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ExplorarBackground Mild cognitive impairment (MCI) may evolve into dementia. Early recognition of possible evolution to Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) is of importance, but actua...
lewy body dementia alzheimer dementia mild cognitive decline meta-analysis disease accuracy clinical studies markers Leer másThis study is based on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset and aims to explore early detection and disease progression in Alzheimer's disease (AD). We employ innovative da...
disease alzheimer data Leer másCHRFAM7A is a human-specific gene that encodes the nicotinic acetylcholine receptor (nAChR) subunit dupα7. This gene originated after a fusion between a partial duplication of the CHRNA...
cultures levels significant exposure ma aβ-induced cerveau exposition exprimant aß sous-unité au subunit alzheimer α7-nachr human role disease interneurons neuronal ins chrfam7a aβ gene maladie gène Leer másThe activation of the Wnt signaling pathway is implicated in a neuroprotective mechanism against the Alzheimer disease. When this pathway is blocked, it activates GSK3 beta, leading to tau hyperphosph...
binding potential molecular alzheimer disease dkk1 compounds lrp6 Leer másBackground Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and inflammation. Microglia mainly participate in the inflammat...
alzheimer’s disease microglia bibliometrics citespace vosviewer alzheimer publications bibliometric hotspots disease microglia research Leer másDeep learning methods have significantly advanced medical image segmentation, yet their success hinges on large volumes of manually annotated data, which require specialized expertise for accurate l...
alzheimer disease segmentation model Leer másDisinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism rem...
chloride treatment decline alzheimer kcc2 cognitive Leer másRetinal optical coherence tomography (OCT) images are the biomarkers for neurodegenerative diseases, which are rising in prevalence. Early detection of Alzheimer's disease using retinal OCT is a pri...
oct swin transnetoct computer science transformer alzheimer disease images accuracy retinal Leer másRetinal optical coherence tomography (OCT) images are the biomarkers for neurodegenerative diseases, which are rising in prevalence. Early detection of Alzheimer's disease using retinal OCT is a pri...
oct swin transnetoct computer science transformer alzheimer disease images accuracy retinal Leer másIL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells...
alzheimer Leer másAlzheimer's Disease is a global health challenge that requires early and accurate detection to improve patient outcomes. Magnetic Resonance Imaging (MRI) holds significant diagnostic potential, but ...
system alzheimer data mri disease blockchain Leer másBackground Dementia is one of the major causes of disability and dependency among older people worldwide. The formation of an aging population in Iran can be associated with societal problems, includi...
alzheimer dementia prevalence iran systematic review meta-analysis review studies systematic 0 estimated dementia prevalence ci 95% iran Leer másAlzheimer's disease (AD) is a progressive and irreversible brain disorder that unfolds over the course of 30 years. Therefore, it is critical to capture the disease progression in an early stage suc...
alzheimer learning disease ad risk Leer másBackground Mild cognitive impairment (MCI) may evolve into dementia. Early recognition of possible evolution to Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) is of importance, but actua...
lewy body dementia alzheimer dementia mild cognitive decline meta-analysis disease accuracy clinical studies markers Leer másBackground Evidence on the relative risk of death across all stages of Alzheimer’s disease (AD) is lacking but greatly needed for the evaluation of new interventions. We used data from the Uniform Dat...
mortality alzheimer mild cognitive impairment prodromal ad predementia comorbidity institution study stage relative severity alzheimer’s participants mortality dementia death risk Leer másInternational audience; Age, sex and APOE-ε4 genotype have been identified as the strongest predictors of the risk of developing Alzheimer's Disease (AD). This work models the pathologic...
disease genotype alzheimer sex Leer másInternational audience; The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the identification of many diseases. This article aimed to ...
alzheimer diseases biomarker parkinson molecularly imprinted polymers disease biomarkers Leer másInternational audience; Age, sex and APOE-ε4 genotype have been identified as the strongest predictors of the risk of developing Alzheimer's Disease (AD). This work models the pathologic...
disease genotype alzheimer sex Leer másBackground Alzheimer’s disease (AD) is a neurodegenerative disease with complex disease etiology and pathological processes. These include formation of plaques and tangles, aberrant lipid processing, ...
alzheimer clinical trial design oxidative stress stress functional oxidative cognitive biomarkers eeg endpoints disease tw001 Leer másInternational audience; Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including accumulation of abnormal proteins...
dementia alzheimer csf markers sequence disease cognitive latent time clinical progression Leer másNeurodegeneration as measured through magnetic resonance imaging (MRI) is recognized as a potential biomarker for diagnosing Alzheimer's disease (AD), but is generally considered less specific than ...
dataset alzheimer computer imaging model mri Leer másInsoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer’s ...
alzheimer tau seeding spreading microglia propagation oligomeric compared seeding tau Leer másBackground Research into the neurobiological underpinnings of learning and memory has demonstrated the cognitive-enhancing effects associated with diverse classes of phosphodiesterase (PDE) inhibitors...
mild cognitive impairment dementia alzheimer cognitive dysfunction roflumilast phosphodiesterase 4 memory drug intervention randomized controlled trial 2020 mci protocol impairment trial ad pde memory roflumilast participants study Leer másAlzheimer's Disease is an incurable cognitive condition that affects thousands of people globally. While some diagnostic methods exist for Alzheimer's Disease, many of these methods cannot detect Al...
science disease anns alzheimer Leer másAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide, necessitating early and accurate diagnosis for optimal patient management. In recent years, advancements in dee...
3d deep computer mri learning accuracy vit-bilstm science disease alzheimer cnn-bilstm models ad video diagnosis Leer másBiallelic pathogenic repeat expansions in RFC1 were recently identified as molecular origin of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) as well as of one of the most commo...
repeat analysis oxford nanopore sequencing amyotrophic lateral sclerosis rfc1 mnd motor neuron disease additional clinical repeat mnd expansions rfc1 Leer másBackground Amyotrophic lateral sclerosis (ALS) is characterized by a rapid disease course, with disease severity being associated with declining health-related quality of life (HRQoL) in persons livin...
amyotrophic lateral sclerosis quality of life patient-reported outcomes disease progression real-world evidence disease stages als clinical outcomes cals Leer másBackground Given the large genetic heterogeneity in amyotrophic lateral sclerosis (ALS), it seems likely that genetic subgroups may benefit differently from treatment. An exploratory meta-analysis ide...
amyotrophic lateral sclerosis lithium carbonate snp rs12608932 randomized controlled trial genetic trial homozygous snp c-allele unc13a rs12608932 als patients Leer másAmyotrophic lateral sclerosis (ALS) is the most common subtype of motor neuron disease (MND). The current gold-standard measure of progression is the ALS Functional Rating Scale—Revised (ALS-FRS(R)), ...
amyotrophic lateral sclerosis motor neuron disease devices sensors clinical trials technology function evaluate mnd included motor progression studies Leer másBackground Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease whose spreading and progression mechanisms are still unclear. The ability to predict ALS prognosis would improve the patie...
amyotrophic lateral sclerosis progression trajectories process mining process discovery patient stratification prognosis patients’ onset data als–bs patients terms process progression als pro-act disease impairment trajectories Leer másBackground Amyotrophic lateral sclerosis (ALS) is phenotypically heterogeneous in motor manifestations, and the extent of upper vs. lower motor neuron involvement is a widespread descriptor. This stud...
amyotrophic lateral sclerosis frontotemporal degeneration cognitive impairment: upper motor ... lower motor neuron neuron scores ecas-total cognition motor phenotypes classical Leer másBackground Although percutaneous endoscopic gastrostomy (PEG) offers better access to the gastrointestinal system, in patients with previous abdominal surgery, PEG can be unsuccessful. Laparoscopicall...
gastrostomy laparoscopic surgery amyotrophic lateral sclerosis remnant performed stomach percutaneous patients gastrostomy Leer másNeurodegenerative diseases are a group of disorders characterized by progressive loss of certain populations of neurons, which eventually lead to dysfunction. These diseases include Alzheimer’s diseas...
th17 il-17a alzheimer’s disease parkinson’s disease amyotrophic lateral sclerosis targeted therapy th17/il-17a diseases Leer másBackground The time of survival in patients with amyotrophic lateral sclerosis (ALS) varies greatly, and the genetic factors that contribute to the survival of ALS are not well studied. There is a lac...
amyotrophic lateral sclerosis genes variants modifier survival review pairwise articles systematic network genes survival factors Leer másAmyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in adults with no curative treatment. Neurofilament (NF) level in patient’ fluids have recently emerged as the prime bi...
amyotrophic lateral sclerosis human induced pluripotent stem cel... motoneurons neurofilaments axonal initial segment degeneration pnf-m/h mns ais als axonal nf Leer másAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons, leading to paralysis and eventually death. Symptomatic treatments such as i...
amyotrophic lateral sclerosis motor neurons autophagy stem cells gene editing progression therapies als Leer másAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of both upper and lower motoneurons, leading to motor and non-motor symptoms. Recent evidence...
amyotrophic lateral sclerosis sensory neuropathy systematic review neurodegeneration non-motor symptoms disease symptoms patients Leer másBackground The present study aimed at evaluating the diagnostic properties of the Frontal Assessment Battery (FAB) in non-demented ALS patients by addressing the Edinburgh Cognitive Behavioural ALS Sc...
frontal assessment battery amyotrophic lateral sclerosis cognitive screening executive diagnostics psychometrics predicted motor als stages administrability below-cut-off scores Leer másBackground Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metaboli...
raav2 agranular insula orbitofrontal cortex lateral hypothalamus hypermetabolism amyotrophic lateral sclerosis lateral patients cortex mouse disruption murine hypothalamic projections als Leer másBackground Sarcopenia is the age-related loss of muscle mass and strength. Undiagnosed late-onset neuromuscular disorders need to be considered in the differential diagnosis of sarcopenia. Aim Based o...
sarcopenia neuromuscular disease amyotrophic lateral sclerosis myotonic dystrophy type 2 inclusion body myositis diagnosis criteria diseases late-onset patients neuromuscular Leer másThe most prominent genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) is a repeat expansion in the gene C9orf72 . Importantly, the transcriptomic co...
c9orf72 amyotrophic lateral sclerosis frontotemporal lobar degeneration transcriptomics cryptic exons transcriptomic cerebellum repeat expansion Leer másBehavioral disorders, with an average prevalence of 30–60% are important non-motor symptoms in amyotrophic lateral sclerosis (ALS) that have a negative impact on prognosis, management and quality of l...
amyotrophic lateral sclerosis behavioral disorders apathy anxiety epidemiology neuroimaging functional connectivity biomarkers treatment options disorders current brain symptoms behavioral als Leer másSoccer is one of the most popular sports worldwide, played by over 270 million people and followed by many more. Several brain health benefits are promoted by practising soccer and physical exercise a...
sports concussions heading chronic traumatic encephalopathy amyotrophic lateral sclerosis neurological disorders head trauma health soccer Leer másBackground Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways h...
amyotrophic lateral sclerosis -repeat e... pre-clinical models transcriptome genome-wide mechanisms of neuropro... srsf1-dependent rna nuclear export... disease-modifying gene expression ... voltage-gated potassium ion channe... genome-wide export motor pathological human patient-derived therapeutic neuroprotective nuclear transcripts rna neurons Leer másBackground Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease. Pathologically, it is characterized by eosinophilic hyaline intranuclear inclusions in the cells of the v...
neuronal intranuclear inclusion di... amyotrophic lateral sclerosis magnetic resonance imaging autopsy paravermal lesion case report disease autopsy lesions motor als niid coexistence intranuclear Leer másBackground Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease; most ALS patients die within 3 to 5 years after symptom onset, usually as a consequence of respirato...
amyotrophic lateral sclerosis peak expiratory flow prognosis survival < 0 0001 peak flow als patients pef function pulmonary disease = 0 Leer másAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motor neurons (MNs). Since the identification of the first ALS mutation in 1993, more than 40 genes h...
amyotrophic lateral sclerosis autophagy mutations animal models protein involved als autophagy Leer másObjective This study investigated whether cognitive screening tools used for people with amyotrophic lateral sclerosis (pwALS) are affected by the screen being administered face-to-face or remotely on...
amyotrophic lateral sclerosis cognition screening tools psychometrics telehealth tools pwals als total cognitive scores administered mini-ace face-to-face screening significantly screen administration ecasc Leer másObjectives The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis (ALS), abbreviated as the ‘Gold Coast Criteria’, with t...
