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ExplorarAIMS: To evaluate the potential superiority of donanemab vs. aducanumab on the percentage of participants with amyloid plaque clearance (≤24.1 Centiloids [CL]) at 6 months in patients with early sympt...
disease symptomatic alzheimer tau plaque intermediate arms event months 001 amyloid aducanumab 0 ± ad donanemab doses] q4w iv baseline clearance participants cl Leer másAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Early detection of AD is crucial for effective intervention and treatment. In...
spontaneous alzheimer language disease pause method information speech detection ad Leer másBackground Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease. Me...
alzheimer's disease mitogen peripheral blood mononuclear cell pha lps cell-free levels secretion stimulated pbmcs alzheimer disease mitochondrial dna Leer másBrain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a comm...
mri science disease model alzheimer computer hybrid Leer másBackground Dementia is one of the major causes of disability and dependency among older people worldwide. The formation of an aging population in Iran can be associated with societal problems, includi...
alzheimer dementia prevalence iran systematic review meta-analysis review studies systematic 0 estimated dementia prevalence ci 95% iran Leer másBackground Luffa cylindrica (L.) is an annual climbing plant that produces fibrous fruit and can also be used as a vegetable in northern parts of India. Various studies have been carried out on the pl...
lc–ms alzheimer’s disease in silico amyloid beta docking fruit various perlolyrine disease alzheimer promising activity lc–ms analysis cylindrica luffa Leer másAlzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory and cognitive decline, affecting millions worldwide. Diagnosing AD is challenging due to its heterogeneou...
gnns computer science neuroimaging cognitive brain alzheimer ad layer Leer másBackground Working memory capacity impairment is an early sign of Alzheimer's disease, but the underlying mechanisms remain unclear. Clarifying how working memory capacity is affected will help us bet...
alzheimer's disease working memory capacity 5xfad mice fos excitatory neuron results wild-type neurons activation disease alzheimer capacity memory cortex excitatory 5xfad prelimbic Leer másMotivation: Electronic Health Records (EHR) represent a comprehensive resource of a patient's medical history. EHR are essential for utilizing advanced technologies such as deep learning (DL), enabl...
attention rnn alzheimer propose clinical performance ehr dl visits Leer másMotivation: Electronic Health Records (EHR) represent a comprehensive resource of a patient's medical history. EHR are essential for utilizing advanced technologies such as deep learning (DL), enabl...
attention rnn alzheimer propose clinical performance ehr dl visits Leer másBackground The neuropathological confirmation serves as the gold standard for diagnosing Alzheimer's disease (AD), but it is usually not available to the living individuals. In addition, the gold stan...
alzheimer’s disease mild cognitive impairment bayesian latent class model neuropsychological tests sensitivity specificity cognitive alzheimer specificity gold standard sensitivity 0 vs tests disease detecting adas-cog moca mmse Leer másMultimodal medical data (e.g. MR and PET imaging, CSF measurements, clinical assessments) reflect different aspects of Alzheimer's Disease, including early changes in brain structure an...
multimodal ad alzheimer feature stages disease cognitive Leer másThis review explains how allosteric stabilizers of γ-secretase may prevent Alzheimer’s disease by specifically exerting opposite effects as pathogenic presenilin mutations. Two phase-III clinical tria...
presenilin gamma-secretase-modulator γ-secretase allosteric stabilizer alzheimer cancer prevention mutations ad γ-secretase presenilin alzheimer’s disease Leer másThis research underscores the efficacy of Fourier topological optimization in refining MRI imagery, thereby bolstering the classification precision of Alzheimer's Disease through convolutional neura...
disease mri contrast alzheimer Leer másIntroduction Alzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. Blood is frequently used as a source for biomarkers; however, its complexity prevents pro...
alzheimer metabolites biomarker serum nuclear magnetic resonance single molecule array panel involved ad Leer másThe persistence and ubiquity of polycyclic aromatic hydrocarbons (PAHs) in the environment necessitate effective remediation strategies. Hence, this study investigated the potential of purified Laccas...
alzheimer anthracene abts laccase flu12 flu1 acid flu1l flu12l cells metabolites pathway values degradation system tl tp Leer másMultimodal medical data (e.g. MR and PET imaging, CSF measurements, clinical assessments) reflect different aspects of Alzheimer's Disease, including early changes in brain structure an...
multimodal ad alzheimer feature stages disease cognitive Leer másBrain development and maturation leads to grey matter networks that can be measured using magnetic resonance imaging. Network integrity is an indicator of information processing capacity which decline...
alzheimer changes disease axonal integrity loss Leer másDisinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism rem...
chloride treatment decline alzheimer kcc2 cognitive Leer másINTRODUCTION: For many patients and caregivers, a major goal of disease-modifying treatments (DMT) for Alzheimer disease (AD) dementia is to extend independence in instrumental and basic activities of...
ad dementia disease alzheimer treatments time clinical extend cdr months Leer másInternational audience; A fusion scheme of EEG epoch durations for an improved Alzheimer's disease detection
epoch disease alzheimer fusion Leer másLarge-scale brain networks undergo widespread changes with older age and in neurodegenerative diseases such as Alzheimer's disease (AD). Research in young adults (YA) suggest that the underlying funct...
emn correlated architecture alzheimer organization brain fc tau networks ad network memory rest adults Leer másInternational audience; A fusion scheme of EEG epoch durations for an improved Alzheimer's disease detection
epoch disease alzheimer fusion Leer másDeep learning methods have significantly advanced medical image segmentation, yet their success hinges on large volumes of manually annotated data, which require specialized expertise for accurate l...
alzheimer disease segmentation model Leer másLarge-scale brain networks undergo widespread changes with older age and in neurodegenerative diseases such as Alzheimer's disease (AD). Research in young adults (YA) suggest that the underlying funct...
emn correlated architecture alzheimer organization brain fc tau networks ad network memory rest adults Leer másBackground Studying whether medications act as potential risk factors for amyotrophic lateral sclerosis (ALS) can contribute to the understanding of disease etiology as well as the identification of n...
medication amyotrophic lateral sclerosis risk association articles systematic included risk studies als medication review drugs Leer másIntroduction Even if electromyography (EMG) is routinely used to confirm the diagnosis of amyotrophic lateral sclerosis (ALS), few studies have analysed the correlation between electrophysiological pa...
amyotrophic lateral sclerosis motor neuron disease electromyography clinical neurophysiology respectively parameters progression p = scores als Leer másBackground Psychiatric presentations similar to that observed in primary psychiatric disorders are well described across the amyotrophic lateral sclerosis–frontotemporal dementia (ALS–FTD) spectrum. D...
frontotemporal dementia amyotrophic lateral sclerosis motor neuron disease schizotypy neuropsychiatry personality disorders als–ftd schizotypy psychiatric traits schizotypal Leer másBackground Using the Clinical Audit Research and Evaluation of Motor Neuron Disease (CARE-MND) database and the Scottish Regenerative Neurology Tissue Bank, we aimed to outline the genetic epidemiolog...
motor neuron disease amyotrophic lateral sclerosis genetic epidemiology genotype-phenotype sod1 c9orf72 mnd using variant sod1 pathogenic genetic expansion c9orf72 Leer másBackground Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by the gradual loss of upper and lower motor neurons that leads to progressive muscle atrophy and wea...
edaravone amyotrophic lateral sclerosis adverse effect safety mean study als edaravone patients Leer másBackground The rationale for this paper is a description of a patient from Southeast Europe with genetically confirmed Huntington’s disease (HD), coexisting with sporadic, bulbar-onset amyotrophic lat...
huntington’s disease amyotrophic lateral sclerosis bulbar-onset als co-occurrence co-existence Leer másObjective In amyotrophic lateral sclerosis (ALS), respiratory muscle involvement and sleep-disordered breathing relate to worse prognosis. The present study investigated whether respiratory outcomes o...
amyotrophic lateral sclerosis sleep-disordered breathing non-invasive ventilation survival nocturnal hypercapnia base ecxess embe study embe > 2 mmol/l nocturnal respiratory + studies baseline – sleep als Leer másObjectives Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disease that can overlap with pregnancy, but little is known about its clinical characteristics, course, and outcom...
amyotrophic lateral sclerosis motor neuron disease als pregnancy case reports systematic review progression rapid severe overlapping pregnancy als Leer másAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motor neurons (MNs). Since the identification of the first ALS mutation in 1993, more than 40 genes h...
amyotrophic lateral sclerosis autophagy mutations animal models protein involved als autophagy Leer másAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons, leading to paralysis and eventually death. Symptomatic treatments such as i...
amyotrophic lateral sclerosis motor neurons autophagy stem cells gene editing progression therapies als Leer másBackground Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal cord. As in many other neurodege...
amyotrophic lateral sclerosis kif1a axonal transport presynaptic vesicle precursors motor patients kif1a als Leer másBackground Prior studies on the role of gut-microbiome in Amyotrophic Lateral Sclerosis (ALS) pathogenesis have yielded conflicting results. We hypothesized that gut- and oral-microbiome may different...
amyotrophic lateral sclerosis microbiome lou gehrig’s disease disease associated subtypes gut- oral-dysbiosis = 0 ratio symptoms sals translocation blood f/b- bals als 0001 < 0 gut-dysbiosis Leer másTranscribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for detecting RNA foci, fluorescence in situ hyb...
amyotrophic lateral sclerosis fragile x fxtas repeat-associated non-aug (ran) tr... rna gelation rna foci stress granules g3bp hybridization r-hcr patient Leer másBackground Despite being a useful strategy for providing respiratory support to patients with advanced or terminal illnesses, non-invasive ventilation (NIV) requires in-depth investigation in several ...
non-invasive ventilation palliative care bibliometrics vosviewer citespace cancer amyotrophic lateral sclerosis specialized palliative care palliative non-invasive ventilation care key studies analysis Leer másBackground Among clinicians and researchers, it is common knowledge that, in ALS, cognitive and behavioral involvement within the spectrum of frontotemporal degenerations (FTDs) begun to be regarded a...
amyotrophic lateral sclerosis frontotemporal degeneration neuropsychology century changes involvement Leer másBackground Motor neuron diseases (MND), with amyotrophic lateral sclerosis constituting most cases, are rare conditions of unknown etiology. There have been reports of an increase in incidence during ...
motor neuron disease amyotrophic lateral sclerosis incidence epidemiology age data rate mnd sweden incidence Leer másBackground Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by the gradual loss of upper and lower motor neurons that leads to progressive muscle atrophy and wea...
edaravone amyotrophic lateral sclerosis adverse effect safety mean study als edaravone patients Leer másBackground Amyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the molecular mechanisms underlying ALS, there have be...
statistical analysis plan randomized double-blind clinical trial phase iii amyotrophic lateral sclerosis bile acids 2019 trial treatment analysis Leer másBackground Interventional trials in amyotrophic lateral sclerosis (ALS) suffer from the heterogeneity of the disease as it considerably reduces statistical power. We asked if blood neurofilament light...
neurofilament light prediction model disease progression amyotrophic lateral sclerosis interventional trials statistical power decrease study observational score heterogeneity alsfrs-r als trial onset disease power model Leer másIndividuals with amyotrophic lateral sclerosis (ALS) frequently develop speech and communication problems in the course of their disease. Currently available augmentative and alternative communication...
brain–computer interface implant amyotrophic lateral sclerosis ethics clinical application tracheostomy invasive ventilation technology als implanted people clinical Leer másBackground As amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) is a fatal progressive neurodegenerative disorder, patients experience severe impairments, with patients and family caregiver...
amyotrophic lateral sclerosis caregiver motor neuron disease psychosocial intervention scoping review supportive care review caregivers scoping als/mnd patients interventions psychosocial Leer másAmyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic eff...
amyotrophic lateral sclerosis als pten bpv akt motor neuron survival = 0 loss mn treatment significantly pic bpv als msod1^g93a Leer másBackground and purpose Muscle ultrasonography has been increasingly recognized as a useful tool for detection of fasciculations. Separately, concordance between dominant hand and onset side has been r...
ultrasonography amyotrophic lateral sclerosis fasciculation handedness exercise [0 fdi als 0 muscle limb dominant fasciculations 3] Leer másBackground When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their jeopa...
stroke traumatic brain injury sudden cardiac arrest concussion modeling migraine ischemia na/k pump huntington's disease alzheimer's disease amyotrophic lateral sclerosis ketamine penumbra persistent vegetative state dendritic beading brain swelling neurons brain glutamate blood sd Leer másNeurodegenerative diseases are a group of disorders characterized by progressive loss of certain populations of neurons, which eventually lead to dysfunction. These diseases include Alzheimer’s diseas...
