Selección de día 23/11/2024

Alzheimer's disease (AD) is a multi-facet pathology, that can be monitored through a variety of data types. This thesis aims to leverage multimodal longitudinal data, especially imaging...

International audience; Background: The association between omega-3 (ω-3) PUFAs and cognition, brain imaging and biomarkers is still not fully established.Objectives: The aim was to anal...

Background Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease. Me...

Alzheimer's disease (AD) is a progressive brain disorder characterized by extracellular amyloid-β (Aβ) plaques, intracellular neurofibrillary tangles formed by hyperphosphorylated Tau p...

Background Solanum lycopersicum Linn. (Tomato, Family Solanaceae) is one of the fruits that are most consumed worldwide. The current research intends to emphasise the possibility of positive and thera...

International audience; The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the identification of many diseases. This article aimed to ...

This study presents an innovative method for Alzheimer's disease diagnosis using 3D MRI designed to enhance the explainability of model decisions. Our approach adopts a soft attention mechanism, ena...

Alzheimer's disease (AD) is a leading neurodegenerative condition and the primary cause of dementia, characterized by progressive cognitive decline and memory loss. Its progression, marked by shrink...

Background This systematic review synthesizes the most recent neuroimaging procedures and machine learning approaches for the prediction of conversion from mild cognitive impairment to Alzheimer’s dis...

Synaptic loss is intrinsically linked to Alzheimer's disease (AD) neuropathology and symptoms, but its direct impact on clinical symptoms remains elusive. The postsynaptic protein Shank3 (SH3 and mult...

BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenera...

Disinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism rem...

Alzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have sh...

BACKGROUND: Alzheimer's disease (AD) has become a common illness affecting the elderly, adding to society's social and financial burden. We used two‐sample Mendelian randomization (MR) in this study t...

International audience; Age, sex and APOE-ε4 genotype have been identified as the strongest predictors of the risk of developing Alzheimer's Disease (AD). This work models the pathologic...

While the link between aging and mortality from dementia is widely appreciated, the mechanism is not clear. The objective of this study was to determine whether there is a direct relationship between ...

Alzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have sh...

This research underscores the efficacy of Fourier topological optimization in refining MRI imagery, thereby bolstering the classification precision of Alzheimer's Disease through convolutional neura...

The activation of the Wnt signaling pathway is implicated in a neuroprotective mechanism against the Alzheimer disease. When this pathway is blocked, it activates GSK3 beta, leading to tau hyperphosph...

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory and cognitive decline, affecting millions worldwide. Diagnosing AD is challenging due to its heterogeneou...

BACKGROUND: Neuroimaging studies often quantify tau burden in standardized brain regions to assess Alzheimer disease (AD) progression. However, this method ignores another key biological process in wh...

Alzheimer's disease has an increasing prevalence in the population world-wide, yet current diagnostic methods based on recommended biomarkers are only available in specialized clinics. Due to these ...

The organization of brain functional connectivity (FC) has been shown to differ between sexes. Amyotrophic lateral sclerosis (ALS) is characterized by sexual dimorphism, showing sex-specific trends in...

Individuals with amyotrophic lateral sclerosis (ALS) frequently develop speech and communication problems in the course of their disease. Currently available augmentative and alternative communication...

Background Amyotrophic lateral sclerosis (ALS) is a degenerative disease that affects the upper and lower motor neurons. The onset of the disease is frequently focal, usually involving the distal segm...

Behavioral disorders, with an average prevalence of 30–60% are important non-motor symptoms in amyotrophic lateral sclerosis (ALS) that have a negative impact on prognosis, management and quality of l...

Introduction Hereditary spastic paraparesis (HSP) is a group of central nervous system diseases primarily affecting the spinal upper motor neurons, with different inheritance patterns and phenotypes. ...

The microglial reaction is a hallmark of neurodegenerative conditions, and elements thereof may exert differential effects on disease progression, either worsening or ameliorating severity. In amyotro...

Purpose Amyotrophic lateral sclerosis (ALS) is a progressive motor impairment leading to early death. Religiousness is one of the factors potentially alleviating the psychological burden of patients. ...

Background Although percutaneous endoscopic gastrostomy (PEG) offers better access to the gastrointestinal system, in patients with previous abdominal surgery, PEG can be unsuccessful. Laparoscopicall...

Background Magnetic resonance imaging (MRI) of the brain and cervical spinal cord is often performed in diagnostic evaluation of suspected motor neuron disease/amyotrophic lateral sclerosis (MND/ALS)....

Background Major efforts have been made in the last decade to develop and improve therapies for proximal spinal muscular atrophy (SMA). The introduction of Nusinersen/Spinraza™ as an antisense oligonu...

Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways h...

Objectives This systematic review and meta-analysis aimed to determine the frequency and correlates of fatigue in patients with amyotrophic lateral sclerosis (ALS). Methods Three databases were search...

Background This study aimed at providing diagnostic properties and normative cut-offs for the Italian ECAS Carer Interview (ECAS-CI). Materials N  = 292 non-demented ALS patients and N  = 107 healthy ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axo...

Background People with amyotrophic lateral sclerosis (ALS) are at high risk for severe outcomes from Covid-19 infection. Researchers exploring ALS and Covid-19 have focused primarily on system respons...