amyotrophic lateral sclerosis diagnostic criteria gold coast sensitivity reec diagnostic patients gold sensitivity Leer másAmyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the disease status...
amyotrophic lateral sclerosis cytokines short chain fatty acids ttv virome metabolism microbiome research patient Leer másPurpose To investigate the relation between a diabetes risk reduction diet (DRRD) and ovarian cancer. Methods We used data from a multicentric case-control study conducted in Italy, including 1031 inc...
ovarian cancer case-control study diabetes diet glycemic index 0 diabetes risk cancer diet ovarian Leer másBackground Bladder urothelial carcinoma (BLCA) is the most common malignancy of the urinary tract, presenting with a wide range of clinical symptoms and prognosis. Disulfidptosis is a newly identified...
disulfidptosis gene bladder urothelial carcinoma immune therapy immune microenvironment infiltrati... cancer model identified immunotherapy disulfidptosis-score low blca subgroup patients prognosis Leer másCalibration, a critical step in the development of simulation models, involves adjusting unobservable parameters to ensure that the outcomes of the model closely align with observed target data. This ...
target measure models simulation parameter cancer calibration method Leer másGenomics is a crucial part of managing surgical disease. This review focuses on some of the genomic advances that are available now and looks to the future of their application in surgical practice. W...
whole-genome surgical approach vaccines genomic sequencing cancer Leer másOvarian cancer is one of the common tumors of the female reproductive organs. It has a high mortality rate, is highly heterogeneous, and early detection and primary prevention are very complex. Autoph...
cancer mirnas expression cellular cells ovarian Leer másBackground Primary care practitioners (PCPs) play a key role in cancer screening decisions for older adults (≥ 65 years), but recommendations vary by cancer type and jurisdiction. Purpose To examine t...
studies life expectancy clinician health characteristics screening adults decisions pcps recommendations data factors patient cancer Leer másBackground Lymph node metastasis is the main determinant of survival in penile cancer patients. Conventionally clinical palpability is used to stratify patients to Inguinal Lymph node dissection (ILND...
inguinal imaging lymph node penile cancer sentinel node staging criteria disease mean clinically palpability outcome patients survival dsnb cancer positive penile inguinal lymph negative Leer másTrace elements are minerals that are present in very low concentrations in the human body and yet are crucial for a wide range of physiological functions. Zinc, the second most abundant trace element,...
zinc deficiency trace elements cancer diagnosis cancer prognosis biomarker zinc cancer Leer másBackground Granzyme K (GZMK) is a crucial mediator released by immune cells to eliminate tumor cells, playing significant roles in inflammation and tumorigenesis. Despite its importance, the specific ...
gzmk prognosis immunotherapy breast cancer apoptosis analysis correlations cells assays methods significant differentiation immunotherapy breast cancer < 0 cor = 0 001 expression gzmk Leer másHigh-dose hypofractionated radiotherapy (HRT) is an important anticancer treatment modality that activates antitumor host immune responses. However, HRT for oligometastases of colorectal cancer (CRC) ...
cancer tme cells sirpα hrt Leer másBackground Whole-genome doubling (WGD) has been observed in 30% of cancers, followed by a highly complex rearranged karyotype unfavourable to breast cancer's outcome. However, the macro-alterations th...
breast cancer liver metastasis macro-alteration whole-genome doubling complex structural variation whole-genome metastatic patients node copy lymph primary tumours liver breast cancer samples macro-alterations metastasis complex Leer másCancer patients are susceptible to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Different antitumor treatments have attracted wide attention in the context of coronavirus disease 2019...
26 patients sars-cov-2 cancer icis Leer másLow molecular weight heparins (LMWH) and anti-Xa direct oral anti-coagulants (DOACs) are recommended for the long-term treatment of cancer-associated thrombosis (CAT) based on well-documented randomis...
treatment risk drug–drug cancer patients interactions Leer másEndocrine-resistance remains a major challenge in estrogen receptor α positive (ERα(+)) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is...
erα estrogen degraders receptor cancer breast 29c novel Leer másColorectal cancer (CRC) is presently a health challenge in China. Although clinical chemotherapy is prescribed availably, the negative effects and poor prognoses still occur. Genistein has antitumor p...
mechanisms cancer esr1 egfr genistein crc targets Leer másClinically significant prostate cancer (csPCa) is a leading cause of cancer death in men, yet it has a high survival rate if diagnosed early. Bi-parametric MRI (bpMRI) reading has become a prominent...
cancer stage Leer másPurpose For patients with a cancer diagnosis, coping abilities are of high importance. Cancer patients with a high sense of coherence may cope better. The purpose of this study is to learn more about ...
sense of coherence cancer general life satisfaction resilience spirituality self-efficacy aspects psychological level patients resilience 001 = 0 demographics cancer Leer másPurpose Women cancer survivors, especially those in rural areas, with high levels of depression may be acutely susceptible to pain due to the ways they think, feel, and behave. The current study seeks...
depression pain cancer survivors women self-efficacy managing pain women survivors severity depression Leer másPurpose More women diagnosed with breast cancer (BC) are living with oncology treatment–induced hot flushes (HFs). This Australian-based survey explores why some women experience more severe or ongoin...
breast neoplasms/cancer hot flushes hot flashes vasomotor symptoms chemotherapy hormone therapy predictive factors survey hot oncology occurrence severe aor −0 cancer premenopausal experiencing 0 ci 95% aco hfs survey women 001 Leer másBackground Tumors are able to acquire new capabilities, including traits such as drug resistance and metastasis that are associated with unfavorable clinical outcomes. Single-cell technologies have ma...
cancer evolution clonal selection genetic-transcription perturbation... metastasis drug resistance metabolism tumor microenvironment transcriptional evolution profiles cancer Leer másMinimally invasive surgery is safe and effective in colorectal cancer. Conversion to open surgery may be associated with adverse effects on treatment outcomes. This study aimed to assess risk factors ...
predictors impact conversion minimally invasive colectomy open colectomy colon cancer surgery associated conversion colectomy < 0 = 0 colon patients minimally invasive 001 cancer Leer másOBJECTIVE: To identify key areas for research in prostate cancer (PC) in the Ugandan context by establishing the major health system, socioeconomic and clinical barriers to seeking, reaching and recei...
care costs radiotherapy improve critical services pc diagnostic medicines delphi consensus lack cancer research statements Leer másInternational audience; Editorial on the Research Topic Cancer and nutrients: new chemicals, signals, and biomarker-based therapy Nutrients such as vitamins, minerals, fats, and amino ac...
metabolism biomarker-based signaling [sdv retinoid clinical chemicals signals cancer nutrients sciences hcc Leer másBACKGROUNDS: The perceived supportive care needs (SCNs) of cancer patients are essential components of a care program. The first step in planning and intervening for supportive care is the proper iden...
treatment study patients cancer supportive scns Leer másPurpose To describe the overall survival and progression-free survival in patients diagnosed with differentiated thyroid carcinoma with synchronous and metachronous metastatic involvement. Materials a...
metastases progression radioiodine thyroid cancer involvement survival progression median metastatic thyroid cancer differentiated time metastases metachronous Leer másWith the rapid advancement of large language models (LLMs), recent years have witnessed many promising studies on leveraging LLM-based agents to simulate human social behavior. While prior work has ...
science large-scale agents social simulation Leer másIn computer-assisted surgery, automatically recognizing anatomical organs is crucial for understanding the surgical scene and providing intraoperative assistance. While machine learning models can i...
scene computer organs generated multi-class organ Leer másThis study introduces a training-free conditional diffusion model for learning unknown stochastic differential equations (SDEs) using data. The proposed approach addresses key challenges in computat...
model data stochastic systems diffusion Leer másIt is generally perceived that Dynamic Sparse Training opens the door to a new era of scalability and efficiency for artificial neural networks at, perhaps, some costs in accuracy performance for th...
artificial dense robustness computer training dynamic sparse Leer másMany organizations depend on human decision-makers to make subjective decisions, especially in settings where information is scarce. Although workers are often viewed as interchangeable, the specifi...
framework behavior decision-aware worker optimization Leer másAs Large Language Models (LLMs) continue to evolve, they are increasingly being employed in numerous studies to simulate societies and execute diverse social tasks. However, LLMs are susceptible to ...
multi-agent interactions implicit Leer másOne key challenge to video restoration is to model the transition dynamics of video frames governed by motion. In this work, we propose TURTLE to learn the truncated causal history model for efficie...
turtle model science causal truncated video computer Leer másGenerative diffusion processes are state-of-the-art machine learning models deeply connected with fundamental concepts in statistical physics. Depending on the dataset size and the capacity of the n...
learning machine data Leer másDeep neural network based systems deployed in sensitive environments are vulnerable to adversarial attacks. Unrestricted adversarial attacks typically manipulate the semantic content of an image (e....
efficient computer unrestricted semantic Leer másAccurate prediction of human or vehicle trajectories with good diversity that captures their stochastic nature is an essential task for many applications. However, many trajectory prediction models ...
model computer prediction trajectory Leer másExplanation constitutes an archetypal feature of human rationality, underpinning learning and generalisation, and representing one of the media supporting scientific discovery and communication. Due...
inference explanation-based natural language nli Leer másDeep learning is making a profound impact in the physical layer of wireless communications. Despite exhibiting outstanding empirical performance in tasks such as MIMO receive processing, the reasons...
domain systems mimo knowledge wireless processing receive Leer másAlthough the diffusion model has achieved remarkable performance in the field of image generation, its high inference delay hinders its wide application in edge devices with scarce computing resourc...
rdd model knowledge models methods sampling Leer másThis paper presents a human verification scheme in two independent stages to overcome the vulnerabilities of attacks and to enhance security. At the first stage, a hand image-based CAPTCHA (HandCAPT...
stage bu subjects finger hand 5% accuracy verification Leer másWe explore how an AI model's decision fairness affects people's engagement with and perceived fairness of the model if they are subject to its decisions, but could repeatedly and strategically respo...
subjects people decisions model decision Leer másPrivate deep neural network (DNN) inference based on secure two-party computation (2PC) enables secure privacy protection for both the server and the client. However, existing secure 2PC frameworks ...
secure privquant Leer másA driving force behind the diverse applicability of modern machine learning is the ability to extract meaningful features across many sources. However, many practical domains involve data that are n...
machine sources target task denotes source } risk tasks dependent learning g$ $\hat \mathcal data $ Leer másThis study evaluates the effectiveness of machine learning (ML) and deep learning (DL) models in detecting COVID-19-related misinformation on online social networks (OSNs), aiming to develop more ef...
osns health learning misinformation dl models Leer másDespite the recent progress, existing frame interpolation methods still struggle with processing extremely high resolution input and handling challenging cases such as repetitive textures, thin obje...
context cascaded model diffusion interpolation frame Leer másRecommender systems play a crucial role in alleviating information overload by providing personalized recommendations tailored to users' preferences and interests. Recently, Graph Neural Networks (G...
environmental Leer másSearch engine results often misalign with users' goals due to opaque algorithms, leading to unhelpful or detrimental information consumption. To address this, we developed a Google Chrome plugin tha...
Leer másThe Informational Braess' Paradox (IBP) illustrates a counterintuitive scenario where revelation of additional roadway segments to some self-interested travelers leads to increased travel times for ...