th17 il-17a alzheimer’s disease parkinson’s disease amyotrophic lateral sclerosis targeted therapy th17/il-17a diseases Leer másObjectives The objective of this study was to explore the feature of generative artificial intelligence (AI) in asking sexual health among cancer survivors, which are often challenging for patients to...
non-pharmacological interventions cancer generative Leer másThis study investigates molecular changes in the response of NSCLC patients to ICI using spatial transcriptomics. Activation of B cellassociated pathways correlates with improved prognosis and guides ...
cells patients treatment prognosis response activated analysis immunotherapy cancer cell lung Leer másObjective Prostate cancer hormonal treatments (e.g. androgen deprivation therapy) yield clinical benefits. However, there is increasing evidence these treatments may adversely impact cognitive functio...
prostate cancer cognition qualitative research cancer survivorship rehabilitation interviews treatments following prostate hormonal impact difficulties cancer pcs cognitive reported Leer másInflammasomes, primarily responsible for the activation of IL-1β, have emerged as critical regulators of the tumor microenvironment. By using in vivo and in vitro brain metastasis models, as well as h...
mcc950 cancer cells peritumoral metastatic brain nlrp3 il-1β Leer másTertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in shaping the immune st...
cancer neoadjuvant rectal associated patients increased < 0 tls neotx Leer másMalignant tumours area leading cause of death globally, accounting for approximately 13% of all deaths. A detailed understanding of the mechanism(s) of the occurrence and development of malignant tumo...
tsrnas malignant tumour trna-derived fragments diagnosis treatment malignant trna tumours tsrnas cancer Leer másOBJECTIVE: Interstitial lung disease (ILD) is relatively common in patients with lung cancer with an incidence of 7.5%. Historically pre-existing ILD was a contraindication to radical radiotherapy owi...
long-term disease radical cancer lung Leer másCervical cancer is one of the leading causes of cancer death in women. Mitochondrial-mediated ferroptosis (MMF) is a recently discovered form of cancer cell death. However, the role and the underlying...
ferroptosis cancer cervical mtch1 mitochondrial Leer másAnaplastic lymphoma kinase (ALK) fusion-positive colorectal cancer (CRC) is a rare and chemotherapy-refractory subtype that lacks established and effective treatment strategies. Additionally, the effi...
cancer alki alk crc Leer másPurpose This study aimed to investigate the effects of two different positions on lower extremity hemodynamics during robot-assisted laparoscopic radical prostatectomy (RARP) for prostate cancer. Meth...
robot-assisted laparoscopic radica... position deep vein lower extremity hemodynamics rarp march arch reverse femoral february underwent velocity calf volume diameter operating trendelenburg lithotomy low internal cancer surgery prostate minutes vein patients flow blood position deep extremity hemodynamics Leer másObjectives Relatively few studies have investigated the effects of rehabilitation-based physical activity therapy as a treatment for older patients with advanced cancer. This study evaluated the effec...
advanced cancer older patients physical activity therapy rehabilitation advanced t1 physical cancer t2 supportive symptomatic pat patients activity sst therapy exercise rehabilitation = 0 Leer másThe controversy regarding the causal relationship between circulating glutamine and cancer risk remains unresolved. Here, we aim to assess the causal impact of glutamine on the risk of six prevalent c...
0 thyroid risk glutamine cancer causal circulating Leer másThis commentary summarized the most important findings in the first half 2023 year based on Society of Gynecologic Oncology (SGO) annual meeting and publications in crucial journals. This commentary p...
gynecologic cancer targeted therapy immunotherapy pd-1 blockage poly (adp-ribose) polymerase inhib... advanced commentary recurrent anti-angiogenic discussed parp inhibitors endometrial cancer combined therapy oncology chemotherapy gynecologic cervical immune checkpoint Leer másAlcohol dehydrogenase (ADH) oxidizes alcohol into acetaldehyde (AA), which is a known carcinogen. Aldehyde dehydrogenase (ALDH) oxidizes AA into acetate. Therefore, pancreatic cancer that expresses a ...
features aggressive rates proliferation aa pancreatic alcohol pdac expression cancer associated lower 0 Leer másPurpose Breast cancer is the most common cancer among Japanese women and often yields a better prognosis than other cancers. However, few studies have been conducted on pain control using opioids in J...
breast neoplasm japan longitudinal study opioid pain management real world data dosage increased month cancer breast opioid average amount mmes patients opioids percentage metastasis bone patient prescribed Leer másBackground and objectives Piflufolastat F 18 is a novel prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) radiotracer that is superior to standard of care (SOC) ima...
healthcare tomography perspective qaly mix fluciclovine study antigen prostate-specific therapy f 18 imaging piflufolastat results prostate cancer soc psma 11 Leer másBACKGROUND: High treatment prices of new cancer drugs are a global public health challenge to patients and healthcare systems. Policymakers in the US and Europe are debating reforms to drug pricing. T...
observed mortality significant ci premium usd 95% efficacy cancer switzerland expensive characteristics drugs treatment study non-cancer epidemiological drug Leer másMetastasis is a bottleneck in cancer treatment. Studies have shown the pivotal roles of long noncoding RNAs (lncRNAs) in regulating cancer metastasis; however, our understanding of lncRNAs in gastric ...
metabolism expression metastasis c-myc loop lncrnas translation cancer Leer másDeregulated glucose metabolism termed the “Warburg effect” is a fundamental feature of cancers, including the colorectal cancer. This is typically characterized with an increased rate of glycolysis, a...
tumor pdk2 c-myc cancer cells tca cycle colorectal pyruvate Leer másCancer is one of the most life-threatening diseases worldwide, and head and neck (H&N) cancer is a prevalent type with hundreds of thousands of new cases recorded each year. Clinicians use medical i...
cancer Leer másBACKGROUND: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. METHODS: In a case–control stud...
phosphatidylcholines study patterns development prospective 95% pre-diagnostic metabolites circulating associated cancer lipid 0 Leer másWe aimed to investigate the demographic characteristics, common chief complaints, and diagnosis of geriatric cancer-related emergency department (ED) visits and trends of ED outcomes. This retrospecti...
cancer emergency department epidemiology geriatrics common increased 1% ed mortality visits cancer-related Leer másBackground Breast cancer (BC) is the most common cancer type in women. The purpose of this study was to assess the eligibility criteria in recent clinical trials in BC, especially those that can limit...
breast cancer clinical trial eligibility criteria enrollment criteria exclusion criteria elderly older adult comorbidity performance status patients cancer comorbidities clinical exclusion bc eligibility Leer másInternational audience; Cancer is any disease characterised by the rapid proliferation of abnormal cells in normal body tissue. Recent years have been marked by an increase in the number...
dihydropyrazole antiproliferative cancer model Leer másCellular proliferation, function and survival is reliant upon maintaining appropriate intracellular polyamine levels. Due to increased metabolic needs, cancer cells elevate their polyamine pools throu...
polyamine tumor microenvironment amino acid metabolism immunotherapy types cell cells cancer Leer másAccurately detecting objects at long distances remains a critical challenge in 3D object detection when relying solely on LiDAR sensors due to the inherent limitations of data sparsity. To address t...
detection features detecting computer information generation semantic data objects Leer másCancer drug response prediction (DRP) models present a promising approach towards precision oncology, tailoring treatments to individual patient profiles. While deep learning (DL) methods have shown...
response sharing model reusability drp Leer másVarious Earth anomalies have destroyed the stable, balanced state, resulting in fatalities and serious destruction of property. With the advantages of large-scale and precise observation, high-resol...
detection anomaly images change anomalies Leer másWe study the identification of quantum phases of matter, at zero temperature, when only part of the phase diagram is known in advance. Following a supervised learning approach, we show how to use ou...
learning matter Leer másThis paper is aimed at developing a method that reduces the computational cost of convolutional neural networks (CNN) during inference. Conventionally, the input data pass through a fixed neural net...
neural computer early-exit confidence eenets inference Leer másA numerical scheme for approximating the nonlinear filtering density is introduced and its convergence rate is established, theoretically under a parabolic H\"ormander condition, and empirically in ...
equation fokker--planck numerical scheme Leer másCervical cancer remains the fourth most common malignancy amongst women worldwide.1 Concurrent chemoradiotherapy (CRT) serves as the mainstay definitive treatment regimen for locally advanced cervic...
treatment routine contouring science segmentation tumor pocketnet computer Leer másTreebanks are important linguistic resources, which are structured and annotated corpora with rich linguistic annotations. These resources are used in Natural Language Processing (NLP) applications,...
annotation linguistic tamil Leer másLarge Language Models (LLMs) have the potential to significantly enhance threat intelligence by automating the collection, preprocessing, and analysis of threat data. However, the usability of these...
llms intelligence Leer másThere is an urgent and pressing need to optimize usage of Graphical Processing Units (GPUs), which have arguably become one of the most expensive and sought after IT resources. To help with this goa...
method workloads Leer másLarge Language Models (LLMs) have excelled in various tasks but are still vulnerable to jailbreaking attacks, where attackers create jailbreak prompts to mislead the model to produce harmful or offe...
templates jailbreak jailbreaking attack papillon Leer másTracking any point based on image frames is constrained by frame rates, leading to instability in high-speed scenarios and limited generalization in real-world applications. To overcome these limita...
frame image tracking fusion Leer másThe functional interpretation of language-related ERP components has been a central debate in psycholinguistics for decades. We advance an information-theoretic model of human language processing in...
components theory information-theoretic information model language erp processing Leer másThis paper introduces a novel deep-learning method for the automatic detection and segmentation of lung nodules, aimed at advancing the accuracy of early-stage lung cancer diagnosis. The proposed ap...
diagnosis detection computer science squeeze channel lung Leer másResearch in music understanding has extensively explored composition-level attributes such as key, genre, and instrumentation through advanced representations, leading to cross-modal applications us...
language performance Leer másWe propose HyperSteiner -- an efficient heuristic algorithm for computing Steiner minimal trees in the hyperbolic space. HyperSteiner extends the Euclidean Smith-Lee-Liebman algorithm, which is grou...
steiner hypersteiner Leer másRecent psycholinguistic research has compared human reading times to surprisal estimates from language models to study the factors shaping human sentence processing difficulty. Previous studies have...
models transformers language attention human alibi Leer másIn feed-forward neural networks, dataset-free weight-initialization methods such as LeCun, Xavier (or Glorot), and He initializations have been developed. These methods randomly determine the initia...
neural proposed gaussian networks learning deviation lc machine standard based dataset-free method weight-initialization Leer másEnd-to-end web testing is challenging due to the need to explore diverse web application functionalities. Current state-of-the-art methods, such as WebCanvas, are not designed for broad functionalit...
navigation web Leer másRobot swarms, systems of many robots that operate in a distributed fashion, have many applications in areas such as search-and-rescue, natural disaster response, and self-assembly. Several of these ...
using environment algorithm levy walk based information random allocation task tasks Leer másImplicit neural representations map a shape-specific latent code and a 3D coordinate to its corresponding signed distance (SDF) value. However, this approach only offers a single level of detail. Em...
level smooth implicit detail Leer másMachine learning (ML) potentials typically target a single quantum chemical (QC) level while the ML models developed for multi-fidelity learning have not been shown to provide scalable solutions for...
chemical qc levels all-in-one learning model models Leer másFor privacy-preserving graph learning tasks involving distributed graph datasets, federated learning (FL)-based GCN (FedGCN) training is required. A key challenge for FedGCN is scaling to large-scal...
training fedgcn science computer communication federated learning Leer másIn the context of few-shot classification, the goal is to train a classifier using a limited number of samples while maintaining satisfactory performance. However, traditional metric-based methods e...
computer features feature Leer másThe SaaS paradigm has popularized the usage of pricings, allowing providers to offer customers a wide range of subscription possibilities. This creates a vast configuration space for users, enabling...
support pricings changes Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Leer másAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Leer másWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Leer másThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Leer másArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másPediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...
conditions pediatric covid Leer másAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Leer másAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Leer másIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Leer másArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Leer másPediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...
conditions pediatric covid Leer másArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Leer másLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Leer másAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Leer másWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Leer másBACKGROUND: India has rolled out Early Infant Diagnosis (EID) program for HIV infection in all states. EID program consists of testing of Infants exposed to HIV periodically over 18 months of age whic...
key testing delayed program test facilitators infants access study caregivers’ hiv eid Leer másBACKGROUND: Human immunodeficiency virus (HIV) drug prophylaxis, including post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP), has not yet been generally recognized and accepted by th...