Background Peer support is effective in improving psychological well-being of family caregivers of people with conditions such as dementia, cancer, and brain injury. However, there are limited data on...

Introduction Even if electromyography (EMG) is routinely used to confirm the diagnosis of amyotrophic lateral sclerosis (ALS), few studies have analysed the correlation between electrophysiological pa...

Amyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the disease status...

Objective There is increasing evidence that amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting large-scale brain networks. However, it is still unclear which stru...

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with average lifespan of 2–5 years after diagnosis. The identification of novel prognostic and pharmacodynamic bi...

Background Growing evidence suggests a mutual interaction between gut microbiome alterations and ALS pathogenesis. However, previous studies were susceptible to potential confounding factors and rever...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motor neurons (MNs). Since the identification of the first ALS mutation in 1993, more than 40 genes h...

Purpose To investigate the effect of urocortin-1 (UCN-1) on growth, migration, and apoptosis in colorectal cancer (CRC) in vivo and vitro and the mechanism by which UCN-1 modulates CRC cells in vitro....

Aggregatibacter actinomycetemcomitans is an opportunistic Gram-negative periodontopathogen strongly associated with periodontitis and infective endocarditis. Recent evidence suggests that periodontopa...

Background Preoperative discrimination between non-muscle-invasive bladder cancer (NMIBC) and the muscle invasive bladder cancer (MIBC) is a determinant of management. The purpose of this research is ...

Stromal fibroblasts are a major stem cell niche component essential for organ formation and cancer development. Fibroblast heterogeneity, as revealed by recent advances in single-cell techniques, has ...

Genetics and molecular biology research have progressed for over a century; however, no laws of biology resembling those of physics have been identified, despite the expectations of some physicists. I...

Purpose Achieving a pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) remains a challenge for most patients with rectal cancer. Exploring the potential of combining NCRT wi...

Background Cancer-associated thrombosis is a frequent complication of cancer; however, little evidence is available regarding the association between cancer history and coronary artery stent thrombosi...

Breast cancer's complexity and variability pose significant challenges in understanding its progression and guiding effective treatment. This study aims to integrate protein sequence data with expre...

YY1 affects tumorigenesis and metastasis in multiple ways. However, the function of YY1 and the potential mechanisms through which it operates in gastric cancer (GC) progression by regulating autophag...

Purpose People treated for head and neck cancer (HNC) face various barriers in communicating concerns with consultants. Our aim was to investigate the number of concerns raised between patients using ...

Background Timely initiation of advance care planning (ACP) in general practice is challenging, especially in patients with non-malignant conditions. Our aim was to investigate how perceived optimal t...

Multiple cancer types have limited targeted therapeutic options, in part due to incomplete understanding of the molecular processes underlying tumorigenesis and significant intra- and inter-tumor hete...

Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s). According to estimations, metastasis results in over 90% ...

Objective To determine the impact of acute SARS-CoV-2 infection on patient with concomitant active cancer and CVD. Methods The researchers extracted and analyzed data from the National COVID Cohort Co...

Background Insulin-mediated pathways plausibly explain the pathogenesis of colorectal cancer (CRC). The triglyceride-glucose index (TyG) is a surrogate of insulin resistance (IR), but its association ...

Gene expression profiles obtained through DNA microarray have proven successful in providing critical information for cancer detection classifiers. However, the limited number of samples in these da...

BACKGROUND: The frailty index (FI) is an established predictor of all-cause mortality among older adults, but less is known with regard to cause-specific mortality, and whether the predictive power of...

Background Dolomiaea costus  (syn: Saussurea costus ; Family Asteraceae) occupies an important place in the traditional Chinese medicinal plants and is prescribed for a wide range of disorders. The cu...

Predicting the response to cancer immunotherapy remains an unmet challenge in triple-negative breast cancer (TNBC) and other malignancies. T cells, the major target of current checkpoint inhibitor imm...

Background Recently, many studies have shown that the progress of conversion therapy can provide surgical opportunities for patients with advanced gastric cancer (GC) and bring survival benefits. Howe...

Childhood, adolescent, and young adult (CAYA) cancer survivors are at risk of pulmonary dysfunction. Current follow-up care guidelines are discordant. Therefore, the International Late Effects of Chil...

Breast cancer was diagnosed for over 7.8 million women between 2015 to 2020. Grading plays a vital role in breast cancer treatment planning. However, the current tumor grading method involves extrac...

Multi-objective optimization can be found in many real-world applications where some conflicting objectives can not be optimized by a single solution. Existing optimization methods often focus on fi...

In speech emotion recognition (SER), using predefined features without considering their practical importance may lead to high dimensional datasets, including redundant and irrelevant information. C...

Low earth orbit (LEO) satellite internet of things (IoT) is a promising way achieving global Internet of Everything, and thus has been widely recognized as an important component of sixth-generation...

Vehicular edge intelligence (VEI) is a promising paradigm for enabling future intelligent transportation systems by accommodating artificial intelligence (AI) at the vehicular edge computing (VEC) s...

In this work, from a theoretical lens, we aim to understand why large language model (LLM) empowered agents are able to solve decision-making problems in the physical world. To this end, consider a ...

We propose a framework for global-scale canopy height estimation based on satellite data. Our model leverages advanced data preprocessing techniques, resorts to a novel loss function designed to cou...