Leer másThe task of Stance Detection involves discerning the stance expressed in a text towards a specific subject or target. Prior works have relied on existing transformer models that lack the capability ...
transformer targets detection stanceformer models Leer másTransformers have been the cornerstone of current Large Language Models (LLMs); however, its linear growth in overhead during inference with respect to sequence length poses challenges for modeling ...
dp sequence size transformers Leer másThis document presents a framework for lidar-inertial localisation and mapping named 2Fast-2Lamaa. The method revolves around two main steps which are the inertial-aided undistortion of the lidar da...
registration map 2fast-2lamaa lidar Leer másWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Leer másWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Leer másArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Leer másArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Leer másChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Leer másWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másLong COVID continues to challenge public health by affecting a considerable number of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
health computer science advanced 0 research covid media social Leer másLong COVID continues to challenge public health by affecting a considerable number of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
health computer science advanced 0 research covid media social Leer másBACKGROUND: HIV infection is associated with more rapid progression of some comorbidities. This study assessed the impact of HIV-infection on the presentation and outcome of HCC. METHODS: HCC patients...
associated care cd4 rapid survival hiv plwh mortality hcc Leer másBackground Adolescent girls and young women (AGYW) account for 29% of new HIV infections in Uganda despite representing just 10% of the population. Peer support improves AGYW linkage to HIV care and m...
young women oral prep hiv self-testing peer delivery participants support intervention six feasibility acceptability uganda hiv adherence peer prep delivery women hivst Leer másBACKGROUND: Eliminating HIV vertical transmission (VT) and is a global priority. Estimates of paediatric HIV infections are commonly derived through mathematical models relying on rates of VT stratifi...
status updated global immunological treatment odds suppression women study class probability eliminating vertical hiv vt studies meta-regression spectrum-aim estimates assess probabilities regimen transmission art maternal delivery 0 Leer másBackground Human immunodeficiency virus (HIV) has a protean clinical picture, in rare instances manifesting as systemic autoimmune disorders such as vasculitides. HIV-induced autoimmune diseases often...
hiv aids iga vasculitis cmv treatment immunodeficiency colitis Leer másObjective We aimed to compare antiretroviral non-adherence in the behaviourally infected (BIAs) and congenitally infected adolescents (CIAs) and explore its associations with depression, cognitive imp...
hiv non-adherence depression cognitive impairment vertical infection alwhiv botswana bias hiv cias non-adherence 95%ci adolescents aud aor = 2 depression Leer másSouth Africa has the largest share of people living with HIV in the world and this population is ageing. The social context in which people seek HIV care is often ignored. Apart from clinical interven...
viral suppression older adults detectable viral load socio-behavioral internalized stigma detectable aor socio-behavioural hiv Leer másBackground Poor adherence and under-utilization of antiretroviral therapy (ART) services have been major setbacks to achieving 95-95-95 policy goals in Sub-Saharan Africa. Social support and mental he...
interpersonal support adherence depression antiretroviral therapy living associated status 95% art hiv p = 0 depression interpersonal adherence support Leer másBackground Exclusive breastfeeding (EBF) in the first six months remains low globally, despite known benefits of lower morbidity and mortality among breastfed infants. It is important to understand fa...
exclusive breastfeeding women living with hiv hiv-exposed uninfected children immunization visits breastfeeding sub-saharan africa infant 6-months apr 95% ci women lower 0 breastfeeding prevalence wlwh hiv ebf Leer másBackground Integrase strand transferase inhibitors (INSTI), including raltegravir (RAL), elvitegravir (ELV), and dolutegravir (DTG), have demonstrated better efficacy and tolerability than other combi...
hiv integrase inhibitors antiretroviral therapy survival analysis master cohort cd4 + t-cell italian regimen interruptions study regimens insti naïve persons baseline interruption insti-based associated due nationality drugs ral dtg age efficacy cohort hazards safety Leer másBackground Mental health and substance use disorders disproportionately affect people with HIV (PWH), and may have been exacerbated during COVID-19. The Promoting Access to Care Engagement (PACE) tria...
hiv screening substance use mental health covid-19 rates completion pwh substance covid-19 mental hiv health primary 2020 care screening covid vs Leer másBackground Immediate initiation of antiretroviral treatment (iART) is a proven intervention that significantly decreases time to viral suppression and increases patient retention. iART involves starti...
hiv rapid treatment kap mixed methods art antiretroviral treatment practices attitudes analyses results clinic respondents ci knowledge implementation hiv iart 0 staff Leer másBackground People living with human immunodeficiency virus (PLWH) have an increased risk of developing noncommunicable diseases (NCDs) compared with people without HIV. The multimorbidity of NCDs and ...
sustainability integration plwh hypertension diabetes perceived plwh people leadership hiv integrated ethiopia diabetes hypertension sustainability care staff Leer másINTRODUCTION: Pre-exposure prophylaxis (PrEP) is an HIV prevention strategy that can reduce the risk of HIV acquisition by more than 90% if taken consistently. Although South Africa has been implement...
adolescent participants kwazulu-natal boys education rates hiv prep africa south Leer másOBJECTIVES: To make clear the roles of social interaction and social support in HIV infection among elderly men who visit female sex workers (FSW). METHODS: We conducted a case-control study: 106 newl...
material interaction hrhe protective partner life experiences social fsw sexual controls hiv visiting Leer másBackground Lesotho’s government has shown consistent efforts to implement social protection programmes. However, while recent evidence established a positive causal relationship between some of these ...
social protection education sexual and reproductive health hiv condom use multiple sexual partners transactional sex child marriage poverty adolescents sub-saharan africa cash transfers hiv sex programmes school findings lesotho adolescents associated child marriage outcomes ci aor 95% programs social receipt adolescent educational protection Leer másINTRODUCTION: People who inject drugs (PWID) have remained a contributor to the consistent HIV incidence rates in the US for decades. Pre-exposure prophylaxis (PrEP) is a promising biomedical interven...
dysfunction cognitive study hiv pwid Leer másBackground HIV self-testing (HIVST) has shown the potential for reaching people with heightened vulnerability to HIV, including young sexual minority men (YSMM), yet implementation of HIVST among YSMM...
hiv hiv self-testing hivst sexual minority men men who have sex with men determinants cfir sexual participants barriers hiv ysmm hivst implementation Leer másBackground Adolescents living with Human Immunodeficiency Virus (HIV) have an increased risk of depression, negatively affecting their adherence to antiretroviral therapy (ART) and treatment outcomes....
adolescents mental health hiv/aids depression integrated care psychological intervention implementation opportunities facilitators living caregivers hiv care hcps tanzania treatment mental health depression psychological intervention Leer másBACKGROUND: Urinary tract infections, a prevalent global infectious disease, are clinical issues not well studied in HIV-positive individuals. UTIs have become a global drug resistance issue, but the ...
tigray utis-causing prevalence patterns identified isolates hiv utis agar resistant bacterial patients using hospital Leer másBackground While Option B + has made great strides in eliminating vertical transmission of HIV and improving access to lifelong antiretroviral therapy (ART) for women, the postpartum period remains a ...
hiv pregnancy postpartum behavioral intervention treatment transition postpartum hiv intervention Leer másBackground Some studies indicate that pregnant Kenyan women were concerned about Coronavirus disease 2019 (COVID-19) exposure during maternity care. We assessed concern regarding COVID-19 exposure and...
prevention of mother to child tran... hiv kenya hitsystem covid-19 appointments enrollment pmtct covid-19 concerns exposure pregnant hiv delivery care Leer másOBJECTIVE: The purpose of this study is to investigate the incidence of determinants for virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling this global publ...
studies quality included art failure virologic determinants hiv Leer másBackground Over one-third of people living with HIV (PLH) in Ukraine are not on treatment. Index testing services, which link potentially exposed partners (named partners) of known PLH (index patients...
hiv care continuum hiv testing differentiated care index testing services linkage to care ukraine named time ukraine potentially 001 < 0 initiation 0 hiv treatment index services plh ci = 0 partners 95% Leer másBACKGROUND: Human immunodeficiency virus (HIV) significantly increases the risk of non-Hodgkin lymphoma (NHL) development, yet the population-level impact on NHL burden is unquantified. We aim to quan...
incidence population study region sichuan significantly unaids ci 95% burden nhl global eastern risk hiv Leer másIntroduction People who use drugs (PWUD) are at increased risk for HIV infection. HIV self-testing (HIVST) is a promising method for identifying new infections, but optimal distribution strategies rem...
hiv/aids hiv self-testing people who use drugs harm reduction syringe services program ehe strategies ci via pwud cisgender hivst 95% mail peers distribution hiv 0 received vs testing Leer másInternational audience; Highly pathogenic avian influenza viruses (HPAIV) are a major threat to the global poultry industry and public health due to their zoonotic potential. Since 2016,...
highly avian influenza pathogenic [sdv sciences clinical 4b clade hpaiv h5 assay rt-lamp Leer másBackground Respiratory syncytial virus (RSV)-induced disease is one of the important causes of flu-like illness in older adults and can cause serious disease in those who are at high-risk medical cond...
rsv influenza covid-19 case report pcr respiratory virus coronavirus disease Leer másHighly pathogenic avian influenza viruses (HPAIV) have been responsible for causing several severe outbreaks across the world. To protect poultry farms and to prevent the possible spread of new influe...
plant-based vaccine hemagglutinin oligomers avian flu challenge experiments oligomer oligomers vaccinated induced influenza h5n1 vaccine h5 crude chickens virus extracts Leer másAcute viral infections can have durable functional impacts on the immune system long after recovery, but how they affect homeostatic immune states and responses to future perturbations remain poorly u...
recoverees mild healthy monocytes genes innate influenza day responses covid-19 Leer másBACKGROUND: With increased attention to the importance of integrating the One Health approach into zoonotic disease surveillance and response, a greater understanding of the mechanisms to support effe...
information sectors influenza approach effective human communication channels animal stakeholders swine Leer másEquine influenza virus (EIV) remains a threat to horses, despite the availability of vaccines. Strategies to monitor the virus and prevent potential vaccine failure revolve around serological assays, ...
nucleotide sequencing equine influenza equine influenza virus h3n8 nanopore pb1-f2 virulence long-read sequencing virus horse influenza virulence antigenic pb1-f2 potential equine strains Leer másBACKGROUND AND OBJECTIVES: The number of pediatric patients diagnosed with influenza types A and B is increasing annually, especially in temperate regions such as Shanghai (China). The onset of pandem...
outpatients statistically minimum seasonality factors temperature p < 0 mean significant weekly pandemic ambient correlation shanghai meteorological influenza pediatric Leer másBackground Influenza virus disease remains one of the most contagious diseases that aided the deaths of many patients, especially in this COVID-19 pandemic era. Recent discoveries have shown that the ...
modeling binding score receptor neuraminidase residual interaction 3d-qsar predictions 2d-qsar admet modeling lead docking }}}^{2}$$ $$r_{{\text{train ^2 = 0 influenza compounds train inhibitors na = 0 Leer másBACKGROUND: Influenza vaccination is recommended in Canada for older adults and those with underlying health conditions due to their increased risk of severe outcomes. Further research is needed to id...
factors recommended identify 95% vaccine participants vaccination influenza risk canadian coverage adults severe outcomes Leer másInternational audience; During annual influenza epidemics, influenza B viruses (IBVs) co-circulate with influenza A viruses (IAVs), can become predominant and cause severe morbidity and ...
rna rnap influenza viral ctd binding ii viruses Leer másVaccines are a recommended strategy for controlling influenza A infections in humans and animals. Here, we describe the effects of hydrostatic pressure on the structure, morphology and functional char...
virus hydrostatic inactivation influenza pressure Leer másBACKGROUND: To compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. METHODS: Retrospective cohort study ...