study analyse china r = 0 prep pep cascade knowledge prophylaxis services hcws drug hiv Leer másBackground Self-management is the most important strategy to improve quality of life in patients with a chronic disease. Despite the increasing number of people living with HIV (PLWH) in low-income co...
self-management hiv/aids care perspectives on self-management low-income settings experts perspectives life medical health self-management patients plwh providers treatment hiv service Leer másEnding AIDS by 2030 would depend on how successful health systems are in linking people living with HIV (PLHIV) into care. The World Health Organization recommended the ‘Universal Test and Treat’ (UTT...
barriers enablers hiv treatment plhiv south africa universal test and treat factors systems diagnosis positive participants hiv-positive linkage hiv care Leer másWith the advancement of artificial intelligence(AI), platforms like ChatGPT have gained traction in different fields, including Medicine. This study aims to evaluate the potential of ChatGPT in addres...
hiv prep ai llm chatgpt hiv transmission communication median responses potential accuracy hiv chatgpt Leer másBACKGROUND: Knowledge and use of sexual reproductive health and human immunodeficiency virus (SRH and HIV) services are crucial for the prevention of pregnancy and sexually transmitted infections (STI...
facility maputo study facilities roughly counseling adolescent services hiv srh satisfied knowledge health Leer másBackground Early diagnosis of HIV infection decreases the time from HIV diagnosis to viral suppression and reduces further HIV transmission. The Chinese Guidelines for the Diagnosis and Treatment of H...
hiv low viral load values diagnosis acute hiv infection 2434 antibody results patients hiv load infection confirmatory diagnosis values Leer másBackground Pre-exposure prophylaxis (PrEP) for HIV prevention is highly effective, but disparities in PrEP access remain considerable, particularly among Black and Latino men who have sex with men (MS...
hiv prevention implementation science community-based participatory rese... staff hiv mobile implementation program Leer másBackground Ethiopia is one of the sub-Saharan African countries most affected by the human immunodeficiency virus (HIV) epidemic and also by severe undernutrition, which is particularly prevalent amon...
hiv nutritional status reproductive age women ethiopia prevalent living hiv-positive urban underweight hiv study nutritional rural reproductive women Leer másBACKGROUND: The impact of starting HIV pre-exposure prophylaxis (PrEP) on diagnoses of sexually transmitted infections (STI) remains unclear. We used data from German HIV/STI Checkpoints collected fro...
age data partner months six hiv prep 95%ci aor partners diagnoses chemsex gonorrhoea checkpoints 0 testing chlamydia cai Leer másEl objetivo del estudio fue evaluar los efectos de la enfermedad avanzada de sida (EAS) en la calidad de vida relacionada con la salud (CVRS) en personas que viven con el VIH (PVVIH), los cambios expe...
advanced hiv disease health related quality of life systematic review meta-analysis hiv aids low cd4 enfermedad avanzada de sida calidad de vida realacionada con l... revision sistemática meta-analisis vih sida bajos cd4 metaanálisis se enfermedad avanzada diferencias health differences using utilizando por plhiv health-related meta-analysis 2021 1996 quality life los cvrs hrqol con estudios ahd studies advanced disease vih hiv eas salud el Leer másBACKGROUND: Tuberculosis (TB) preventive treatment (TPT) is recommended for people living with HIV (PLHIV) in high TB burden settings. While 6 months of daily isoniazid remains widely used, shorter re...
19 features treatment months dosing hiv plhiv choice art adjustment preferences regimens dosage pills [95% ci tpt Leer másBackground Same-sex attracted men in Tanzania and globally carry a disproportionate burden of HIV. Drawing on qualitative research, this article explores healthcare providers’ ideas and recommendation...
same-sex attracted men healthcare workers healthcare services hiv access to care key populations tanzania improve ideas measures qualitative education sex workers same-sex healthcare attracted study Leer másOBJECTIVES: The effectiveness of HIV index testing (IT) in Eastern Europe has not been described. This study reports the performance of a scaled IT programme in Ukraine. DESIGN: This observational stu...
integrated health physician-led included 14 study services ics partner pwid hiv index 0 Leer másIntroduction Globally, adults 50 years and older are an increasing proportion of persons living with HIV (PLHIV), accounting for 16% of the patient group globally. The long-term effects of antiretrovi...
experiences challenges ageing with hiv less developed country health adults appropriate diagnosis experiences ageing plhiv hiv care Leer másBACKGROUND: Regular HIV and STI testing remain a cornerstone of comprehensive sexual health care. In this study, we examine the efficacy of Get Connected, a WebApp that combines test locators with per...
connected observed intervention included hiv Leer másBackground People Who Inject Drugs (PWID) are at a higher risk of acquiring bloodborne infections. We aimed to estimate the seroprevalence of the Hepatitis C Virus (HCV) in PWID and identify correlate...
hiv nhbs puerto rico pwid hcv risk 4% pwid seroprevalence hcv Leer másBackground As the crisis-based approach to HIV care evolves to chronic disease management, supporting ongoing engagement with HIV care is increasingly important to achieve long-term treatment success....
adherence antiretroviral therapy engagement hiv care continuum retention self-management behaviour system measurable self-management individual health hiv framework success people engagement dimensions care Leer másBackground South Africa bears a large HIV burden with 7.8 million people with HIV (PWH). However, due to suboptimal antiretroviral therapy (ART) adherence and retention in care, only 66% of PWH in Sou...
hiv antiretrovirals medication adherence electronic adherence monitoring behavior change most framework cost-effectiveness interventions implementation south africa care intervention hiv monitoring adherence components Leer másBACKGROUND: Maternal transmission of human immunodeficiency virus (HIV) commonly occurs from mother to child during pregnancy, delivery, and breastfeeding which accounts for almost all the new HIV inf...
reproductive-age transmission aged indonesia factors associated 95%ci = 1 aor = 1 odds hiv knowledge mtct women study Leer másBackground Significant disparities continue to exist in the HIV care continuum, whereby Hispanic and Black people living with HIV (PLWH) are less likely to achieve viral suppression compared to their ...
hiv care art viral suppression intervention peer navigation mhealth implementation randomized controlled trial hispanic black receive rct plwh hispanic black improve follow-up mobile intervention hiv path peer Leer másPregnant and lactating persons in sub-Saharan Africa face a heightened risk of HIV acquisition, due to biological and behavioral factors, combined with limited access to prevention and treatment servi...
hiv/aids acceptability pregnant persons oral prep dapivirine vaginal ring eastern and southern africa participants hiv pregnancy using prevention acceptability Leer másBackground Racial/ethnic inequities along the HIV care continuum persist in the United States despite substantial federal investment. Numerous studies highlight individual and social-level impediments...
qualitative hiv care continuum racial/ethnic inequities systemic barriers structural barriers systemic racism structural racism viral perspectives findings inequities racial/ethnic hiv systemic care barriers continuum american/black african latino Leer másBackground Binge drinking, inequitable gender norms and sexual risk behaviour are closely interlinked. This study aims to model the potential effect of alcohol counselling interventions (in men and wo...
hiv/aids structural intervention alcohol gender norms mathematical modelling south africa sexual transmission intervention incidence behaviour risk effects period 0 model gender-transformative 2% hiv africa south drinking counselling Leer másBackground Relationships established between nurses and midwives, and their patients have far-reaching implications; the most significant being their impact on the health-related outcomes of patients....
pmtct nurse-patient relationship client-provider interaction retention appreciative inquiry mothers midwives professional relationship nurses conducted building nurse-patient pmtct hiv Leer másCOVID-19 has impacted populations across the globe and has been a major cause of morbidity and mortality. Influenza is another potentially deadly respiratory infection that affects people worldwide. W...
covid-19 influenza co-infection pandemic vaccination pneumonia characteristics outcomes systematic review covid-19 clinical co-infected influenza patients Leer másBACKGROUND: Influenza vaccination is uncommon in low-resource settings. We evaluated aspects of operational feasibility of influenza vaccination programs targeting risk groups in the World Health Orga...
risk targeting capacity 0% vaccination country influenza pregnant <5 ≥65 women storage persons Leer másInternational audience; Recent highly pathogenic avian influenza A(H5N1) outbreaks in two Korean cat shelters highlight the need to enhance surveillance for cross-species viral transmiss...
influenza mesh Leer másBackground Respiratory infections such as influenza account for significant global mortality each year. Generating lipid profiles is a novel and emerging research approach that may provide new insight...
lipidomics viral infection sputum influenza bayesian regression 18 human clusters 0_19 16 respiratory infections 0_18 species sputum 0 viral infection cluster lipid Leer másBACKGROUND: The world is threatened by future pandemics. Vaccines can play a key role in preventing harm, but there will inevitably be shortages because there is no possibility of advance stockpiling....
influenza etc review vaccines pandemic Leer másUnderstanding Influenza B virus infections is of critical importance in our efforts to control severe influenza and influenza-related disease. Until 2020, two genetic lineages of influenza B virus – Y...
infection cultures host influenza lineages b/victoria cells virus b/yamagata Leer másBACKGROUND: Few studies have directly compared the risk and magnitude of post-acute sequelae following COVID-19 and influenza, and most of these studies were conducted before emergence of the Omicron....
hospitalizations deaths study ed visits influenza risk hr 95% ci patients compared vs Leer másBACKGROUND: Although results from studies of first‐trimester influenza vaccination and congenital heart defects (CHDs) have been reassuring, data are limited for specific CHDs. METHODS: We assessed as...
chd heart tapvr 0 delivery chds defects influenza vaccination Leer másInfluenza virus infection can cause severe respiratory disease and is estimated to cause millions of illnesses annually. Studies of the contribution of the innate immune response to influenza A virus ...
influenza innate immune zebrafish infection model Leer másBACKGROUND AND AIM: The World Health Organization (WHO) recommended the concomitant administration (co-administration) of inactivated seasonal influenza and coronavirus disease 2019 (COVID-19) vaccine...
seasonal emr survey vaccines acceptance countries influenza vaccine covid-19 combined Leer másA brief overview of the past and present trajectories made by the A(H5N1) avian influenza virus among domestic birds, avian and mammalian wildlife species and humans is presented here, ...
domestic grippe interface influenza avian Leer másInfluenza infection induces lung epithelial cell injury via programmed cell death. Glutathione, a potent antioxidant, has been reported to be associated with influenza infection. We hypothesized that ...
inhibition injury model murine cells metabolism glutathione cell infection death reductase influenza epithelial Leer másBACKGROUND: The pharmacokinetics and appropriate dose regimens of favipiravir are unknown in hospitalized influenza patients; such data are also needed to determine dosage selection for favipiravir tr...
concentrations day bid time study patients influenza regimens trough dose Leer másIntroduction For pregnant women, vaccination with inactivated influenza vaccine (IIV) and tetanus, diphtheria, acellular pertussis vaccine (Tdap) is recommended. In Peru, uptake is nonetheless low. A ...
coverage knowledge maternal immunization influenza pertussis tetanus peru vaccine tdap pregnant health conducted practices attitudes immunization recommended peru women knowledge vaccination pregnant/postpartum Leer másBACKGROUND: A commensal microbiota regulates and is in turn regulated by viruses during host infection which can influence virus infectivity. In this study, analysis of colon microbiota population cha...
lines day post aiv diversity influenza virus microbiota infection Leer másSIMPLE SUMMARY: A novel reassortant highly pathogenic H5N8 avian influenza virus spread through migratory birds in many countries in Europe in 2016 and 2017. In November 2016, the virus was first dete...
reported spread birds hemorrhages h5n1 influenza avian virus highly serbia pathogenic h5n8 backyard poultry Leer másObjectives To automatically label chest radiographs and chest CTs regarding the detection of pulmonary infection in the report text, to calculate the number needed to image (NNI) and to investigate if...
radiology report epidemiology influenza disease outbreaks labels correlated infections radiographs detection automatically • ct clinical diagnoses moderately rate reports positive radiology nni 001 data chest infection pulmonary Leer másWhile often believed to be a passive agent that merely exploits its host's metabolism, influenza virus has recently been shown to actively move across glycan-coated surfaces. This form of enzymatica...
influenza Leer másOBJECTIVE: To study the efficacy and safety of arbidol hydrochloride tablets as a treatment for influenza-like diseases. METHODS: In this multicenter, randomized, controlled, open label study, a total...
treated patients remission incidence adverse influenza time influenza-like tablets significant difference Leer másThe ferret transmission model is routinely used to evaluate the pandemic potential of newly emerging influenza A viruses. However, concurrent measurement of viral load in the air is typically not a co...