Can large language models (LLMs) simulate social surveys? To answer this question, we conducted millions of simulations in which LLMs were asked to answer subjective questions. A comparison of diffe...

Federated learning (FL) has recently emerged as a compelling machine learning paradigm, prioritizing the protection of privacy for training data. The increasing demand to address issues such as ``th...

Large Language Models (LLMs) are increasingly applied in various real-world scenarios due to their excellent generalization capabilities and robust generative abilities. However, they exhibit positi...

In motion generation, controllability as well as generation quality and speed is becoming more and more important. There are various motion editing tasks, such as in-betweening, upper body editing, ...

Effective ownership of software artifacts, particularly code, is crucial for accountability, knowledge sharing, and code quality enhancement. Researchers have proposed models linking ownership of so...

The creation of high-fidelity, digital versions of human heads is an important stepping stone in the process of further integrating virtual components into our everyday lives. Constructing such avat...

Despite impressive advances in recent multimodal large language models (MLLMs), state-of-the-art models such as from the GPT-4 suite still struggle with knowledge-intensive tasks. To address this, w...

The Segment Anything Model (SAM) marks a notable milestone in segmentation models, highlighted by its robust zero-shot capabilities and ability to handle diverse prompts. SAM follows a pipeline that...

Uncertainty quantification in Large Language Models (LLMs) is crucial for applications where safety and reliability are important. In particular, uncertainty can be used to improve the trustworthine...

Explainability and transparency of AI systems are undeniably important, leading to several research studies and tools addressing them. Existing works fall short of accounting for the diverse stakeho...

Recently, Large Language Models (LLMs) have witnessed remarkable performance as zero-shot task planners for robotic manipulation tasks. However, the open-loop nature of previous works makes LLM-base...

Image reconstruction for dynamic inverse problems with highly undersampled data poses a major challenge: not accounting for the dynamics of the process leads to a non-realistic motion with no time r...

Cambodia's agricultural landscape is rapidly transforming, particularly in the cashew sector. Despite the country's rapid emergence and ambition to become the largest cashew producer, comprehensive ...

Existing few-shot segmentation (FSS) only considers learning support-query correlation and segmenting unseen categories under the precise pixel masks. However, the cost of a large number of pixel ma...

In this paper, we primarily address the issue of dialogue-form context query within the interactive text-to-image retrieval task. Our methodology, PlugIR, actively utilizes the general instruction-f...

The advent of Vision Transformers (ViTs) marks a substantial paradigm shift in the realm of computer vision. ViTs capture the global information of images through self-attention modules, which perfo...

INTRODUCTION: The novel and expanding field of long COVID research has undergone diverse methodological approaches in recent years. This protocol lays out the methodological approach, which aims at id...

More than three years after the start of the COVID-19 pandemic, individuals are frequently reporting multiple COVID-19 infections. However, these reinfections remain poorly understood. Here, we invest...

Objective Long COVID, characterized by persistent symptoms post-acute COVID-19, remains a subject of intense investigation. This study focuses on pain, a common and notable symptom reported by long CO...

Long COVID is characterized by persistent symptoms, particularly pulmonary impairment, which necessitates advanced imaging for accurate diagnosis. Hyperpolarised Xenon-129 MRI (XeMRI) offers a promi...

Background Findings from studies assessing Long Covid in children and young people (CYP) need to be assessed in light of their methodological limitations. For example, if non-response and/or attrition...

Objective Long COVID, characterized by persistent symptoms post-acute COVID-19, remains a subject of intense investigation. This study focuses on pain, a common and notable symptom reported by long CO...

More than three years after the start of the COVID-19 pandemic, individuals are frequently reporting multiple COVID-19 infections. However, these reinfections remain poorly understood. Here, we invest...

Background Since the declaration of COVID-19 as a pandemic in 2020, its main symptoms have primarily affected the respiratory system. However, it also presents other systemic manifestations, including...

INTRODUCTION: The relationship between SARS-CoV-2 viral dynamics during acute infection and the development of long COVID is largely unknown. METHODS: A total of 7361 asymptomatic community-dwelling p...

Objective Long COVID, characterized by persistent symptoms post-acute COVID-19, remains a subject of intense investigation. This study focuses on pain, a common and notable symptom reported by long CO...

Objective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...

Introduction The COVID-19 pandemic period (2020 to 2022) challenged and overstretched the capacity of primary health care services to deliver health care globally. The sector faced a highly uncertain ...

Zang et al. use RECOVER EHR data to study Long COVID risk factors and apply mathematical modeling to predict the development of long COVID conditions. They find that severe acute SARS-CoV-2 infection,...

Telogen effluvium is characterized by excessive hair shedding usually following a stressful event. Ferritin has been used in clinical practice as a biomarker of nonanemic iron deficiency in cases of t...

BACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...

BACKGROUND: Severe COVID and multisystem inflammatory syndrome (MIS-C) are characterized by excessive inflammatory cytokines/chemokines. In adults, disease severity is associated with SARS-CoV-2-speci...

Objective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...

BACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...

Zang et al. use RECOVER EHR data to study Long COVID risk factors and apply mathematical modeling to predict the development of long COVID conditions. They find that severe acute SARS-CoV-2 infection,...

Aim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...