30-day clinical consumption resource outcomes influenza 001 vs patients mortality covid-19 requiring supplemental oxygen Leer másInfluenza A(H7N9) virus showed high pathogenicity in humans when it emerged in 2013. Cigarette smoke (CS) causes pulmonary diseases including bronchitis, emphysema, and lung cancer. Although habitual ...
infection expression due influenza virus h7n9 Leer másPurpose Bacterial pneumonia, a major cause of respiratory tract infections (RTI), can be challenging to diagnose and to treat adequately, especially when seasonal viral pathogens co-circulate. The aim...
pneumonia diagnostics rsv influenza emergency fall 2022 rti bacterial burden viral Leer másThe intricacy of the maternal immune system arises from its ability to prevent a maternal immune response against a semi-allogenic fetus, while protecting the mother against harmful pathogens. However...
influenza clinical Leer másBACKGROUND: Previous studies suggest that the nose/throat microbiome may play an important role in shaping host immunity and modifying the risk of respiratory infection. Our aim is to quantify the ass...
h3n2 virus nose/throat cri associated respiratory microbiome 95% household influenza infection susceptibility Leer másThe porcine reproductive and respiratory syndrome virus (PRRSV) and the swine influenza A virus (swIAV) are leading players of the porcine respiratory disease complexe. While much is kn...
vaccine au study swiav sdrpv virus prrsv influenza porcine mlv porcin infection respiratory Leer másBackground Acute respiratory distress syndrome (ARDS) is responsible for 400,000 deaths annually worldwide. Few improvements have been made despite five decades of research, partially because ARDS is ...
acute respiratory distress syndrom... mycobiota microbiota cap-related aetiologies patients = 0 mycobiota ards microbiota covid-19 lower bacterial influenza Leer másInternational audience; Abstract Purpose At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation. Materials...
publique-hôpitaux flu assistance critical ap-hp paris study acute severe burden medical warehouse influenza patients clinical data Leer másAdult females of reproductive ages develop greater antibody responses to inactivated influenza vaccine (IIV) than males. How sex, age, and sex steroid changes impact B cells and durability of IIV-indu...
h1n1 iiv-induced live gonadal fcg reduced mice estradiol influenza responses protection adult females cells sex Leer másBACKGROUND: Given the current pandemic, differentiation between pneumonia induced by COVID-19 or influenza viruses is of utmost clinical significance in the patients’ management. For this purpose, thi...
ai differentiate resnet-50 inceptionv3 model radiologists viruses versus fine-tuned induced pneumonia models influenza vgg Leer másBACKGROUND: We sought to determine if racial differences in influenza vaccination among nursing home (NH) residents during the 2008–2009 influenza season persisted in 2018–2019. METHODS: We conducted ...
percentage level vaccination influenza nh residents Leer másBACKGROUND: Influenza epidemics pose a threat to human health. It has been reported that meteorological factors (MFs) are associated with influenza. This study aimed to explore the similarities and di...
prediction prs lstm based absolute meteorological tem effect influenza mfs low risk error daily mean Leer másThe care home staff influenza vaccination rate in England is significantly lower than the 75% World Health Organisation recommendation. This represents a substantial potential for resident harm. Barri...
residential homes nursing homes care homes long-term care facilities influenza vaccination staff employees randomised controlled trial proportion practice barriers influenza rates compared rate trial control data monthly homes vaccination staff care Leer másBACKGROUND: We aimed to investigate the clinical characteristics of severe influenza virus-associated pneumonia complicated with bacterial infection in children. METHODS: We retrospectively analysed d...
significant children statistically bacteria 05 p < 0 clinical complicated observation infection influenza severe virus-associated pneumonia Leer másObjective The association between heart failure (HF) and intestinal inflammation caused by a disturbed intestinal microbiota in infants with congenital heart disease (CHD) was investigated. Methods Tw...
congenital heart disease heart failure intestinal microbiota intestinal inflammation infant enterococcus inflammatory compared significantly levels infants positively negatively associated hf correlated control heart intestinal 05 < 0 Leer másThe Microsporum canis complex consists of one zoophilic species, M. canis , and two anthropophilic species, M. audouinii and M. ferrugineum . These species are the most widespread zoonotic pathogens c...
dermatophytes host shift phylogeny mat idiomorph distribution physicochemical features tinea capitis canis zoophilic anthropophilic species Leer másBackground Lagoons are important natural systems, with attractive favorable conditions for aquaculture production, such as shellfish cultivation. Despite their socio-economic relevance for human activ...
gills mussels 16s rdna amplicon sequencing bacterial profile microbiota-environment interaction... bacterial microbiota sequencing seawater Leer másBackground Gut microbiome is critical to our human health and is related to postmenopausal osteoporosis (PMO). Strontium ranelate (SrR) is an anti-osteoporosis oral drug that can promote osteoblast fo...
strontium ranelate gut microbiome postmenopausal osteoporosis lycopene significantly albus gut microbiome srr Leer másMost fungi display a mixed mating system with both asexual and sexual reproduction. The timing of the two modes of reproduction must be carefully coordinated through signal perception and coordination...
asf1 dj-1 pi3k/akt signaling pathway asexual and sexual reproduction sedj-1 sepi3k sexual asexual seasf1 reproduction Leer másBackground People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19...
sars-cov-2 covid-19 hiv microbiota post-acute covid-19 syndrome observed bacteria infection associated microbiota plwh-cov onset plwh covid-19 gut sars-cov-2 severity Leer másBackground Acinetobacter baumannii is one of the main causes of healthcare-associated infections that threaten public health, and carbapenems, such as meropenem, have been a therapeutic option for the...
outer membrane protein persistence meropenem virulence persister proteins persisters ompw baumannii cells Leer másBackground Emerging evidence emphasized the role of oral microbiome in oral lichen planus (OLP). To date, no dominant pathogenic bacteria have been identified consistently. It is noteworthy that a dec...
oral lichen planus oral microbiota lactic acid bacteria bacteria oral decreased severity hc lactis olp lactococcus lab patients Leer másBackground Attenuated live bacterial therapy and medical BSA materials have their own advantages in anti-cancer research, and their combination is expected to overcome some of the disadvantages of con...
() bovine serum albumin (bsa) surface modification anti-cancer surface cells live modification bladder cancer coli Leer másSarcodon and Hydnellum are two ectomycorrhizal genera of important ecological and economic value in Southwest China, and they are common in the free markets in this region. It was estimated that more ...
cryptic species ectomycorrhizal edible mushroom markets complex new taxa genera southwest china based species phylogenetic imbricatus edible markets Leer másBackground Pseudomonas aeruginosa is an opportunistic pathogen in the health-care systems and one of the primary causative agents with high mortality in hospitalized patients, particularly immunocompr...
quorum sensing system biofilm formation drug resistance method respectively infections lowest 0% antibiotic strains rhli formation 6% pattern aeruginosa 3% frequency drug lasi biofilm system rhlr isolates resistance Leer másBackground Ticks are blood-feeding significant arthropods that can harbour various microorganisms, including pathogens that pose health risks to humans and animals. Tick-symbiont microorganisms are be...
ticks bacterial component 16s rrna environment engorged status environmental environments carried tick-borne ticks pathogenic statuses bacterial pathogens tick Leer másBackground The utilization of fructose as a carbon source and energy provider plays a crucial role in bacterial metabolism. Additionally, fructose metabolism directly impacts the pathogenicity and vir...
transcriptional regulator deor fructose metabolism utilization role pts fructose metabolism frur frurkt Leer másBackground Endometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear. Results The present study investigated the uterine microbiom...
microbiome endometrial hyperplasia uterus 16s rdna microbiome hyperplasia Leer másBackground Carbon and nitrogen are essential energy and nutrient substances in the composting process. Corn steep liquor (CSL) is rich in soluble carbon and nitrogen nutrients and active substances an...
spent mushroom substrate corn steep liquor compost bacterial community composition carbon and nitrogen conversion mushroom network spent compost degrading substrate core abundance adding bacteria carbon nitrogen csl conversion functional community bacterial composting Leer másZoonoses represent a major challenge for many disciplines, including microbiology, epidemiology, veterinary, medicine and ecology. Moreover, they pose severe risks to human health and economy. In this...
zoonoses emerging pathogens virulence factors virus bacteria protozoa fungi zoonoses Leer másBackground Many studies reported the association between gut microbiota and type 2 diabetes mellitus (T2D), but it is still unclear which bacterial genus plays a key role and how the metabolic functio...
type 2 diabetes mellitus metabolic function gut microbiota mongolian population carotene intake association dietary role changes main function clostridium relative abundance mongolian microbiota population bacterial genus t2d gut Leer másBackground The development of sequencing technologies to evaluate bacterial microbiota composition has allowed new insights into the importance of microbial ecology. However, the variety of methodolog...
16s rrna qiime2 mothur dada2 pcr artifacts pcr biases pcr errors chimera polymerase sequencing errors v4-v4 polymerase bioinformatic community sequencing using workflows accuracy Leer másArbuscular mycorrhizal fungi (AMF) represent a critical component of terrestrial ecosystems, forming symbiotic relationships with the majority of plant species. This mutualistic association has profou...
plant growth nutrient uptake soil health nutrient cycling environmental sustainability systems amf agricultural Leer másThe interplay among cigarette smoking status, oral microbiota, and cardiometabolic health is poorly understood. We aimed to examine the association of cigarette smoking status with oral microbiota and...
oral microbiome cigarette smoking cardiometabolic health chinese adults status features association smoking cigarette microbiota oral cardiometabolic Leer másBackground This study was aimed to evaluate the prevalence and molecular characteristics of ciprofloxacin resistance among 346 Escherichia coli isolates collected from clinical specimens ( n = 82), h...
ciprofloxacin qrdr antibiotic resistance pmqr patients healthy carriers wastewater respectively pmqr iran identified 03% ciprofloxacin resistance wastewater genes ciprofloxacin-resistant isolates Leer másBackground The soil biota consists of a complex assembly of microbial communities and other organisms that vary significantly across farming systems, impacting soil health and plant productivity. Desp...
agroecosystem sustainability amplicon sequencing cropping system ecosystem services soil and maize-root microbiomes soil health systems diversity relative abundance mono bacterial fungal push–pull soil cropping maize-root genera microbial plant Leer másBackground Functional constipation (FC) in children affects their growth, development and quality of life. L-pipecolic acid (L-PA) was decreased in FC children based on gut microbiome and serum metabo...
functional constipation gut microbiota metabolite profiles l-pipecolic acid children 5-ht4r fecal aqp3 content loperamide intestinal microbiota reduced constipation significantly fc children l-pa expression Leer másThe surge in multidrug-resistant pathogens worldwide has jeopardized the clinical efficiency of many current antibiotics. This problem steered many researchers in their quest to discover new effective...
nmr gc-ms bioguided fractionation antimicrobial susceptibility spiculosporic acid hedera cejpii isolated aspergillus active helix fraction endophytic antimicrobial activity Leer másBackground Helicobacter pylori lipopolysaccharide (LPS) structures vary among strains of different geographic origin. The aim of this study was to characterize the LPS O-antigen profiles of H. pylori ...
lipopolysaccharide o-antigen heptan lewis antigen antibiotic resistance lewis pylori lps southwest china isolates strains Leer másIntracranial pressure (ICP) is an important parameter in clinical management and diagnosis of several neurological diseases which is indirectly measured via lumbar puncture (LP). In routine measuremen...
via combination lumbar manometer spinal Leer másCSF-venous fistulas are an increasingly recognized type of CSF leak that can be particularly challenging to detect, even with recently improved imaging techniques. Currently, most institutions use dec...
imaging photon-counting myelography Leer másBACKGROUND: Obesity rates in the U.S. continue to increase, with nearly 50% of the population being either obese or morbidly obese. Obesity, along with female sex, are leading risk factors for sporadi...
hippocampus cognitive based markers effects restriction sex caloric obesity Leer másOBJECTIVE: Previous research has suggested that neurodevelopmental conditions may be associated with distinctive cognitive profiles on the Wechsler intelligence tests (of which the most recent edition...
wisc-v wais-iv adults children associated cognitive scores profile Leer másPost-translational modifications (PTMs) are protein modifications that occur after protein biosynthesis, playing a crucial role in regulating protein function. They are involved in the functional expr...
modifications vitro protein aplnr Leer másBACKGROUND: Migraine is the second most common prevalent disorder worldwide and is a top cause of disability with a substantial economic burden. Many preventive migraine medications have notable side ...
aes medications bta incidence migraine drugs disorders Leer másINTRODUCTION: The challenge of treating Glioblastoma (GBM) tumors is due to various mechanisms that make the tumor resistant to radiation therapy. One of these mechanisms is hypoxia, and therefore, de...
results based tumor study treatment images patients Leer másThis case describes a 30-year-old Hispanic male who presented with a significant headache that started after a period of weightlifting and squatting. The patient was diagnosed with a basilar artery di...
dissection Leer másAstrocytes are the largest glial population in the mammalian brain. However, we have a minimal understanding of astrocyte development, especially fate specification in different regions of the brain. ...
dorsal glia brain produce fate developing radial diencephalon region wall 3v Leer másThe current project was funded by the Global Engagement Seed Grant from the International Brain Research Organisation (IBRO) as part of the IBRO-led Global Engagement Initiative. The project was focus...
report current engagement neuroscience public project Leer másOBJECTIVE: We aim to describe the long-term outcome of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) after immune treatment in a Chinese cohort. METHODS: Between March 2015 and Marc...
long-term patients incat treatment cidp relapse Leer másMitochondria exert powerful control over cellular physiology, contributing to ion homeostasis, energy production, and metabolite biosynthesis. The trafficking and function of these organelles are part...
mfn2 cycle particularly control sv fusion axons network axonal function qc 2+ ca presynaptic Leer másBACKGROUND: Cerebral venous sinus thrombosis (CVST) presents with a wide variety of neurological symptoms in various combinations and has a high mortality rate of up to 50%. Recent advances in neuroim...
thrombosis 001 p<0 involvement sinus prognostic study factors outcome poor associated Leer másBACKGROUND: Alzheimer’s disease (AD) and age-related macular degeneration (AMD) share similar pathological features, suggesting common genetic aetiologies between the two. Investigating gene associati...
gene diagnostic based analysis amd ad apoe apoc1 identified genes pleiotropy Leer másBACKGROUND: Parkinson disease (PD) is the fastest growing neurodegenerative disease. The molecular pathology of PD in the prodromal phase is poorly understood; as such, there are no specific prognosti...