virus emission transmission influenza Leer másIntroduction Certain drug characteristics, including dosage and form, are associated with either convenience or inconvenience for the patients taking them, and any inconvenience can be considered as a...
administration route antivirals baloxavir conjoint analysis formulation influenza neuraminidase inhibitors online survey pediatric patients patient preference formulation pediatric parents relative responses inconvenience antivirals jpy influenza costs conjoint patients analysis Leer másInternational audience; Seasonal influenza vaccination rates remain low, and contribute to preventable influenza cases, hospitalizations, and deaths in the US. While numerous interventio...
using relative willingness influenza adults access interventions vaccination Leer másBackground The guideline-driven and widely implemented single room isolation strategy for respiratory viral infections (RVI) such as influenza or respiratory syncytial virus (RSV) can lead to a shorta...
isolation droplet precautions hospital-acquired infection respiratory viral infection health-care acquired infections healthcare epidemiology virus influenza infections alternative harvi infection droplet precautions on-site wards respiratory drops strategy Leer másDiabetes mellitus is on the rise globally and is a known susceptibility factor for severe influenza virus infections. However, the mechanisms by which diabetes increases the severity of an influenza v...
adaptive immune response t cell receptor complex hyperglycemia high glucose mellitus functionality cd8^+ diabetes virus influenza Leer másBACKGROUND: Influenza illness causes several disruptions to the workforce. The absenteeism that often ensues has economic implications for employers. This study aimed to estimate the cost-benefit of i...
setting influenza costs cost-benefit Leer másBackground Klebsiella pneumoniae is one of the main pathogens of clinical isolation and nosocomial infections, as K. pneumoniae show broad-spectrum resistance to β-lactam and carbapenem antibiotics. I...
intestin... secondary metabolites antibacterial activity secondary pneumoniae achromobacter actinomycin Leer másThe outer membrane (OM) of Gram-negative bacteria acts as an effective barrier to protect against toxic compounds. By nature, the OM is asymmetric with the highly packed lipopolysaccharide (LPS) at th...
outer membrane asymmetry gram-negative mlaa phospholipids mla system properties composition mla system om glycerophospholipids lipid leaflet outer Leer másBackground Arsenic (As) with various chemical forms, including inorganic arsenic and organic arsenic, is the most prevalent water and environmental toxin. This metalloid occurs worldwide and many of i...
sp. arsenic resistance cluster bifunctional protein inorganic arsenic detoxify sp brevundimonas difunctional roxarsone cluster activity protein mm arsenic arsr^m Leer másStudying the effects of the microbiome on the development of different types of cancer has recently received increasing research attention. In this context, the microbial content of organs of the gast...
microbiome pancreatic cancer biomarker treatment probiotics diagnosis prognosis cancer microbiome pc Leer másThe Yanomami are one of the oldest indigenous tribes in the Amazon and are direct descendants of the first people to colonize South America 12,000 years ago. They are located on the border between Ven...
yanomami 16s rrna sequencing gut microbiome manaus, westernization experiencing yanomami microbiota diversity populations Leer másBackground Resistance to antifungal medications poses a significant obstacle in combating fungal infections. The development of novel therapeutics for Candida albicans is necessary due to the increasi...
antifungal compounds chemical profiling gc/ms tem medium study cell properties bacillus filtrate antifungal albicans cells isolates candida activity subtilis Leer másBackground The interplay between gut microbiota (GM) and the metabolization of dietary components leading to the production of short-chain fatty acids (SCFAs) is affected by a range of factors includi...
colonic ph in vitro colonic fermentation gut microbiota short-chain fatty acids prebiotics activity influenced dietary effect production metabolite increased gm vitro substrates ph Leer másBackground More than 90% of colorectal cancer (CRC) arises from advanced adenomas (AA) and gut microbes are closely associated with the initiation and progression of both AA and CRC. Objective To anal...
advanced adenomas gut bacteria enteroviruses metagenomic sequencing prediction model abundance results typing risk bacteria accuracy felixounavirus prevotella sp900557255 subtypes based gut microbes diversity aa Leer másBackground Grapevine fanleaf virus (GFLV) is one of the most detrimental viral pathogens of grapevines worldwide but no information is available on its effect on the root system architecture (RSA) of ...
virus plant root architecture phenotype infection symptoms reactive oxygen species immune response host infected ros infection dpi position viral 802 gflv wildtype plants plant rsa Leer másMangroves are coastal environments that provide resources for adjacent ecosystems due to their high productivity, organic matter decomposition, and carbon cycling by microbial communities in sediments...
bacterial community mangrove plant degradation succession microcosms climate change microbial community simulated decomposition change due Leer másProteus mirabilis , a naturally resistant zoonotic bacterium belonging to the Enterobacteriaceae family, has exhibited an alarming increase in drug resistance. Consequently, there is an urgent need to...
phage isolation and identification biological characteristics whole genome analysis resistance phages approximately phage q29 proteus mirabilis Leer másBackground Cutaneous Leishmaniasis (CL) is a parasitic disease with diverse outcomes. Clinical diversity is influenced by various factors such as Leishmania species and host genetic background. The ro...
rna viru... virulence factors pro-inflammatory biomarkers vfs factors including genes isolates pcr pro-inflammatory lrv2 biomarkers leishmania Leer másThe genus Wetmoreana was studied using quantitative integrative taxonomy methods to resolve the genus delimitation and explore its taxonomy diversity at the species level. As a result, the genus Fulgo...
phylogenetic binning mrpp pca south america 6 new species 8 new combinations comb taxonomy species nov sp genus Leer másWood-inhabiting fungi have important economic values as well as playing a major ecological role in forest ecosystem cycles. The Dabie Mountains, at the junction of Henan, Hubei, and Anhui Provinces, C...
conservation funga macrofungi taxonomy community genera dabie mountains wood-inhabiting species basidiomycetous fungi Leer másPurpose This research was conducted to investigate the potential of short-chain fatty acids (SCFAs) in protecting organs from heat stress-induced injuries and gut microbiota modulation. Methods Spragu...
short-chain fatty acids heat stress gut microbiota intestinal training heat metabolites microbiota scfas gut Leer másDespite repeated spillover transmission and their potential to cause significant morbidity and mortality in human hosts, the New World mammarenaviruses remain largely understudied. These viruses are e...
new world mammarenaviruses zoonosis rodent surveillance one health outbreaks socioeconomic exposure transmission risk public health hosts review spillover virus Leer másMulti-drug-resistant Staphylococcus aureus infections necessitate novel antibiotic development. D-3263, a transient receptor potential melastatin member 8 (TRPM8) agonist, has potential antineoplastic...
antibacterial activity biofilm d-3263 phospholipids concentrations membrane antibacterial aureus Leer másBackground Recent studies have more focused on gut microbial alteration in tuberculosis (TB) patients. However, no detailed study on gut fungi modification has been reported till now. So, current rese...
tuberculosis gut microbiota gut mycobiota dysbiosis ifn-γ il-17 bacteria dysbiosis microbiome decreased gut fungi Leer másThis study aims to evaluate the antibacterial activity of Lactobacillus acidophilus , alone and in combination with ciprofloxacin, against otitis media-associated bacteria. L. acidophilus cells were i...
anti-biofilm activity antimicrobial combinations chronic otitis media ciprofloxacin vb1 otitis biofilm combination activity lactobacillus bacterial Leer másBackground Anti-desiccant is a class of agrochemicals widely used to protect plants from water stresses, rapid temperature variations, heat and sunburn, frost and freeze damages, transplant shock, and...
anti-transpirant di-1-p-menthene phytobiomes boxwood crop protection systems approach nanopore minion sequencing microbiome phyllosphere anti-desiccants fungal bacterial communities Leer másEfficiently mitigating and managing environmental pollution caused by the improper disposal of dyes and effluents from the textile industry is of great importance. This study evaluated the effectivene...
azo dyes decolorization biodegradation gc-ms hplc ro dyes db Leer másBackground The guts of mammals are home to trillions of microbes, forming a complex and dynamic ecosystem. Gut microbiota is an important biological barrier for maintaining immune homeostasis. Recentl...
antibiotic cocktail gut microbiota fecal microbiota local immune response mimicking germ-free mice changes local microbiota immune gut antibiotic significant Leer másBackground Adenomyosis is a commonly observed benign gynecological disease that affects the quality of life and social psychology of women of childbearing age. However, because of the unknown etiology...
adenomyosis vaginal microbiome menstrual cycles phase individualized luteal = 0 menstrual differences adenomyosis patients Leer másSpontaneous fermentation of cereals like millet involves a diverse population of microbes from various sources, including raw materials, processing equipment, fermenting receptacles, and the environme...
lactic acid bacteria yeast fermented millet whole genome sequencing (wgs) species limosilactobacillus millet counts yeast Leer másIntroduction: Lumbosacral transitional vertebra (LSTV) is the most common congenital anomaly of the lumbosacral junction and is a frequent cause of back pain in young patients with a prevalence of 4.6...
lordosis lumbar study patients ache compared low lstv parameters lumbosacral pelvic vertebra transitional Leer másBACKGROUND: Obesity rates in the U.S. continue to increase, with nearly 50% of the population being either obese or morbidly obese. Obesity, along with female sex, are leading risk factors for sporadi...
hippocampus cognitive based markers effects restriction sex caloric obesity Leer másBACKGROUND: Potentially substantial impacts on the prognosis have been observed in individuals undergoing endovascular treatment due to cytochrome P450 2c19 (CYP2C19) polymorphism. In an attempt to im...
stenting artery events carotid adverse statistical cerebral difference polymorphism patients cyp2c19 endovascular prognosis Leer másBACKGROUND AND PURPOSE: Few studies have reported the utility of high-resolution vessel wall MR imaging in the follow-up of endovascularly treated vertebrobasilar dissecting aneurysms. This study aime...
3% vertebrobasilar dissecting combined intracranial treatment endovascular reconstructive diagnostic performance 0% aneurysms 100 Leer másBACKGROUND: Most neurodevelopmental tests used to assess child development in sub-Saharan Africa were developed in western or high-income countries, raising the question of their usefulness with Afric...
sub-saharan performance review systematic africa age childhood Leer másBACKGROUND: Multiple sclerosis is a demyelinating chronic neurologic disease that can lead to disability and thus to deterioration of quality of life. Psychological parameters such as ego defense mech...
quality style psychological life 5% sclerosis health mental 0 defense Leer másBACKGROUND: A central feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM), which is an acute worsening of symptoms after a physical, emotional and/o...
severity volunteer time bothersome qi cpet data me/cfs symptom r=0 vas Leer másBACKGROUND: Most neurodevelopmental tests used to assess child development in sub-Saharan Africa were developed in western or high-income countries, raising the question of their usefulness with Afric...
sub-saharan performance review systematic africa age childhood Leer másIn the macaque monkey, area V6A, located in the medial posterior parietal cortex, contains cells that encode the spatial position of a reaching target. It has been suggested that during reach planning...
movements v6a information timing medial target sent human planning hv6a reaching cortex m1 stimulation ms reach Leer másPrevious findings show that the morphology of folds (sulci) of the human cerebral cortex flatten during postnatal development. However, previous studies did not consider the relationship between sulca...
thickness sulcal findings morphologic structures behaviorally human individual lpfc cortex lateral changes development longitudinal participants morphology Leer másBACKGROUND: Lymphomatosis cerebri (LC) is a rare manifestation of primary central nervous system lymphoma (PCNSL) with only a few cases reported in the literature, appearing as diffuse infiltrating pr...
