInternational audience; In this paper, we study the problem of detecting early signs of Parkinson's disease during an indirect human-computer interaction via a computer mouse activated b...
parkinson detection Leer másThe prevalence of negative stimuli conventionally observed in young adults decreases during normal aging, oreven evolves into a prevalence of positive stimuli. This age-related effect i...
cerebral scenes émotionnelle effet effect appraisal pd suggesting aux disease l’évolution personnes émotionnelles suggérant scènes emotional patients aging tâche émotionnel task evolution parkinson normal tendency processing study étude l’action tendance chez vieillissement sain au traitement vs action Leer másParkinson's disease (PD) has a large impact on patients' physical and mental health, which also greatly affects their family caregivers. Deep brain stimulation (DBS) has emerged as an effective treatm...
family study person caregivers dbs patients impact parkinson disease Leer másBackground Parkinson's disease (PD) is a chronic progressive neurodegenerative disabling disease and involves about 1–3% of the worldwide population over the age of 60. A significant prevalence of psy...
parkinson's disease depressive symptoms non-motor symptoms mmse cas cognition parkinson females mean males age disease scale symptoms Leer másParkinson's disease (PD) is a progressive neurodegenerative disorder that impacts motor functions and speech characteristics This study focuses on differentiating individuals with Parkinson's diseas...
speech healthy accuracy features parkinson machine learning classification Leer másBACKGROUND: Individuals with Parkinson's disease present arm swing alterations that can adversely affect their locomotion. OBJECTIVE: To identify differences in arm swing asymmetry (ASA) between indiv...
evidence parkinson -0 amplitude 05 arm swing individuals disease 0 ci 95% Leer másBACKGROUND: Glucocerebrosidase gene mutations are a common genetic risk factor for Parkinson's disease. They exhibit incomplete penetrance. The objective of the present study was to measure microglial...
microglial activation parkinson c‐ ‐pk11195 disease binding glucocerebrosidase carriers gene mutation Leer másObjectives: To improve the self-management with Parkinson's disease (PD) for patients and their caregivers through a group empowerment experimentation next door. Methods: A qualitative ...
disease program empowerment parkinson patients Leer másBACKGROUND: The aim of this systematic review was (1) to identify the brain regions involved in anxiety in Parkinson's disease (PD) based on neuroimaging studies and (2) to interpret the findings agai...
striatum circuits studies amygdala fc parkinson reduced cortex pd limbic cortico‐striato‐thalamocortical anxiety circuit Leer másOBJECTIVE: We utilized human midbrain‐like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α‐synuclein (α‐syn; SNCA) perturbations to investig...
generated disease carrying parkinson human hmlos body–like inclusions Leer másBackground Parkinson's disease (PD) is a chronic progressive neurodegenerative disabling disease and involves about 1–3% of the worldwide population over the age of 60. A significant prevalence of psy...
parkinson's disease depressive symptoms non-motor symptoms mmse cas cognition parkinson females mean males age disease scale symptoms Leer másA number of new balloon or space-based gamma-ray observatories have been proposed to close a "MeV gap" in sensitivity to gamma rays in the MeV-GeV energy band. One aspect of the science case for the...
energy Leer másIn this study, we employ the combined charged particle measurements from Integrated Science Investigation of the Sun (\ISOIS) onboard the Parker Solar Probe (PSP) and Energetic Particle Detector (EP...
energetic he/h energy composition solar fe/o 0 ratio solo psp particle Leer másWhite dwarf-main sequence (WDMS) binary systems are essential probes for understanding binary stellar evolution and play a pivotal role in constraining theoretical models of various transient phenom...
white binaries wdms astrophysics Leer másSpin-2 ultralight dark matter (ULDM) is a viable dark matter candidate and it can be constrained using gravitational wave (GW) observations. In this paper, we investigate the detectability of spin-2...
ultralight matter dark detectors spin-2 Leer másThe intrinsic magnetic fields of exoplanets affect the structure of their atmospheres and plasmaspheres and, therefore, the observational manifestations of transit absorptions. This work proposes a ...
method fields Leer másWe present measurements of the gas-phase Oxygen and Nitrogen abundances obtained by applying the direct method to JWST NIRspec $R\sim1000$ spectroscopy for 6 galaxies at redshift greater than 3. Our...
nitrogen objects Leer másThe total lunar eclipse on March 14, 2025 UT occurs nearly exactly 521 years (one Hypersaros) after a similar eclipse on March 1, 1504 UT that is renowned for its importance to the voyage of Columbu...
march eclipses similar Leer másThe Fe K$\alpha$ fluorescence line emission in X-ray spectra is a powerful diagnostic tool for various astrophysical objects to reveal the distribution of cold matter around photo-ionizing sources. ...
k$\alpha$ fe velocity surface ns star Leer másThis study introduces a line list for the abundance analysis of F and G type stars across the 4080-9675 A wavelength range. A systematic search employing lower excitation potentials, accurate log gf...
refined physics lines spectrum solar Leer másWe demonstrate that the orbital eccentricity in compact binary mergers can be used to improve their sky localization using gravitational wave observations. Existing algorithms that conduct the local...
using eccentricity Leer másWe present a study of correlations between high Li abundances and strong chromospheric He I 10830 \AA\ absorption line strengths in Kepler field giant stars. Our sample includes 84 giants with detec...