Background The emergence of COVID-19 precipitated containment policies (e.g., lockdowns, school closures, etc.). These policies disrupted healthcare, potentially eroding gains for Sustainable Developm...

Pediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...

Using multiple pharmacies has been linked to negative outcomes including increased inappropriate drug use, toxicity, and mortality, yet up to half of all patients in the US use multiple pharmacies. A ...

HIV-related stigma has been associated with poor mental health among people with HIV (PWH). Social support is a potentially modifiable factor that may buffer negative mental health sequelae of HIV-rel...

Introduction Granulomatosis due to immune reconstitution inflammatory syndrome (IRIS) and disseminated Mycobacterium avium-intracellulare ( M. avium ) infection may trigger hypercalcemia. Here, we rep...

Background Mycobacterium avium complex (MAC) is an uncommon clinical pathogen, especially in the central nervous system (CNS), and carries a poor prognosis. MAC infections commonly present as immune r...

Background Acquired immunodeficiency syndrome (AIDS) is an acquired defect of the cellular immunity associated with the infection by the human immunodeficiency virus (HIV). The disease has reached pan...

Background Despite tremendous progress in improving antiretroviral therapy (ART) access, advanced HIV disease (AHD) still remains a challenge globally. Reasons for delayed presentation to care and ART...

Background In 2015, Togo introduced the “test-and-treat” strategy for the prevention of mother-to-child transmission (PMTCT) of HIV. Pediatric HIV infection remains a public health problem in Togo, wi...

Peer advocacy can promote HIV protective behaviors, but little is known about the concordance on prevention advocacy(PA) reports between people living with HIV(PLWH) and their social network members. ...

Background Human immunodeficiency virus (HIV) infection and sexually transmitted infections (STIs) are major global public health issues. Migrants represent a vulnerable group that faces multiple barr...

BACKGROUND: In Peru, HIV cases are highly concentrated among men who have sex with men (MSM). Despite the availability of anti-retroviral therapy, people living with HIV (PWH) have higher levels of or...

Background Adverse socio-cultural factors compromise the implementation of HIV prevention strategies among displaced youth. While condoms are an affordable and effective HIV prevention strategy for yo...

Background Index-linked HIV testing for children, whereby HIV testing is offered to children of individuals living with HIV, has the potential to identify children living with undiagnosed HIV. The “Br...

Background Universal recommendation for antiretroviral drugs and their effectiveness has put forward the challenge of assuring a chronic and continued care approach to PLHIV (People Living with HIV) ,...

OBJECTIVE: The purpose of this study is to investigate the incidence of determinants for virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling this global publ...

Background Human Immunodeficiency Virus (HIV) continues to be the major cause of childhood deaths, particularly in the sub-Saharan African region. In Ethiopia, though several primary studies have been...

Innovative interventions are needed to improve HIV outcomes among adolescents and young adults (AYAs) living with HIV. Engaging AYAs in intervention development could increase effectiveness and youth ...

Background Advanced HIV disease (AHD) in young people living with HIV (PLHIV) is an increasingly pressing public health issue in sub-Saharan Africa. Despite global progress in early HIV testing and re...

BACKGROUND: Ciswomen constitute a disproportionately low percentage of pre-exposure prophylaxis for HIV prevention (PrEP) users compared to men. Despite PrEP’s effectiveness, women are 5.25 times less...

Background Sexual uses of alcohol and drugs are pervasive among men who have sex with men (MSM) and associated with increased risk of HIV infection. However, there are limited studies related to sexua...

Introduction Significant progress has been made in the HIV response in South Africa; however, gaps remain in ensuring engagement in care to support life-long medication adherence and viral suppression...

BACKGROUND: Human Immunodeficiency Virus (HIV) has claimed the lives of millions of people during the past decades. While several antiretroviral drugs like Integrase Strand Transfer Inhibitors (INSTIs...

Background Limited research has been conducted on the forms, manifestations and effects of intersectional stigma among young HIV-positive men who have sex with men (MSM) and transgender women (TGW) in...

INTRODUCTION: Infection with SARS-CoV-2 is typically compared with influenza to contextualize its health risks. SARS-CoV-2 has been linked with coagulation disturbances including arterial thrombosis, ...

The 10 years between the last influenza pandemic and start of the severe acute respiratory syndrome coronavirus 2 pandemic have been marked by great advances in our ability to follow influenza occurre...

Background Influenza is a major cause of morbidity, mortality and exacerbation of extant chronic disease worldwide. Influenza vaccination is thus fundamental to reduce the burden of disease. In this s...

International audience; Introduction: Influenza vaccination coverage currently remains below the 75% recommended threshold by the World Health Organization. To correct this situation, ex...

Respiratory infections are one of the most frequent reasons for medical consultations in children. In low resource settings such as in Lao People's Democratic Republic, knowledge gaps and the dearth o...

Background and Objective In Germany, influenza vaccination is mainly advised for persons aged 60 years and over and individuals with health risks. Since 2021, an inactivated, quadrivalent high-dose in...

Background Health-care workers (HCWs) are at a higher occupational risk of contracting and transmitting influenza. Annual vaccination is an essential tool to prevent seasonal influenza infection. Howe...