Leer másMild cognitive impairment (MCI) is often considered a precursor to Alzheimer's disease (AD) and early diagnosis may help improve treatment effectiveness. To identify accurate MCI biomarkers, researche...
review research mci Leer másBACKGROUND: Studies of the molecular mechanisms of nerve regeneration have led to the discovery of several proteins that are induced during successful nerve regeneration. RICH proteins were identified...
fold differentiation catalytically increase inactive neurites rich secondary nerve formation proteins regeneration neurite protein Leer másBACKGROUND AND PURPOSE: This retrospective, 2-center study investigated the feasibility, safety, and efficacy at 12-month follow-up of the treatment of ruptured, unruptured, and recurrent intracranial...
compared feasibility 95 occlusion 0% 9% aneurysm treatment results web-17 respectively aneurysms Leer másIn the macaque monkey, area V6A, located in the medial posterior parietal cortex, contains cells that encode the spatial position of a reaching target. It has been suggested that during reach planning...
movements v6a information timing medial target sent human planning hv6a reaching cortex m1 stimulation ms reach Leer másIndividuals on the autism spectrum often exhibit atypicality in their sensory perception, but the neural underpinnings of these perceptual differences remain incompletely understood. One proposed mech...
regions integration contour neurotypical autistic attenuated processing sensory autism Leer másBACKGROUND AND PURPOSE: Flow diverters with antithrombotic coatings are increasingly used to improve the safety of flow diverter treatments of intracranial aneurysms. This study aimed to investigate t...
intracranial 2% diverter thrombotic treatment rate aneurysms events fred flow Leer másMotor improvements, such as faster movement times or increased velocity, have been associated with reward magnitude in deterministic contexts. Yet whether individual inferences on reward probability i...
probability tendency healthy movement faster patients [hya vigor females beliefs tempo reward pd study Leer másThe COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non-Epileptic Seizures multicentre randomised controlled trial is the largest, fully-powered study to te...
trial Leer másBACKGROUND AND PURPOSE: This retrospective, 2-center study investigated the feasibility, safety, and efficacy at 12-month follow-up of the treatment of ruptured, unruptured, and recurrent intracranial...
compared feasibility 95 occlusion 0% 9% aneurysm treatment results web-17 respectively aneurysms Leer másBACKGROUND: Nationally representative studies evaluating the impact of the COVID-19 pandemic on haemorrhagic stroke outcomes are lacking. METHODS: In this pooled cross-sectional analysis, we identifie...
00 month p<0 0 patients outcomes ich Leer másMany social animals can recognize other individuals by their vocalizations. This requires a memory system capable of mapping incoming acoustic signals to one of many known individuals. Using the zebra...
songs individual vocalizations male communication hvc recognition memory auditory memories ncm Leer másBACKGROUND: Alzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting 44 million people worldwide, leading to cognitive decline, memory loss, and significant impairment in daily f...
sequencing types single-cell risk intracellular cell genes neurons signaling ad communication Leer másIncreasingly, non-pharmacological interventions are being identified and applied to post-stroke dysphagia. Nevertheless, there is insufficient evidence to assess which type of interventions are more e...
meta-analysis network training post-stroke dysphagia non-pharmacological interventions Leer másBackground There are increasing reports of cases of Guillain-Barré syndrome (GBS), as an adverse event of an immune checkpoint inhibitor (ICI) but postmarket data on the incidence of this remains scar...
data event reports reporting study avelumab faers checkpoint associated adverse ror Leer másBACKGROUND: GBA mutations are a common risk factor for Parkinson's disease (PD). A recent study has suggested that GBA haplotypes, identified by intronic variants, can affect age at diagnosis of PD. O...
study parkinson age diagnosis cohort haplotypes disease Leer másFlexible Endoscopic Evaluation of Swallowing (FEES) is one of two diagnostic gold standards for pharyngeal dysphagia in Parkinson's disease (PD), however, validated global outcome measures at the pati...
digest oropharyngeal dysphagia parkinson aspiration pneumonia malnutrition validity dysphagia pharyngeal swallowing overall outcome digest-fees = 0 pd < 0 001 Leer másSpastische Lähmung ist eine der häufigsten Folgen von Schlaganfall, manchmal sichtbar vor dem 15. Tag der Verletzung. Eines der größten Probleme für Patienten Körperdeformität und Funkt...
der die und zu eine den marche médication parésie für phase healthy nicht neuromusculaire mouvement movement cérébrale au dann neuronal auch déformante cinématiques paramètres tempo circuits parameter erholung durch bewegung kinematischen parameters étude plastizität antagonistes das walking mit plasticité von auf im influence cadence techniques muscles muscle bei studie study spastique recovery récupération plasticity parkinson stroke Leer másCortical cholinergic deficits contribute to cognitive decline and other deficits in Parkinson's disease. Cross-sectional imaging studies suggest a stereotyped pattern of posterior-to-anterior cortical...
posterior-to-anterior parkinson’s decline interval ± synapses subjects denervation cholinergic disease posterior cortical parkinson deficits cortices changes flow synapse blood cerebral frontal acetylcholinesterase regional Leer másDysregulation of autophagic pathways leads to accumulation of abnormal proteins and damaged organelles in many neurodegenerative disorders, including Parkinson's disease (PD) and Lewy body dementia (L...
lewy parkinson misfolded dementia body disease s-nitrosylation α-synuclein p62 autophagic spread Leer másINTRODUCTION: Given the rapidly aging population in both the United States and Mexico, rates of Parkinson's disease (PD) are likely to rise in both countries, suggesting that the number of individuals...
parkinson mexico united pd Leer másParkinson's disease (PD) is currently diagnosed based on characteristic motor dysfunctions induced by the loss of dopaminergic neurons in the substantia nigra pars compacta [1], [2]. The animal model ...
electromyographic animal muscular control dataset muscle model parkinson rats disease function time Leer másNearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent “neurologica...
diseases alzheimer parkinson drugs protein Leer másPhysical activity, together with its ameliorative effects on Parkinson’s disease (PD) symptoms, remains a relatively unappreciated factor which may be beneficial for the treatment outcome. Contemporar...
review activity symptoms exercise effects disease physical parkinson Leer másAbstract Background Exergaming has been proposed to improve gait and balance disorders in Parkinson's disease (PD) patients. We aimed to assess the efficacy of a home‐based, tailored, e...
difference randomized control = 0 duration disorders exergaming swst change home‐based disease parkinson gait balance active training Leer másParkinson's disease (PD) is a neurodegenerative disease that includes motor impairments, such as tremor, bradykinesia, and postural instability. Although eye movement deficits are commonly found in sa...
demonstrate hand tasks task parkinson patients controls eye movement pd targets oculomotor movements disease Leer másInternational audience; BackgroundDevelopment of reliable and accurate imaging biomarkers of dopaminergic cell neurodegeneration is necessary to facilitate therapeutic drug trials in Par...
corrected included progressing significant intracranial total longitudinal neuromelanin parkinson volume patients signal changes ratio pd disease volunteers Leer másBackground The loss of dopamine neurons in the substantia nigra, as well as other mostly catecholaminergic neurons, causes many of the motor symptoms that define Parkinson's disease. Parkinson's disea...
parkinson’s disease neurodegeneration mitochondrial dysfunction pink1 snca dementia variety complications parkinson disease Leer másIntroduction The aim of this systematic review is to present the existing literature on the clinical motor, and non-motor factors contributing to sit-to-stand transfer in individuals with Parkinson's ...
cognition joint torque parkinson’s disease sit-to-stand speed strength contributing phase literature peak individuals studies transfer parkinson Leer másObjective: We present the PaHaW Parkinson's disease handwriting database, consisting of handwriting samples from Parkinson's disease (PD) patients and healthy controls. Our goal is to show that kine...
diagnosis writing disease parkinson pacc controls handwriting patients healthy Leer másEfficient early diagnosis is paramount in addressing the complexities of Parkinson's disease because timely intervention can substantially mitigate symptom progression and improve patient outcomes. ...
graph parkinson disease Leer másThe endotoxin hypothesis of Parkinson's disease (PD) is the idea that lipopolysaccharide (LPS) endotoxins contribute to the pathogenesis of this disorder. LPS endotoxins are found in, and released fro...
neurons blood α‐synuclein reducing parkinson pd hypothesis Leer másBACKGROUND: No clinical trials have been specifically designed to compare medical treatments after surgery in Parkinson's disease (PD). OBJECTIVE: Study's objective was to compare the efficacy and saf...
parkinson short‐ surgery pd symptoms follow‐up outcome dopamine monotherapy patients levodopa agonist Leer másInternational audience; Liu et al. recently reported that biallelic mutations in DAGLB are responsible for autosomal recessive early-onset Parkinson’s disease. They identified six patien...
onset typical identified mutation disease daglb recessive autosomal parkinson pd early-onset Leer másBackground: Early brainstem neurodegeneration is common in Parkinson's disease (PD) and progressive supranuclear palsy (PSP). While previous work showed abnormalities in vestibular evoked myogenic pot...
sleep parkinson total 01 iii vestibular neurology clinic pd 0 patients disease scores psp vemp Leer másA robust body of evidence from randomized controlled trials has established the efficacy of deep brain stimulation (DBS) in reducing off time and dyskinesias in levodopa‐treated patients with Parkinso...
pd milestones parkinson follow‐up studies long‐term observational disease motor disability Leer másGenetic testing for persons with Parkinson's disease is becoming increasingly common. Significant gains have been made regarding genetic testing methods, and testing is becoming more readily available...
parkinson gaps controversies testing genetic Leer másBackground The loss of dopamine neurons in the substantia nigra, as well as other mostly catecholaminergic neurons, causes many of the motor symptoms that define Parkinson's disease. Parkinson's disea...
parkinson’s disease neurodegeneration mitochondrial dysfunction pink1 snca dementia variety complications parkinson disease Leer másα‐Synuclein aggregation is a hallmark of Parkinson's disease and a promising biomarker for early detection and assessment of disease progression. The prospect of a molecular test for Parkinson's disea...
amplification methods α‐synuclein patients parkinson detection disease Leer másThe aim of this prospective study was to investigate autonomic function in Parkinson’s disease with a multidimensional approach including clinical evaluation tools, head-up tilt test and morphological...
function orthostatic significantly vagal parasympathetic patients frequency tilt parkinson Leer másThere is increasing evidence for the presence and variability of circumstellar dust and gas around white dwarfs that are polluted with exoplanetary material, although the origin of this dust and gas...
white timescales gas lines astrophysics Leer másThis work considers the impact of resolution in the construction of mock observations of simulated galaxies. In particular, when building mock integral field spectroscopic observations from galaxy f...
galaxies astrophysics stellar mock Leer másContext. S26 is an extragalactic microquasar with the most powerful jets ever discovered. They have a kinetic luminosity of $L_{\rm j}\sim5\times 10^{40}\,{\rm erg\,s^{-1}}$. This implies that the a...
$l_{\rm system x-ray s^{-1}}$ erg\ wind {\rm lobes microquasar jet disk super-eddington Leer másThe Sun's chromosphere is a critical region to understand when considering energy and mass deposition into the transition region and corona, but many of the smaller, faster events which transport a ...
chromospheric transition transfer solar observations energy chromosphere mg mass region {\aa} spicules ii astrophysics Leer másAtmospheric compositions preserve the history of planet formation processes. Jupiter has the remarkable feature of being uniformly enriched in various elements compared to the Sun, including highly ...
disk radial enrichment ice volatile gas nh$_3$ salts transport planetary solar ammonium jupiter nitrogen astrophysics Leer másCore ellipticals, massive early-type galaxies have an almost constant inner surface brightness profile. The size of the core region correlates with the mass of the finally merged black hole. ...
1272 ngc galaxy size euclid galaxies black Leer másSmall planets ($\lesssim 1$ M$_\oplus$) at intermediate orbital distances ($\sim$1 au) represent an uncharted territory in exoplanetary science. The upcoming microlensing survey by the Nancy Grace R...
disk au ganymede mass function initial Leer másIn recent years, a significant number of oxygen-bearing complex organic molecules (COMs) have been detected in the gas phase of cold dark clouds such as TMC-1. The formation of these COMs cannot be ...
formation cold oxygen-bearing coms mechanisms Leer másRecent determinations of the total rate of the 12C+12C nuclear reaction show non-negligible differences with the reference reaction rate commonly used in previous stellar simulations. In addition, t...
branching ultra-massive progenitors ratios impact nuclear current reaction rate uncertainties Leer másWe study the dynamics of spherically symmetric black holes in scalar Gauss-Bonnet gravity with an additional coupling between the scalar field and the Ricci scalar using non-linear simulations that ...
holes ricci scalar singularity coupling black Leer másWe study the electrostatic energy of binary ionic mixtures (BIMs) in the form of Coulomb crystals with the main focus on ordered crystals. We consider 15 different binary bcc-like lattices, accurate...
binary results electrostatic Leer másIn this chapter, we will discuss the use of Machine Learning methods for the identification and localization of cometary activity for Solar System objects in ground and in space-based wide-field all...
methods objects astrophysics Leer másGas-phase abundance ratios between \ce{C2H4O2} isomers methyl formate (MF), glycolaldehyde (GA), and acetic acid (AA) are typically on the order of 100:10:1 in star-forming regions. However, an unex...
sources chemical astrophysics ratios ga Leer másA century or less separates the thermonuclear-powered eruptions of recurrent novae in the hydrogen-rich envelopes of massive white dwarfs. The colliding ejecta of successive recurrent nova events ar...
ejecta light predict narrowband recurrent astrophysics nova Leer másThe high electron temperature in galaxy clusters ($>1\,$keV or $>10^7\,$K) leads to corrections at the level of a few percent in their thermal Sunyaev-Zeldovich effect signatures. Both the size and ...
effect temperature corrections Leer másIn June 2023, multiple pulsar timing array collaborations provided evidence for the existence of a stochastic gravitational wave background. Scalar induced gravitational waves (SIGWs), as one of the...
$n_{\text{eff}}$ waves gravitational sigws Leer másWe perform a study to obtain the initial spin or the nondimensional Kerr parameter $a_{*}$ of primordial black holes (PBHs) created during the radiation dominated phase of the universe from not only...
$\sim scale broad curvature Leer másGamma/hadron discrimination in ground-based gamma-ray observatories at the GeV energy range is challenging as traditional muon-based methods become less effective at lower energies. This work explor...
energy gamma/hadron discrimination Leer másWe present theoretical predictions and extrapolations from observed data of the stellar halos surrounding central group/cluster galaxies and the transition radius between them and the intracluster o...
data galaxies model theoretical galaxy diffuse halos halo radius mass stellar Leer másE to B mixing or "leakage" due to time-ordered data (TOD) filtering has become an important source of sensitivity loss that ground-based cosmic microwave background polarization experiments must add...
tod satellite levels experiment noise e-mode Leer másLunar ejecta, produced by meteoroidal impacts, have been proposed for the origin of the near-Earth asteroid (469219) Kamo'oalewa, supported by its unusually Earth-like orbit and L-type reflectance s...
launch al eccentricity simulations outcomes co-orbital earth Leer másNEO Surveyor will detect asteroids and comets using mid-infrared thermal emission, however ground-based followup resources will require knowledge of the expected visible light brightness in order to...
astrophysics Leer másWe present JWST broadband images of the highly inclined protoplanetary disk SSTc2d J163131.2-242627 (Oph163131) from 2.0 to 21$\mu$m. The images show a remarkable evolution in disk structure with wa...
disks emission 0 oph163131 jwst disk astrophysics Leer másPebble accretion refers to the growth of planetary bodies through the accretion of pebble-sized particles. Pebbles are defined in terms of their aerodynamically size $\tau_s$, which describes the le...
planet particles accretion Leer másQuasiperiodic eruptions (QPEs) are a novel class of transients recently discovered in a few extragalactic nuclei. It has been suggested that a QPE can be produced by a main-sequence star undergoing ...
system astrophysics postmerger formation qpe Leer másBackground Caregivers of elderly patients with multiple chronic conditions have heavy caregiver burden and poor sleep quality, which has an important impact on both caregivers and patients. This study...
multiple chronic conditions sleep quality caregiver burden self efficacy well-being china rural population study serial mediating effect well-being multiple caregivers patients sleep quality self-efficacy Leer másBackground Type 2 diabetes mellitus (DM) is a frequent co-morbidity among patients suffering from infective endocarditis (IE). The aim of the study was to evaluate the impact of type 2 DM on the early...
infective endocarditis cardiac surgery diabetes mellitus epidemiology mortality study = 0 diabetes long-term surgical treatment mortality vs endocarditis patients Leer másBackground Cancer-associated malnutrition is associated with worse symptom severity, functional status, quality of life, and overall survival. Malnutrition in cancer patients is often under-recognized...
nutrition oncology cancer care esas patient-reported outcomes quality of life study population assessment adult parameters malnutrition symptom esas-r severity lack appetite patients risk cancer scores Leer másInternational audience; Robot-Assisted Laparoscopic Surgery (RALS) is now prevalent in Operating Rooms (ORs). This situation requires future surgeons to learn Classic Laparoscopic Surger...
study cls rals skills training co-rals Leer másBackground The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavi...
covid-19 sars-cov-2 mis-c severity mortality study acute syndrome significantly sars-cov-2 hospitalized children covid-19 disease Leer másAIM: To evaluate the efficacy of iGlarLixi by C‐peptide levels and duration of diabetes in an exploratory analysis of the LixiLan‐G study. METHODS: LixiLan‐G was a 26‐week, randomized, open‐label stud...
study −1 arm reductions adults lixilan‐g levels −0 efficacy baseline ra range quartiles diabetes glp‐1 duration iglarlixi Leer másINTRODUCTION: Preterm birth complications are the most common cause of death in children under 5 years. The presence of multiple microorganisms and genital tract inflammation could be the common mecha...
africa south pregnant ethics pregnancy study birth women gestational age microorganisms genital tract Leer másOBJECTIVE: The iWalk study showed significant increase in use of the 10-Meter Walk Test (10MWT) and 6-Minute Walk Test (6MWT) poststroke following provision of a toolkit. This paper examined the influ...
poststroke study assessment implementation evaluation strategy participants practices rehabilitation settings onsite toolkit walking facilitation walk Leer másReducing body weight has been shown to lower blood pressure in obesity-related hypertension. However, success of those lifestyle interventions is limited due to poor long-term compliance. Emerging evi...
weight light food calories feeding study blood fat mass lower trf control pressure Leer másPurpose The study evaluated the efficacy of SC arthrodesis with lunate preservation for treating patients diagnosed with stage IIIB or IIIC Kienböck’s disease, who also exhibit neutral ulnar variance....
kienböck’s disease scaphocapitate arthrodesis intercarpal arthrodesis fusion wrist differences study time rs angle grip strength significant disease kienböck’s patients stage score diagnosed iiib iiic arthrodesis Leer másBACKGROUND: As chronic kidney disease (CKD) is amongst the current global health challenges, this study is aiming to evaluate the long-term intake of total polyphenol and its subclasses in association...
polyphenol total incidence intake study ckd Leer másBACKGROUND: Patients with polymetastatic cancer are most often treated with systemic therapy to improve overall survival and/or delay progression, with palliative radiotherapy reserved for sites of sy...
cancer sites weekly fractions sabr disease study Leer másSIMPLE SUMMARY: Patients who receive carbon ion radiotherapy (C-ion RT) for tumors near the temporomandibular joint are likely to experience trismus, a condition characterized by reduced jaw opening. ...
study 0 ion trismus dose carbon c-ion Leer másBackground Clinical evidence is commonly obtained through individual trials that are time-, cost- and resource-consuming, and which often leave unanswered clinically relevant questions. Umbrella studi...
study design medical devices aortic valve mitral valve and tricuspid heart valve medical data endpoints clinical devices substudies concept study umbrella valve device heart Leer másINTRODUCTION: ERAS protocols are widely endorsed after colorectal surgery. This study aims to describe compliance with the individual principles of ERAS across an international setting. METHODS: A hos...
elective 17 international hospitals study avoidance eras surgery items colorectal Leer másInternational audience; Introduction: The rise in the number of cesarean sections (CS) is a major health public problem which concerns nearly all countries. It is suggested that the Ten ...
january 31 perinatal study decrease post-period december pre-period cesarean rate cs feedback variability network ten classification audit maternity Leer másObjective: Accurate prognostic prediction in patients with high-grade aneruysmal subarachnoid hemorrhage (aSAH) is essential for personalized treatment. In this study, we developed an interpretable pr...
outcome analysis study machine learning high-grade prediction patients model asah ci auc 95% 0 Leer másBACKGROUND: As the number of people living with human immunodeficiency virus (HIV; PLHIV) in Indonesia has increased in recent years, more efforts have been expended to improve their health status. Ho...
social study healthcare health indonesia plhiv research Leer másOBJECTIVE: To study the prognostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and platelet count in patients with platinum-sensitive recurrent epithelial ov...
epithelial platinum-sensitive recurrent study cancer ovarian poor analysis ps-roc pfs count survival plr nlr prognostic ratio os patients platelet associated Leer másBackground The current study aimed to explore the team members’ experiences in the socialization process for becoming a collaborator in an interprofessional team. Method This qualitative study is cond...
interprofessional practice interprofessional collaboration interprofessional identity professionalism socialization interprofessional professionalism uni-professional socialization team explored study professionalism interprofessional Leer másCONTEXT: The variety of tumor-seeking radiopharmaceuticals, which are currently in clinical use, may have a potential role as imaging agents for adrenal gland tumors, due to physiological characterist...
a/b study analysis patients tumor-seeking tumors 99m Leer másBACKGROUND: The utility of echocardiographic left ventricular (LV) geometry in the prediction of stroke/coronary heart disease (CHD) and all-cause mortality is not well characterized. This study aimed...
study cohort stroke/chd hypertrophy lv concentric eccentric ci = 1 95% incident geometry all-cause hr = 1 Leer másBACKGROUND: Rapidly increasing healthcare costs and the growing burden of non-communicable diseases have increased the out-of-pocket (OOP) spending (63.3% of total health expenditure) in Bangladesh. T...
healthcare conducted government study protection bangladesh population estimate implementation services health ssk project scheme Leer másRecent Earth observation spatial missions will provide very high spectral, spatial and temporal resolution optical images, which represents a huge amount of data. The objective of this ...
stored tiling obtained thesis car résultat dataset contrainte study classification segmentation données mémoire training algorithms memory apprentissage ne thèse algorithme algorithm solutions datasets solution Leer másBackground: Indonesia ranks second in terms of maternal mortality in Southeast Asia while the highest maternal mortality rate in Indonesia was contributed by the provinces of West Java, East Java, and...
maternal mortality maternal emergency management maternal emergency course indonesia central study mortality maternal emergency respondents brati java Leer másBackground Evidence on the impact of thyroid hormone treatment (LT4) on maternal pregnancy outcomes in women with subclinical hypothyroidism (SCH) without thyroid peroxidase antibodies (TPOAb) positiv...
pregnancy thyroid hormone treatment maternal outcomes subclinical hypothyroidism 74 outcomes positivity 0% 18 miu/l impact maternal treatment women vs prevalence ref = 0 thyroid tpoab sch Leer másBACKGROUND: The etiology of thyroid cancer especially in women in not well recognized in Yazd, at the center of Iran. The aim of present study was to investigate the risk factors of thyroid cancer amo...
neck 95%ci radiation history or = 6 head exposure 001 papillary thyroid study control women Leer másPURPOSE: Recurrent laryngeal nerve injury after thyroid surgery may cause vocal cord palsy (VCP), which leads to unexpected additional costs. In recent years, intraoperative neural monitoring (IONM) h...
total vs 0 411 thyroid patients non-ionm ± Leer másThe prevalence of thyroid disease continues to rise. As a consequence, the research in the thyroid field has significantly increased over time. Thus, clinicians, and endocrinologists first, have to be...
thyroid cancer microbiota graves insights papers Leer másThe detection of low-risk thyroid carcinoma has increased in recent decades, although disease-specific mortality remained without changes. The high prevalence of occult carcinomas in autopsy studies, ...
active surveillance low risk papillary thyroid carcinoma observation papillary thyroid microcarcinoma thyroid cancer indeterminate thyroid nodules low-risk thyroid Leer másBackground Lenvatinib is widely used to treat unresectable and advanced thyroid carcinomas. We aimed to determine whether ^18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography...
lenvatinib early prediction treatment outcome f-fdg pet... differentiated thyroid carcinoma thyroid 0 ct initiation suvmax lenvatinib value Leer másPrimary acquired hypothyroidism in children manifests with a myriad of clinical presentations. Clinical features can be insidious in nature, often under the guise of non-specific presentations to othe...
hypothyroidism thyroid growth puberty clinical children Leer másPurpose Regorafenib demonstrated encouraging results in recurrent glioblastoma patients. Some studies showed that changes in circulating thyroid hormones (fT3, fT4, fT3/fT4 ratio) can be considered as...
glioblastoma regorafenib thyroid ft3/ft4 ft3 ft4 study p = 0 rate relationship median treated os idh pfs function patients thyroid glioblastoma ratio baseline Leer másBackground To explore the distinguishing diagnostic value and clinical application potential of deep neural networks (DNN) for pathological images of thyroid tumors. Methods A total of 799 pathologica...
deep neural network thyroid tumor pathology diagnostics artificial intelligence thyroid results images dnn pathological tumors set 0 Leer másBackground PTEN hamartoma tumour syndrome (PHTS) is a rare hereditary disorder caused by germline pathogenic mutations in the PTEN gene. This study presents a case of PHTS referred for genetic evaluat...
cowden syndrome phts hamartom... early diagnosis colorectal polyposis case reports case series breast hereditary multiple thyroid cancer literature polyps Leer másPurpose The purpose of this study was to investigate the impact of autofluorescence technology on postoperative parathyroid function and short-term outcomes in patients undergoing thyroid surgery. Met...
thyreoidectomy central lymph node dissection hypoparathyroidism autofluorescence reduced outcomes study short-term surgery parathyroid calcium dysfunction technology thyroid levels function autofluorescence Leer másInternational audience; Most marine organisms have a biphasic life cycle during which a pelagic larva is transformed into a radically different juvenile. In vertebrates the role of thyro...
thyroid hormones Leer másPapillary thyroid carcinoma (PTC) stands as the leading cancer type among endocrine malignancies, and there exists a strong correlation between thyroid cancer and obesity. However, the clinical signif...
mettl16 ptc lipid metabolism rna ma methylation targeted therapy thyroid progression cancer mettl16 metabolism lipid ptc Leer másBACKGROUND: This study investigates the effects of intranasal dantrolene nanoparticles on inflammation and programmed cell death by pyroptosis in 5XFAD Alzheimer’s Disease (AD) mice. METHODS: 5XFAD an...
months 5xfad mice significantly thyroid liver kidney intranasal dantrolene nanoparticles proteins Leer másBackground Subclinical hyperthyroidism (SCH) is found to be associated with renal dysfunction. Hyperthyroidism is a well-known cause of secondary systolic hypertension. However, the effect of SCH on t...
hyperthyroidism renal function hypertension renal arterial distensibility compared significantly thyroid function mean patients = 0 sch renal vs Leer másBackground Thyroid carcinoma is the most common endocrinological malignancy, but its spread to bone is rare. Particularly, bone metastases leading to complete resorption of the humerus are extremely u...
thyroid carcinoma bone metastasis humeral metastasis surgical treatment individualized treatment multidisciplinary approach metastases carcinoma thyroid surgical humeral amputation bone limb Leer másPapillary thyroid cancer (PTC) spreads preferentially to lymph nodes. When central or lateral cervical lymph node basins are macroscopically affected by PTC, compartmental clearance is the treatment o...
papillary thyroid cancer prophylactic neck dissection elective neck dissection lymph node metastases lymphadenectomy thyroid surgery thyroid pcnd cancer Leer másBACKGROUND: Thyroid cancer (THCA) is the most common type of endocrine cancers, and the disease recurrences were usually associated with the risks of metastasis and fatality. Butyrophilin-like protein...
clinical associated cell thca cancer thyroid prognostic expression btnl9 Leer másSIMPLE SUMMARY: Gastrointestinal signs are reported in humans with hypothyroidism, and resolution of GI signs was reported with thyroid hormone supplementation; however, GI involvement in the clinical...
concurrent findings clinical ultrasound hypo-t gastrointestinal thyroid hypothyroid signs 0 thrt therapy euthyroid gi Leer másObjective Thyroid cancer is one of the most frequently reported endocrine system malignancies. It is difficult to distinguish follicular thyroid cancer (FTC) from follicular thyroid adenoma (FTA) duri...
slc5a8 thyroid cancer follicular dna mrna follicular diagnosis tt-ump prognosis rate cancer patients thyroid methylation Leer másBackground Little is known about the association of dietary patterns with thyroid function. Since thyroid function and cardiometabolic variables are inter-related, we investigated whether cardiometabo...
hypothyroidism hyperthyroidism tpoab euthyroidism thyroid-stimulating hormone thyroxine nutrition ci 95% food pattern dietary odds tertile hypothyroidism adjusted study thyroid function patterns Leer másBackground Thyroid nodules were widely encountered in the population, and the selection of thyroid nodules for fine needle aspiration cytology (FNAC) remains confusing. It is essential to investigate ...
thyroid nodules fnac tirads dyslipidemia tsh 4% disease patients 6% acr-tirads benign thyroid fnac association classification nodules Leer másBackground Inhibitor of DNA Binding 2 (ID2) plays a crucial role in tumor cell proliferation, invasion, metastasis, and stemness. Aberrant ID2 expression is associated with poor prognosis in various c...
id2 pi3k/akt pathway emt stemness thyroid cancer cell thyroid promotes proliferation cancer id2 Leer másBackground According to the 2010 European Health Interview Survey, 51% of women in Hungary have a chronic disease, and is among the poorest quartile in the EU countries. Thyroid diseases affected more...
adherence quality of life social support thyroid disorders women’s health hungary found differences thyroid quality adherence support social life patients Leer másBACKGROUND: Mitochondrial DNA (mtDNA) copy number is associated with tumor activity and carcinogenesis. This study was undertaken to investigate mtDNA copy number in papillary thyroid cancer (PTC) tis...
tissues patients significantly dna 001 p < 0 thyroid risk copy Leer másBackground Inflammatory myofibroblastic tumor (IMT) of urinary bladder is a rare entity of genitourinary tract which has baffled urologists worldwide. Sign and symptoms are site specific. Usually diag...
inflammatory myofibroblastic tumor... imt urinary bladder partial cystectomy case report patient managed inflammatory myofibroblastic tumor Leer másSince 2015, Japanese researchers have made great progress in developing a method to differentiate human pluripotent stem cells (hPSCs) into kidney organoids. Protocols have been established to produce...
kidney organoid scrna-seq kidney disease model collecting duct biology maturation scrna-seq Leer másThe role of robotic surgery in the curative-intent treatment of esophageal cancer patients is yet to be defined. To compare short-term outcomes between conventional minimally invasive (cMIE) and robot...
esophagectomy esophageal cancer robotic surgery minimally invasive surgery short-term outcomes patients esophageal cancer < 0 rln studies short-term invasive minimally md = 0 nodes outcomes ramie cmie Leer másBackground After the introduction of cisplatin-based chemotherapy, the survival time of testicular cancer (TC) patients has improved dramatically. However, the overall risk of death in patients with T...
testicular cancer cancer survivorship causes of death surveillance, epidemiology, and en... database common diseases tc death Leer másPurpose This study aims to report on functional outcomes in a large cohort of patients who underwent inpatient rehabilitation (IR) in a highly specialized, high-volume German urologic rehabilitation c...
urinary incontinence erectile dysfunction functional outcome inpatient rehabilitation ileal neobladder 95% women ci p = 0 urinary inb t3 patients Leer másBackground The Japan Renal Biopsy Registry (J-RBR), a nationwide, web-based, registry system, started in 2007. This study aimed to summarise the epidemiology of biopsy-diagnosed kidney disease in Japa...
kidney biopsy renal pathology disease aetiology japan renal biopsy registry registry minimal kidney 2007 patients change glomerulonephritis immunoglobulin vasculitis japan biopsy nephropathy predominant renal Leer másHintergrund Zur Behandlung des tiefen anterioren Resektionssyndroms („low anterior resection syndrome“, LARS) nach schließmuskelerhaltender Rektumresektion stehen verschiedene Behandlungsmöglichkeiten...
rektumkarzinom funktionelles outcome stuhldrang inkontinenz anteriores resektionssyndrom rectal cancer functional outcome urgency incontinence low anterior resection syndrome als life zur das mit sowie anterior symptoms recommendations follow-up functional rektumresektion der lars eine und werden therapeutic patients den patienten im options funktionelle nachsorge die studie nach Leer másBackground An analysis of European and American individuals revealed that a reduction in estimated glomerular filtration rate (eGFR) slope by 0.5 to 1.0 mL/min/1.73 m^2 per year is a surrogate endpoin...
egfr slope diabetic kidney disease chronic kidney disease surrogate endpoint kidney diabetes disease 95% surrogate patients m^2 0 73 baseline egfr Leer másIn order to provide decision-making support for the auxiliary diagnosis and individualized treatment of calculous pyonephrosis, the study aims to analyze the clinical features of the condition, invest...
machine learning pyonephrosis upper urinary tract calculi prediction model diagnosis analysis data machine learning 0 model lr auc gbdt rf training svm calculous xgboost followed models pyonephrosis test prediction using Leer másBackground The laparoscopic approach is the standard of care for living-donor nephrectomy. A rare postoperative complication is small bowel obstruction due to a retroperitoneal hernia. We present a ca...
retroperitoneal hernia laparoscopic living-donor nephrect... renal transplantation complication donor living-donor laparoscopic nephrectomy hernia bowel defect retroperitoneal Leer másBackground Infantile nephropathic cystinosis (INC) is a systemic lysosomal storage disease causing intracellular cystine accumulation, resulting in renal Fanconi syndrome, progressive kidney disease (...
infantile nephropathic cystinosis chest biacromial diameter anterior–posterior chest diameter chronic kidney disease fanconi syndrome clinical kidney disease patients ckd chest Leer másObjectives To compare the efficacy and safety of thulium fiber laser (TFL) to holmium: YAG (Ho: YAG) laser in ureteroscopic lithotripsy for urolithiasis. Methods PubMed, Web of Science, Embase, CENTRA...
thulium fiber laser ho:yag urolithiasis ureteroscopic lithotripsy systematic review meta-analysis meta-analysis ci time = 0 95% laser 0 Leer másPoststreptococcal acute kidney glomerulonephritis (PSAGN) has been seen in adults in recent years, especially in patients with type 2 diabetes mellitus, and the renal prognosis has not always been goo...
diabetes mellitus infection-related glomerulonephrit... poststreptococcal glomerulonephrit... c3 glomerulonephritis anti-factor h antibody convertase secondary c3gn c3nef antibodies c3 afh psagn Leer másBackground We investigated the association between premature ejaculation (PE) and the quality of residential environment from a new perspective to explore the influencing factors of PE, especially in ...
premature ejaculation preqis depression residential environment éjaculation précoce preqi dépression environnement résidentiel quality l’ats assessed control premature pe cs gs corrélation ejaculation correlation ats environment residential score 20 -0 Leer másBackground EAU guidelines strongly recommend kidney sparing surgery (KSS) as the primary treatment option for the low-risk UTUC patients. While there are few reports involving the KSS treated for the ...
high-risk kidney sparing surgery segmental ureterectomy ureteral carcinoma su ureteral patients high-risk pfs os Leer másBackground and objective The effectiveness of immunosuppressive and corticosteroid treatments for Immunoglobulin A (IgA) nephropathy (IgAN) remains thoroughly evaluated. We undertook a meta-analysis t...
meta-analysis iga nephropathy leflunomide corticosteroids proteinuria 0 rate progressive -0 nephropathy iga corticosteroids Leer másPatients with end-stage kidney disease (ESKD) have a high symptom-burden and high rates of morbidity and mortality. Despite this, evidence has shown that this patient group does not have timely discus...
advance care planning dialysis end-stage kidney disease end of life palliative review current care advance planning Leer másPurpose To date, our understanding of IgA nephropathy (IgAN) pathophysiology has remained incomplete; therefore, treatment remains largely empiric, and the efficacy and safety of immunosuppressants re...
iga nephropathy hydroxychloroquine leflunomide proteinuria hematuria inhibitor-only follow-up hematuria efficacy safety system renin-angiotensin igan inhibitor leflunomide patients hydroxychloroquine Leer másPurpose Preoperative proteinuria is a prognostic factor of chronic kidney disease (CKD). We assessed the association between preoperative proteinuria and postoperative renal function after partial nep...
partial nephrectomy renal function chronic kidney disease proteinuria carcinoma, renal cell lrm 12 months age follow-up renal patients ckd-iii differences function egfr proteinuria baseline Leer másBackground To demonstrate the technical feasibility of percutaneous nephrolithotomy (PCNL) guided by 5G-powered robot-assisted teleultrasound diagnosis system (RTDS) in a complex kidney-stone (CKS) co...
intraoperative tele-assistance 5g technology robot-assisted teleultrasound diagnosis system complex kidney stones percutaneous nephrolithotomy tele-assistance Leer másBackground Erythropoiesis-stimulating agents (ESAs) have played an important role in the treatment of renal anemia in children, but cannot improve hemoglobin to target level in some cases. Roxadustat,...
anemia roxadustat chronic kidney disease infant hypoxia-inducible factor prolyl hy... erythropoiesis-stimulating agent anemia children Leer másBackground Trans-Urethral Resection of Bladder Tumors (TURBT) is a critical step in diagnosis, staging and treatment of bladder tumors. Conventional TURBT (cTURBT) involves the electro-resection of th...
bladder tumors thulium laser en-block resection treatment en-bloc time feasibility resection patients mean laser thulium cancer bladder Leer másBackground Cystinuria is a rare genetic kidney stone disease, with no cure. Current treatments involve lowering urinary cystine levels and increasing cystine solubility. This systematic review evaluat...
cystinuria cystine cystine stone intervention quality volume reduced solubility interventions studies cystinuria using levels stone drugs agents Leer másBackground Duplex kidneys represent an embryologic maldevelopment at time of renogenesis resulting in a spectrum of bifurcation anomalies of the reno-ureteric system. Though most are antenatally detec...
duplex kidney ureteral transection urinoma appendix interposition management system mass Leer másSIMPLE SUMMARY: Pet animals’ bacterial skin infections represent the main reason for presentation in small animal practice and are generally secondary complications of other pathological conditions. P...
gram-positive university naples veterinary skin study strains cats bacteria dogs Leer másSIMPLE SUMMARY: Veterinary care of companion animals, particularly dogs and cats, continues to advance, with some companion animals receiving a standard of care equal to or exceeding that of human pat...
veterinary avc review companion ethical improved Leer másBACKGROUND: The Old world Alphavirus, Middelburg virus (MIDV), is not well known and although a few cases associated with animal illness have previously been described from Southern Africa, there has ...
manifestations ad veterinary hoc illness edta africa patients sample middelburg study genome nhls virus samples csf neurological Leer másBACKGROUND: Communication skills are a necessary competency in veterinary medicine, and shared decision-making (SDM) between practitioners and patients is becoming increasingly important in veterinary...
study medicine 0 results conducted relationship decision-making sdm-q-9 veterinary veterinarians owners sdm-q-doc sdm Leer másSIMPLE SUMMARY: Chemotherapy is becoming an increasingly difficult antitumor therapy to practice due to the multiple mechanisms of drug resistance. To overcome the problem, it is possible to use alter...
resistance tumors solid review veterinary ect electrochemotherapy therapy cancer drug Leer másSIMPLE SUMMARY: Antimicrobial resistance is a threat that poses a great risk to public health. It has been predicted that, by 2050, there will have been 10 million deaths worldwide due to drug-resista...
procedure blood medicine risk antimicrobial resistance veterinary bacteremia Leer másEarly disease detection in veterinary care relies on identifying subclinical abnormalities in asymptomatic animals during wellness visits. This study introduces an algorithm designed to distinguish ...
ci 95% visit classification 0 algorithm veterinary visits Leer másThis study aims to evaluate the role of Jordanian veterinarians in terms of their knowledge, attitudes and common practices in combating antimicrobial resistance (AMR) and summarize the registered vet...
antimicrobial resistance veterinarian knowledge practices attitudes jordan knowledge participants veterinary study amr Leer másPigmentary uveitis (PU), also known as Golden Retriever Pigmentary Uveitis (GRPU), is a common ocular condition of Golden Retrievers that has severe, vision‐threatening ocular complications and can re...
golden retriever diagnosis veterinary ocular pigmentary uveitis Leer másSouth Africa has two types of animal farming systems, being the commercial industry and subsistence farming in more rural areas, with commercial farmers having more access to veterinary services. To c...
farmer training; rational drug use... food safety drug disposal drug storage farm income medication veterinary farming training Leer másBackground: Antimicrobial stewardship programs (ASPs) are important tools to foster prudent antimicrobial use. Objective: To evaluate antimicrobial prescriptions by Swiss veterinarians before and aft...
proportion infection veterinary significantly 001 vs decreased 2018 antimicrobial 2016 antimicrobials prescriptions Leer másAntimicrobial resistance is an increasingly widespread phenomenon that is of particular concern because of the possible consequences in the years to come. The dynamics leading to the resistance of mic...
veterinary drug resistance Leer másBACKGROUND: Dental disease is very common in dogs and veterinary professional dental cleaning and examination, together with daily dental home care, is the foundation for good dental health. To our kn...
radiography anesthesia routines respondents access equipment dental performed vn swedish veterinarians nurses veterinary cleaning Leer másSouth Africa has two types of animal farming systems, being the commercial industry and subsistence farming in more rural areas, with commercial farmers having more access to veterinary services. To c...
farmer training; rational drug use... food safety drug disposal drug storage farm income medication veterinary farming training Leer másBackground: Tube feeding is a common procedure in neonatology. In humans, tube misplacement reportedly occurs in up to 59% of all cases and may lead to perforation in 1.1% of preterm intubated neonate...
feline canine kittens ultrasonography veterinary feeding tube placement neonates Leer másBackground The English Cocker Spaniel (ECS) is one of the most popular dog breeds in the UK but information on disorder predisposition and protection is limited. Using anonymised veterinary clinical d...
vetcompass electronic patient record epr breed dog epidemiology primary-care veterinary pedigree purebred english cocker spaniel predisposition disorder uk protection 0 001 ci 95% odds 14 Leer másBACKGROUND: Animals are a reservoir for ESBL/pAmpC-producing Escherichia coli/Klebsiella pneumoniae (ESBL-E/K). We investigated the association between occupational contact with different types of ani...
factors positive workers months coli esbl prevalence animals veterinary healthcare Leer másInternational audience; The global action plan (GAP) on antimicrobial resistance (AMR) advocated the development of national action plans on AMR and the implementation of plans aimed at ...
health resistance animal amu importance amr veterinary implementation antimicrobial oie Leer másSIMPLE SUMMARY: Decision making in veterinary medicine can be extremely difficult. Often, different choices can have vastly different costs, complications, and outcomes associated with them. Bayesian ...
veterinary management inference medicine choice identify decision analysis clinical bayesian diagnosis Leer másInternational audience; AbstractThis article investigates, using a sociology of profession approach, why veterinarians and aqua medicine biologists share jurisdiction in fish health in N...
development model diseases hitra scientific shared medicine health aqua jurisdiction biologists vaccine profession norway inter-professional cross-sectoral disease collaboration veterinarians veterinary fish aquaculture Leer másInternational audience; AbstractThis article investigates, using a sociology of profession approach, why veterinarians and aqua medicine biologists share jurisdiction in fish health in N...
development model diseases hitra scientific shared medicine health aqua jurisdiction biologists vaccine profession norway inter-professional cross-sectoral disease collaboration veterinarians veterinary fish aquaculture Leer másAntimicrobial resistance is a complex One Health issue that exists in both human and veterinary medicine. To mitigate this ever-growing problem, efforts have been made to develop guidelines for approp...
one health antimicrobial resistance antimicrobial use veterinary bacterial conditions exotic amu review n = antimicrobial treatment Leer másPastoral and agro-pastoral farming are extensively practised in Ethiopia, and the main livestock kept are cattle, goats, sheep, poultry, and camels. The livestock sector is faced with complex challeng...
ethiopia livestock training animal health veterinarian veterinary professionals cpd survey ethiopia disease veterinary Leer másInternational audience; Dr. Peter Rossdale (1927-2021) practiced all his life in Newmarket, England. Founder of the most important equine clinic in Europe, he is also one of the major co...
médecine profession sa vétérinaire medicine veterinary Leer másSARS-CoV-2 has clearly shown that efficient management of infectious diseases requires a top-down approach which must be complemented with a bottom-up response to be effective. Here we investigate a n...
veterinary data surveillance diseases Leer másBACKGROUND: Chronic spontaneous urticaria (CSU) can be extremely debilitating to the patient and challenging for the treating clinician. The National Institute of Health and Clinical Excellence (NICE)...
treatment csu options immunosuppressive omalizumab patients Leer másBACKGROUND: Oral food challenge (OFC) is useful for diagnosing food allergies and assessing tolerance, but severe reactions may occur during the procedure. OBJECTIVE: To characterize the frequency and...
challenge tests patients ige-mediated anaphylaxis oral food ofc milk cm Leer másPURPOSE: Asthma is a complex, heterogeneous chronic inflammatory airway disease with multiple phenotypes. There has been a great progress in managing asthma, but there are still unmet needs for develo...
airway allergic inflammation asthma cell oaa mast Leer másPURPOSE: Recent studies had shown that gut microbiota played a significant role in the development of the immune system and may affect the course of airway allergic disease. We conducted this study to...
microbiota level microbial disease sequencing asthma gut significantly children rhinitis Leer másBACKGROUND: The specificity of extract‐based pollen allergy diagnosis is decreased due to cross‐reactivity via cross‐reactive carbohydrate determinants (CCDs) or panallergens such as profilins or polc...
100% misdiagnosis positive seasonal pollen diagnosis allergy sensitivity patients Leer másBackground: Coronavirus disease-2019 (COVID-19) has significantly hampered the regular workflow for allergists and allergy departments. Materials and methods: The purpose of this review is to highligh...
tests patients anaphylaxis vaccines vaccination reactions allergy Leer másBACKGROUND: Exposure to smoking is recognized as a health hazard; however, a longitudinal analysis of the impact of smoking exposure in families on the allergic reactions related to childhood atopic d...
atopic cotinine urine prevalence study months childhood significantly p < 0 levels children Leer másINTRODUCTION: In allergy diagnostics, component-resolved diagnostics (CRD) allows the clinician to assess the presence of specific IgE (sIgE) to allergenic proteins. Molecular diagnostics has improved...
panallergen georgian diagnostics population 0% nsltp patients plant ige sensitization pr-10 allergic 0 Leer másBACKGROUND: Autophagy protein 5 (ATG5) regulates airway epithelial cell autophagy, immune response, and inflammation, which is involved in asthma progression. This study aimed to evaluate ATG5 levels ...
inflammation serum autophagy 001 asthma patients p < 0 atg5 positively adult exacerbation p = 0 Leer másBACKGROUND: To compare the safety and efficacy between endoscopic sinus surgery and different biologics in treating chronic rhinosinusitis with nasal polyps in adults by reviewing the existing clinica...
surgery sinus scores chronic polyps trials endoscopic rhinosinusitis ess dupilumab efficacy nasal Leer másBACKGROUND: Secretory immunoglobulin A (sIgA) plays an important role in antiviral protective immunity. Although salivary testing has been used for many viral infections, including severe acute respir...
infections infection results serum salivary subjects samples spike–specific antibody total iga igg Leer másBACKGROUND: Oral immunotherapy (OIT) can help children with persistent food allergies achieve sustained unresponsiveness (SU). However, the optimal therapeutic period for obtaining SU remains unclear....
oral rate median iqr su period py peanut oit Leer másBACKGROUND: The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised meth...
associated reduced normallf asthma genetic function lung reducedlf clusters late‐onset Leer másINTRODUCTION: Acne vulgaris is a prevalent skin disorder influenced by a variety of factors, including a high body mass index (BMI) and obesity. AIM: To investigate the association between BMI z-score...
results index severity body mass acne bmi Leer másBACKGROUND: The impact of non‐pharmacological interventions (NPIs) on asthma prevention and management is insufficiently examined. We aim to comprehensively evaluate and synthesize existing evidence r...
review adulthood adults quality various management reviews interventions course prevention npis control evidence Leer másBACKGROUND: Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critic...
allergy activation Leer másINTRODUCTION: Skin diseases affect patients at any age, but as each period in life is different, tools used to assess quality of life impairment should be adjusted according to the particular age grou...
time teenagers life 0 quality Leer másBACKGROUND: Severe Congenital Neutropenia type 4 (SCN4), is a rare autosomal recessive condition, due to mutations in the G6PC3 gene. The phenotype comprises neutropenia of variable severity and accom...
neutropenia congenital Leer másDrug reaction with eosinophilia and systemic symptoms, known by its acronym in English as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms), clinically manifests with fever, facial edema, ...
review eosinophilia dress Leer másThe number of implanted joint prostheses and damaged spinal components is steadily increasing. At the same time, rejection of the implanted material is observed in operated patients, which manifests i...
material patients metal implanted Leer másBACKGROUND: Activated phosphoinositide3-kinase (PI3K) δ syndrome 1 (APDS1) is a novel inborn errors of immunity (IEIs) caused by heterozygous gain of function mutations in PI3Kδ catalytic p110δ (PIK3C...
report variant thrombocytopenia patient sirolimus syndrome Leer másPURPOSE: Eosinophilic asthma (EA) and non-asthmatic eosinophilic bronchitis (EB) share similar eosinophilic airway inflammation. Unlike EA, EB did not present airway hyperresponsiveness or airflow obs...
sequencing rna growth expression fcn1+ macrophages cells airway gene analysis sputum eosinophilic compared Leer másBACKGROUND: The mainstay of treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is systemic corticosteroid therapy; some patients also receive intravenous immunoglobulins, other immunos...
egpa dose responders eosinophil daily bvas rates p < 0 01 lower patients visit super-responders mepolizumab relapse treatment Leer másBACKGROUND: Eosinophilic gastritis (EoG) has rarely been reported in conjunction with gluten-sensitive enteropathy (GSE). When this does occur, patients typically present with gastrointestinal symptom...
report omalizumab eog hypoproteinemia Leer másMore than 10 years ago, the British Society for Allergy and Clinical Immunology (BSACI) published guidelines for the management of egg allergy [1]. For the first time, these included a stepwise plan f...
introduction food hen’s egg ladder Leer másUtilizamos cookies y otras tecnologías similares para :
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