10830 rc chromospheric giants Leer másGRB$\,$220831A is a gamma-ray burst (GRB) with a duration and spectral peak energy that places it at the interface between the distribution of long-soft and short-hard GRBs. In this paper, we presen...
near-infrared steep grb$\ $220831a Leer másAn in-depth analysis of variability has been carried out on the 2 GHz and 8 GHz light curves from the impressive database of the US Navy's extragalactic source monitoring program at the Green Bank I...
extreme sun-related events sources Leer másThe L9 dwarf SDSS J100711.74+193056.2 is situated 7$^{\circ}$.5 north of the nearest B-type star Regulus (d = 24.3+-0.2 pc), part of a stellar quadruplet. The object is at similar distance (d = 21.9...
pc regulus astrophysics Leer másNearly all star clusters younger than ~600 Myr exhibit extended main sequence turn offs and split main sequences (MSs) in their color-magnitude diagrams. Works based on both photometry and spectrosc...
1818 main fractions 2164 1850 binary binaries stars ms astrophysics Leer másIn binary neutron star mergers, the remnant can be stabilized by differential rotation before it collapses into a black hole. Therefore, the angular momentum transport mechanisms are crucial for pre...
grmhd magnetic field tayler-spruit neutron Leer másAssuming Galactic cosmic rays originate in supernovae and the winds of massive stars, starburst galaxies should produce very-high-energy (VHE; E$>$100 GeV) gamma-ray emission via the interaction of ...
cosmic data 82 energy vhe starburst veritas Leer másIn this article, we look at the current bounds on the coupling strength of axion-like particles (ALPs) with two photons in the context of the Randall-Sundrum (RS) model. We relate the coupling stren...
rs strength coupling bounds current energy model Leer másThe Euclid mission is generating a vast amount of imaging data in four broadband filters at high angular resolution. This will allow the detailed study of mass, metallicity, and stellar populations ...
imaging metallicity galaxies mass stellar Leer másWhen a binary of early-type stars from the young stellar populations in the Galactic center (GC) region is scattered to the vicinity of the supermassive black hole (SMBH) Sgr~$\rm{A}^{*}$, one of th...
astrophysics smbh galactic sgr~$\rm{a}^{*}$ Leer másIt has been recently shown that cosmological models with scale-dependent primordial non-Gaussianities (sPNG) could provide a possible path to solve current cosmic tensions. Moreover, it has been poi...
models dark spng wdm Leer másThe cosmic velocity field is an unbiased probe of the total matter distribution but is challenging to measure directly at intermediate and high redshifts. The large-scale velocity field imprints a s...
field 3d effect cmb velocity Leer másWarm dense matter (WDM) plays an important role in astrophysical objects and technological applications, but the rigorous diagnostics of corresponding experiments is notoriously difficult. In this w...
model-free angles Leer másA relevant fraction of massive stars are runaways, moving with a significant peculiar velocity with respect to their environment. Kicks from supernova explosions or the dynamical ejection of stars f...
massive runaways astrophysics stars Leer másWe investigate size variation with rest-frame wavelength for star-forming galaxies based on the second JWST Advanced Deep Extragalactic Survey data release. Star-forming galaxies are typically small...
star mass formation size 0 \mathrm{m}}$ ${\mu star-forming variation galaxies wavelength Leer másThis dissertation deals with the co-construction of meaning in interaction and the ways in which conversationalists exhibit their interpretative processes. The focus of this study is th...
conversational modélisation séquence informationnelle d’une sequences conversationnelle explicit analyse sequence inference study explicitation d’explicitation processus analysis Leer másBACKGROUND: The VERIPRO SARS-CoV-2 Env assay uses reverse transcriptase PCR (RT-PCR) to detect SARS-CoV-2, the causative agent of COVID-19, from stainless steel environmental sample swabs. OBJECTIVE: ...
stainless steel study sars-cov-2 assay env detect veripro Leer másExtreme Ultraviolet (EUV) waves, frequently produced by eruptions, propagate through the non-uniform magnetic field of the solar corona and interact with distant prominences, inducing their global o...
prominences astrophysics slow numerical solar study euv fast front oscillations dynamics wave distant physics Leer másOBJECTIVE: This study investigated the impacts of waterpipe tobacco (WTP) and cigarette smoking on stomach cancer development in Vietnamese men. METHODS: A total of 80 stomach cancer cases and 146 con...
study cigarette increased p=0 smoking tobacco 95%ci smokers risk stomach cancer Leer másBackground Caring for recommended patients creates work and emotional challenges for nurses. Nurses are obligated to provide care regardless of the patient’s situation. Therefore, knowing the experien...
recommended patient nurses very important person qualitative research lived experiences patient study provide experiences data patients recommended care Leer másBackground The current organizational structure of the Italian healthcare system does not include the institutionalization of clinical ethics services. To describe the need for structured clinical eth...
clinical ethics consultation clinical ethics service intensive care unit study hcps healthcare clinical Leer másThe present study (B‐1201 clinical trial) was conducted as a multicenter, open‐label, single‐arm phase II study to evaluate the long‐term safety, tolerability and efficacy of bexarotene. This study en...
orr response five dlt long‐term japanese safety 3% study bexarotene trial patients Leer másOBJECTIVE: This study investigated prospective bidirectional relationships between depression and metabolic syndrome (MetS), and the moderating effects of race, sex, and health behaviors in a diverse ...
relationships 30 behaviors sex race cesd symptoms depressive study predicted health mets Leer másBACKGROUND: One of the sequalae of breast cancer treatments may be pelvic floor (PF) dysfunction such as urinary incontinence (UI), faecal incontinence (FI), and pelvic organ prolapse (POP). OBJECTIVE...