−/− data rats expression pink1 disease blood gene Leer másBACKGROUND AND PURPOSE: In our clinical practice, we increasingly use intrathecal contrast-enhanced glymphatic MR imaging to assess CSF disturbances. However, because intrathecal MR imaging contrast a...
nonserious including safety study gadobutrol patients Leer másBACKGROUND: Spontaneous intracranial hypotension is an important cause of treatable secondary headaches. Evidence on the efficacy of epidural blood patching and surgery for spontaneous intracranial hy...
surgery using epidural data blood patching efficacy Leer másAn important step in neural information processing is the transformation of membrane voltage into calcium signals leading to transmitter release. However, the effect of voltage to calcium transformati...
drosophila membrane neural neurons information signal cascade cells responses signals voltage Leer másOBJECTIVE: Allelic variation in the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been shown to moderate rates of cognitive decline in preclinical sporadic Alzheimer’s disease (AD...
sporadic tau d = 0 changes neurotrophic bdnf memory val66met csf disease ad decline alzheimer’s Leer másMacroautophagy is a catabolic process that coordinates with lysosomes to degrade aggregation-prone proteins and damaged organelles. Loss of macroautophagy preferentially affects neuron viability and i...
midbrain inhibitors clearance cultures parkinson neurons pd ykt6 Leer másBACKGROUND: We aimed to determine whether sodium valproate (VPA) should be contraindicated in all mitochondrial diseases, due to known VPA-induced severe hepatotoxicity in some mitochondrial diseases....
diseases mitochondrial patients Leer másBACKGROUND: Deep cerebral venous thrombosis (DCVT) can have long-term functional and cognitive sequelae. Although literature exists on cognitive impairment after arterial stroke, cognitive sequelae af...
venous cerebral sequelae thrombosis long-term dcvt patients Leer másINTRODUCTION: The optimum time to mobilise (standing, walking) following spinal cord injury (SCI) is unknown but may have implications for patient outcomes. There are no high-quality experimental stud...
pathophysiological induced injury initiated review outcomes research studies mobilisation ci Leer másGeneral anesthesia shares many similarities with natural sleep in behavior and electroencephalogram (EEG) patterns. The latest evidence suggests that general anesthesia and sleep–wake behavior may sha...
neural decreased neurons isoflurane behavioral cortical activation role bf anesthesia emergence Leer másMild cognitive impairment (MCI) is often considered a precursor to Alzheimer's disease (AD) and early diagnosis may help improve treatment effectiveness. To identify accurate MCI biomarkers, researche...
review research mci Leer másParkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like th...
computer datscan machine parkinson disease Leer másThe external globus pallidus (GPe) is a critical node within the basal ganglia circuit. Phasic changes in the activity of GPe neurons during movement and their alterations in Parkinson's disease (PD) ...
activity control circuit parkinson neurons gpe pallidum pv npas1 disease motor + Leer másParkinson's disease (PD) is a neurodegenerative disorder anatomically characterized by a progressive loss of dopaminergic neurons in the substantia nigra compacta (SNpc). Much less known, yet clinical...
prebötc decreased parkinson disease pd neurons model Leer másNeovascular age-related macular degeneration (nAMD) remains a major cause of visual impairment, despite the continuous repeated intravitreal administration of anti-VEGF therapies that p...
pd namd maladie néovascularisation disease néovasculaire patients parkinson dmla Leer másInternational audience; Parkinson's disease (PD) and the parkinsonian variant of Multiple System Atrophy (MSA-P) are two neurodegenerative diseases which share similar clinical features,...
parkinson multiple atrophy system voiced disease differential diagnosis Leer másObjective There are two major issues in the MRI image diagnosis task for Parkinson's disease. Firstly, there are slight differences in MRI images between healthy individuals and Parkinson's patients, ...
parkinson’s disease yolov5 coordinate attention dynamic full dimensional convoluti... decoupling joint detection based results features parkinson mri diagnosis disease images Leer másOBJECTIVE: The aim of this study was to examine what factors make people with Parkinson's disease more susceptible to stereotype threat (i.e., the concern of being evaluated in line with negative grou...
consequences parkinson disease stereotype threat Leer másBACKGROUND: Sex hormones affect the pathogenesis of Parkinson patients and it has been suggested that gender is the most important factor in the development and progression of Parkinson’s disease. Stu...
significant healthy results hgs left elderly respectively strength ratio parkinson p = 0 disease 4d 2d Leer másBACKGROUND: Parkinson's disease (PD) causes a loss of neuromelanin‐positive, noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor dysfunction. OBJECTIVES: We used “...
attenuation parkinson patients cnr mtw pd symptoms disintegration structural lc Leer másSpeech disorder is an early and prominent manifestation of neurological disorders. Therefore, the breakdown of speech disorders and detecting underlying pathophysiology have invaluable ...
thèse voyelles thesis ams-p au multiple speech parole differential diagnosis diagnostic troubles disease différentiel données vocales database base disorders neurological vocaux neurologiques vowel marqueurs markers objective disorder maladies parkinson msa-p pd Leer másIn recent years, deep learning methods have achieved great success in various fields due to their strong performance in practical applications. In this paper, we present a light-weight neural networ...
disease parkinson learning methods machine model Leer másBackground Very few studies have assessed the presence of a possible correlation between speech variables and limb bradykinesia in patients with Parkinson's disease (PD). The objective ...
upper parkinson phonation extremity study 0 disease advanced tapping patients Leer másInternational audience; The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the identification of many diseases. This article aimed to ...
alzheimer diseases biomarker parkinson molecularly imprinted polymers disease biomarkers Leer másInternational audience; Background: Available treatments for Parkinson's disease (PD) are only partially or transiently effective. Identifying existing molecules that may present a thera...
learning machine causation reverse algorithm identifying disease drugs parkinson Leer másParkinson's disease (PD) is a neurodegenerative illness that progresses and is long-lasting. It becomes more difficult to talk, write, walk, and do other basic functions when the brain's dopamine-gene...
accuracy prediction parkinson Leer másInternational audience; Parkinson disease (PD) is a common neurodegenerative condition affecting people predominantly at old age that is characterized by a progressive loss of midbrain d...
disease parkinson defects pd lamp1 Leer másParkinson's disease (PD) is a neurodegenerative disorder anatomically characterized by a progressive loss of dopaminergic neurons in the substantia nigra compacta (SNpc). Much less known, yet clinical...
prebötc decreased parkinson disease pd neurons model Leer másParkinson's disease (PD), the second most prevalent neurodegenerative disorder worldwide, frequently presents with early-stage speech impairments. Recent advancements in Artificial Intelligence (AI)...
systematic parkinson speech classification disease tl dl pd science deep speech-based learning computer e2e Leer másBACKGROUND: Glucocerebrosidase gene mutations are a common genetic risk factor for Parkinson's disease. They exhibit incomplete penetrance. The objective of the present study was to measure microglial...
microglial activation parkinson c‐ ‐pk11195 disease binding glucocerebrosidase carriers gene mutation Leer másBACKGROUND: Parkinson's disease (PD) causes a loss of neuromelanin‐positive, noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor dysfunction. OBJECTIVES: We used “...
attenuation parkinson patients cnr mtw pd symptoms disintegration structural lc Leer másParkinson's Disease (PD) significantly impacts driving abilities, often leading to early driving cessation or accidents due to reduced motor control and increasing reaction times. To diminish the im...
parkinson individuals panda pd driving Leer másParkinson's Disease (PD) significantly impacts driving abilities, often leading to early driving cessation or accidents due to reduced motor control and increasing reaction times. To diminish the im...
parkinson individuals panda pd driving Leer másBackground Mobile gait sensors represent a compelling tool to objectify the severity of symptoms in patients with idiopathic Parkinson’s disease (iPD), but also to determine the therapeutic benefit of...
deep brain stimulation low frequency nucleus subthalamicus gait mobile sensors inertial measurement unit parkinson lift improvements mobile ipd results frequencies sensors patients stimulation Leer másParkinson's disease (PD), a severe and progressive neurological illness, affects millions of individuals worldwide. For effective treatment and management of PD, an accurate and early diagnosis is c...
resting parkinson disease using diagnosis dataset eeg model pd Leer másObjective: We present the PaHaW Parkinson's disease handwriting database, consisting of handwriting samples from Parkinson's disease (PD) patients and healthy controls. Our goal is to show that kine...
diagnosis writing disease parkinson pacc controls handwriting patients healthy Leer másThe formation of supermassive black holes (SMBHs) in the early Universe is a subject of significant debate. In this study, we examine whether non-evaporating primordial black holes (PBHs) can offer ...
primordial hr radiation black astrophysics holes Leer másIcy dust particles emerge in star-forming clouds and are subsequently incorporated in protoplanetary disks, where they coagulate into larger pebbles up to mm in size. In the disk midplane, ices are ...
mm disks uv composition midplane icy disk astrophysics Leer másWe report the discovery of a peculiar X-ray transient, EP240408a, by Einstein Probe (EP) and follow-up studies made with EP, Swift, NICER, GROND, ATCA and other ground-based multi-wavelength telesco...
transients detection intermediate found ep240408a x-ray Leer másPersistence effects in HgCdTe infrared detectors cause significant artifacts that can impact the quality of science observations for up to many hours after exposure to bright/saturating sources. Thi...
infrared strategy fast Leer másThe accretion of material onto a black hole modifies the properties of that hole owing to the capture of both matter and radiation. Adding matter to the hole through an accretion disc generally acts...
matter plunging region radiation thorne hole accretion Leer másClustered stellar feedback creates expanding voids in the magnetized interstellar medium known as superbubbles. Although theory suggests that superbubble expansion is influenced by interstellar magn...
assumptions $\mathrm{i}$ interstellar local bubble magnetic polarization orientation Leer másWe analyze 192 sets of binary black hole merger data in eccentric orbits obtained from RIT, decomposing the radiation energy into three distinct phases through time: inspiral, late inspiral to merge...
black binary radiation initial hole average merger ${e_t}_0 0 inspiral energy orbital Leer másGravitational wave observations by ground based detectors such as LIGO and Virgo have transformed astrophysics, enabling the study of compact binary systems and their mergers. However, transient noi...
wave gravitational artifacts noise signals data astrophysics glitches aware Leer másWe characterize the overdensity (spike) of fermionic dark matter (DM) particles around a supermassive black hole (SMBH) within a general relativistic analysis. The initial DM halo distribution is ob...
halo spikes mass dm Leer másWe present the discovery and analysis of a nearby eclipsing ultra-compact accreting binary at coordinates 11:38:10.91 $-$51:39:49.15 (SMSS J1138$-$5139), the first well-constrained LISA-detectable T...
astrophysics supernova ia smss j1138$-$5139 Leer másThe sensitivity and field of view of the MeerKAT radio telescope provides excellent opportunities for commensal transient searches. We carry out a commensal transient search in supernova and short g...
variability sources astrophysics source commensal transient Leer másDetached eclipsing binaries (DEBs) allow for the possibility of precise characterization of its stellar components. They offer a unique opportunity to derive their physical parameters in a near-mode...
g4iii aim code $r_\odot$ $m_\odot$ + $m_2=3 precise giant eclipsing masses radii late-type parameters stars Leer másThe first and second laws of thermodynamics should lead to a consistent scenario for discussing the cosmological constant problem. In the present study, to establish such a thermodynamic scenario, c...
law constant thermodynamic $h_{\textrm{b}} $f_{\lambda} consistent terms scenario cosmological $ Leer másWe present a novel dataset of simulations of the photodissociation region (PDR) in the Orion Bar and provide benchmarks of emulators for the dataset. Numerical models of PDRs are computationally exp...
regions models dataset astrophysics Leer másThe image of a Kerr-Newman (KN) black hole (BH) surrounded by a thin accretion disk is derived. By employing elliptic integrals and ray-tracing methods, we analyze photon trajectories around the KN ...
intensity inclination distribution bh Leer másPulse profile stability is a central assumption of standard pulsar timing methods. Thus, it is important for pulsar timing array experiments such as the North American Nanohertz Observatory for Grav...
psr data j1022+1001 astrophysics nanograv pulsar profile pulse Leer másWe illustrate the main points behind the computation of the gravitational wave spectrum originated from a phase in the early universe where the energy density is dominated by highly excited fundamen...
string cosmology energy phase Leer másWe present new James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) Medium-Resolution Spectrometer (MRS) observations of the nearby ultra-luminous infrared galaxy (ULIRG) F08572+3915 NW....
h$_2$ jwst outflow Leer másBased on the Newtonian mechanics, in this article, we present a heuristic derivation of the Friedmann equations, providing an intuitive foundation for these fundamental relations in cosmology. Addit...
equations cosmology Leer másWe study the dynamics and interactions of the solitonic domain walls that occur in realistic axion electrodynamics models including the Chern-Simons interaction, $a\epsilon_{\mu\nu\lambda\sigma}F^{\...
axion walls chern-simons thermal domain plasma wall Leer másParametrized nucleon density distributions are widely employed for the calculation of the properties of atomic nuclei and dense inhomogeneous matter in compact stars within the Thomas-Fermi method a...
method Leer másWe analyze the evolution of red and blue galaxies in different cosmic web environments from redshift $z=3$ to $z=0$ using the IllustrisTNG simulation. We use Otsu's method to classify the red or blu...