Diabetes mellitus is on the rise globally and is a known susceptibility factor for severe influenza virus infections. However, the mechanisms by which diabetes increases the severity of an influenza v...

The genome data were generated and shared via GISAID (Supplementary Data 2). All anonymized data, code, and analysis files are available in the GitHub repository (https://github.com/vjlab/episodic-h5)...

Background Influenza is responsible for more than 5 million severe cases and 290,000 to 650,000 deaths every year worldwide. Developing countries account for 99% of influenza deaths in children under ...

Forecasting the hospitalizations caused by the Influenza virus is vital for public health planning so that hospitals can be better prepared for an influx of patients. Many forecasting methods have b...

Background Maternal vaccinations against Influenza, Pertussis, and Covid-19 are recommended in the UK, and vaccines against further infections may become available soon. However, many pregnant women, ...

There is large county-level geographic variation in pneumonia and influenza hospitalizations among short-stay and long-stay long-term care facility residents in the United States. Long-term care facil...

Purpose of Review To review the recent literature surrounding immune responses to influenza vaccination in solid organ transplant (SOT) recipients, in addition to reviewing future directions for novel...

International audience; Background: Influenza has been shown to increase the risk for severe bacterial infection, in the tropics the seasonality of influenza epidemics is less marked, an...

Let us study viruses and the role of sialic acids in their first step of reproduction, the attachment to cells. We begin our study with the help of the "Earth's virology course", created by Vincent Ra...

INTRODUCTION: Influenza is a globally occurring viral respiratory infection that can lead to hospitalizations and death. An influenza outbreak can interfere with combat readiness in a military setting...

BACKGROUND: Available data on influenza burden across Southeast Asia are largely limited to pediatric populations, with inconsistent findings. METHODS: We conducted a multicenter, hospital-based activ...

BACKGROUND: H7 subtype avian influenza has caused great concern in the global poultry industry and public health. The conventional serological subtype-specific diagnostics is implemented by hemaggluti...

A number of disease states, including type 2 diabetes (T2D), are associated with an increased risk of pulmonary infection. Glucagon-like peptide-1 (GLP-1) receptor agonists are used to treat T2D and e...

BACKGROUND: Adult hematopoietic cell transplant (HCT) recipients are at high risk for influenza-related morbidity and mortality and have suboptimal influenza vaccine immune responses compared to healt...

BACKGROUND: Influenza vaccination is recommended for those at increased risk of influenza complications and their household contacts to help reduce influenza exposure. Adults who require care often ex...

Background The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body...

Fungal infections in humans range in severity from superficial, cutaneous manifestations to deep-seated, invasive infection, particularly in immunocompromised patients. The mycology laboratory must be...

Purpose Biovalorization of lignin-derived aromatic monomers such as ferulic acid (FA) has attracted considerable interest. The cold-adapted strain Paraburkholderia aromaticivorans AR20-38 converts FA ...

Background Campylobacter species (spp.) are one of the most important zoonotic bacteria possessing potential hazards for animal and human health worldwide. Migratory birds are implicated as significan...

Background Antibiotic-associated diarrhea (AAD) refers to symptoms of diarrhea that cannot be explained by other causes after the use of antibiotics. AAD is thought to be caused by a disruption of int...

Background Alternaria alternata is the primary pathogen of potato leaf spot disease, resulting in significant potato yield losses globally. Endophytic microorganism-based biological control, especiall...

Background Despite advances in our understanding of the critical role of the microbiota in stroke patients, the oral microbiome has rarely been reported to be associated with stroke-associated pneumon...

Background The clam Chamelea gallina is an ecologically and economically important marine species in the Northwestern Adriatic Sea, which currently suffers from occasional, and still unexplained, wide...

Background Clostridioides difficile is the main pathogen of antimicrobial-associated diarrhoea and health care facility-associated infectious diarrhoea. This study aimed to investigate the prevalence,...

Purpose This research was conducted to investigate the potential of short-chain fatty acids (SCFAs) in protecting organs from heat stress-induced injuries and gut microbiota modulation. Methods Spragu...

Background The increasing spread of fluoroquinolone resistant enteric bacteria is a global public health concern. Children recently discharged from the hospital are at high risk of carriage of antimic...

Meloidogyne nematodes cause diseases in economically important plants. These sedentary endoparasites modify plant roots, creating feeding sites and leading to the formation of root galls. Arbuscular m...

Background Cordyceps fumosorosea is one of the common species within the Cordyceps genus, which are cultured on Periplaneta americana . This study aimed to determine the composition of bioactive compo...

Background Rhizosphere and endophytic fungi play important roles in plant health and crop productivity. However, their community dynamics during the continuous cropping of Knoxia valerianoides have ra...

There has been considerable research into the understanding of the healthy skin microbiome. Similarly, there is also a considerable body of research into whether specific microbes contribute to skin d...

Background The pathogenesis of anti-tuberculosis (TB) drug-induced liver injury (ADLI) is complicated and remains unclear. We aimed to analyse the relationship between the characteristics of gut micro...

Vibrio cholerae , as a natural inhabitant of the marine environment is among the world-leading causes of diarrheal diseases. The present study aimed to investigate the genetic relatedness of Iran 2012...

Background Thermophilic composting is a promising method of sanitizing pathogens in manure and a source of agriculturally important thermostable enzymes and microorganisms from organic wastes. Despite...