distress study 0 women pelvic pf urinary symptoms floor impact dysfunction Leer másBACKGROUND: Lung hyperinflation and systemic inflammation are currently believed to be the most important causes of right heart alterations in chronic obstructive pulmonary disease (COPD) patients. A ...
functional heart value subjects rv association tapse study copd mace patients Leer másBACKGROUND: Multiple duty hour reforms have been implemented to optimize resident wellness through increasing opportunities for sleep recovery, but few studies have recorded objectively measured sleep...
p < 0 ophthalmology study resident 001 time stress wellness sleep cohort lower optional recorded relief call Leer másBACKGROUND AND PURPOSE: We aimed to assess the incidence of anterior cruciate ligament reconstruction (ACLR) and concomitant procedures in Finland. PATIENTS AND METHODS: We identified all the patients...
included 2014 2004 finland study person-years increased patients incidence aclr Leer másAims/hypothesis This prospective, observational study examines associations between 51 urinary metabolites and risk of progression of diabetic nephropathy in individuals with type 1 diabetes by employ...
diabetic nephropathy metabolite profiling nmr progression type 1 diabetes metabolite diabetes progression individuals diabetic nephropathy study [1 urinary Leer másThe urban environment is complex and needs to be studied in a multidisciplinary way to better understand the interacting processes. A modelling approach based on the urban canopy model ...
calage based versants bassins soil vulnérabilités vulnerabilities study données catchments environment urban hydrological model hydrologiques modèle paris Leer másIntroduction Difficult laryngoscopy and intubation are serious problems among critically ill patients in emergency department (ED) so utility of a rapid, accurate and noninvasive method for predicting...
airway management intubation, intratracheal laryngoscopy ultrasonography study p = 0 ultrasound significant difficult correlation intubation patients laryngoscopy Leer másBackground Sleep disturbances are frequently observed in patients with epilepsy (PWE), with adversely effects on life quality and seizure control. The study aimed to assess the gender differences in i...
epilepsy gender sleep disturbances insomnia sleep quality study = 0 healthy disturbances factors sleep epilepsy quality gender Leer másBackground Headaches are frequent neurological disorders that are yet to be unveiled and treated comprehensively worldwide. Bearing in mind that the distribution of headache subtypes in neurology clin...
ichd-3 headache frequency neurology clinics migraine moh pain perception geographic regions the head-menaa study africa patients pain study primary criteria common secondary headache headaches regions Leer másBackground Population ageing is considered one of the biggest challenges facing the world, and the status of the elderly in society and their quality of life (QOL) have proved to be a concern in profe...
pain self-efficacy sense of coherence spiritual well-being self-compassion quality of life aged cardiovascular disease role study results pain β = 0 elderly path significant soc pse qol Leer másBACKGROUND: There is concern that the COVID-19 pandemic has had a negative impact on the psychological wellbeing of many populations, including increase of fear, anxiety, and uncertainty. Since the st...
korean study influencing adolescents pandemic covid-19 health 0 Leer másBACKGROUND: The field of neurology encompasses the study and treatment of disorders that affect the nervous system, and patients with neurological conditions often require specialized care, particular...
score mean icu study hospital care systems scoring patients ii Leer másOBJECTIVE: Limited research has assessed the association between patterns of body mass index (BMI) change across adulthood and mortality. We aimed to identify groups of individuals who followed specif...
study lower-normal melbourne cohort associated class normal overweight trajectories mortality adulthood obesity hr 0 ci 95% Leer másBACKGROUND: Autologous hematopoietic stem-cell transplantation (HSCT) is the standard of care in many relapsed and refractory lymphoid malignancy, neuroblastoma, and multiple myeloma (MM). This study ...
gram-negative nhl hl 6% hsct palestine study autologous patients Leer másBackground Access to fertility treatments is considered a reproductive right, but because of the quarantine due to the coronavirus pandemic most infertility treatments were suspended, which might affe...
anxiety assisted reproductive technology covid-19 depression infertility mental health stress meta-analysis observational study treatments health studies coronavirus pandemic treatment due suspension infertile mental patients 95% ci Leer másWithin the framework of this PhD we present the design and realization of a bench dedicated to the study of the reliability of piezoelectric structures and more precisely micro-devices ...
energy harvesting au dedicated piezoelectric bench study reliability vieillissement sciences [spi structures modes fiabilité Leer másOBJECTIVES: Patients with kidney failure receiving maintenance dialysis are a particularly important population and carry a heavy disease burden. However, evidence related to palliative care for patie...
treatment −0 significantly admission home aggressive palliative death dialysis receiving kidney failure maintenance study days 30 Leer másBackground Thyroid carcinoma is the most common endocrinological malignancy, but its spread to bone is rare. Particularly, bone metastases leading to complete resorption of the humerus are extremely u...
thyroid carcinoma bone metastasis humeral metastasis surgical treatment individualized treatment multidisciplinary approach metastases carcinoma thyroid surgical humeral amputation bone limb Leer másThyroglobulin (TG) is a dimeric glycoprotein produced exclusively by mature thyroid tissue and stored within the follicular lumen. It is essential for the organification of iodine and the production o...
thyroglobulin thyroid thyroiditis immune‐checkpoint inhibitors covid-19 tissue clinical Leer másBackground Compared to the recurrent laryngeal nerve, the EBSLN (or external laryngeal nerve) is less studied in terms of its course and relationship with the thyroid gland. This is a prospective intr...