$z<1$ environment filaments fractions red evolution environments clusters blue Leer másAs imaging surveys progress in exploring the large-scale structure of the Universe through the use of weak gravitational lensing, achieving subpercent accuracy in estimating shape distortions caused...
galaxies shape noise bias shear estimator Leer másBinary star systems can accrete material originating from a circumbinary disc. Since it is common for the circumbinary disc to be tilted with respect to the binary orbital plane, we test whether the...
onto circumbinary preferential alternating towards accretion coplanar initial binary polar Leer másPhotometric galaxy surveys, despite their limited resolution along the line of sight, encode rich information about the large-scale structure (LSS) of the Universe thanks to the high number density ...
method mock data surveys astrophysics selection effects galaxy 2pcf Leer másThe identification of risk situations is essential in the process of MSD prevention: this identification called "MSD risk assessment" relies on the "simple" risk assessment tools to tar...
leeway situational operational risque study situationnelle marge suffisance l’activité critiques avons activity mms tools simples outils situations sol simple indicators msd assessment risk Leer másBACKGROUND: Although health disparities have been documented between Medicare beneficiaries based on age (<65 years vs. older age groups), underuse of recommended medical care in younger beneficiaries...
study underuse disparities medicare beneficiaries age Leer másActive Matter deals with the study of colloidal systems for which Brownian motion is replaced by a persistent self-propulsion. The main motivation of Active Matter is to provide a the...
model interplay living dynamics induite ordre ensuite collective interaction nonequilibrium je matter phase active mouvement au chapitre collectif study chapter embouteillages long-ranged modèle flocking étude jams motion matière transition fluctuations portée quincke Leer másBACKGROUND: Lumbar spinal stenosis (LSS) is a common degenerative condition that contributes to back and back-related leg pain in older adults. Most patients with symptomatic LSS initially receive non...
protocol 12 months data model prognostic care patients using lss study Leer másEmotional intelligence is a main area in educational psychology and a key factor in the academic life of students. It deals with deviant behavior through self-awareness and self-motivation, regulates ...
students environments approach study habits engagement cognitive intelligence emotional Leer másInternational audience; New manufacturing concepts, that includes the digitalization of Human Factors, constitute a challenge of the next industry generations. The introduction of collab...
study multimodal human health Leer másBACKGROUND: Guideline-directed medical therapy (GDMT), optimized to target doses, improves health outcomes in patients with heart failure. However, GDMT remains underused, with <25% of patients receiv...
doses failure heart study trial barriers qualitative remote clinicians implementation intervention patients titration gdmt Leer másBACKGROUND: Existing evidence shows that there is an independent correlation between nephrolithiasis and gout, and hyperuricemia is the most important risk factor for gout. However, hyperuricemia was ...
increased study explore relationship increase nephrolithiasis participants risk hyperuricemia Leer másWe present an empirical study in which model-based testing (MBT) was applied to a mobile system: the Android client of QuizUp, the largest mobile trivia game in the world. The study shows that tradi...
study app mobile Leer másIntroduction Individuals with spinal cord injury (SCI) can experience accelerated cognitive aging. Myokines (factors released from muscle cells during contractions), such as brain-derived neurotrophic...
spinal cord injury myokine neuromuscular electrical stimulati... cognition neuroplasticity brain-derived neurotrophic factor single case experimental design chronic rehabilitation care phase baseline 12 weeks cognitive study Leer másA great variety of molecular components is encapsulated in cells. Each of these components is replicated for cell reproduction. To address an essential role of the huge diversity of cellular compone...
species resources cell study complex reaction diversity components molecular Leer másThis research work deals with the application of Reflectance Confocal Microscopy to the study of in-vivo skin structures, with a view to understand and characterize markers associated w...
partir mesures méthode cellules study science epidermis cliniques dermatologues regular product surface derme régularité l’âge algorithme dej jde image 3d aging microscopy dermatologists reflectance methods proposed pattern clinical skin confocal quantification vieillissement annotations in-vivo motif Leer másSIMPLE SUMMARY: The use of immune checkpoint inhibitors (ICI) is expanding with the approval for locally advanced and metastasizing keratinocyte carcinoma. Most cases, however, are non-aggressive. Sys...
non-aggressive basal ablative fractional laser injection local safety broaden ratio immune keratinocyte monotherapy study tumor response afl anti-pd1 carcinoma cell Leer más[Image: see text] This study delved into the consequences of prolonged administration of vitamin D(3) on innate immune systems, particularly NF-κB and JAK/STAT, in Drosophila melanogaster. The outcome...
pgrp-lb drosophila heat-killed immune study survival vitamin Leer másBACKGROUND: The study aims to evaluate the perceptions of pediatric residents under the night float (NF) on-call system and its impact on well-being, education, and patient safety compared with the tr...
education study well-being 0 perceived 24-h pediatric system compared nf on-call Leer másINTRODUCTION: The clinician’s skill, impression techniques, and materials play a very important role in recording fine details in an impression for accuracy of fixed partial denture prosthesis. Impres...
stainless viscosity die study steel standard dual-arch accuracy subgroups buccolingual impression accurate dimensions mesiodistal sequence trays dual Leer másBACKGROUND: With more emergency visits, there is increasing pressure to provide emergency medical services globally and locally. This study aimed to investigate the epidemiological characteristics and...
2017 statistical study services 23 distribution 0 diseases respiratory medicine medical system patients Leer másBackground Falls are a major public health concern globally. While falls are associated with osteoarthritis and persistent pain at the hip and knee, falls have not been investigated in people with chr...
ankle pain ankle osteoarthritis falls falls self-efficacy individuals study controls balance pain falls chronic confidence participants concern symptoms associated Leer másBACKGROUND: Weaning of goat kids immediately after birth and feeding them on bovine or heat-treated caprine colostrum, referred to as snatching, is considered an effective control measure in some infe...
snatching study kids goat concentration metabolites lipid Leer másBACKGROUND: High levels of sedentary behaviour (i.e., sitting) are a risk factor for poor health. With high levels of sitting widespread in desk-based office workers, office workplaces are an appropri...
reduce rct cluster desk-based workers trial study intervention behaviour smart health Leer másEmerging droplet-based microfluidic platform provide new opportunities to develop complex immunoassay with low sample consumption. This manuscript is dedicated on the development of an ...
study focusing microsystème d’analyse dedicated development permis gouttes platform separation microfluidic droplet-based immunoassay amyloid séparation dyneon alzheimer peptides Leer másBackground Internet-based Cognitive Behaviour Therapy (iCBT) for depression have been implemented in routine care across Europe in varying ways, at various scales and with varying success. This study ...
organisational implementation clim... organisational context internet-based cognitive behaviour... acceptance implementers service deliverers usability methods supportive care routine services satisfaction climate icbt service implementers study implementation Leer másBackground Ovarian cancer (OC) has the worst prognosis among gynecological malignancies, most of which are found to be in advanced stage. Cell reduction surgery based on platinum-based chemotherapy is...
cald1 ovarian cancer platinum resistance prognosis value target gene auc = 0 study target data geo oc platinum cald1 resistance expression ovarian prognosis patients Leer másThis work relates the characterization of materials inside Roman amphorae. It aimed to determine at once thewaterproofing material on the internal walls, but also to identify their cont...
tartric syringique tartrique ir-tf extraction presence results échantillons matière study bien samples poix sestius amphorae acids présence contenu roman d’amphores amphores vin cpg-sm Leer másAxonal guidance is a very important process during brain development, allowing to give it its structure and organization. The neuroscience scientific community has a growing interest in...
permis cells leurs device dissociés growth dissociated motifs growing microfluidic dispositif goal au guidage axonal guidance avons molécules neurones molecules neurons gradient axons effect l’effet study microfluidique obtain étudier axones gradients Leer másPurpose The main objective of this study was to evaluate the ability of a large field Cadmium Zinc Telluride (CZT) camera to estimate thyroid uptake (TU) on single photon emission compu...
estimated camera acquisitions patients thyroid respectively uptake atha czt tomo-noac tomo-ac images spect/ct Leer másAims To study the correlation between clinicopathological risk factors and the risk for intervention-requiring cancer recurrence in patients with small papillary thyroid cancers (sPTCs). Materials and...
papillary thyroid cancer (ptc) small ptc recurrence lateral lymph node metastasis (n1b... risk factors n0 thyroid cancer patients sptc 0 factors vs n1b compared n1a risk Leer másPurpose Graves’ ophthalmopathy (GO) is an autoimmune disease that affects orbital soft tissues and represents the most common extrathyroidal manifestation of Graves’ disease (GD). The European Group o...
graves ophthalmopathy clinical presentation severity hyperthyroidism independent thyroid severity graves’ Leer másBackground Tumor size plays an important role in the staging and treatment of thyroid carcinoma. A tumor with a maximum diameter of 1 cm or less is referred to as microcarcinoma. It is unclear if the ...
medullary thyroid carcinoma microcarcinoma macrocarcinoma cumulative survival rate tumor microcarcinoma rate log-rank clinicopathological medullary characteristics prognosis survival patients thyroid Leer másBackground This study aimed to investigate the association between central sensitivity to thyroid hormones and all-cause mortality in euthyroid patients with chronic kidney disease (CKD). Methods Dat...
nhanes chronic kidney disease all-cause mortality sensitivity to thyroid hormone thyroid feedback quantile-based in... association thyroid analysis mortality Leer másMultiple endocrine neoplasia type 2B is a rare autosomal dominant disease characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, Marfan-like fatigue, a peculiar face with thic...
multiple endocrine neoplasia type ... constipation megacolon volvulus ganglioneuromatosis thyroid medullary carcinoma intestinal Leer másSpindle epithelial tumor with thymic like elements (SETTLE) is a biphasic tumor composed of epithelial and spindle cell components. It is an uncommon indolent tumor arising in the thyroid gland and mo...
settle thyroid biphasic tumor settle Leer másThyroid cancer is the most prevalent endocrine malignancy and comprises a wide range of lesions subdivided into differentiated (DTC) and undifferentiated thyroid cancer (UTC), mainly represented by th...
role development levels atc rmst lncrna thyroid Leer másBACKGROUND: Thyroid disorders are common endocrine conditions impacting multiple organs, including the reproductive system and often lead to sexual dysfunction. These effects can vary by gender; for e...
hypothyroidism ci 95% studies women sexual dysfunction prevalence thyroid Leer másNivolumab was approved for relapsed/refractory classic Hodgkin lymphoma (cHL) in Japan in 2016. After its approval, a prospective, non-interventional, observational post-marketing surveillance was ini...
classic hodgkin lymphoma japan post-marketing surveillance safety 6% thyroid relapsed/refractory chl hepatic traes safety nivolumab effectiveness patients Leer másObjective To explore the preoperative influential factors of difficult thyroidectomy and establish a preoperative nomogram for predicting the difficulty of thyroidectomy. Methods A total of 753 patien...
difficult thyroidectomy nomogram predictive factors thyroid surgery < 0 thyroid or = 1 001 factors nomogram thyroidectomy difficult 95% ci Leer másBilateral superficial cervical plexus block (BSCPB) is widely used in thyroid surgery. However, its ability to reduce patients’ perioperative pain remains controversial. Therefore, this study aimed to...
bilateral superficial cervical ple... thyroid surgery postoperative analgesia perioperative prognosis pain vomiting nausea 0001 using meta-analysis 0 surgery thyroid postoperative −1 studies review wmd systematic bscpb 95% ci −0 Leer másObjective Radioiodine (I-131) therapy for hyperthyroidism is a well-established and safe treatment option. This study aimed to investigate the relationship between the computed tomography (CT) value a...
graves disease plummer disease ct value radioiodine therapy effective half-life thyroid volume study hyperthyroidism riu function ehl gland correlation ct value Leer másBackground PTEN hamartoma tumour syndrome (PHTS) is a rare hereditary disorder caused by germline pathogenic mutations in the PTEN gene. This study presents a case of PHTS referred for genetic evaluat...
cowden syndrome phts hamartom... early diagnosis colorectal polyposis case reports case series breast hereditary multiple thyroid cancer literature polyps Leer másBACKGROUND: Thyroid cancer is the most common malignant tumor of the endocrine system. There have been some reports on kidney cancer with thyroid metastasis. However, kidney cancer has rarely been det...
due cancer kidney thyroid metastasis Leer másSomatic and biallelic DICER1 mutations are reported in subsets of thyroid tumors, supporting the role of this gene in thyroid tumor development. As recent studies have brought attention to macrofollic...
somatic mutation atrophic changes macrofollicular pattern histological clinical lesions constitutional wildtype versus = 0 mutations mutated tumors thyroid dicer1 Leer másBackground Thyroid dysfunction is the leading endocrine disorder worldwide. Iodine deficiency disorders, which were once the major etiology of thyroid dysfunctions, now have been succeeded by autoimmu...
subclinical hyperthyroidism subclinical hypothyroidism anti-thyroid peroxidase anti-thyroglobulin anti-thyroid stimulating hormone r... hashimoto’s thyroiditis grave’s disease patients trab nepal disorders autoimmune thyroid subclinical Leer másBackground Thyroid nodules were widely encountered in the population, and the selection of thyroid nodules for fine needle aspiration cytology (FNAC) remains confusing. It is essential to investigate ...
thyroid nodules fnac tirads dyslipidemia tsh 4% disease patients 6% acr-tirads benign thyroid fnac association classification nodules Leer másIn 2022, the new WHO Classification of Endocrine and Neuroendocrine Tumors, Fifth Edition (beta version) (WHO 5th), was published. Large-scale genomic analyses such as The Cancer Genome Atlas (TCGA) h...
classification high-grade molecular thyroid follicular tumors 5th Leer másThe histories of thyroid and parathyroid surgery offer interesting contrasts: in thyroid surgery, surgeons started to operate to relieve symptoms resulting from anatomic problems such as dislocation a...
thyroid surgery leonardo da vinci thomas wharton theodor billroth theodor kocher william halsted conventional thyroidectomy minimally invasive video-assisted ... robot-assisted transaxillary thyro... transoral endoscopic thyroidectomy... surgical surgery thyroid Leer másBackground Contradictory relationships have been observed between thyroid function and gestational diabetes mellitus (GDM). Previous studies have indicated that pre-pregnancy BMI (pBMI) could modify t...
sensitivity to thyroid hormones pre-pregnancy obesity tfqi gdm index tt4ri relationships indices 0 levels occurrence obesity association thyroid tfqi tshi 05 non-obese ptfqi sensitivity pre-pregnancy hormone women Leer másBackground Guidelines for thyroid surgery have evolved to reflect advances in medical knowledge and decrease the overdiagnosis of low-risk thyroid cancer. Our goal was to analyze the change made in op...
thyroid cancer thyroid surgery fine-needle aspiration thyroid weight thyroid recommendation study periods decrease low-risk ptc < 0 01 approximately increased evolution thyroid surgery cancer Leer másInternational audience; The comparative analysis of the expression of the reactive oxygen species-generating NADPH oxidase NOX4 from TCGA data shows that the NOX4 transcript is upregulat...
carcinomas mutation c-ptc comparative analysis non-malignant braf thyroid Leer másPurpose Gestational diabetes mellitus (GDM) and thyroid dysfunction during gestation (GTD) are the two most prevalent endocrinopathies during pregnancy. The aim of the present review is to provide an ...
thyroid pregnancy hypothyroidism gestational diabetes mellitus clinical consequences Leer másBackground Whether prophylactic central lymph node dissection is necessary for patients with clinically node-negative (cN0) papillary thyroid microcarcinoma (PTMC) remains controversial. Herein, we ai...
papillary thyroid microcarcinoma radiomics central lymph node metastasis nomogram machine learning clnm node clinically cohort thyroid clinical cn0 central cohorts ptmc lymph patients 0 rad score radiomics Leer másBackground In patients with steroid-resistant nephrotic syndrome (SRNS), the presence of monogenic variants influences therapeutic strategies. Large cohort studies reported the detection of monogenic ...
steroid-resistant nephrotic syndro... monogenic variants edema acute kidney injury associated wit... complete remission syndrome criteria onset nephrotic variants patients srns Leer másPurpose To evaluate the rate of and predictors of ureteral obstruction after mini-percutaneous nephrolithotomy (mPCNL) for kidney stones. Methods We analyzed data from 263 consecutive patients who und...
percutaneous nephrolithotomy ureteral obstruction stone complications exit strategies pyelography mpcnl stones = 0 pelvis renal transient canalization patients obstruction stone < 0 Leer másPurpose Metaverse is becoming an alternative world in which technology and virtual experiences are mixed with real life, and it holds the promise of changing our way of living. Healthcare is already c...
metaverse urology virtual reality healthcare internet of things 5g metaverse-assisted surgery potential surgery metaverse urology Leer másPurpose Accurate measurement of renal mass size is crucial in the management of renal cancer. With the burdensome cost of imaging yet its need for management, a better understanding of the variability...
renal mass imaging modality body mass index size estimation renal cell carcinoma mass contrast compared difference size imaging ct bmi Leer másBackground Peritoneal dialysis (PD) catheter related infections continue to be a major cause of morbidity and transfer to hemodialysis (HD) in PD patients. The treatment of tunnel infection (TI) could...
peritoneal dialysis exit-site infection tunnel infection peritonitis ultrasonography ultrasound cuff shaving cuff removal partial reimplantation splicing infectious infection therapy pd catheter ti Leer másObjectives Comparing the long-term tumor control results of partial cystectomy(PC)and radical cystectomy(RC)in the treatment of muscle-invasive bladder cancer, and to explore the feasible method of bl...
muscle-invasive bladder cancer partial cystectomy radical comparing operative incidence significant 50 8% 75 days perioperative cystectomy p < 0 6% bladder 4% patients 001 p = 0 0% 9% partial median ml hospital 3% 00 radical muscle-invasive cancer vs time 25 Leer másWorldwide, in Africa and Ethiopia prevalence of Benign Prostatic Hyperplasia among patients with lower urinary tract symptoms was 26.2%, 44.2%, and 33.4% respectively. However, there is limited eviden...
benign prostatic hyperplasia magnitude urology wolaita sodo university male 0 southern benign hyperplasia prostatic ci 95% associated factors ethiopia study consumption Leer másBackground Primary hyperoxaluria is a genetic disorder of the metabolism of glyoxylate, the precursor of oxalate. It is characterized by high endogenous production and excessive urinary excretion of o...
dialysis kidney transplant nephrocalcinosis primary hyperoxaluria nephrolithiasis nephrocalcinosis currently forms oxalate genetic dialysis survey hyperoxaluria primary Leer másObjectives This study aimed to develop machine learning models for risk prediction of continuous renal replacement therapy (CRRT) following coronary artery bypass grafting (CABG) surgery in intensive ...
machine learning risk factors continuous renal replacement thera... coronary artery bypass grafting prediction prediction study models features risk model cabg machine learning surgery Leer másPurpose To predict the post transurethral prostate resection(TURP) urethral stricture probability by applying different machine learning algorithms using the data obtained from preoperative blood para...
urethral stricture transurethral prostate resection machine learning,blood parameters value patients predictive preoperative models 82 urethral stricture accuracy 0 Leer másBackground Prostate cancer stands as the most frequently diagnosed cancer among men globally, with over 600,000 new cases annually. In-depth epidemiological studies play a pivotal role in delineating ...
prostate cancer epidemiology registry screening program morocco prostate cancer Leer másPurpose Neurogenic stress urinary incontinence (N-SUI) is a condition with serious impact on the quality of life. There are several treatment modalities of which the artificial urinary sphincter (AUS)...
neurogenic stress incontinence neurogenic lower urinary tract dys... artificial urinary sphincter sphincter deficiency sphincter artificial urinary Leer másMost solid metastatic cancers are resistant to chemotherapy. However, metastatic testicular germ cell tumors (TGCT) are cured in over 80% of patients using cisplatin-based combination therapy. Publish...
cisplatin tumor cell resistance apoptotic signaling manipulation of apoptotic signalin... testis tumor cell lines bladder tumor cancer cisplatin cells ttc Leer másPurpose The present systematic review and meta-analysis aimed at evaluating the effect of low dialysate sodium concentration on interdialytic weight gain (IDWG) in chronic hemodialysis patients. Metho...
hemodialysis hemodiafiltration sodium dialysate concentration interdialytic weight gain review systematic reduction quality included interdialytic gain weight sodium dialysate concentration idwg cross-over chronic hemodialysis patients low Leer másBackground Tamsulosin, an alpha-blocker in medical expulsive therapy, selectively relaxes ureteral smooth muscle, while Tadalafil, a PDE5-Is, is recommended for treating lower urinary tract symptoms. ...
tadalafil tamsulosin ureteric stones expulsion stone ureteric 34 patients lower tadalafil study Leer másBackground Inflammatory myofibroblastic tumor (IMT) of urinary bladder is a rare entity of genitourinary tract which has baffled urologists worldwide. Sign and symptoms are site specific. Usually diag...
inflammatory myofibroblastic tumor... imt urinary bladder partial cystectomy case report patient managed inflammatory myofibroblastic tumor Leer másObjective To report the experience of partial inferior pubicectomy in the treatment of complex posterior urethral stricture after trauma. Methods A total of 46 patients with post-traumatic posterior u...
urethroplasty inferior partial pubicectomy complex posterior urethral strictu... postoperative surgical inferior repair operation urethral stricture pubicectomy partial posterior Leer másBackground Retroperitoneal liposarcoma (RPLPS), a rare tumor, is often treated using surgical procedures as the first choice for treatment. However, there is no consensus on the scope of surgical rese...
recurrence metastasis dedifferentiated liposarcoma combined organ resection targeted therapy lps dedifferentiated tumors left surgical tumor rplps retroperitoneal Leer másBackground Few studies are focusing on the mechanism of erastin acts on prostate cancer (PCa) cells, and essential ferroptosis-related genes (FRGs) that can be PCa therapeutic targets are rarely known...
ferroptosis erastin prostate cancer tmeff2 nrxn3 rna-seq genes pathways pc3 increased degs cells lncap tmeff2 erastin pca cell Leer másIntroduction and Hypothesis The gold standard for quantifying pelvic organ prolapse is the pelvic organ prolapse quantification (POP-Q) system; however, upright magnetic resonance imaging (MRI) is a p...
correlation magnetic resonance imaging pelvic organ prolapse pop-q quantification upright pelvic study measurement prolapse mri-pics mri upright uterus bladder patients cm Leer másBackground Benign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract symptoms and quantifiable ur...
bladder obstruction gene expression urodynamics omics patients obstruction molecular values outlet bladder de-obstruction bpo pdetqmax Leer másBackground The success of workplace clinical training (WCT) is important given that veterinary students are licensed to work independently upon graduation. Considering this, it is perhaps surprising t...
workplace learning clinical placements rotations expectations readiness preparedness student prepared study learning veterinary Leer másBackground To report the first case of bull’s eye maculopathy associated with veterinary niclosamide. Case presentation A 27-year-old Iranian female presented with a history of reduced vision and phot...