Background Sustainable aquaculture relies on multiple factors, including water quality, fish diets, and farmed fish. Replacing fishmeal (FM) with alternative protein sources is key for improving susta...

Wolbachia are endosymbiotic bacteria found within many arthropods, including insects. A variety of benefits are provided by these bacteria to human and insect hosts, including protection from viruses ...

Background The emergence of carbapenem-resistant and extensively drug-resistant (XDR) Acinetobacter baumannii as well as inadequate effective antibiotics calls for an urgent effort to find new antibac...

Recovery of motor function after stroke is accompanied by reorganization of movement representations in spared cortical motor regions. It is widely assumed that map reorganization parallels recovery, ...

Primary familial brain calcification (PFBC) is an inherited neurodegenerative disorder mainly characterized by progressive calcium deposition bilaterally in the brain, accompanied by various symptoms,...

The behavioral state of a mammal impacts how the brain responds to visual stimuli as early as in the dorsolateral geniculate nucleus of the thalamus (dLGN), the primary relay of visual information to ...

Chronic pain is associated with dysfunctional cortical excitability. Research has identified altered intracortical motor cortex excitability in Chronic Lower Back Pain (CLBP). However, research identi...

Repetitive transcranial magnetic stimulation (rTMS) has been widely used as a therapy for refractory obsessive-compulsive disorder (OCD). However, it remains unclear which exact target and stimulation...

Hintergrund Die schnelle und zuverlässige Diagnose einer Multiplen Sklerose (MS) ist entscheidend, um eine angepasste verlaufsmodifizierende Therapie zu beginnen. Die 2017-Revision der McDonald-Kriter...

BACKGROUND: The habenula is a major regulator of serotonergic neurons in the dorsal raphe, and thus of brain state. The functional connectivity between these regions is incompletely characterized. Her...

INTRODUCTION: It is widely demonstrated that high frequency (HF) repetitive transcranial magnetic stimulation (rTMS) has facilitative effects and is therefore capable to inducing changes in motor resp...

INTRODUCTION: Peroxisomes are essential organelles in lipid metabolism. They contain enzymes for β-oxidation of very long-chain fatty acids (VLCFA) that cannot be broken down in mitochondria. Reduced ...

BACKGROUND: Middle meningeal artery embolization is an emerging treatment option for chronic subdural hematomas. PURPOSE: Our aim was to assess outcomes following middle meningeal artery embolization ...

The secondary motor cortex (M2) encodes choice-related information and plays an important role in cue-guided actions. M2 neurons innervate the dorsal striatum (DS), which also contributes to decision-...

BACKGROUND: In Australia, tixagevimab/cilgavimab 150 mg/150 mg was a government-funded pre-exposure prophylaxis for COVID-19 people with multiple sclerosis (pwMS) and other neuroimmunological conditio...

Hintergrund Als Bundesland mit dem höchsten Altersdurchschnitt in Deutschland und besonderen Strukturmerkmalen ländlich geprägter Gebiete sind die Folgen des demographischen Wandels bereits heute in S...

INTRODUCTION: It is widely demonstrated that high frequency (HF) repetitive transcranial magnetic stimulation (rTMS) has facilitative effects and is therefore capable to inducing changes in motor resp...

INTRODUCTION: Serotonergic system hyperactivity at 5-HT2A receptors on glutamate neurons in the cerebral cortex is one of the pathways that is theoretically linked to psychosis. In addition to neurotr...

Multiple sclerosis (MS) is a global health concern affecting around 2.6 million people. It is characterised by neural inflammation, myelin breakdown and cognitive decline. Cognitive impairment, especi...

Successful vaccination (adequate elevation of anti-spike protein antibodies) is attributed with sufficient protection against a severe course of coronavirus disease 2019 (COVID-19). For patients with ...

BACKGROUND AND OBJECTIVE: Retinal vascular density (VD) measured using optical coherence tomography with angiography (OCTA) has been suggested as a potential marker of intracerebral vascular changes i...

The brain-gut axis refers to the communication between the central nervous system and the gastrointestinal tract, with the gut microbiome playing a crucial role. While our understanding of the interac...

Chronic pain is associated with dysfunctional cortical excitability. Research has identified altered intracortical motor cortex excitability in Chronic Lower Back Pain (CLBP). However, research identi...

Heterozygous loss-of-function variants of FOXP4 are associated with neurodevelopmental disorders (NDDs) that exhibit delayed speech development, intellectual disability, and congenital abnormalities. ...

BACKGROUND AND PURPOSE: Wrong-level spinal surgery, especially in the thoracic spine, remains a challenge for a variety of reasons related to visualization, such as osteopenia, large body habitus, sev...

Objective : Parkinson’s Disease affects the PcP’s and caregiver’s quality of life in every-day life. A global multi-professional, person- centered accompaniment is essential. An ambulat...

International audience; Autosomal recessive early-onset parkinsonism is clinically and genetically heterogeneous. Mutations of three genes, PRKN, PINK1, and DJ-1 cause pure phenotypes us...

OBJECTIVE: To study the effect of dual tasking and deep brain stimulation frequency parameters on gait in advanced Parkinson's disease MATERIALS AND METHODS: This is an open label interventional study...