external branch of the superior la... external laryngeal nerve thyroidectomy external prospective superior study laryngeal thyroid nerve Leer másPURPOSE: Our study aimed to diagnose benign or malignant thyroid nodules larger than 4 cm using quantitative diffusion-weighted imaging (DWI) analysis. METHODS: Eighty-two thyroid nodules were investi...
multivariate benign analysis calculated thresholds rate acr-tirads unnecessary biopsy sir dwi value quantitative adc malignant combined thyroid min model 0 Leer másBackground: In the last years growing evidences on the role of radiomics and machine learning (ML) applied to different nuclear medicine imaging modalities for the assessment of thyroid diseases are s...
thyroid machine learning radiomics texture analysis positron emission tomography systematic role radiomics diseases ml review Leer másSIMPLE SUMMARY: The lambing trait is an important production trait in sheep, and the FecB gene is one of the major genes affecting sheep reproduction. In order to explore the molecular regulatory mech...
molecular regulatory multiple analysis sheep thyroid mechanisms trait decs Leer másBackground While thyroid dysfunction develops in about 50% of untreated children with cystinosis, there is no data about how the sonography of thyroid tissue appears in this disease. Therefore, the pu...
cystinosis doppler elastography stiffness thyroid ultrasound lower patients gland swe disease findings thyroid Leer másThyroid hormones(THs) are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead ...
autoimmune thyroid disease hyperthyroidism hypothyroidism ovarian premature ovarian failure disease thyroid autoimmune Leer másSpindle epithelial tumor with thymic like elements (SETTLE) is a biphasic tumor composed of epithelial and spindle cell components. It is an uncommon indolent tumor arising in the thyroid gland and mo...
settle thyroid biphasic tumor settle Leer másBackground Primary thyroid lymphoma (PTL) is a rare malignant disorder, and ultrasound plays an important role in PTL diagnosis and follow-up surveillance. Prediction of refractory/relapse events in P...
primary thyroid lymphoma ultrasound relapse refractory treatment outcome refractory/relapse features diffuse ultrasound efs thyroid lymphoma Leer másMicrogravity in space impacts human health. In particular, thyroid cancer, which has a high incidence rate, has been the subject of numerous studies with respect to microgravity. However, most studies...
genes cells studies cancer thyroid lines cell microgravity Leer másBackground The family of perfluoroalkyl and polyfluoroalkyl substances (PFAS) raised concern for their proven bioaccumulation and persistence in the environment and animals as well as for their hazard...
pfoa pfos endocrine disruptor thyroid pfos compounds similar function structure pfoa thyroid pfas Leer másBACKGROUND: Parathyroid glands are important endocrine glands, and the identification of normal parathyroid glands is crucial for their protection. The aim of this study is to explore the sonographic ...
blood flow ultrasound characteristics glands display normal thyroid parathyroid Leer másPurpose Our study aimed to diagnose benign or malignant thyroid nodules larger than 4 cm using quantitative diffusion-weighted imaging (DWI) analysis. Methods Eighty-two thyroid nodules were investiga...
diffusion-weighted imaging quantitative evaluation large thyroid nodule benign and malignant multivariate benign analysis calculated thresholds rate acr-tirads unnecessary biopsy adc dwi quantitative dwi_sir adc_min thyroid malignant combined model value 0 Leer másAims To study the correlation between clinicopathological risk factors and the risk for intervention-requiring cancer recurrence in patients with small papillary thyroid cancers (sPTCs). Materials and...
papillary thyroid cancer (ptc) small ptc recurrence lateral lymph node metastasis (n1b... risk factors n0 thyroid cancer patients sptc 0 factors vs n1b compared n1a risk Leer másBACKGROUND: Microwave ablation is a new, minimally invasive technique for the treatment of thyroid nodules. Hyperthyroidism due to destructive thyroiditis is a known risk of microwave ablation, though...
nearly report levels nodule patient graves’ disease microwave thyroid ablation Leer másBackground Thyrotropin-secreting adenoma (TSHoma) is the least common type of pituitary adenoma, these patients often present with symptoms of hyperthyroidism. When TSHoma patients combined with autoi...
thyrotropin-secreting adenoma autoimmune hypothyroidism thyrotropin treatment results difficult patients combined patient test autoimmune revealed thyroid hypothyroidism tshoma Leer másObservational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may...
thyroid putative inflammatory suggest ptsd significant effect crp autoimmune causal disease shared Leer másDisturbances in the homeostasis of the elemental composition of thyroid tissue may have serious metabolic and health consequences. It is believed that the accumulation of some metals or the deficiency...
thyroid nodular goiter metallomics glycation inflammation thyroid Leer másBackground Individuals whose gender identity differs from the biological sex and the social norms are defined as transgender. Sometimes transgender undergo gender affirming hormone therapy, which last...
hormone therapy testosterone estrogen cyproterone acetate risk assessment effects specific gender sex therapy levels implementation people serum liver transgender doses risk thyroid assessment Leer másINTRODUCTION: In recent years, the incidence of thyroid cancer has increased manyfold and young adults, who have a greater financial burden and occupational stress, comprise a large number. Previous s...
risk thyroid cancer Leer másBackground Cancer is a life-threatening disease in humans; yet, cancer genes are frequently reported to be under positive selection. This suggests an evolutionary-genetic paradox in which cancer evolv...
cancer driver genes positive selection primates modern human populations thyroid cancer types humans analysis thyroid genes evolution populations human selection Leer másThyroid hormones are crucial regulators of metamorphosis and development in bilaterians, particularly in chordate deuterostomes. Recent evidence suggests a role for thyroid hormone signaling, principa...