niclosamide drug toxicity bull’s-eye maculopathy retinopathy maculopathy retinal veterinary Leer másThis paper explores the innovative use of simulation environments to enhance data acquisition and diagnostics in veterinary medicine, focusing specifically on gait analysis in dogs. The study harnes...
acquisition medicine veterinary Leer másBACKGROUND: The FAIR (Findable, Accessible, Interoperable, Reusable) principles were proposed in 2016 to set a path towards reusability of research datasets. In this systematic review, we assessed the...
veterinary articles research principles data fair epidemiology available Leer másOBJECTIVE: To provide a systematic assessment of the efficacy of preoperative skin asepsis using chlorhexidine versus povidone‐iodine based protocols for surgical site infection (SSI) prevention in ve...
veterinary search surgery bacterial colonization systematic Leer másAntimicrobial resistance (AMR) is a profound threat to human and animal health. Antimicrobial prescribing behaviours are influenced by psychological factors such as knowledge, beliefs, and emotions. A...
stewardship abr veterinary resistance responsibility behaviors vet beliefs amr knowledge Leer másSIMPLE SUMMARY: Research suggests that half of all veterinary clients fail to adhere to veterinarians’ dietary recommendations, which can lead to serious consequences for pet health. However, little i...
clients study health proposals changes clients’ veterinary resistance Leer másLarge language models (LLMs) can extract information from veterinary electronic health records (EHRs), but performance differences between models, the effect of temperature settings, and the influen...
ehrs extraction 9% 81 4% 96 iqr information veterinary performance temperature Leer másInternational audience; Abstract Many cases of wildlife poisoning in Europe have been reported causing population declines, especially in raptors. Toxicovigilance and risk assessment stu...
forensic toxicology institutions communication veterinary laboratories network european Leer másPlatelet-rich plasma (PRP) is a nontransfusional hemocomponent, considered as a powerful concentrate of growth factors (GFs) therapeutically used to stimulate tissue regeneration. The use of autologou...
treatments veterinary °c prp Leer másSIMPLE SUMMARY: The objective of this study was to evaluate the signalment of dogs used in veterinary research in six different specialties. In total, 150 randomly chosen clinical studies (25 studies ...
median deficits trials evaluated conditions 25 animals results dogs 7% information signalment breed veterinary research Leer másSIMPLE SUMMARY: College students, specifically from veterinary, animal, agricultural, and life sciences majors represent the future professionals who will closely work with animal industry stakeholder...
concerns veterinary considered college towards welfare majors attitudes laboratory animal chinese Leer másMonitoring veterinary antimicrobial use is part of the global strategy to tackle antimicrobial resistance. The purpose of this study was to quantify veterinary antimicrobials imported into Timor-Leste...
import 0 administration antimicrobial timor-leste veterinary antimicrobials imported Leer másSIMPLE SUMMARY: Chymase is a protease stored in mast cell granules and is released triggered by tissue, especially cardiovascular, damage. Many studies showed the potentials of measuring chymase activ...
veterinary study pda cardiac disease alacepril activity plasma Leer másBackground Traumatic brain injury (TBI) is a common condition in veterinary medicine that is difficult to manage.Veterinary regenerative therapy based on adipose mesenchymal stem cells seem to be an e...
traumatic brain injury adipose-derived mesenchymal stem c... therapy microglia attenuating inflammation veterinary cells brain injury traumatic microglia stem mesenchymal ad-mscs tbi canine Leer másThe English Bulldog has risen sharply in popularity over the past decade in the UK. However, its distinctive and extreme conformation has raised concerns because many of these physical features render...
vetcompass electronic patient record epr breed dog epidemiology primary-care veterinary pedigree purebred english bulldog health skin overall risk 01 95% ci odds dogs disorders conformation compared breed 0 uk disorder health study extreme × 0 Leer másBackground Multidrug resistance in companion animals poses significant risks to animal and human health. Prolonged antimicrobial drug (AMD) treatment in animals is a potential source of selection pres...
antimicrobial resistance genes veterinary sepsis microbiota d7 d60 animals dogs d1 treatment 9% fecal = 0 antimicrobial resistance Leer másThe treatment of feline sporotrichosis is a challenge for veterinary clinicians since refractory cases may occur, due either to patient and/or to pharmacological management errors or due to the develo...
therapeutic veterinary itz sporotrichosis cat feline itraconazole-resistant brasiliensis cats Leer másSIMPLE SUMMARY: Parasitic infections are a significant problem in veterinary medicine, and their management requires an in-depth understanding of the parasite life cycle, host-parasite interactions, a...
methods veterinary medicine diagnosis knowledge control infections resistance antiparasitic diseases animal türkiye veterinarians study survey Leer másVeterinary systems biology is an innovative approach that integrates biological data at the molecular and cellular levels, allowing for a more extensive understanding of the interactions and functions...
biology animal approach welfare veterinary Leer másSIMPLE SUMMARY: COVID-19 has impacted veterinary medicine and cat guardians in numerous ways. The purpose of this study was to better understand cat guardians’ fears and concerns pertaining to veterin...
ability obtain impact veterinary concerns Leer másAntibiotic resistance is a global public health concern that could lead to millions of deaths if nothing is done. As a One Health problematic, it needs to be addressed both in human, an...
changes veterinary barrières resistance secteur distribution changement médicament participative chaîne vétérinaire participatory pratiques codévelopper reduce chicken avons antibiotic identifié chain utilisation au identified farms acteur·rices barriers élevages réduire filière stakeholders regulations étude value study farmers production strategies stratégies antibiotiques solutions vietnam Leer másIntervertebral disc disease, as well as the associated alteration of the radiographic intervertebral disc space width, has been reported in horses. Disc height index (DHI) has proven to be an accurate...
veterinary significantly diagnostic radiographic index width parameter edwi disc horses intervertebral Leer másThe COVID-19 pandemic has resulted in the global recognition for greater inter-disciplinary and multi-disciplinary working, and the need for systematic approaches which recognise the interconnectednes...
medicine systematic approach veterinary Leer másInternational audience; Various pharmaceuticals are essential for livestock farming, but some are highly toxic to aquatic life if they reach surface water bodies. Mediterranean Climate i...
fbz concentration periods veterinary livestock Leer másBACKGROUND: There are gaps in our understanding of the epidemiology of atopic dermatitis (AD) in adults. OBJECTIVE: To evaluate the prevalence and severity of AD in adults from countries/regions withi...
range 4% survey – adults disease Leer másBackground: On the occasion of the 110(th) anniversary of allergen-specific immunotherapy (AIT), the question arises of “how do patients feel about AIT?”. Materials and methods: Informed by questions ...
survey Leer másBACKGROUND: Half of U.S. households own a dog despite 10% of individuals being sensitized to dog. Assessment and treatment options for dog allergy include the use of commercial dog extracts which have...
hair dander commercial results extract ap extracts fel Leer másBACKGROUND: Immunoglobulin E (IgE) blood tests are used to detect sensitizations and potential allergies. Recent studies suggest that specific IgE sensitization patterns due to molecular interactions ...
stings clusters allergy allergens patterns hymenoptera venom specific sensitization Leer másBACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects children and adults. Poor treatment adherence in AD requires interventions to promote self-management; patient ed...
scoping studies review education Leer másPURPOSE: Despite the emerging biologics, biomarkers and treatment options for asthma–chronic obstructive pulmonary disease (COPD) overlap (ACO) are still limited, requiring further research. METHODS: ...
2% ≥ 049 lung function ± 0 vs t2-high eosinophil sputum aco Leer másINTRODUCTION AND OBJECTIVES: Due to the lack of structured and systematic information available, the aim of this study was to describe the epidemiology, diagnosis, healthcare processes, and treatment ...
patients systematic hae Leer másModern living conditions and the recent surge in global urbanization have transformed the human microbiome. This transformation is believed to be a significant factor in the recent spike of common chr...
prebiotics asthma probiotics changes conditions human Leer másPURPOSE: We present a convenient and safe allergen-specific immunotherapy using injectable hyaluronic acid (HA) hydrogel containing house dust mite (HDM) crosslinked via visible-light-induced thiol-en...
rhinitis model hydrogels murine subcutaneous levels received symptoms increased cells scit using compared control nasal hdm treatment hydrogel immunotherapy allergic ha Leer másPURPOSE: Chronic rhinosinusitis (CRS) is classified into type 2 (T2) and non-T2 inflammation. T2 CRS presents as a severe form, CRS with nasal polyps (CRSwNP), which often occurs with asthma as a como...
crswnp non-t2-em t2 nasal nets crs non-t2-np refractoriness non-t2 Leer másFood protein induced enterocolitis syndrome (FPIES) belongs to a group of IgE-independent food allergies. It is the domain of paediatric patients, but it can also occur in adults. In this disease ther...
adults food disease Leer másPrimary immunodeficiency diseases (PIDs) are uncommon in adults; however, immunoglobulin G subclass deficiency (IGGSCD) is often found in a subset of adult patients with chronic respiratory diseases. ...
respiratory iggscd chronic Leer másINTRODUCTION: Information and communication technologies (ICTs) improve patient‐centered care and are routinely used in Allergic Rhinitis (AR), but patients' preferences and attitudes are unexplored. ...
allergic 0 education quality life information communication 95% ci ar patient Leer másBACKGROUND: Anaphylaxis is a growing public health problem in Australia. To determine the extent of the problem, we linked multiple health datasets to examine temporal trends in anaphylaxis events acr...
linked 8% 95%ci 0 hospital 6% 9% 2010 annual anaphylaxis health 2019 ambulance 2020 australia 000 trends Leer másBACKGROUND: Penicillin allergy is the most commonly reported drug allergy in the US. Despite evidence demonstrating that up to 90% of labels are incorrect, scalable interventions are not well establis...
care tdf pharmacists skills inpatient de-labeling penicillin allergy domains barriers outpatient Leer másBACKGROUND: Bronchodilator responsiveness (BDR) in asthma involves both the central and peripheral airways but is primarily relieved with beta-2-agonists and evaluated by spirometry. To date, antimusc...
spirometry mild-moderate fev minutes responsiveness asthma saba+sama saba bdr inhaling patients sama Leer másINTRODUCTION: Dupilumab is the first biologic agent used to clinically treat moderate and severe atopic dermatitis (AD) and is currently the only biologic agent used for this condition. Many studies h...
moderate-to-severe facial atopic dupilumab dermatitis treatment patients Leer másBACKGROUND: The mainstay of treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is systemic corticosteroid therapy; some patients also receive intravenous immunoglobulins, other immunos...
egpa dose responders eosinophil daily bvas rates p < 0 01 lower patients visit super-responders mepolizumab relapse treatment Leer másBACKGROUND: Inborn errors of immunity (IEIs) are considered significant challenges for children with IEIs, their families, and their medical providers. Infections are the most common complication of I...
3% included review 6% syndrome severe combined studies infection covid-19 5% immune systematic sars-cov-2 immunodeficiencies children diseases ieis Leer másBACKGROUND: Neurturin (NRTN) is a neurotrophic factor that was originally identified in the development and maintenance of neural cells. Recent studies involving NRTN knockout mice have reported its a...
clinical level nrtn subjects sputum Leer másBACKGROUND: Poor adherence to inhaled corticosteroids (ICS) is a significant challenge in pediatric asthma, contributing to health inequities. Text-message reminders for ICS therapy are an evidence-ba...
medication parents nurses facilitators school-linked text-message asthma adherence barriers school implementation Leer másIt has been more than a decade since the most recent allergen immunotherapy (AIT) practice parameter was published and 5 years since a focused practice parameter on sublingual immunotherapy (SLIT) was...
primer efficacy information allergy/immunology allergen slit ait immunotherapy scit Leer másThere have been many studies on the association between vitiligo and metabolic syndrome, while only few scientific papers on vitiligo and insulin resistance. In recent years, there have been significa...
vitiligo syndrome metabolic Leer másBACKGROUND: Inborn errors of immunity (IEIs) are considered significant challenges for children with IEIs, their families, and their medical providers. Infections are the most common complication of I...
3% included review 6% syndrome severe combined studies infection covid-19 5% immune systematic sars-cov-2 immunodeficiencies children diseases ieis Leer másPURPOSE: Wheezing in early life is most frequently caused by viral lower respiratory tract illnesses, constituting a significant disease burden in children. This study aimed to investigate the associa...
matched study wheezing autoimmune exposed childhood unexposed age cohort Leer másUtilizamos cookies y otras tecnologías similares para :
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