As the second most common neurodegenerative disease, Parkinson's disease has caused serious problems worldwide. However, the cause and mechanism of PD are not clear, and no systematic early diagnosi...

International audience; L-Dopa induced dyskinesia (LID) is a debilitating side effect of dopamine replacement therapy for Parkinson's Disease. The mechanistic underpinnings of LID remain...

International audience; Liu et al. recently reported that biallelic mutations in DAGLB are responsible for autosomal recessive early-onset Parkinson’s disease. They identified six patien...

International audience; IntroductionProdromal non-motor symptoms precede, often by decades, motor signs and diagnosis of Parkinson's disease. It is however still uncertain if cognitive c...

OBJECTIVE: To determine the evolution of numerous neuropsychiatric symptoms and cognitive abilities in Parkinson disease from disease onset. METHODS: Prospectively collected, longitudinal (untreated, ...

Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases globally. Both are proteinopathic conditions and while occasionally inherited, are la...

The prevalence of negative stimuli conventionally observed in young adults decreases during normal aging, oreven evolves into a prevalence of positive stimuli. This age-related effect i...

Parkinson's disease (PD) is a common and incurable neurodegenerative disease, affecting 1% of the population over the age of 65. Although the disease remains defined clinically by its c...

Neuronal action potential firing patterns are key components of healthy brain function. Importantly, restoring dysregulated neuronal firing patterns has the potential to be a promising strategy in the...

Background Clinical trials have provided evidence that transplants of dopaminergic precursors, which may be replaced by new in vitro stem cell sources, can integrate into the host tissue, and alleviat...

Parkinson's disease (PD) is a multifactorial neurodegenerative disease characterized by the degeneration of dopaminergic neurons from the substantia nigra pars compacta (SNc) leading to...

In this contribution, we present the results of a case study on the impact of rhythmic priming, i.e. listening to rhythmic auditory stimuli, on speech production in Parkinson’s disease....

α‐Synuclein aggregation is a hallmark of Parkinson's disease and a promising biomarker for early detection and assessment of disease progression. The prospect of a molecular test for Parkinson's disea...

International audience; INTRODUCTION:Multiple immunity biomarkers have been suggested as tracers of neuroinflammation in neurodegeneration. This study aimed to verify findings in cerebro...

Deep-Brain Stimulation (DBS) is a therapy used in conjunction with medication to help alleviate the motor symptoms of Parkinson's Disease (PD). However, the monitoring and adjustment of DBS settings...

Parkinson's Disease (PD) affects millions globally, impacting movement. Prior research utilized deep learning for PD prediction, primarily focusing on medical images, neglecting the data's underlyin...

Parkinson's disease (PD) is a common and incurable neurodegenerative disease, affecting 1% of the population over the age of 65. Although the disease remains defined clinically by its c...

Parkinson's disease (PD) is mainly characterized by the aggregation of α-synuclein (α-syn) into Lewy bodies and the selective degeneration of dopaminergic neurons associated with locomo...

Parkinson's disease (PD) is a debilitating neurodegenerative disease that has severe impacts on an individual's quality of life. Compared with structural and functional MRI-based biomarkers for the ...

We do a detailed study on vortex formation in a magnetized plasma within the spacetime of a moving cosmic string using analytical and numerical methods. The conical spacetime around the cosmic strin...

We report the timing and spectral studies of the accreting X-ray pulsar 4U 2206+54 using astrosat and hxmt observations taken in 2016 and 2020 respectively. X-ray pulsations from the system are dete...

By using high-resolution spectra acquired with FLAMES-GIRAFFE at the ESO/VLT, we measured radial and rotational velocities of 115 stars in the Galactic globular cluster M55. After field decontaminat...

The high contrast and spatial resolution requirements for directly imaging exoplanets requires effective coordination of wavefront control, coronagraphy, observation techniques, and post-processing ...

We present a spatially resolved study of the kinematical properties of known supernova remnants (SNRs) in the nearest galaxies of the SIGNALS survey, namely NGC 6822 (one object) and M33 (163 object...

The intermediate-mass-ratio inspirals (IMRIs) may be surrounded by dark matter (DM) minispikes. The dynamical friction from these DM minispike structures can affect the dynamics and the gravitationa...

The inner parts of the hot discs surrounding massive young stellar objects (MYSOs) are still barely explored due to observational limitations in terms of angular resolution, scarcity of diagnostic l...

A rare subclass of Type Ia supernovae (SNe Ia), named after the prototype SN 2003fg, includes some of the brightest SNe Ia, often called "super Chandrasekhar-mass" SNe Ia. We calculate the $\gamma$-...

We analyzed the Atacama Large Millimeter/submillimeter Array (ALMA) band 6 data for the outbursting massive protostar M17~MIR. The ALMA CO $J=2-1$ data reveal a collimated and bipolar north-south ou...

I summarize the stellar side of the cosmological lithium problem(s). Evidence from independent studies is accumulating and indicates that stars may very well be fully responsible for lowering their ...

The $f(R)$ modified gravity theory can explain the accelerating expansion of the late Universe without introducing dark energy. In this study, we predict the constraint strength on the $f(R)$ theory...

Using photospheric vector magnetograms obtained by the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory and a magnetic connectivity-based method, we compute the magnetic heli...