stars metamorphic echinoderm mapk echinoids hormone sea signaling thyroid development Leer másBACKGROUND: Prediction of lymph node metastasis (LNM) is critical for individualized management of papillary thyroid carcinoma (PTC) patients to avoid unnecessary overtreatment as well as undesired un...
carcinoma papillary performance radiologists mmd-dl enrolled metastasis lymph node ptc thyroid prediction patients diagnostic 0 Leer másPURPOSE: Current clinical practices favor less or no thyroid-stimulating hormone (TSH) suppression for low- to intermediate-risk thyroid cancer patients who receive thyroid lobectomy. The association ...
high-tsh tsh thyroid suppression patients study lobectomy Leer másBackground Salvage radical prostatectomy (sRP) is an important treatment option for patients with recurrent prostate cancer (PCa) after radiotherapy (RT) or focal therapy (FT). However, health-related...
quality of life salvage radical prostatectomy long-term outcome salvage recurrent pca erectile primary prostate mean = 0 rt-srp ft-srp patients srp vs Leer másBackground This study investigated the relaxation effect of PGE2 on the ureter and its role in promoting calculi expulsion following calculi development. Methods By using immunofluorescence and Wester...
pge2 ep2 camp ureteral calculi relaxation blot expression calculi western ep4 muscle smooth ep2 relaxation ureter pge2 Leer másDas fortgeschrittene/metastasierte Urothelkarzinom ist eine aggressive Erkrankung mit daraus resultierender begrenzter Lebenserwartung der Patienten. Die bisherige Standardtherapie beschränkte sich la...
chemotherapie immuntherapie enfortumab-vedotin erdafitinib sacituzumab-govitecan chemotherapy immunotherapy enfortumab vedotin erdafitinib sacituzumab govitecan bei option mit für disease chemotherapy der die eine ist platinum-based oder chemotherapie line und weitere nach treatment Leer másPurpose This study aims to report on functional outcomes in a large cohort of patients who underwent inpatient rehabilitation (IR) in a highly specialized, high-volume German urologic rehabilitation c...
urinary incontinence erectile dysfunction functional outcome inpatient rehabilitation ileal neobladder 95% women ci p = 0 urinary inb t3 patients Leer másObjectives Among different renal replacement therapies (RRTs), peritoneal dialysis (PD) is a family based treatment method with multiple advantages, which allowing patients to maintain autonomy, avoid...
peritoneal dialysis volume management visualization research hotspots bibliometric analysis trends pd emergence methods volume patients dialysis hotspots research peritoneal keyword Leer másBackground Postinfectious glomerulonephritis with C3-dominant glomerular deposition (C3-PIGN) involves C3-dominant glomerular deposition without immunoglobulin. Atypical C3-PIGN involves persistent hy...
postinfectious glomerulonephritis hypocomplementemia complement-related gene mutation atypical c3-pign pathway complement mutations genes patients Leer másThe Catholic world is shaped by papal directives and their interpretation over time by appointed theologians. There are strict prohibitions on key questions about life and death, but in the context of...
glaubenslehre verhütung ehe impfung naturheilkunde masturbation ethik doctrine of faith contraception marriage vaccination naturopathy masturbation ethics der die Leer másPurpose To identify the risk factors for 5-year cancer-specific (CSS) and overall survival (OS) and to compare the accuracy of logistic regression (LR) and artificial neural network (ANN) in the predi...
non-muscle-invasive bladder cancer... t1 stage survival artificial neural network deep learning bladder survival factors cancer tumour accuracy analysis t1 risk prediction css lr Leer másBackground Patients with localized prostate cancer (PC) are faced with a wide spectrum of therapeutic options at initial diagnosis. Following radical prostatectomy (RP), PC patients may experience reg...
decision regret radical prostatectomy psa-anxiety prostate cancer-related anxiety depression anxiety symptoms depressive regret patients long-term decision following rp Leer másObjective To report the experience of partial inferior pubicectomy in the treatment of complex posterior urethral stricture after trauma. Methods A total of 46 patients with post-traumatic posterior u...
urethroplasty inferior partial pubicectomy complex posterior urethral strictu... postoperative surgical inferior repair operation urethral stricture pubicectomy partial posterior Leer másRobotic-assisted surgery (RAS) is increasingly adopted in the pediatric population. This retrospective multicenter study aimed to report application of RAS for gynecological indications in pediatric p...
robot gynecology tumors robotic-assisted adolescents children ovarian cyst pediatric pathology gynecological median = 1 time Leer másObjectives Comparing stone-free rates and associated outcome measures between two surgical modalities of lithotripsy fragmentation and removal or spontaneous passage of dust during retrograde intraren...
ureteroscopy ... nephrectomy calculi lithotripsy ... surgery excluded ci studies terms = 0 articles – dust rate fragmentation Leer másBackground Wilms tumor (WT), also known as nephroblastoma, is rare in adults, accounting for merely 3% of all nephroblastomas or 0.2 cases per million individuals. Extrarenal Wilms tumor (ERWT) emerge...
wilms tumor nephroblastoma extrarenal wilms tumor extra-renal nephroblastoma spinal dysraphism spinal tumors spinal wilms tumor Leer másBackground Although the widespread use of long-acting erythropoiesis-stimulating agents (ESAs) has facilitated the improvement of anemia in patients with chronic kidney disease (CKD), the improvement ...
anemia cardiovascular disease chronic kidney disease iron transferrin saturation 95% long-acting darbepoetin alfa confidence iron deficiency improvement agents agent ratio hazard non-dialysis-dependent significantly treated transferrin events erythropoiesis-stimulating saturation patients cardiovascular 0 Leer másPurpose Circumcision is the most common surgical procedures performed in males. Medical circumcision is recommended for diseases such as phimosis, paraphimosis, balanoposthitis and common urinary trac...
circumcision clamp ring devices children suturless operation patients time circumcision Leer másPurpose To evaluate the role of certain radiological parameters and patient characteristics in predicting the success of endoscopic treatment in ureteral stricture disease. Methods Fifty one adult pat...
ureteral stricture endoscopic treatment ureteric stone ureteral wall thickness value patient disease stricture parameters radiological failure treatment endoscopic uwt ureteral patients Leer másThe MMI Symani^® is a recently approved robotic microsurgical system for surgical procedures in adults. The system enables the surgeon to create microanastomoses. Clinical applications so far include ...
minimal invasive microsurgery coronary surgery microanastomoses robotic surgery vascular surgery porcine evaluation anastomosis performed anastomoses system Leer másPurpose To evaluate our experience with different surgical techniques and to find clinical factors that affect the outcome of treatment in cases of redo-hypospadias. Methods We have retrospectively ev...
hypospadias hypospadias surgery cripple hypospadias pediatric urology 1% 32 underwent 25 17 meatal surgery technique 9% surgical = 0 Leer másPurpose Despite advances in technology, such as advent of laser enucleation and minimally invasive surgical therapies, transurethral resection of the prostate (TURP) remains the most widely performed ...
benign prostatic hyperplasia international prostatic symptom sc... resection volume transurethral resection of the pro... parameters bph ipss resection patients data retreatment rv Leer másBackground LncRNA has an effective value in many diseases, which has long been applied in the diagnosis, treatment and prognosis of prostate cancer. This study focused on lncRNA PITPNA-AS1, and its di...
lncrna pitpna-as1 prostate cancer mir-129-5p diagnosis tumor progression expression silencing assay lncrna diagnostic cells Leer másThe endogenous capacity of the kidney to repair is limited, and generation of new nephrons after injury for adequate function recovery remains a need. Discovery of factors that promote the endogenous ...
pediatric nephrology kidney regenerative medicine Leer másPurpose The combined approach (CB) of magnetic resonance imaging (MRI)-guided biopsy (TB) and systematic biopsy (SB) is strongly recommended based on numerous studies in biopsy naïve men with suspicio...
clinically significant prostate ca... biopsy method mri systematic biopsy patients mri cspca biopsy cb Leer másBackground Prostate cancer with bone metastasis has significant invasiveness and markedly poorer prognosis. The purpose of this study is to establish two nomograms for predicting the overall survival ...
bone metastases nomogram overall survival prostate cancer cancer stage study ajcc os system patients nomograms bone survival prostate metastasis nomogram Leer másPurpose The study aimed to assess the efficacy of OpenAI's advanced AI model, ChatGPT, in diagnosing urological conditions, focusing on kidney stones. Materials and methods A set of 90 structured ques...
artificial intelligence chatgpt urology kidney stones descriptive questions accuracy responses Leer másPurpose To provide a descriptive report of mortality and morbidity in the first 30 days of diagnosis of urosepsis. Secondary aim is to identify risk factors of unfavourable outcomes. Methods Prospecti...
severe uti urosepsis antibiotic resistance morbidity failure study urosepsis ci Leer másProfessor Gerhard Sand (1861–1921) was the first professor of veterinary obstetrics at the Royal Veterinary and Agricultural University, Copenhagen, Denmark. He began teaching the theory and practice ...
calving foaling obstetrics sand emasculator castration clamp teaching veterinary curriculum veterinary horses dystocia cattle illustrations sand Leer másBackground: Antimicrobial stewardship programs (ASPs) are important tools to foster prudent antimicrobial use. Objective: To evaluate antimicrobial prescriptions by Swiss veterinarians before and aft...
proportion infection veterinary significantly 001 vs decreased 2018 antimicrobial 2016 antimicrobials prescriptions Leer másBackground Bovine uterine prolapse is a sporadic but life-threatening postpartum condition. The aims of this study were; (i) to determine which clinical findings determined the likelihood of treatment...
bovine cow hazard obstetrics prognosis veterinary bovine correlated time determine likelihood identify days methods cows clinical ci data 95% dairy beef performed 0 p = 0 hazard prolapse uterine Leer másBACKGROUND: Dental disease is very common in dogs and veterinary professional dental cleaning and examination, together with daily dental home care, is the foundation for good dental health. To our kn...
radiography anesthesia routines respondents access equipment dental performed vn swedish veterinarians nurses veterinary cleaning Leer másSIMPLE SUMMARY: Veterinary electronic prescription (VEP) is mandatory by law, dated 20 November 2017, No. 167 (European Law 2017) Article 3, and has been implemented in Italy since April 2019. In this...
mandatory university teaching hospital medicine veterinary prescription vep Leer másThe treatment of feline sporotrichosis is a challenge for veterinary clinicians since refractory cases may occur, due either to patient and/or to pharmacological management errors or due to the develo...
therapeutic veterinary itz sporotrichosis cat feline itraconazole-resistant brasiliensis cats Leer másSIMPLE SUMMARY: Veterinary electronic prescription (VEP) is mandatory by law, dated 20 November 2017, No. 167 (European Law 2017) Article 3, and has been implemented in Italy since April 2019. In this...
mandatory university teaching hospital medicine veterinary prescription vep Leer másSIMPLE SUMMARY: COVID-19 has impacted veterinary medicine and cat guardians in numerous ways. The purpose of this study was to better understand cat guardians’ fears and concerns pertaining to veterin...
ability obtain impact veterinary concerns Leer másBackground Recognition of the factors that influence academic performance in university students constitutes one of the key objectives of education researchers. Few studies have been conducted in this...
psychological characteristics academic fit well-being academic performance veterinary students study factors veterinary fit relationship students academic Leer másPigmentary uveitis (PU), also known as Golden Retriever Pigmentary Uveitis (GRPU), is a common ocular condition of Golden Retrievers that has severe, vision‐threatening ocular complications and can re...
golden retriever diagnosis veterinary ocular pigmentary uveitis Leer másSIMPLE SUMMARY: Aerosolized particulates are potential sources of contamination for working dogs across a variety of environments. This work describes a simple wipe-down procedure using common veterin...
dogs common particulates contamination 0 coat pvd veterinary effective removal chx simple decontamination wipe-down aerosolized canine procedure Leer másSIMPLE SUMMARY: Interprofessional learning is increasingly important across all health care sectors, including veterinary medicine. Communication with animal owners and within the team is considered a...
pre- course ripls study veterinary readiness interprofessional learning Leer másLarge language models (LLMs) can extract information from veterinary electronic health records (EHRs), but performance differences between models, the effect of temperature settings, and the influen...
ehrs extraction 9% 81 4% 96 iqr information veterinary performance temperature Leer másSIMPLE SUMMARY: On 23 March 2020, the UK Government introduced its first nationwide lockdown as part of efforts to reduce the impact of COVID-19. There have since been two more. “Lockdown” control mea...
using data telephone march vets trainers 2020 care racehorse veterinary changes covid-19 Leer másThe exposure to Brucella species is an occupational hazard for veterinary personnel in India. In our previous study, paraveterinarians and animal handlers were found to be at higher risk of being sero...
exposure high-risk compared india 0 ppe veterinary amongst personnel 95% handlers ci animal Leer másBackground In animals, the endocannabinoid system regulates multiple physiological functions. Like humans, animals respond to preparations containing phytocannabinoids for treating several conditions....
cannabis endocannabinoid system cats dogs veterinary medicine cats dogs cannabis Leer másSARS-CoV-2 has clearly shown that efficient management of infectious diseases requires a top-down approach which must be complemented with a bottom-up response to be effective. Here we investigate a n...
veterinary data surveillance diseases Leer másThis paper explores the innovative use of simulation environments to enhance data acquisition and diagnostics in veterinary medicine, focusing specifically on gait analysis in dogs. The study harnes...
acquisition medicine veterinary Leer másThe AllergoVet study longitudinally examines the influence of animal exposure on the development of sensitization and allergic diseases among veterinary medicine students. In this group, contact to an...
veterinary prevalence contact students medicine p = 0 trend increasing allergens sx1 animals animal allergic study exposure dogs symptoms Leer másBackground Retractions are a key proxy for recognizing errors in research and publication and for reconciling misconduct in the scientific literature. The underlying factors associated with retraction...
editorial policies publication ethics publication misconduct research misconduct veterinary journals published animal 2% retractions retraction misconduct health journal veterinary articles Leer másSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people globally since its first detection in late 2019. Besides humans, cats and, to some extent, dogs were shown ...
pandemic oropharyngeal 1% positive rna ci swab 95% dog dogs infection veterinary 0 Leer másHigh-quality, well-annotated, healthy tissue specimens are crucial to the success of basic and translational research, but often difficult to procure. Postmortem (PM) tissue collections provide the op...
cornell average research postmortem tissue biospecimens collections veterinary cvb Leer másThe Boxer is a medium-large sized, active dog with a short coat and a moderately flat-faced (brachycephalic) skull shape. Despite many decades of popularity in the UK, there is limited published evide...
vetcompass electronic patient record epr breed dog epidemiology primary-care veterinary pedigree purebred ear average evidence female male non-white boxer disorder health disorders study white recorded breed Leer másThe genus Tenacibaculum (family Flavobacteriaceae, phylum Bacteroidetes) was proposed in 2001 by Suzuki et al. and currently includes 28 valid species. These bacteria are found exclusiv...
typing belonging d’identification spectral reference strains l’espèce cadre d’un fish typage bactéries veterinary species genus maldi-tof genre mass based masse méthode developed j’ai au method bacteria projet project génomes identification genomes ainsi spectrométrie espèces spectrometry tenacibaculum Leer másThe indiscriminate usage and overuse of antimicrobials in pets or companion animals are underlying causes of antimicrobial resistance (AMR). Despite the multi-faceted global challenge presented by ant...
clean veterinary surgical resistance amr reported antimicrobial pet Leer másBACKGROUND: The prevalence of allergic rhinitis (AR) has been increasing steadily worldwide, especially in countries with increasing industrialization such as China. However, available evidence regard...
region ci china 95% prevalence risk 0 Leer másBackground: Animal allergies are common, with reactions ranging from rhinoconjunctivitis from respiratory exposure to anaphylaxis, usually from animal bites. Since animal bites are also common, this r...
bite Leer másBACKGROUND: The mainstay of treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is systemic corticosteroid therapy; some patients also receive intravenous immunoglobulins, other immunos...
egpa dose responders eosinophil daily bvas rates p < 0 01 lower patients visit super-responders mepolizumab relapse treatment Leer másMorphea en coup de sabre and progressive hemifacial atrophy are extremely rare connective tissue disorders causing facial deformity. In extreme cases, morphological disorders are accompanied by sympto...
system atrophy stomatognathic morphea tissue Leer másINTRODUCTION: Skin diseases affect patients at any age, but as each period in life is different, tools used to assess quality of life impairment should be adjusted according to the particular age grou...
time teenagers life 0 quality Leer másBACKGROUND: There is considerable interest in improving the scoring methods for evaluating the efficacy of allergen immunotherapy (AIT) and to show if this is associated with clinically meaningful res...
slit immunotherapy −1 placebo relevance 5‐grass tablet clinical Leer másOBJECTIVE: Transforming growth factor-β-associated kinase 1 (TAK1) mediates non-canonical TGF-β signalling by promoting adhesive, migratory, proliferative and contractile responses of fibroblasts to T...
p-tak1 obstruction fixed tgf-β sputum tak1 fao airway Leer másBACKGROUND: Anaphylaxis is a serious systemic hypersensitivity reaction that requires immediate recognition and prompt administration of epinephrine/adrenaline. The present study aimed to assess the a...
pediatric children emergency discharge included management epinephrine/adrenaline ed anaphylaxis Leer másBACKGROUND: Significant morbidity and mortality are associated with poor asthma control. The aim of this study was to determine factors associated with poor control and referral to specialist secondar...
poorly controlled asthma referral associated factors poor Leer másBACKGROUND: Patients with non-mast cell mediator-induced angioedema (NM-AE) usually experience a diagnostic delay. Therefore, a clinical tool for predicting NM-AE diagnosis is essential. OBJECTIVE: To...
diagnosis ci mediator-induced clinical diagnostic participants m-ae 95% hands analysis angioedema photomax cell 0 nm-ae Leer másBACKGROUND: The Angioedema Control Test (AECT) is a patient‐reported outcome measure developed and validated for the assessment of disease control in patients with recurrent angioedema. Its sensitivit...
anchors recurrent control angioedema patients changes mcid Leer másPURPOSE: The abnormal expression of tight junction (TJ) plays a vital role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, there is no appropriate tool to distinguis...
study tj 05 levels 0 crswnp predictive claudin-3 barrier epithelial Leer másINTRODUCTION: Specific immunoglobulins E (sIgE) are important parameters for the estimation of severity of allergic diseases. AIM: To determine the relationship between the concentration of specific I...
concentration healthy weakly types serum negative ige respondents test detected specific antibodies skin-prick 0 asthma sige Leer másPURPOSE: In chronic spontaneous urticaria (CSU), autoimmune thyroid disease is the most common autoimmune comorbidity, and many CSU patients have immunoglobulin (Ig)E or IgG autoantibodies to thyroid ...
responses elevated and/or disease igg csu autoantibodies ige anti-tpo Leer másBACKGROUND: The prevalence of asthma among children has been on the rise worldwide, leading to significant morbidity and mortality. Our study was conducted to determine the prevalence of asthma and it...
wheezing arabia 6% reported study children jazan region saudi factors risk prevalence asthma Leer másPURPOSE: Chronic cough (CC) is associated with health-related quality of life (HRQoL) impairment. However, the determinants of HRQoL are under-investigated. METHODS: Patients aged 19–80 years with CC ...
healthy ± non-cough life quality index cough controls hrqol chronic 0 Leer másBACKGROUND: While the impacts of atopic dermatitis (AD) on maternal and child sleep outcomes have been previously explored, less is known about the associations between infantile AD and sleep quality ...
quantity outcomes quality data atopic dermatitis sleep ad severity maternal infantile Leer másBACKGROUND: Despite the low prevalence of IgE sensitivity to fresh or boiled coconut milk and coconut oil, those may contain allergens of which the clinical significance remains undetermined. This stu...
milk allergen 128 kda boiled 110 kda ige unrefined oil allergens coconut 87 Leer másBACKGROUND: Atopic dermatitis and food allergy are two frequently concomitant manifestations of the presence of atopy. A substantial number of studies have been published on the association of birth o...
0 common spt birth rr 95% ci food allergy atopic dermatitis atopy Leer másBACKGROUND: Real world data on the response to the SARS-CoV-2 vaccine in patients with immunomediated diseases (IMIDs) treated with immunesuppressants is of great interest because vaccine response may...
lower humoral treated rituximab controls response sars-cov-2 ab vaccination levels tnfi imids patients Leer másBACKGROUND: Astigmatic mites contain potent allergens that can trigger IgE‐mediated immune responses, leading to allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. In house dus...
allergens evolution gene mite Leer másFood-dependent exercise-induced anaphylaxis is a disorder in which a reaction develops only in association with physical exertion that generally takes place postprandially. The reaction that occurs fo...
exercise-induced banana food-dependent Leer másBACKGROUND: Childhood atopic dermatitis can have a negative effect on caregivers’ quality of life and stress levels due to the burdensome nature of its treatment. Given that the condition often emerge...
negative impact infantile controls bonding Leer másBACKGROUND: Eosinophil inflammation often persists in the airways of severe asthmatics, even under treatment with high-dose inhaled corticosteroids. Biologics for various type 2 cytokines have been re...
− functions directly edn generation il-5 various severe adhesiveness eosinophils eosinophil healthy cytokines Leer másBACKGROUND: The impact of non‐pharmacological interventions (NPIs) on asthma prevention and management is insufficiently examined. We aim to comprehensively evaluate and synthesize existing evidence r...
review adulthood adults quality various management reviews interventions course prevention npis control evidence Leer másUtilizamos cookies y otras tecnologías similares para :
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