Highly r-process-enhanced stars are rare and usually metal-poor ([Fe/H] < - 1.0), and mainly populate the Milky Way halo and dwarf galaxies. This study presents the discovery of a relatively bright ...

The treatment of convection remains a major weakness in the modelling of stellar evolution with one-dimensional (1D) codes. The ever increasing computing power makes now possible to simulate in 3D p...

Despite recent progress in the spectroscopic characterization of individual exoplanets, the atmospheres of key ultra-hot Jupiters (UHJs) still lack comprehensive investigations. These include WASP-1...

We present an analysis of JWST Ly$\alpha$ spectroscopy of $z\gtrsim6.5$ galaxies, using observations in the public archive covering galaxies in four independent fields (GOODS-N, GOODS-S, Abell 2744,...

The solar-type subgiant $\beta$ Hyi has long been studied as an old analog of the Sun. Although the rotation period has never been measured directly, it was estimated to be near 27 days. As a southe...

cosmosage is a natural-language assistant intended for a wide audience, from laypersons interested in cosmology to students, teachers, and professional cosmologists. cosmosage provides a novel way t...

The problem of a hydrogen atom in a strong magnetic field is a notorious example of a quantum system that has genuinely different asymptotic behaviors in different directions. In the direction perpe...

Fifth forces are ubiquitous in modified gravity theories, and must be screened to evade stringent local tests. This can introduce unusual behaviour in galaxy phenomenology by affecting galaxies' com...

Gravitational lensing offers unique opportunities to learn about the astrophysical origin of distant sources, the abundance of intervening objects acting as lenses, and gravity and cosmology in gene...

In recent years, the continued detection of complex organic molecules of prebiotic interest has refueled the interest on a panspermic origin of life. The prebiotic molecule glyceraldehyde is propose...

BACKGROUND: Oral health surveys aid in estimating the oral health of a population and provide a projection for future oral health care needs. We report the procedures and rationale of a survey carried...

Introduction Increasing the rate of vaccination is crucial in combating the COVID-19 pandemic. However, a survey of 112,888 Indonesians found that only 64.8% Indonesians were willing to be vaccinated,...

SIMPLE SUMMARY: Laparoscopic ovariectomy is currently considered the gold standard for neutering female dogs thanks to the reduced surgical trauma, lower perioperative pain, and decreased hospitalizat...

INTRODUCTION: Sleep deprivation is a method, which has being used in order to comprehend the functions of sleep both in healthy individuals and for the patients of depression with in treatment, for a ...

OBJECTIVE: To assess safety and efficacy of hyaluronic acid (HA) gel injection in glans penis for treatment of premature ejaculation (PE) using our new five puncture technique. PATIENTS AND METHODS: T...

BACKGROUND/AIMS: In this retrospective study we aimed to compare the effect of tranexamic acid (TXA) vs etamsylate, two hemostatic agents, on hematuria duration in autosomal dominant polycystic kidney...

Background Prostate cancer (PCa) is the most common cancer in men. For medical treatment of PCa, a number of therapies are available. The economic consequences associated with these individual treatme...

Mercury (Hg) is a highly toxic heavy metal for all organisms. In the present study, the mitigative role of 190 mg/L and 380 mg/L doses of green tea extract (GTex) against mercury(II) chloride (HgCI(2)...

Background This study investigated the association between body mass index (BMI) and myopia in the United States. Methods This cross-sectional study included 8,000 participants from the 1999 to 2008 N...

Background Pathological alterations of lateral pterygoid muscle (LPM) are implicated in temporomandibular joint anterior disk displacement (ADD). However, quantification of the fatty infiltration of L...

In this study, we address image retargeting, which is a task that adjusts input images to arbitrary sizes. In one of the best-performing methods called MULTIOP, multiple retargeting operators were c...

Background Obstetric fistula repair failure is a combination of unsuccessful fistula closure and/or incontinence following a successful closure. It causes a burden on both the patients and the fistula...

Background This study aimed to determine the predictive factors for post-conization of residual disease in subsequent hysterectomy for cervical intraepithelial neoplasia grade 2 or 3. Methods This ret...

SIMPLE SUMMARY: A 6-month-old male Korean native calf, known for its highly marbled meat, was purchased but found dead three days later, without any notable medical history. The calf had a significant...

Background The prognosis of back pain (BP) in the older adults is less favorable than in younger adults and progress to adverse outcomes and consequent worsening of health-related quality of life (HRQ...

Oxidative stress has been implicated to play a critical role in the pathophysiology of coronavirus disease 2019 (COVID-19) and may therefore be considered as a relevant therapeutic target. Serum free ...

Background Hand osteoarthritis (OA) is a prevalent joint disorder and a great burden to both patients and society. While electroacupuncture (EA) and topical diclofenac sodium gel (DSG) are both curren...

BACKGROUND AND AIM: Antithyroid drugs are first treatment for Graves hyperthyroidism worldwide. Although remission can be achieved in approximately 40-50% of patients in 12-18 months with antithyroid ...

Objectives In this study we aimed to explore EMCC triage of suspected and confirmed stroke patients to gain more knowledge about the initial phase of the acute stroke response chain. Accurate dispatch...

Part 5: Diffusion of Information Technology and Systems (Conference Theme);International audience; This study examines the impact of organisational change management on the outcome of di...

Background Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflamm...