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ErkundenNeuroinflammation plays an important role in the pathophysiology of Alzheimer's disease. The cannabinoid type 2 receptor (CB2R) is an emerging target for neuroinflammation and therapeutics of Alzheime...
immunofluorescence mouse model imaging 17-month-old autoradiography specific 24 months expression 17 age mice arcaß disease ntl alzheimer neuroinflammation cb2r Mehr lesenOBJECTIVE(S): We evaluated the relationship between regional accumulations of the tau positron emission tomography (PET) tracer THK5351 and cognitive dysfunction in the Alzheimer's disease (AD) contin...
alzheimer adas bilateral mean parietotemporal thk5351 pet scores ad accumulations Mehr lesenINTRODUCTION: Previous studies have applied normative modeling on a single neuroimaging modality to investigate Alzheimer Disease (AD) heterogeneity. We employed a deep learning-based multimodal nor...
ad individual-level modeling alzheimer abnormality normative disease atn Mehr lesenOBJECTIVE: To study the clinical effect of nano drug particles in the diagnosis and treatment of Alzheimer's disease in the elderly, we promote the research on the treatment of Alzheimer's disease and...
level elderly diagnosis research clinical alzheimer disease treatment control Mehr lesenNo disease-modifying therapies are currently available for Alzheimer’s disease (AD) in Europe. Current evidence from clinical trials testing anti-beta amyloid (Aβ) monoclonal antibodies (mAbs) in pati...
expert opinion alzheimer italy disease-modifying therapies monoclonal antibodies therapies clinical center ad Mehr lesenFinding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new s...
nanoparticles alzheimer treatment disease Mehr lesenProlonged exposure to glucocorticoids, the main stress hormones, damages the brain and is a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid-related neurotoxicit...
mitochondria pore permeability disease transition alzheimer tau Mehr lesenEarly detection of Alzheimer's disease's precursor stages is imperative for significantly enhancing patient outcomes and quality of life. This challenge is tackled through a semi-supervised multi-mo...
introduce multi-modal alzheimer hypergraph Mehr lesenInternational audience; Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including accumulation of abnormal proteins...
dementia alzheimer csf markers sequence disease cognitive latent time clinical progression Mehr lesenInternational audience; Developed as a regulator of copper homeostasis in the brain of patients affected by Alzheimer's disease (AD), TDMQ20 is a specific copper(II) chelator able to res...
alzheimer chelator disease tdmq20 copper Mehr lesenBackground Caring for a person with Alzheimer’s disease is stressful for caregivers. So that, considering all the emotional and financial costs imposed on the families of Alzheimer’s patients, stress ...
stress management validity reliability psychometrics properties alzheimer results csms designed factor validity analysis patients caregivers caring care alzheimer’s family items study management stress scale Mehr lesenFinding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new s...
nanoparticles alzheimer treatment disease Mehr lesenInternational audience; Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including accumulation of abnormal proteins...
dementia alzheimer csf markers sequence disease cognitive latent time clinical progression Mehr lesenBackground Evidence on the relative risk of death across all stages of Alzheimer’s disease (AD) is lacking but greatly needed for the evaluation of new interventions. We used data from the Uniform Dat...
mortality alzheimer mild cognitive impairment prodromal ad predementia comorbidity institution study stage relative severity alzheimer’s participants mortality dementia death risk Mehr lesenBackground This systematic review synthesizes the most recent neuroimaging procedures and machine learning approaches for the prediction of conversion from mild cognitive impairment to Alzheimer’s dis...
systematic review alzheimer mild cognitive impairment prediction neuroimaging machine learning neuroimaging systematic Mehr lesenInternational audience; The link between Alzheimer's disease (AD) and network hypersynchrony-manifesting as epileptic activities-received considerable attention in the past decade. Howev...
alzheimer model noradrenergic transmission cycle tg2576 disease Mehr lesenThe causal influence of sarcopenia on cardiometabolic disease and Alzheimer's disease and whether and to what extent insulin resistance plays a mediating role therein were unclear. We performed two‐st...
strength grip effect associations alm [1 causal insulin resistance cardiometabolic traits sarcopenia‐related walking pace alzheimer disease Mehr lesenPurpose Predicting the progression of MCI to Alzheimer's disease is an important step in reducing the progression of the disease. Therefore, many methods have been introduced for this task based on ...
based computer science roi method results disease alzheimer rois Mehr lesenIntroduction Alzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. Blood is frequently used as a source for biomarkers; however, its complexity prevents pro...
alzheimer metabolites biomarker serum nuclear magnetic resonance single molecule array panel involved ad Mehr lesenThe retrosplenial cortex (RSC) plays a significant role in spatial learning and memory and is functionally disrupted in the early stages of Alzheimer's disease (AD). In order to investigate neurophysi...
alzheimer formation learning disease underlie neurophysiological retrosplenial cortex cortical neuronal novelty spatial spiking bursts mice memory bursting Mehr lesenThis study aimed to develop new equations to estimate cardiorespiratory fitness specifically for older adults and, secondly, to analyze the associations of cardiorespiratory fitness, both objectively ...
alzheimer cognitive impairment physical fitness aerobic capacity aging adults associated tests measured objectively set cardiorespiratory estimated cognitive Mehr lesenAlzheimer's disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins i...
mutation disease alzheimer amyloid-β peptides connectivity pathology osa synaptic osaka cerebral Mehr lesenBackground Evidence on the relative risk of death across all stages of Alzheimer’s disease (AD) is lacking but greatly needed for the evaluation of new interventions. We used data from the Uniform Dat...
mortality alzheimer mild cognitive impairment prodromal ad predementia comorbidity institution study stage relative severity alzheimer’s participants mortality dementia death risk Mehr lesenAlzheimer's Disease is a devastating neurological disorder that is increasingly affecting the elderly population. Early and accurate detection of Alzheimer's is crucial for providing effective treat...
mri detection alzheimer disease Mehr lesenEmerging plasma biomarkers of Alzheimer's disease might be non-invasive tools to trace early Alzheimer's disease-related abnormalities such as the accumulation of amyloid-beta peptides, neurofibrillar...
non-carriers levels concentrations carriers mutation autosomal tau dominant p-tau181 nfl gfap alzheimer Mehr lesenBackground Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disorder for which no successful therapeutics are available. Valproic acid (VPA), a monocarboxylate derivative, is a kno...
amyotrophic lateral sclerosis monocarboxylate transporter 1 sodium-coupled monocarboxylate tra... neuroprotection valproic acid mt lines monocarboxylate uptake wt vpa als Mehr lesenAxonal transport ensures long-range delivery of essential cargoes between proximal and distal compartments, and is needed for neuronal development, function, and survival. Deficits in axonal transport...
axonal transport amyotrophic lateral sclerosis motor neuron bdnf trkb p75 mice fmns vivo als bdnf transport Mehr lesenA central event in the pathogenesis of motor neuron disease (MND) is the loss of neuromuscular junctions (NMJs), yet the mechanisms that lead to this event in MND remain to be fully elucidated. Mainte...
amyotrophic lateral sclerosis als neuromuscular junction musk agrin motor neurons acetylcholine receptors patients muscle mnd Mehr lesenObjective To translate Amyotrophic Lateral Sclerosis-Specific Quality of Life-Short Form (ALSSQOL-SF) and test its reliability and validity, so that explore feasibility in Chinese mainland and make up...
amyotrophic lateral sclerosis quality of life scale chinese adaptation reliability validity als version patients chinese quality alssqol-sf validity 0 reliability c-alssqol-sf Mehr lesenBackground When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their jeopa...
stroke traumatic brain injury sudden cardiac arrest concussion modeling migraine ischemia na/k pump huntington's disease alzheimer's disease amyotrophic lateral sclerosis ketamine penumbra persistent vegetative state dendritic beading brain swelling neurons brain glutamate blood sd Mehr lesenBackground Prior studies on the role of gut-microbiome in Amyotrophic Lateral Sclerosis (ALS) pathogenesis have yielded conflicting results. We hypothesized that gut- and oral-microbiome may different...
amyotrophic lateral sclerosis microbiome lou gehrig’s disease disease associated subtypes gut- oral-dysbiosis = 0 ratio symptoms sals translocation blood f/b- bals als 0001 < 0 gut-dysbiosis Mehr lesenAmyotrophic lateral sclerosis (ALS) is a rare, incurable, and fatal neurodegenerative disease with median survival time from onset to death ranging from 20 to 48 months. Breaking bad news about ALS di...
breaking bad news amyotrophic lateral sclerosis diagnosis communication bad breaking news als Mehr lesenDysfunction and degeneration of synapses is a common feature of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene is the...
c9orf72 amyotrophic lateral sclerosis frontotemporal dementia synapsin synapse reduced c9als/ftd hippocampal haploinsufficiency als/ftd excitatory interaction synapsin Mehr lesenPurpose Amyotrophic lateral sclerosis (ALS) is a progressive motor impairment leading to early death. Religiousness is one of the factors potentially alleviating the psychological burden of patients. ...
amyotrophic lateral sclerosis religiosity depression quality of life pain culture psychological disease cultural controls functional patients als Mehr lesenBackground Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by the gradual loss of upper and lower motor neurons that leads to progressive muscle atrophy and wea...
edaravone amyotrophic lateral sclerosis adverse effect safety mean study als edaravone patients Mehr lesenALCAR (Acetyl-L-carnitine) is a donor of acetyl groups and increases the intracellular levels of carnitine, the primary transporter of fatty acids across the mitochondrial membranes. In vivo studies s...
observational study treatment amyotrophic lateral sclerosis neurological disease case–control efficacy nor baseline compared treated subjects 0 Mehr lesenBackground Home-monitoring of spirometry has the potential to improve care for patients with a motor neuron disease (MND) by enabling early detection of respiratory dysfunction and reducing travel bur...
motor neuron disease amyotrophic lateral sclerosis respiratory function vital capacity remote monitoring validity test tests supervised patients vc unsupervised home-monitoring mnd Mehr lesenAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle weakness. Presence of pain in ALS patients is heterogeneously reported in studies, and mostly und...
amyotrophic lateral sclerosis pain pain management medication therapy management pharmacological systematic review trials clinical five efficacy strategies patients als management Mehr lesenBackground Amyotrophic lateral sclerosis (ALS) is characterized by a rapid disease course, with disease severity being associated with declining health-related quality of life (HRQoL) in persons livin...
amyotrophic lateral sclerosis quality of life patient-reported outcomes disease progression real-world evidence disease stages als clinical outcomes cals Mehr lesenBackground Amyotrophic lateral sclerosis (ALS) is a degenerative disease that affects the upper and lower motor neurons. The onset of the disease is frequently focal, usually involving the distal segm...
amyotrophic lateral sclerosis split foot index split elbow index split leg index cmap sfi significantly index amplitude muscle related disease als Mehr lesenBackground Using the Clinical Audit Research and Evaluation of Motor Neuron Disease (CARE-MND) database and the Scottish Regenerative Neurology Tissue Bank, we aimed to outline the genetic epidemiolog...
motor neuron disease amyotrophic lateral sclerosis genetic epidemiology genotype-phenotype sod1 c9orf72 mnd using variant sod1 pathogenic genetic expansion c9orf72 Mehr lesenBackground Amyotrophic lateral sclerosis (ALS) can present with either bulbar or spinal symptoms, and in some cases, both types of symptoms may be present. In addition, cognitive impairment has been o...
amyotrophic lateral sclerosis als cognitive impairment fab moca individuals cognitive als Mehr lesenObjective Half of ALS patients are cognitively and/or behaviourally impaired. As cognition/behaviour and cerebral glucose metabolism can be correlated by means of ^18F-Fluorodeoxyglucose positron emis...
amyotrophic lateral sclerosis cerebral glucose metabolism fdg-pet cognition grey matter volume cognitively patients results behaviourally cerebral als metabolism impaired alsni alsci alscbi glucose Mehr lesenBiallelic pathogenic repeat expansions in RFC1 were recently identified as molecular origin of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) as well as of one of the most commo...
repeat analysis oxford nanopore sequencing amyotrophic lateral sclerosis rfc1 mnd motor neuron disease additional clinical repeat mnd expansions rfc1 Mehr lesenAmyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the disease status...
amyotrophic lateral sclerosis cytokines short chain fatty acids ttv virome metabolism microbiome research patient Mehr lesenBiallelic pathogenic repeat expansions in RFC1 were recently identified as molecular origin of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) as well as of one of the most commo...
repeat analysis oxford nanopore sequencing amyotrophic lateral sclerosis rfc1 mnd motor neuron disease additional clinical repeat mnd expansions rfc1 Mehr lesenBackground New effective treatments for dementia are lacking, and early prevention focusing on risk factors of dementia is important. Non-pharmacological intervention therapies aimed at these factors ...
dementia population prediction alzheimer’s disease parkinson’s disease vascular dementia amyotrophic lateral sclerosis non-pharmacological intervention savings population cost eu costs eur potential therapies prevalence factors intervention dementia diseases neurodegenerative Mehr lesenBackground Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by the gradual loss of upper and lower motor neurons that leads to progressive muscle atrophy and wea...
edaravone amyotrophic lateral sclerosis adverse effect safety mean study als edaravone patients Mehr lesenAmyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent progression rates, t...
amyotrophic lateral sclerosis neuroimaging biomarkers motor neuron disease diffusion imaging clinical trials patients profiles subtypes clinical based disease Mehr lesenIntroduction Amyotrophic lateral sclerosis (ALS) is an inevitably fatal condition that leads to a progressive loss of physical functioning, which results in a high psychosocial burden and organization...
amyotrophic lateral sclerosis caregiver burden palliative care quality of care motor neuron disease psychosocial care pwals Mehr lesenBackground Despite the advent of neoadjuvant chemoradiotherapy (CRT), overall survival rates of esophageal adenocarcinoma (EAC) remain low. A readily induced mesenchymal transition of EAC cells contri...
expression study predictive models adenocarcinoma esophageal plasticity cancer crt mesenchymal patients nanog eac Mehr lesenBackground As the number of patients with inflammatory bowel disease (IBD) increases, the incidence of IBD-related colorectal cancer (CRC) is also on the rise. Crohn’s disease (CD)-related CRC has bee...
anal fistula cancer crohn’s disease inflammatory bowel disease colorectal cancer anorectal cancer examination under anesthesia coexistence multiple anesthesia disease tract anorectal cd-related perianal crc cancer anal cd fistula Mehr lesenObjective To evaluate the feasibility of an internet-facilitated community model for cervical cancer screening using self-collected HPV testing as primary screening. Method A population-based cervical...
cervical cancer screening internet-community model hpv testing self-collection positives samples participants hpv data assays screening women cancer cervical Mehr lesenNEK2 is a serine/threonine protein kinase that is involved in regulating the progression of various tumors. Our previous studies have found that NEK2 is highly expressed in gastric cancer and suggests...
nek2 ferroptosis hmox1 keap1/nrf2 levels studies promote probe nek2 hmox1 mechanism expression sensitivity level gastric cancer cells ferroptosis Mehr lesenBACKGROUND: Image-guided adaptive brachytherapy (IGABT) demonstrates an excellent local control rate and low toxicity while treating cervical cancer. For intracavitary/interstitial (IC/IS) brachythera...
bt brachytherapy sessions sharp cervical interstitial needles cancer round needle Mehr lesenObjectives To explore the impact of visceral obesity (VO) measured by preoperative abdominal computed tomography (CT) on postoperative infectious complications for colorectal cancer (CRC) patients and...
visceral obesity colorectal cancer postoperative infectious complicat... predictive model machine learning model results infection study visceral obesity = 0 ci infectious 95% complications 001 colorectal or = 2 cancer < 0 postoperative Mehr lesenPancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the Western world. The number of diagnosed cases and the mortality rate are almost equal as the majority ...
pancreatic cancer genetic cancer risk heritability high-risk screening individuals blup pancreatic pdac cancer Mehr lesenBackground The effect of maternal diabetes on childhood cancer has not been widely studied. Methods We examined this in two population-based studies in Denmark ( N = 6420 cancer cases, 160,484 contro...
0 denmark taiwan risk childhood ci 95% gestational cancer diabetes maternal Mehr lesenIn 2021, breast cancer accounted for a substantial proportion of cancer cases and represented the second leading cause of cancer deaths among women worldwide. Although tumor cells originate from norma...
ginsenoside breast cancer hallmarks of cancer apoptosis epithelial-mesenchymal transition cell growth therapeutic cancer hallmarks breast Mehr lesenAim To evaluate and identify predictors of psychosocial distress (PD) in patients after surgical treatment for prostate cancer (PC), bladder cancer (BC), or kidney cancer (KC) during the COVID-19 pand...
psychosocial distress prostate cancer bladder cancer kidney cancer covid-19 pandemic identify partial < 0 independently significantly = 0 cancer surgical 001 radical ir pd kc Mehr lesenImmunotherapy is a promising approach for preventing postoperative tumor recurrence and metastasis. However, inflammatory neutrophils, recruited to the postoperative tumor site, have been shown to exa...
dox@sal combined postoperative cancer Mehr lesenColorectal cancer is a grievous health concern, we have proved long non-coding RNA LINC00689 is considered as a potential diagnosis biomarker for colorectal cancer, and it is necessary to further inve...
colorectal ptbp1 cancer klf15 Mehr lesenCancer-associated stroma (CAS) is widely recognized to influence development and progression of epithelial tumours including breast cancer. Canine mammary tumours (CMTs) such as simple canine mammary ...
stroma breast genes identify mammary canine cancer cmts stromal Mehr lesenBackground Although asbestos use is banned in many countries, long latency of asbestos-related diseases like pleural plaques or asbestosis mean it is still a public health issue. People suffering from...
microrna leukocytes serum pleural plaques asbestosis controls diseases risk asbestosis serum 0 value indicated cancer leukocytes suffering expression micrornas patients Mehr lesenIntroduction Colorectal cancer is the fourth most common cancer in the UK. There remains a need for improved risk stratification following curative resection. Circulating-tumour DNA (ctDNA) has gained...
colorectal curative following review cancer ctdna studies Mehr lesenBackground Acrometastasis is an uncommon finding in non-small cell lung cancer and is usually a sign of multimetastatic disease. Few case reports have suggested solitary digital metastasis as the sing...
acrometastasis oligometastatic lung adenocarcinom... phalanx metastasis non-small presentation digital cancer cell lung Mehr lesenAddressing the global challenge of breast cancer, this research explores the fusion of generative AI, focusing on ChatGPT 3.5 turbo model, and the intricacies of breast cancer risk assessment. The r...
language reasoning chatgpt breast cancer Mehr lesenSIMPLE SUMMARY: Oral squamous cell carcinoma (OSCC) constitutes more than 90% of head and neck cancers and a high prevalence rate in some parts of the world. Alcohol consumption, use of snuff, and sev...
-9 cancer activation death human oscc cells cell oral ho-1 Mehr lesenBACKGROUND: Colon cancer is a common gastrointestinal malignancy. It has been discovered that Farnesoid X receptor (FXR) plays an imperative regulatory role in multitype cancers in recent years. Howev...
regulatory inhibited gene cancer colon cells phosphorylation dhrs9 oxidative Mehr lesenPurpose Tumor necrosis factor exerts many adverse biological effects, from cell proliferation to cell death. Accurate diagnosis and treatment are therefore difficult due to many factors influencing tu...
endometrial cancer tnf-α mirna tnf signaling expression profile factor related nfkb1 activity tnfr1 cav1 protein using expression tnf-α tumor necrosis cancer endometrial signaling Mehr lesenBackground Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely modulate...
post gwas breast cancer risk functional phenotypic screens target discovery loci variants genes identifying risk breast screens gwas targets cancer Mehr lesenBackground and objective Up to 90% of patients with castration-resistant prostate cancer (CRPC) will develop symptomatic bone metastases requiring pain medication, with opioids being the mainstay of t...
auc_0–8 h cancer enz-arm control 001 _max prostate exposure arm oxycodone enzalutamide Mehr lesenBackground This study investigated cause-specific mortality rates in 12 countries during the COVID-19 pandemic in 2020 and 2021. Methods We collected weekly cause-specific mortality data from respirat...
cause-specific mortality covid-19 cardiovascular diseases cancer respiratory tract infections public health measures countries georgia study cumulative and/or associated increased northern ireland excess cause-specific 2020 pneumonia respiratory 2021 Mehr lesenSIMPLE SUMMARY: The expression of androgen receptor variants (AR-Vs) is associated with the development of advanced castration-resistant prostate cancers (CRPCs), while prostate cancer stem cells (PCS...
stem-like signaling cd133 androgen properties jag1 prostate jicd overexpression expression cancer cell pc cells Mehr lesenBackground Pneumonia in cancer patients is often problematic in order to decide whether to admit and administer antibiotics or pursue a comfort care pathway that may avoid in-hospital death. We aimed ...
cancer pneumonia in-hospital mortality rate prognosis lymphocyte oxygen pulse admission pps ci 95% Mehr lesenA fundamental concept related to strings is that of repetitions. It has been extensively studied in many versions, from both purely combinatorial and algorithmic angles. One of the most basic questi...
\log string repetitions strings n^2 $ quartics Mehr lesenThough images are ubiquitous across Wikipedia, it is not obvious that the image choices optimally support learning. When well selected, images can enhance learning by dual coding, complementing, or ...
gujia wikipedia images Mehr lesenWe study the design of auctions with dynamic scoring, which allocate a single item according to a given scoring rule. We are motivated by online advertising auctions when users interact with a platf...
delay session information ad market platform auctioneer quality auction Mehr lesenIn this article we address the colony maintenance problem, where a team of robots are tasked with continuously maintaining the energy supply of an autonomous colony. We model this as a global game, ...
energy colony forage positive feedback robots Mehr lesenLow Earth Orbit Satellite Networks such as Starlink promise to provide world-wide Internet access. While traditionally designed for stationary use, a new dish, released in April 2023 in Europe, prov...
measurements car internet power mobile Mehr lesenLarge Language Models (LLMs) as chatbots have drawn remarkable attention thanks to their versatile capability in natural language processing as well as in a wide range of tasks. While there has been...
language systems Mehr lesenNeural Radiance Fields (NeRFs) have shown impressive results for novel view synthesis when a sufficiently large amount of views are available. When dealing with few-shot settings, i.e. with a small ...
few-shot views nerf Mehr lesenIn this paper, we follow the physics guided modeling approach and integrate a neural differential equation network into the physical structure of a vehicle single track model. By relying on the kine...
guided vehicle differential model Mehr lesenWe revisit two fundamental decentralized optimization methods, Decentralized Gradient Tracking (DGT) and Decentralized Gradient Descent (DGD), with multiple local updates. We consider two settings a...
updates gradient dgt decentralized Mehr lesenTransformers have widely adopted attention networks for sequence mixing and MLPs for channel mixing, playing a pivotal role in achieving breakthroughs across domains. However, recent literature high...
state-of-the-art benchmarks learning mamba networks systems sequence science Mehr lesenScheduling a task graph representing an application over a heterogeneous network of computers is a fundamental problem in distributed computing. It is known to be not only NP-hard but also not polyn...
approach scheduling task Mehr lesenObject counting is pivotal for understanding the composition of scenes. Previously, this task was dominated by class-specific methods, which have gradually evolved into more adaptable class-agnostic...
categories science omnicount multiple Mehr lesenWith the exponential growth of data and its crucial impact on our lives and decision-making, the integrity of data has become a significant concern. Malicious data poisoning attacks, where false val...
trimming poisoning attacks model data Mehr lesenPreference-based reward learning is a popular technique for teaching robots and autonomous systems how a human user wants them to perform a task. Previous works have shown that actively synthesizing...
parameters computer science function reward Mehr lesenIn this paper we investigate formal verification problems for Neural Network computations. Of central importance will be various robustness and minimization problems such as: Given symbolic specific...
neural networks network inputs Mehr lesenIn this paper, we introduce an improved approach of speculative decoding aimed at enhancing the efficiency of serving large language models. Our method capitalizes on the strengths of two establishe...
draft models decoding approach speculative language Mehr lesenSingle RGB or LiDAR is the mainstream sensor for the challenging scene flow, which relies heavily on visual features to match motion features. Compared with single modality, existing methods adopt a...
complementary knowledge features motion space visual scene Mehr lesenExisting person re-identification methods have achieved remarkable advances in appearance-based identity association across homogeneous cameras, such as ground-ground matching. However, as a more pr...
re-identification person vdt Mehr lesenMobile robots are being used on a large scale in various crowded situations and become part of our society. The socially acceptable navigation behavior of a mobile robot with individual human consid...
robots learning approaches computer systems social robot science approach navigation behavior Mehr lesenUnsupervised semantic hashing has emerged as an indispensable technique for fast image search, which aims to convert images into binary hash codes without relying on labels. Recent advancements in t...
unsupervised computer method search distillation Mehr lesenAccurately handling the underlying support values in sentences is crucial for understanding the speaker's tendencies, yet it poses a challenging task in natural language understanding (NLU). In this...
models Mehr lesenIn this work, we introduce the Virtual In-Hand Eye Transformer (VIHE), a novel method designed to enhance 3D manipulation capabilities through action-aware view rendering. VIHE autoregressively refi...
in-hand tasks virtual vihe Mehr lesenIn this paper, we explore the visual representations produced from a pre-trained text-to-video (T2V) diffusion model for video understanding tasks. We hypothesize that the latent representation lear...
model diffusion noise video Mehr lesenTo solve high-dimensional parameter-dependent partial differential equations (pPDEs), a neural network architecture is presented. It is constructed to map parameters of the model data to correspondi...
afem solution architecture error network Mehr lesenThe $\mathrm{Caus}[-]$ construction takes a base category of ``raw materials'' and builds a category of higher order causal processes, that is a category whose types encode causal (a.k.a. signalling...
consistency pomset constraints category graph types logic processes causal Mehr lesenBACKGROUND: Around one in ten people who contract Covid-19 report ongoing symptoms or ‘Long Covid’. Without any known interventions to cure the condition, forms of self-management are routinely prescr...
self-management experience experiences everyday strategies condition people self-generated life covid Mehr lesenBackground Around one in ten people who contract Covid-19 report ongoing symptoms or ‘Long Covid’. Without any known interventions to cure the condition, forms of self-management are routinely prescri...
long covid self-management lived experience narrative qualitative research covid-19 experiences experience everyday condition self-generated people strategies life covid Mehr lesenBackground Studies estimate that at least 7.5% of adults are affected by long-term symptoms such as fatigue or cognitive impairment after the acute phase of COVID-19. COVID-19 vaccination may reduce t...
long covid sars-cov-2 covid-19 vaccination rehabilitation germany qualitative study experiences symptoms qualitative people covid participants vaccination study covid-19 reported Mehr lesenIt is well known the potential of severe acute respiratory coronavirus type 2 (SARS-CoV-2) infection to induce post-acute sequelae, a condition called Long COVID. This syndrome includes several sympto...
cns covid-19 plasma = 0 neurocognitive covid pnfl Mehr lesenPURPOSE: Long COVID brain fog is often disabling. Yet, no empirically-supported treatments exist. This study’s objectives were to evaluate feasibility and efficacy, provisionally, of a new rehabilitat...
treatment pilot findings rct randomized cognitive covid adults iadl immediate-cict tau cict brain fog Mehr lesenBackground Public transportation plays a major role in the transmission of SARS-CoV2, the virus that causes COVID-19, due to the confined spaces in vehicles. It is therefore very crucial to apply COVI...
covid-19 public transportation public transport operators covid-19 preventive measures study risk eastern uganda epidemic aware included interviews participants awareness perceptions public transportation covid-19 perceived covid passengers barriers operators challenges 19 preventive transmission transport measures Mehr lesenINTRODUCTION: The relationship between SARS-CoV-2 viral dynamics during acute infection and the development of long COVID is largely unknown. METHODS: A total of 7361 asymptomatic community-dwelling p...
study times infection development load associated ci covid sars-cov-2 acute 0 arr 95% viral Mehr lesenBackground The COVID-19 pandemic further propelled the recent growth of telemedicine in low-resource countries, with new models of telemedicine emerging, including volunteer-based telemedicine network...
telemedicine volunteerism medical providers incentives covid india stated volunteer-based maintain financial practitioners health networks covid-19 incentives pandemic Mehr lesenINTRODUCTION: The relationship between SARS-CoV-2 viral dynamics during acute infection and the development of long COVID is largely unknown. METHODS: A total of 7361 asymptomatic community-dwelling p...
study times infection development load associated ci covid sars-cov-2 acute 0 arr 95% viral Mehr lesenSince the outbreak in Wuhan (China) at the end of 2019, the Coronavirus Disease 2019 (COVID-19) pandemic has caused instability at various levels of society. While most patients completely recover fro...
long covid covid-19 sars-cov-2 quality of life oncology study impact infection patients covid cancer Mehr lesenBackground Around one in ten people who contract Covid-19 report ongoing symptoms or ‘Long Covid’. Without any known interventions to cure the condition, forms of self-management are routinely prescri...
long covid self-management lived experience narrative qualitative research covid-19 experiences experience everyday condition self-generated people strategies life covid Mehr lesenINTRODUCTION: The novel and expanding field of long COVID research has undergone diverse methodological approaches in recent years. This protocol lays out the methodological approach, which aims at id...
data covid cognitive research Mehr lesenBackground Seeking and obtaining effective health care for Long COVID remains a challenge in the USA. Women have particularly been impacted, as they are both at higher risk of developing Long COVID an...
long covid women qualitative post covid access to care quality of care 30 seen care women symptoms clinic experiences covid Mehr lesenBackground Pain is one of the prevalent Long COVID Symptoms (LCS). Pain interferes with the quality of life (QoL) and induces disease burden. Purpose The study aimed to elicit the clinical presentatio...
long covid pain quality of life bangladesh study bangladesh 1% pain 95% ci covid quality life Mehr lesenThe patient experience is a variable that has been neglected or even ignored for a long time in the health field, even if it is an important resource for improving and adapting patient ...
légitimation experience patients health patient covid processus process Mehr lesenBackground Long covid (post covid-19 condition) is a complex condition with diverse manifestations, uncertain prognosis and wide variation in current approaches to management. There have been calls fo...
long covid covid-19 post-covid-19 syndrome quality improvement breakthrough collaboratives warranted variation unwarranted variation improvement science ethnography idiographic reasoning nomothetic reasoning clinics patients individual reasoning quality condition guidelines evidence-based improvement covid Mehr lesenMany conventional research methods employed in randomized controlled trials were not possible during the height of the COVID-19 pandemic. In particular, behavioral observations are nearly universally ...
observational research observational methodology parenting covid military families parenting in-person reliability methods collected collection observational data remote Mehr lesenBackground In December 2019, a cluster of patients with pneumonia of undetermined etiology was recognized in Wuhan, Hubei, China. Subsequently, a novel coronavirus (Severe Acute Respiratory Distress S...
git symptoms covid 19 diarrhea nausea vomiting coronavirus severe respiratory tract clinical symptoms covid 19 patients covid-19 rectal pcr manifested Mehr lesenThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition characterized by persistent symptoms following the resolution o...
long covid mitochondrial dysfunction chronic fatigue post-infectious syndromes oxidative stress therapeutic strategies metabolic disturbances potential symptoms dysfunction covid mitochondrial Mehr lesenBackground Studies estimate that at least 7.5% of adults are affected by long-term symptoms such as fatigue or cognitive impairment after the acute phase of COVID-19. COVID-19 vaccination may reduce t...
long covid sars-cov-2 covid-19 vaccination rehabilitation germany qualitative study experiences symptoms qualitative people covid participants vaccination study covid-19 reported Mehr lesenMany conventional research methods employed in randomized controlled trials were not possible during the height of the COVID-19 pandemic. In particular, behavioral observations are nearly universally ...
observational research observational methodology parenting covid military families parenting in-person reliability methods collected collection observational data remote Mehr lesenZang et al. use RECOVER EHR data to study Long COVID risk factors and apply mathematical modeling to predict the development of long COVID conditions. They find that severe acute SARS-CoV-2 infection,...
modeling pulmonary covid conditions factors predict develop associated risk acute Mehr lesenThe patient experience is a variable that has been neglected or even ignored for a long time in the health field, even if it is an important resource for improving and adapting patient ...
légitimation experience patients health patient covid processus process Mehr lesenBACKGROUND: China was the last country in the world to relax COVID-19 restrictions. A successful public health policy requires public support. This analysis examined the factors associated with Chines...
covid fatigue results collectivism predicted positively china negatively liberty public restrictions policy zero-covid relaxing support Mehr lesenObjective: We present a simple parameter, calculated from a single wearable sensor, that can be used to objectively measure disease severity in people with myalgic encephalomyelitis/chronic fatigue ...
measure healthy steps/day controls subjects objective disease severity covid 0 $\mathbf{p Mehr lesenBackground Women with HIV have a higher risk of getting cervical cancer due to induced immunosuppression. Though this burden could be avoided through early identification and appropriate management, t...
cervical cancer cancer screening hiv factors utilization uganda study referral hospital regional 001 < 0 cancer cervical lira adjusted screening 95% pr factors services associated women ccs ci utilization hiv-positive 0 Mehr lesenBACKGROUND: To propose a new mode of HIV test and surveillance among population of men who have sex with men (MSM): Internet-based Self-sampling at home plus Laboratory testing of HIV total nucleic ac...
online surveillance results sentinel test dbs isl hiv Mehr lesenBackground Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently described autoimmune inflammatory disorder of the central nervous system (CNS). There is limited data o...
myelin oligodendrocyte glycoprotei... mogad opportunistic infections advanced hiv disease aquaporin-4 autoimmune diseases case report glycoprotein patient myelin oligodendrocyte mogad mog infection positive hiv antibodies Mehr lesenBackground and aims Liver-associated complications still frequently lead to mortality in people with HIV (PWH), even though combined antiretroviral treatment (cART) has significantly improved overall ...
pc3x pro-c5 pro-c6 hiv liver fibrosis hepatic steatosis endotrophin steatosis hiv significantly pro-c6 p = 0 fibrosis liver Mehr lesenInternational audience; HIV-1 Tat is a key viral protein that stimulates several steps of viral gene expression. Tat is especially required for the transcription of viral genes. Neverthe...
capsid enables cyclophilin production tat-cypa-ca encapsidated tripartite hiv-1 viral transcription hiv virions tat required protein complex Mehr lesenIntroduction Because cerebrospinal fluid (CSF) samples are difficult to obtain for paediatric HIV, few studies have attempted to profile neurometabolic dysregulation. Aim and objective The aim of thi...
paediatric hiv cerebrospinal fluid (csf) hiv-associated neurocognitive diso... gcxgc-tof ms csf metabolic profile size paediatric cohort hiv Mehr lesenOBJECTIVES: In 2014, Ontario’s Point-of-Care (POC) test providers were advised to focus efforts on provincially defined priority populations who experience a greater risk of HIV. Our objective was to ...
– confirmatory characteristics positivity positive poc 52 testing percent 7% hiv tests compared 0 test risk overall populations results Mehr lesenBACKGROUND: Uptake of HIV pre-exposure prophylaxis (PrEP) remains low among transgender people as compared to other subgroups, despite high rates of HIV acquisition. In California, Latinx people compr...
project research navigation phe transgender conducted hiv healthcare prep Mehr lesenBackground The community-based antiretroviral therapy delivery (CBART) model was implemented in Benue State in Nigeria to increase access of key populations living with HIV (KPLHIV) to antiretroviral ...
key populations hiv community-based antiretroviral the... art realist evaluation programme theory improve nigeria outcomes using model study ipt safe key delivery populations kplhiv benue programme hiv kp-cbart Mehr lesenBackground The emergence of HIV drug resistance presents a substantial challenge. Current antiretroviral treatments, along with current classes, face the danger of becoming partially or entirely inact...
hiv drug resistance treatment failure ethiopia using heterogeneity ethiopia meta-analysis hiv review systematic studies treatment resistance drug Mehr lesenBackground With access to antiretroviral therapy (ART) HIV infection is a chronic manageable condition and non-sexually transmissible. Yet, many people living with HIV still testify about experiencin...
hiv stigma people living with hiv sweden sweden available interventions scores emotional individual discrimination hiv status reported concerns people manifestations stigma Mehr lesenHalf of all people living with HIV (PLWH) in the United States are not retained in HIV medical care. The utility of appointment reminders and clinic-based retention support services is often limited b...
hiv communication care peer plwh plwh-ooc outreach preferences Mehr lesenOBJECTIVES: In 2019, the WHO released guidelines on HIV testing service (HTS). We aim to assess the adoption of six of these recommendations on HIV testing strategies among African countries. DESIGN: ...
strategies three-test national recommended strategy hts adopted testing countries hiv policies Mehr lesenBackground Understanding the impact of disease associations is becoming a priority in Kenya and other countries bearing the load of infectious diseases. With the increased incidences of non-communicab...
diabetes mellitus hiv antiretroviral therapy study diseases glucose mellitus associated diabetes patients hiv Mehr lesenBackground As children living with HIV transition from adolescence into adulthood, they face a considerable burden of psychiatric disorders (PDs) which may vary between the perinatally and behaviorall...
psychiatric disorders congenitally infected adolescents behaviourally infected hiv adolesc... botswana botswana associated infected psychiatric living adolescents disorders ci 95% pds or = 3 hiv alwhiv Mehr lesenBackground Abacavir is a nucleoside reverse transcriptase inhibitor that is used as a component of the antiretroviral treatment regimen in the management of the human immunodeficiency virus for both a...
abacavir abacavir hypersensitivity abc hsr *57:01 antiretroviral hiv virus immunodeficiency human antiretroviral report reaction treatment 01 *57 hla-b hypersensitivity Mehr lesenHIV remains a significant public health issue among young adults living in Uganda. There is a need for reliable and valid measures of key psychological and behavioural constructs that are related to i...
measures hiv young adults uganda validity validity preliminary measures Mehr lesenInternational audience; HIV-1 Tat is a key viral protein that stimulates several steps of viral gene expression. Tat is especially required for the transcription of viral genes. Neverthe...
capsid enables cyclophilin production tat-cypa-ca encapsidated tripartite hiv-1 viral transcription hiv virions tat required protein complex Mehr lesenINTRODUCTION: In Sofala province (Mozambique), young people living with HIV (YPLHIV) are estimated at 7% among people aged 15–24 years. Even though the COVID-19 pandemic threatened HIV health services...
0 sofala province aor positive 7% 8% antibodies seroprevalence based test hiv covid-19 people Mehr lesenBackground HIV testing in the Northern Kosovo province is challenging, because the infrastructure is being rebuilt after the ethnic conflict. The purpose of this research was to examine self-perceived...
hiv self-perceived risk knowledge of hiv prevention and tr... students kosovo lower self-perceived low prevention knowledge Mehr lesenBackground Understanding why patients experience loss to follow-up (LTFU) is essential for TB control. This analysis examines the impact of travel distance to RR-TB treatment on LTFU, which has yet to...
loss to follow-up care retention care engagement tuberculosis rifampicin-resistant tuberculosis multidrug-resistant tuberculosis hiv south africa south using rr-tb distance ltfu travel patients Mehr lesenBACKGROUND: Malaria and HIV are associated with preterm births possibly due to partial maternal vascular malperfusion resulting from altered placental angiogenesis. There is a paucity of data describi...
partial malperfusion weight vascular compared vs placentae births malaria hiv coinfection villous preterm Mehr lesenWhat is already known on this subject? To analyse and improve quality of care, a national maternal death review is recommended. In Namibia successful implementation was hampered by a blame culture. Ar...
namibia maternal mortality hiv local available improve reported blame implementation review maternal findings national deaths recommendations Mehr lesenBACKGROUND: KwaZulu-Natal ranked second highest among South African provinces for the number of laboratory-confirmed cases during the second wave of the severe acute respiratory syndrome coronavirus 2...
hiv-positive living hiv-negative south immunoglobulin kwazulu-natal wave people specimens hiv seroprevalence Mehr lesenINTRODUCTION: Our aim is to evaluate the implementation of an online telecoaching community-based exercise (CBE) intervention with the goal of reducing disability and enhancing physical activity and h...
living adults participants protocol follow-up month online exercise hiv intervention implementation cbe Mehr lesenVaccines against seasonal infections like influenza offer a recurring testbed, encompassing challenges in design, implementation, and uptake to combat a both familiar and ever-shifting threat. One of ...
respiratory theories challenges influenza infections vaccines Mehr lesenOBJECTIVES: To outline which infectious diseases in the pre-covid-19 era persist in children and adolescents in China and to describe recent trends and variations by age, sex, season, and province. DE...
44 remained influenza infectious 100 000 notifiable incidence china 2008 children adolescents Mehr lesenViral proteins frequently mutate to evade or antagonize host innate immune responses, yet the impact of these mutations on the molecular energy landscape remains unclear. Epistasis, the intramolecular...
pr8 analysis affinity epistasis virus p85β influenza dynamic communications long-range mutations ns1 allosteric Mehr lesenBACKGROUND: Influenza circulated at historically-low levels during 2020 and 2021 due to COVID-19 pandemic travel restrictions. In Australia, international arrivals to Australia were required to undert...
risk influenza australia Mehr lesenBackground Influenza is a contagious disease that affects people of all ages and is linked to considerable mortality during epidemics and occasional outbreaks. Moreover, effective immunological biomar...
severe influenza invasive mechanical ventilation co-expression network analysis hub gene differential correlation potential linked influenza gene using set hub genes Mehr lesenGraph-structured data and their related algorithms have attracted significant attention in many fields, such as influenza prediction in public health. However, the variable influenza seasonality, oc...
data influenza Mehr lesenInternational audience; Growth in pork production during the last decade in South Africa has escalated the risk of zoonotic pathogen emergence. This cross-sectional study was conducted t...
evidence africa molecular samples swine south farms viruses influenza Mehr lesenRecipients of chimeric antigen receptor-modified T (CAR-T) cell therapies for B-cell malignancies are immunocompromised and at risk for serious infections. Vaccine immunogenicity is unknown in this po...
influenza time b-cell baseline ≥1 antibody immunogenicity responses therapy Mehr lesenLet us study viruses and the role of sialic acids in their first step of reproduction, the attachment to cells. We begin our study with the help of the "Earth's virology course", created by Vincent R...
attachment sars-cov-2 influenza acid cells study Mehr lesenInternational audience; Myxovirus resistance protein 1 (MX1) and MX2 are homologous, dynamin-like large GTPases, induced upon interferon exposure. Human MX1 (HsMX1) is known to inhibit m...
viruses gtpase influenza hsmx1 protein region leucine conserved mx1 activity antiviral domain Mehr lesenInternational audience; Influenza infections remain a major and recurrent source of public health concern. Together with vaccines, antiviral drugs play a key role in the prevention and t...
repurposing virus treatment influenza antiviral drug Mehr lesenInfluenza virus infection can cause severe respiratory disease and is estimated to cause millions of illnesses annually. Studies of the contribution of the innate immune response to influenza A virus ...
influenza innate immune zebrafish infection model Mehr lesenAll data generated or analyzed during this study are included in this published article and its Additional files.;International audience; The global spread of avian influenza A viruses i...
evaluated epidemiological estimated [sdv evaluation according vaccination systematic strategies review influenza avian transmission models Mehr lesenInfluenza makes millions of people ill every year, placing a large burden on the healthcare system and the economy. To develop a treatment against influenza, we combined virucidal sialylated cyclodext...
h1n1 combined influenza Mehr lesenInternational audience; Porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza A virus (swIAV) are major pathogens of the porcine respiratory disease complex, bu...
measured viral influenza infections swine interference pigs virus respiratory swiav prrsv porcine Mehr lesenInfluenza poses a significant threat to public health, particularly among the elderly, young children, and people with underlying dis-eases. The manifestation of severe conditions, such as pneumonia...
host viruses computer science protein data influenza sequences Mehr lesenHaving a proper understanding of the impact of influenza is a fundamental step towards improved preventive action. This paper reviews findings from the Burden of Acute Respiratory Infections study on ...
influenza burden epidemiology spain portugal hospitalization vaccination prevention surveillance retrospective studies Mehr lesenBACKGROUND: Frequent waves of corona virus disease (COVID-19) and lack of specific drugs against that, warrant studies to reduce the morbidity and mortality of this pandemic disease. In this study, we...
pulmonary study covid-19 history influenza severity vaccination Mehr lesenInfluenza infection induces lung epithelial cell injury via programmed cell death. Glutathione, a potent antioxidant, has been reported to be associated with influenza infection. We hypothesized that ...
inhibition injury model murine cells metabolism glutathione cell infection death reductase influenza epithelial Mehr lesenBACKGROUND Influenza vaccination efficacy is reduced after hematopoietic stem cell transplantation (HSCT) and patient factors determining vaccination outcomes are still poorly understood. METHOD...
responding response titers influenza patient transplantation regression factors hsct vaccination Mehr lesenA suspected outbreak of influenza A and SARS-CoV-2 at a long-term care facility in Los Angeles County was months later, determined to not involve influenza. To prevent inadvertent transmission of infe...
influenza Mehr lesenBACKGROUND: Influenza vaccination is recommended in Canada for older adults and those with underlying health conditions due to their increased risk of severe outcomes. Further research is needed to id...
factors recommended identify 95% vaccine participants vaccination influenza risk canadian coverage adults severe outcomes Mehr lesenBackground With the progress of globalization, international mobility increases, greatly facilitating cross-border transmission of respiratory infectious diseases (RIDs). This study aimed to analyze t...
imported respiratory infectious di... influenza epidemiological characteristics associated factors china diseases influenza countries seasonality characteristics china imported rids Mehr lesenInternational audience; Tissue-resident memory (TRM) CD8+ T-cells play a crucial role in the protection against influenza infection but remain difficult to elicit using recombinant prote...
vaccine induces recombinant np nucleoprotein lung influenza cd8+ protection t-cells Mehr lesenBackground In Italy, since the 2020–2021 flu season, the flu vaccine recommendation was extended to all children aged 6 months to 6 years and quadrivalent Live-Attenuated Influenza Vaccine (qLAIV) was...
influenza children flu vaccination quadrivalent live attenuated influ... widespread immunization school-located vaccination program... 6% season qlaiv questionnaire families vaccinated schools preschools children influenza vaccine Mehr lesenBackground Bacteria in lung play an important role in sustaining lung health. Understanding the characteristics of bacteriomes in lesions of pulmonary tuberculosis (TB) patients, who excrete Mycobacte...
pulmonary tb lesions status of mtb excretion lung bacteriomes bacterial metacyc functions status lung excretion samples lesions nt tb-e bacteria mtb bacterial pulmonary tuberculosis tb-ne patients bacteriomes metacyc Mehr lesenBackground The dinucleotide alarmone diadenosine tetraphosphate (Ap4A), which is found in cells, has been shown to affect the survival of bacteria under stress. Results Here, we labeled Ap4A with biot...
kanamycin diadenosine tetraphosphate biofilm quorum sensing treated strain bacteria kanamycin Mehr lesenBackground Clostridioides difficile is a spore forming bacterial species and the major causative agent of nosocomial gastrointestinal infections. C. difficile spores are highly resilient to disinfecti...
bacterial spores laser tweezers raman spectroscopy raman spectroscopy ltrs c. difficile terbium spore raman disinfection hypochlorite Mehr lesenBackground Although Basidiomycota produce pharmaceutically and ecologically relevant natural products, knowledge of how they coordinate their primary and secondary metabolism is virtually non-existent...
aromatic acetaldehyde synthase basidiomycota metabolic flux psilocybin tryptophan encoding psilocybe metabolism psilocybin synthase -tryptophan genes biosynthesis Mehr lesenIntroduction Whole genome sequencing (WGS) of bacterial isolates can be used to identify antimicrobial resistance (AMR) genes. Previous studies have shown that genotype-based AMR has variable accuracy...
carbapenem microscan etest assembly methods anti-microbial drugs using assays cre gene ont-only wgs data sequencing assembly short-read methods genes results carbapenems Mehr lesenBackground: It is well known that carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a more problematic public health issue due to its widespread spread worldwide. In China, ST11-type CRKP i...
carbapenem-resistant ... st15 antibiotic resistance β-lactams whole genome sequencing (wgs) virulence factors homologous genes spread isolates crkp china Mehr lesen(1) Gut bacteriome, mycobiome, and virome of GA patients were substantially altered compared with controls. (2) GA-enriched bacteria and fungi include potential pathogens. (3) Multi-kingdom microbial ...
gouty arthritis whole-metagenome shotgun sequencin... gut bacteriome gut mycobiome gut virome microbiota dysbiosis multi-kingdom signatures arthritis microbial virome mycobiome bacteriome signatures votus control-enriched patients gut ga controls multi-kingdom Mehr lesenBackground Colorectal cancer (CRC) is a public health concern and the second most common disease worldwide. This is due to genetic coding and is influenced by environmental aspects, in which the gut m...
crc gut microbiota metagenomic metaproteomic metabolomic tumor marker diagnostic biomarker. study domain-containing gut using patients protein kinase control healthy crc microbiota Mehr lesenBackground: It is well known that carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a more problematic public health issue due to its widespread spread worldwide. In China, ST11-type CRKP i...
carbapenem-resistant ... st15 antibiotic resistance β-lactams whole genome sequencing (wgs) virulence factors homologous genes spread isolates crkp china Mehr lesenBackground Anaerobes are normal flora of the human body. However, they can cause serious infections in humans. Anaerobic bacteria are known to cause respiratory infections like pneumonia and acute exa...
anaerobic bacteria respiratory infections antimicrobial resistance genera anaerobic infections isolates patients respiratory Mehr lesenBackground Staphylococcus aureus , a commensal bacterium, colonizes the skin and mucous membranes of approximately 30% of the human population. Apart from conventional resistance mechanisms, one of th...
methicillin-resistant ... biofilm adhesion genes production staphylococcus ability aureus strong 94 isolates 5% Mehr lesenBackground Hospital infections such as ventilator-associated pneumonia (VAP) due to multidrug-resistant Klebsiella pneumoniae (MDR-KP) strains have increased worldwide. In addition, biofilm production...
combination therapy synergism synergistic effect colistin carbapenem-resistant ... multidrug resistant pathogen biofilm checkerboard method fractional inhibitory concentratio... planktonic pneumonia combination amikacin amoxicillin/clavulanate colistin meropenem combinations isolates biofilm Mehr lesenStudying the effects of the microbiome on the development of different types of cancer has recently received increasing research attention. In this context, the microbial content of organs of the gast...
microbiome pancreatic cancer biomarker treatment probiotics diagnosis prognosis cancer microbiome pc Mehr lesenDevelopment of new topical drugs requires an animal onychomycosis model that can predict the drug efficacy against moderate to severe human onychomycosis because the severity of onychomycosis varies a...
arthrospore in vivo model mycology severe onychomycosis topical antifungal drug efficacy drug topical tinea luliconazole 4-week unguium severe onychomycosis 8-week efinaconazole model Mehr lesenBackground Depression and anxiety are common comorbid diseases of constipation. Fecal microbiota transplantation (FMT) significantly relieves gastrointestinal-related symptoms, but its impact on psych...
constipation depression and anxiety fecal microbiota transplantation metagenomics metabolomics 5-hydroxytryptamine samples levels constipation symptoms microbiota 5-ht anxiety depression fecal Mehr lesenBackground The emergence of different viral infections calls for the development of new, effective, and safe antiviral drugs. Glycyrrhiza glabra is a well-known herbal remedy possessing antiviral prop...
antiviral cytotoxicity hsv-1 molecular docking synergy herpes stomatitis vesicular antiviral Mehr lesenBackground A common task in analyzing metatranscriptomics data is to identify microbial metabolic pathways with differential RNA abundances across multiple sample groups. With information from paired ...
metatranscriptomics shotgun sequencing microbiome differential analysis metatranscriptomics rna analysis controlling differential dna taxa data Mehr lesenIntroduction Globally, the highest burden of bovine and human tuberculosis resides in Africa and Asia. Tuberculosis (TB) is the second leading single infectious killer after severe acute respiratory s...
prevalence bovine and human tuberculosis culture and isolation genus typing deletion analysis spoligotyping complex culture borno positive human hospitals/clinics sputum complex revealed mycobacterium humans bovine tb maiduguri tuberculosis cattle obtained Mehr lesenThe colonization of alien plants in new habitats is typically facilitated by microorganisms present in the soil environment. However, the diversity and structure of the archaeal, bacterial, and fungal...
rhizosphere soil microorganisms amplicon sequencing total bacterial fungal communities odorata bulk archaeal Mehr lesenBackground Hundreds of millions of tons coal fly ash are produced annually to support economic development and industrial production. However, directly applying coal fly ash to agricultural production...
coal fly ash soil amendment soil microbial community land productivity enhancement humic acid study g1 ash coal fly Mehr lesenBackground Fluoride-resistant Streptococcus mutans ( S. mutans ) strains have developed due to the wide use of fluoride in dental caries prevention. However, the metabolomics of fluoride-resistant S. ...
fluoride resistance metabolomics fructose-1,6-bisphosphate dental caries mass spectrometry //www analysis strains mutans fluoride-resistant Mehr lesenA safe and ecofriendly biocontrol of pathogenic Fusarium equiseti was developed based on chitosan nanoparticles (CNPs) combined with Trichoderma longibrachiatum and Penicillium polonicum. Two strains ...
chitosan nanoparticles antifungal pathogenic fungi antagonistic fungi antifungal strains isolated trichoderma activity penicillium polonicum longibrachiatum fungi antagonistic equiseti Mehr lesenBackground COVID-19 diagnosis lies on the detection of SARS-CoV-2 on nasopharyngeal specimens by RT-PCR. The Xpert-Xpress SARS-CoV-2 assay provides results in less than one hour from specimen receptio...
covid-19 cepheid xpert c29200t detection impairment n gene ct xpert snp pandemic sars-cov-2 Mehr lesenUnderstanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models rema...
diseases brain Mehr lesenNeuropeptide S (NPS), which is a peptide that is involved in the regulation of the stress response, seems to be relevant to the mechanism of action of antidepressants that have anxiolytic properties. ...
antidepressants brainstem exposed mrna amygdala ms nps Mehr lesenInterval timing is involved in a variety of cognitive behaviors such as associative learning and decision-making. While it has been shown that time estimation is adaptive to the temporal context, it r...
alm trial recent interval timing Mehr lesenIntroduction Although CD20 is classically a B cell marker, in the last three decades, dim expression has been noted on a subset of T cells as well that has been independently verified by a number of g...
cd20 cellular immunology flow cytometry cells cell understanding including function diseases cells Mehr lesenFor decades, memory research has centered on the role of neurons, which do not function in isolation. However, astrocytes play important roles in regulating neuronal recruitment and function at the lo...
role memory Mehr lesenIt is increasingly understood that moment-to-moment brain signal variability – traditionally modeled out of analyses as mere “noise” – serves a valuable functional role related to development, cogniti...
estimation developmental automated mse preprocessing scale-wise entropy Mehr lesenThe cover image is based on the Review Article Relationship between chronic hypoxia and seizure susceptibility by YuanHang Xu et al., https://doi.org/10.1111/cns.13942. [Image: see text]
cover Mehr lesenBACKGROUND: It has been suggested that individuals predisposed to or recovered from anorexia nervosa experience a hyperserotonergic state associated with anxiety that might be mitigated by restricted ...
central associated condition study availability acute depletion network resting-state functional connectivity salience tryptophan 5-ht Mehr lesenBACKGROUND: The drug 3‐n‐butylphthalide (NBP) was developed and approved in China, where it has been used to treat ischemic cerebrovascular diseases. It is also considered to have a neuroprotective ef...
ais ischemic study associated mortality included efficacy safety combined 90 days ci adjusted due outcome outcomes patients nbp 0 Mehr lesenIndividuals on the autism spectrum often exhibit atypicality in their sensory perception, but the neural underpinnings of these perceptual differences remain incompletely understood. One proposed mech...
regions integration contour neurotypical autistic attenuated processing sensory autism Mehr lesenFederated learning has received sustained attention in recent years for its distributed training model that fully satisfies the need for privacy concerns. However, under the nonindependent identical d...
shared heterogeneity federated model Mehr lesenText generation has always been limited by the lack of corpus data required for language model (LM) training and the low quality of the generated text. Researchers have proposed some solutions, but th...
solutions text Mehr lesenOBJECTIVE: The Financial Capacity Instrument-Short Form (FCI-SF) is a performance-based measure of everyday financial skills that takes 15 min to administer. Although the FCI-SF has demonstrated excel...
psychometric results capacity fci-sf financial cognitively Mehr lesenAnxiety symptoms and anxiety disorders are frequent in patients with schizophrenia and are associated with greater severity of both positive and negative symptoms, cognitive impairment, poorer functio...
review systematic superior studies symptoms Mehr lesenBACKGROUND AND AIMS: Guillain-Barré syndrome (GBS) is usually triggered by an infection. Vaccination is mentioned as a possible trigger in a small number of GBS cases. The aim of this study was to not...
precipitating pandemic significantly characteristics syndrome patients gbs clinical vaccination covid-19 infection Mehr lesenHow do children’s experiences relate to their naturalistic emotional and social processing? Because children can struggle with tasks in the scanner, we collected fMRI data while 4-to-11-year-olds watc...
associated parent-child social emotional behaviors parenting events experiences Mehr lesenIschemic stroke is a major public health problem worldwide. Although the circadian clock is involved in the process of ischemic stroke, the exact mechanism of the circadian clock in regulating angioge...
protein stroke ischemic pathway circadian Mehr lesenAdolescence is a period of social re-orientation in which we are generally more prone to peer influence and the updating of our beliefs based on social information, also called social learning, than i...
influence framework adolescence social Mehr lesenBACKGROUND: Heterozygous mutations in the GBA gene, encoding the lysosomal enzyme β-glucocerebrosidase (GCase), are the most frequent genetic risk factor for Parkinson’s disease (PD). GBA-related PD (...
disease risk abx study 52 weeks trial Mehr lesenOBJECTIVE: As personality changes and personality disorders are frequently observed in multiple sclerosis (MS), personality may be a prognostic factor for this disease. The present study investigated ...
multiple facet personality p = 0 ms Mehr lesenContemporary motor control theories propose competition between multiple motor plans before the winning command is executed. While most competitions are completed before movement onset, movements are ...
plans target command wave activity reach motor competition intermediate Mehr lesenRATIONAL: Several tools exist to assess comorbidities in neurological disorders, the most widely used being the Charlson Comorbidity Index (CCI), but it has several limitations. The Comorbidity and Ge...
questionnaire burden disorders symptom cghq cci scores eq-5d-5l neurological comorbidities comorbidity correlated Mehr lesenLateral decubitus digital subtraction myelography is an effective technique for precisely localizing CSF-venous fistulas, a common cause of spontaneous intracranial hypotension. However, despite an op...
technique Mehr lesenIntracranial pressure (ICP) is an important parameter in clinical management and diagnosis of several neurological diseases which is indirectly measured via lumbar puncture (LP). In routine measuremen...
via combination lumbar manometer spinal Mehr lesenBACKGROUND AND PURPOSE: An increased number of pathogenic variants have been described in mitochondrial encephalomyopathy lactic acidosis and strokelike episodes (MELAS). Different imaging presentatio...
presentations mitochondrial strokelike patients variability phenotype clinical melas Mehr lesenDementia in Parkinson's disease (PD) has become a major factor affecting the quality of life of patients with Parkinson's disease. Early detection and timely prevention can delay the progression of de...
meta-analysis smart patient improve moxibustion seen article medicine treatment parkinson Mehr lesenAdvanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device‐aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG),...
disease nonmotor articles dyskinesia time lcig parkinson advanced Mehr lesenInternational audience; Objective: Survival of patients with monogenic Parkinson's disease may depend on the causative genes associated with the disease. In this study, we compare surviv...
monogenic forms p = 0 disease lrrk2 mutations survival patients parkinson Mehr lesenAIMS: This study aimed to identify the functional connectivity (FC) changes of nucleus accumbens (NAc) subregions and characterize the association of network changes and non‐motor symptoms (NMS) in Pa...
network associated parkinson shell core fc changes subregions left Mehr lesenDetecting Parkinson's Disease in its early stages using EEG data presents a significant challenge. This paper introduces a novel approach, representing EEG data as a 15-variate series of bandpower a...
n1 eeg classification models parkinson data Mehr lesenBACKGROUND: The most common genetic risk factor for Parkinson's disease known is a damaging variant in the GBA1 gene. The entire GBA1 gene has rarely been studied in a large cohort from a single popul...
d140h + p compared e326k gene controls 0 parkinson gba1 patients Mehr lesenBackground: Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and gender differences have been described on several aspects of PD. In the present ...
genetic biomarkers parkinson symptoms sex disease differences Mehr lesenInternational audience; IntroductionProdromal non-motor symptoms precede, often by decades, motor signs and diagnosis of Parkinson's disease. It is however still uncertain if cognitive c...
daily phase depressive global cohort follow-up symptoms parkinson disease Mehr lesenBACKGROUND: Individuals with Parkinson's disease present arm swing alterations that can adversely affect their locomotion. OBJECTIVE: To identify differences in arm swing asymmetry (ASA) between indiv...
evidence parkinson -0 amplitude 05 arm swing individuals disease 0 ci 95% Mehr lesenOBJECTIVE: To study the effect of dual tasking and deep brain stimulation frequency parameters on gait in advanced Parkinson's disease MATERIALS AND METHODS: This is an open label interventional study...
frequency parkinson score 0001 disease fog dual tasking patients brain hz 0 mean deep 130 stimulation Mehr lesenParkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and, consequently, motor c...
lewy pathology cellular disease parkinson cholesterol Mehr lesenBACKGROUND: Both patients and physicians may choose to delay initiation of dopamine replacement therapy in Parkinson's disease (PD) for various reasons. We used observational data to estimate the effe...
initiation disease scores parkinson mds‐updrs pd treatment Mehr lesenEpidemiological studies on the role of environmental factors in Parkinson's disease (PD) have shown several associations, but it is still debated whether they are causal, in particular ...
exposures consumption role bias health expositions sciences rôle causalité mendelian disease randomization causal pd associations consommation smoking parkinson Mehr lesenBACKGROUND: Glucocerebrosidase gene mutations are a common genetic risk factor for Parkinson's disease. They exhibit incomplete penetrance. The objective of the present study was to measure microglial...
microglial activation parkinson c‐ ‐pk11195 disease binding glucocerebrosidase carriers gene mutation Mehr lesenParkinson's disease (PD) is a neurodegenerative disorder anatomically characterized by a progressive loss of dopaminergic neurons in the substantia nigra compacta (SNpc). Much less known, yet clinical...
prebötc decreased parkinson disease pd neurons model Mehr lesenPURPOSE: Parkinson's disease (PD) is a neurodegenerative disorder with progressive motor defects. Therefore, the aim of the present investigation was to examine whether catalepsy, asymmetry, and nocic...
dopamine parkinson disease induction test tg significantly control nociceptive rats pd Mehr lesenBackground Parkinson’s disease (PD) is characterized by intra-neuronal deposition of the protein α-synuclein (α-syn) and by deficiencies of the catecholamines dopamine and norepinephrine (NE) in the b...
synuclein tyrosine hydroxylase norepinephrine immunofluorescence parkinson post-mortem intra-neuronal nerves = 0 times th pathophysiological increased deposition control myocardial smg α-syn pd Mehr lesenParkinson's Disease(PD) is one of the major nervous system disorders that affect people over 60. PD can cause cognitive impairments. In this work, we explore various approaches to identify Parkinson...
architectures parkinson Mehr lesenThis paper represents a groundbreaking advancement in Parkinson disease (PD) research by employing a novel machine learning framework to categorize PD into distinct subtypes and predict its progress...
parkinson disease pd machine learning research Mehr lesenAs the second most common neurodegenerative disease, Parkinson's disease has caused serious problems worldwide. However, the cause and mechanism of PD are not clear, and no systematic early diagnosi...
classification eeg accuracy parkinson disease Mehr lesenParkinson's disease is a common neurological disease, entailing a multitude of motor deficiency symptoms. In this project, we developed a device with an uploaded edge machine learning algorithm that...
parkinson Mehr lesenBursts of beta frequency band activity in the basal ganglia of patients with Parkinson's disease (PD) are associated with impaired motor performance. Here we test in human adults whether small variati...
parkinson patients activity disease recent networks velocity locally stn ganglia basal cumulative motor performance Mehr lesenInternational audience; Parkinson's disease (PD) and the parkinsonian variant of Multiple System Atrophy (MSA-P) are two neurodegenerative diseases which share similar clinical features,...
parkinson multiple atrophy system voiced disease differential diagnosis Mehr lesenINTRODUCTION: Immune markers are altered in Parkinson's disease (PD), but relationships between cerebrospinal fluid (CSF) and plasma cytokines and associations with neurodegeneration‐associated protei...
parkinson cytokines tau plasma csf pd Mehr lesenDespite growing evidence that has declared the importance of circRNAs in neurodegenerative diseases, the clinical significance of circRNAs in dopaminergic (DA) neuronal degeneration in the pathogenesi...
circrnas mitochondrial patients circeps15 parkinson pd disease Mehr lesenWe report the results of an extensive set of simulations exploring the sensitivity of the BlackCAT CubeSat to long-duration gamma-ray bursts (GRBs). BlackCAT is a NASA APRA-funded CubeSat mission fo...
cubesat astrophysics high-redshift grbs mission blackcat Mehr lesenJWST observations have the potential to provide unprecedented constraints on the history of reionization and the sources responsible for the ionizing photons due to the detection of large population...
photons reionization astrophysics ionizing Mehr lesenThe unprecedented infrared spectroscopic capabilities of JWST have provided high-quality interstellar medium (ISM) metallicity measurements and enabled characterization of the gas-phase mass-metalli...
fire-2 increasing redshift gas-phase mzr simulations Mehr lesenMARTINI is a modular Python package that takes smoothed-particle hydrodynamics (SPH) simulations of galaxies as input and creates synthetic spatially- and/or spectrally-resolved observations of the ...
class martini Mehr lesenA hypothetical photon mass, $m_{\gamma}$, can produce a frequency-dependent vacuum dispersion of light, which leads to an additional time delay between photons with different frequencies when they p...
fast astrophysics photons dispersion mass \times photon Mehr lesenThe Gaia satellite has provided the community with three releases containing astrometrical and photometric data as well as by products, such as stellar parameters and variability indicators. By sele...
star derive stars speed astrophysics Mehr lesenThere has been an attempt to revive the visible QCD axion at the 10 MeV scale assuming that it exclusively couples to the first-generation quarks and the electron. This variant of the QCD axion is c...
physics energy e^-$ qcd Mehr lesenThe Hubble tension has proven to be stubbornly persistent, despite widespread efforts to relax it. As a possible resolution of this problem we propose a radical alternative to the way in which cosmo...
Mehr lesenWithin the coronae of stars, abundances of those elements with low first ionization potential (FIP) often differ from their photospheric values. The coronae of the Sun and solar-type stars mostly sh...
coronae observations stars evidence reconnection magnetic Mehr lesenThe detection of gravitational waves (GWs) has opened a new window to test the fundamental nature of gravity. We present constraints on the nonstandard propagation of GWs using the spectral siren me...
nonstandard propagation gravity Mehr lesenSome electromagnetic outbursts from the nuclei of distant galaxies have been found to repeat on months-to-years timescales, and each of these sources can putatively arise from the accretion flares g...
smbh accretion tidal astrophysics stars transients repeating flares Mehr lesenUsing Keck Planet Imager and Characterizer (KPIC) high-resolution ($R$~35000) spectroscopy from 2.29-2.49 $\mu$m, we present uniform atmospheric retrievals for eight young substellar companions with...
level accretion measurements models core solar companions astrophysics Mehr lesenInfrared emission features toward interstellar gas of the IC 348 star cluster in Perseus have been recently proposed to originate from the amino acid tryptophan. The assignment was based on laborato...
infrared spectra astrophysics data tryptophan Mehr lesenThe impact of winds and jet-inflated bubbles driven by active galactic nuclei (AGN) are believed to significantly affect the host galaxy's interstellar medium (ISM) and regulate star formation. To e...
interaction astrophysics cloudlets star 2024 clouds formation wind Mehr lesenWe present a new SMA survey of 47 Class II sources in the Taurus-Auriga region. Our observations made 12 independent samples of flux densities over the 200-400 GHz frequency range. We tightly constr...
spectral snowline sources indices formation outside water planet dust ii class astrophysics Mehr lesenCompact binary mergers are sources of gravitational waves, and can be accompanied by electromagnetic signals. We discuss the possible features in the kilonova emissions which may help distinguish th...
binary mergers neutron kilonova Mehr lesenWe do a careful investigation of the prospects of dark energy (DE) interacting with cold dark matter (CDM) in alleviating the $S_8$ clustering tension. To this end, we consider various well-known pa...
interacting energy cmb phantom dark 0}$ $\sigma_{8 tension Mehr lesen$\omega$ Centauri, the most massive globular cluster in the Milky Way, has long been suspected to be the stripped nucleus of a dwarf galaxy that fell into the Galaxy a long time ago. There is consid...
stars cluster $ dex Mehr lesen(Abridged) The presence of short-period (< 10 days) planets around main sequence (MS) stars has been associated either with the dust-destruction region or with the magnetospheric gas-truncation radi...
m$_{\odot}$ disks inner planets intermediate-mass orbits migration jupiters hot astrophysics Mehr lesenDebris disks give us the unique opportunity to probe the properties of small $\mu$m-sized particles, allowing us to peer into the constituents of their parent bodies, young analogs of comets and ast...
light particles observations constrain debris intensity disks astrophysics Mehr lesenWe introduce FLAME, a machine-learning algorithm designed to fit Voigt profiles to HI Lyman-alpha (Ly$\alpha$) absorption lines using deep convolutional neural networks. FLAME integrates two algorit...
single double using components component lines ly$\alpha$ real accuracy absorption data Mehr lesenThis study presents bounds on transient variations of fundamental constants, with typical timescales ranging from minutes to months, using clocks in space. The underlying phenomenology describing su...
constants objects fundamental dm clocks matter transient Mehr lesenGG Tau is one of the most studied multiple young stellar systems: GG Tau A is a hierarchical triple surrounded by a massive disc and its companion, GG Tau B, is also a binary. Despite numerous obser...
simulations eccentricity tau gg $\tau_{ecc}$ system astrophysics Mehr lesenThe Major Atmospheric Cherenkov Experiment (MACE) is a large size (21m) Imaging Atmospheric Cherenkov Telescope (IACT) installed at an altitude of 4270m above sea level at Hanle, Ladakh in northern ...
cherenkov atmospheric +/- experiment crab nebula gev 0 Mehr lesenAbsorption lines from exoplanet atmospheres observed in transmission allow us to study atmospheric characteristics such as winds. We present a new high-resolution transit time-series of HD 189733b, ...
na transmission 189733b planetary hd Mehr lesenPart 2: Assessment of ICT enabled Smart Initiatives;International audience; Urbanization is forcing local government to revisit their way of communicating with citizens. By using Informa...
study participatory city Mehr lesenObjectives This study investigated the effects of prematurity and ROP on visual acuity and VRQoL in adults (18–52 years). Methods The Gutenberg Prematurity Eye Study is a retrospective cohort study wi...
dcva prematurity treated ga rop visual preterm weeks study acuity amblyopia Mehr lesenBackground Adolescent pregnancy is an important public health problem and a socio-economic challenge in diverse societies. As a tremendously important problem, this issue has caused major concerns, as...
knowledge attitude adolescent pregnancy adolescent girls mother consequences children age agree study girls adolescent knowledge pregnancy married Mehr lesenBackground The goal of radical prostatectomy is to achieve the optimal balance between complete cancer removal and preserving a patient’s urinary and sexual function. Performing a wider excision of pe...
prostate cancer radical prostatectomy surgeon feedback surgical report cards audit and feedback knowledge translation cancer prostatectomy radical post-feedback urinary patients surgeons pre-feedback study outcomes cohort report cards Mehr lesenBACKGROUND: Dropped head syndrome (DHS) is a rare specific abnormal posture known to develop in Parkinson’s disease (PD). This case series study aimed to characterize DHS by analyzing the characterist...
alignment sva study cervical kyphosis half spinopelvic Mehr lesenOBJECTIVES: To classify older adults with MLTC into clusters based on accumulating conditions as trajectories over time, characterise clusters and quantify associations between derived clusters and al...
adults english ageing associated all-cause clusters study longitudinal long-term mltc time trajectories conditions Mehr lesenBackground: Cystic and alveolar echinococcosis (CE and AE) are neglected tropical diseases caused by Echinococcus granulosus sensu lato and E. multilocularis, and are emerging zoonoses in Kyrgyzstan. ...
kyrgyzstan surveillance health reported institute study ae risk Mehr lesenBACKGROUND: Early postoperative hypoxemia is a common problem after general anesthesia. The identification of factors associated with an increased occurrence of it might help healthcare professionals ...
surgery period study oxygen increased hypoxemia Mehr lesenBACKGROUND: Socialization practices support undergraduates’ transitional processes when beginning their academic careers and afterwards. Anyhow, the absence of specific socialization measures for acad...
specific construct study socialization undergraduates’ academic Mehr lesenIntroduction This study aimed to describe the effects of no-dose full-fluence photodynamic therapy without verteporfin (no-dose PDT) and to compare no-dose PDT with half-dose verteporfin full-fluence ...
central serous chorioretinopathy choroid laser macula photodynamic therapy verteporfin msrf ccsc treated study pdt patients hdff ct photodynamic fsrf therapy no-dose Mehr lesenPurpose: To evaluate the association between varicocele and MPV values in pediatric and adult patients. And its association with different clinical parameters. Materials and methods: We retrospectivel...
varicocele study patients Mehr lesenBACKGROUND: Emergence of the COVID-19 pandemic created unexpected challenges for health care workers. The global and national supply chain system was disrupted, and affected infection, prevention and ...
facility-based descriptive workers compared ipc practices pandemic study covid-19 health attitudes Mehr lesenBackground In verbal irony we often convey meanings that oppose the literal words. To look behind these words, we need to integrate perspectives of ourselves, others, and their beliefs about us. Altho...
schizotypal personality sarcasm negativity bias social cognition pragmatic language mentalization nonliteral personality empathy perceived critical literality bpd schizotypal symptoms study irony patients Mehr lesenOBJECTIVES: The study was designed to evaluate the accuracy of maternally perceived baby birth size assessments as a measure of birth weight and examine factors influencing the accuracy of maternal si...
maternally health study accuracy maternal low baby size Mehr lesenBACKGROUND: The effect of demineralized bone matrix (DBM), bone marrow–derived mesenchymal stromal cells (BMSCs), and platelet-rich plasma (PRP) on bone tunnel healing in anterior cruciate ligament re...
healing platelet-rich plasma sheep study bmd controls aclr trabecular correlated femoral tunnel bone significantly vs received 0 midportion volume widening Mehr lesenBackground and objective Observance of preventive behaviors is one of the main ways to break the coronavirus disease 2019 (COVID-19) chain of transmission. Therefore, the present study was conducted t...
coronavirus disease 2019 behavior prevention knowledge rural centers awareness population study prevention covid-19 behaviors Mehr lesenThis study expects to solve the network delay in college English online teaching, prevent disrupting the normal teaching order of college English classroom caused by network problems, increase college...
study system ec improve learning college teaching online Mehr lesenBackground After total knee arthroplasty (TKA), patients’ physical activity (PA) levels at 6 months are lower than those of healthy subjects. Few studies have investigated the factors associated with ...
knee osteoarthritis total knee arthroplasty physical activity average muscle strength knee-extension using patients study tka knee = 0 count step associated factors pa daily preoperative months Mehr lesenBackground Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stages. Among all BC subtypes, triple...
breast cancer tnbc epigenetics usp22 oxphos cscs therapy resistance role study cancer usp22 Mehr lesenBACKGROUND: Per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) are endocrine disrupting chemicals with widespread exposures across the U.S. given their abundance in ...
95% increase samples study blood 03 quartile change mean associated increase = 0 0 Mehr lesenINTRODUCTION: Patient and caregiver engagement is critical, and often compromised, at points of transition between care settings, which are more common, and more challenging, for patients with complex...
resources university care engagement transitions research ethics study patient caregiver Mehr lesenINTRODUCTION: Biotinidase deficiency is an inherited metabolic disorder with estimated birth incidence of 1 in 61,000 for profound and partial deficiency. Estimated incidence of profound and partial b...
study deficiency 000 months median clinical biochemical biotinidase onset seizure outcome Mehr lesenLocomotion is essential for motile animal to adapt to their environment. This ability to navigate is modulated by the sensory information animals are continuously integrating from their...
avons locomotor activity program involved species locomoteur sa larvae poisson développement neuronal fish cerveau model zebrafish zèbre study swimming modèle larve nage maturation au development chez locomotion dc cerebrum danionella étude larves animal Mehr lesenSIMPLE SUMMARY: Little is known about how incomplete sleep affects a horse’s memorization. Like most mammals, horses need sleep to fully function, with differences in the total sleep time needed. The ...
recumbency rem study interference patterns horses sleep memory Mehr lesenSIMPLE SUMMARY: This study in laboratory rodents shows a sex specific effect of breeder to research facility transfer on several physiological parameters, such as heart rate and blood pressure. We rec...
animals study days increase physiological differences acclimatization research sex transfer Mehr lesenBackground According to the 2010 European Health Interview Survey, 51% of women in Hungary have a chronic disease, and is among the poorest quartile in the EU countries. Thyroid diseases affected more...
adherence quality of life social support thyroid disorders women’s health hungary found differences thyroid quality adherence support social life patients Mehr lesenPurpose Sex hormones are thought to be responsible for the unique gender differences in papillary thyroid cancer(PTC). Most previous studies on these have focused on the expression of estrogen recepto...
papillary thyroid cancer sex hormone testosterone estradiol male correlated hormone tumor ptc pathological thyroid features patients Mehr lesenIntroduction Locally advanced thyroid cancer refers to thyroid cancer that invades important structures of the neck, with poor prognosis. Neoadjuvant targeted therapy has the potential to increase the...
thyroid carcinoma neoadjuvant targeted therapy locally advanced selective studies atc advanced neoadjuvant targeted locally therapy treatment 1% thyroid cancer patients rate resection r0/1 Mehr lesenBackground Identifying thyroid nodules’ boundaries is crucial for making an accurate clinical assessment. However, manual segmentation is time-consuming. This paper utilized U-Net and its improved met...
convolutional neural network deep learning ultrasound images semantic segmentation thyroid nodule u-net thyroid method u-net Mehr lesenBACKGROUND: Cases of subacute thyroiditis (SAT) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination have been reported. A human leukocyte antigen (HLA) allele, HLA-B*35, app...
fever blood pain involved pathogenesis gd hla-b*35 serum typing thyrotoxicosis revealed thyroid 01 alleles hla developed vaccination sars-cov-2 sat Mehr lesenBACKGROUND: Yersinia enterocolitica is a gram-negative zoonotic bacterial pathogen that is typically transmitted via the fecal-oral route. The most common clinical manifestation of a Y. enterocolitica...
adenoma follicular left gland enterocolitica thyrotoxicosis thyroid abscess Mehr lesenPurpose In the last edition of the American Joint Committee on Cancer (AJCC) staging system, differentiated thyroid cancers (DTC) showing microscopic extrathyroidal extension (mETE) are considered com...
differentiated thyroid cancer microscopic extrathyroidal extensi... recurrence risk predictive performance patients thyroid mete considered predictive disease 0% atam-rr specificity pp Mehr lesenPurpose In this retrospective, observational study we aim to compare the outcomes of the RFA treatment of benign thyroid nodules, carried out respectively with the standard fixed-needle approach (FTN)...
adjustable-tip needle benign thyroid nodule radiofrequency ablation minimally-invasive thyroid treatme... thyroid benign approach considered difference rate absolute success terms reduction = 0 Mehr lesenBACKGROUND: The introduction of new targeted therapies for RET-altered lung and thyroid cancers (LC/TC) has impacted pathologists’ practice by making genomic testing more relevant. Variations in healt...
thyroid lung reported lc/tc care challenges testing uk ret tests ret-altered pathologists japan Mehr lesenBackground Anti-programmed cell death-1 (ligand-1) antibody [PD-(L)1-Ab] can cause destructive thyroiditis and/or hypothyroidism. In addition, tyrosine kinase inhibitors (TKIs) frequently induce hypot...
thyroiditis hypothyroidism irae pd-1 pd-l1 tki 1-ab/tki risk patients pd- dysfunction thyroid vs Mehr lesenThe detection of low-risk thyroid carcinoma has increased in recent decades, although disease-specific mortality remained without changes. The high prevalence of occult carcinomas in autopsy studies, ...
active surveillance low risk papillary thyroid carcinoma observation papillary thyroid microcarcinoma thyroid cancer indeterminate thyroid nodules low-risk thyroid Mehr lesenPurpose In clinical practice, thyroid nodules are classified according to TI-RADS by B-mode and color-flow Doppler study. The aim of the study is to evaluate the possible added value of Superb microva...
superb microvascular imaging smi elastonography ti-rads thyroids nodule diagnostic power 0 individually study patients auc nodules thyroid 95% ci smi elastosonography Mehr lesenBACKGROUND: Rheumatoid arthritis (RA) is one of the most common chronic non-organ-specific autoimmune diseases; meanwhile, autoimmune thyroid disease (AITD) is the most common organ-specific autoimmun...
ra anti-tpo p-value > 0 001 or = 2 diseases autoimmune controls thyroid common patients Mehr lesenInternational audience; Triazoles belong to a family of fungicides that are ubiquitous in agroecosystems due to their widespread use in crops. Despite their efficiency in controlling fun...
endocrine exposed house axis levels triazoles tebuconazole condition body sperm quality thyroid impact Mehr lesenI distruttori o interferenti endocrini (IE) sono sostanze o miscele di sostanze che interferiscono con il sistema endocrino con implicazioni negative sull’individuo e sulla sua progenie. Nell’ultimo d...
distruttori endocrini ipofisi tiroide ghiandole surrenaliche gonadi endocrine disruptors pituitary thyroid adrenal glands gonads ie eds Mehr lesenBackground Only one thyroid follicular cell-derived tumor with a purely trabecular growth pattern has previously been described. This report aims to describe the histological, immunohistochemical, and...
thyroid hyalinizing trabecular tumor medullary thyroid carcinoma fusion g... adenoma novel pitfalls diagnostic tumor trabecular Mehr lesenPurpose The purpose of this study was to investigate the impact of autofluorescence technology on postoperative parathyroid function and short-term outcomes in patients undergoing thyroid surgery. Met...
thyreoidectomy central lymph node dissection hypoparathyroidism autofluorescence reduced outcomes study short-term surgery parathyroid calcium dysfunction technology thyroid levels function autofluorescence Mehr lesenThe introduction of tumor necrosis factor-alpha (TNF-α) targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important developm...
ada thyroid Mehr lesenBackground In this study, we observed the frequency of side effects encountered when the neural integrity monitor electromyogram endotracheal tube (NIM-EMG-ETT) was used in thyroidectomy and parathyro...
thyroid and parathyroid surgery nim-emg-ett advers events surgery tube observed encountered irregular patients effects response thyroid parathyroid Mehr lesenThe introduction of tumor necrosis factor-alpha (TNF-α) targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important developm...
ada thyroid Mehr lesenObesity is a well-known public health concern in Western World. Accordingly, an elevated number of obese patients undergo thyroidectomy every year. We aim to assess the impact of obesity on intraopera...
thyroidectomy obesity complications thyroid outcomes outcomes p = 0 thyroidectomy obese patients obesity Mehr lesenPurpose Treating an infiltration of the recurrent laryngeal nerve (RLN) by thyroid carcinoma remains a subject of ongoing debate. Therefore, this study aims to provide a novel strategy for intraoperat...
recurrent laryngeal nerve vocal fold paralysis laryngeal reinnervation ansa cervicalis arytenoid adduction thyroid carcinoma rln macis infiltrated voice thyroid carcinoma patients resection Mehr lesenSIMPLE SUMMARY: Early diagnosis and treatment of cancer is crucial for the survival of cancer patients. Pathologists can use computational pathology techniques to make the diagnosis process more effic...
datasets assist evaluation images soft label cancer diagnosis dish recall accuracy thyroid 14 fish achieves dataset human ± proposed method including u-net deep learning target therapy f1-score Mehr lesenBACKGROUND: Dual-energy computed tomography (DECT) is an advanced imaging method that enables reconstruction of virtual non-contrast (VNC) images from a contrast-enhanced acquisition. This has the pot...
structures mean anatomical region non-contrast images imaging density virtual true neck tnc thyroid vnc Mehr lesenCalcium oxalate kidney stones, the most prevalent type of kidney stones, undergo a multi-step process of crystal nucleation, growth, aggregation, and secondary transition. The secondary transition has...
kidney stones calcium oxalate microstructure x-ray micro-ct solution-mediated phase transition... extracorporeal shock wave lithotri... disease concentrations growth transition calcium oxalate Mehr lesenIntroduction and hypothesis The Australasian Pelvic Floor Procedure Registry (APFPR) collects both clinical and health-related quality of life (HRQoL) data on women undergoing surgery using a prosthes...
pain patient-reported outcome measures pelvic floor disorders pelvic floor procedures pelvic organ prolapse stress urinary incontinence components study following pain women Mehr lesenPedicle screw placement (PSP) is the fundamental surgical technique that requires high accuracy for novice orthopedists studying spinal oncology education. Therefore, we set forth to establish a compu...
pedicle screw placement cumulative sum analysis learning curve spinal oncology education robotic novice computer-assisted training program carn oncology education pedicle screw psp spinal Mehr lesenBackground The sperm flagellum is an evolutionarily conserved specialized organelle responsible for sperm motility and male fertility. Deleterious mutations in genes involved in the sperm flagellum as...
infertility sperm motility asthenozoospermia sperm flagellum icsi fertility infertility flagellum mutées mâles sperm male au spermatozoïdes mobilité motility mice -mutated souris niveau flagelle dnali1 Mehr lesenAim This study aims to evaluate the effectiveness and safety of administering double-dose tamsulosin (0.8 mg) for treating patients with benign prostatic hyperplasia (BPH) who have not responded to th...
bph unfit tamsulosin double dose score intervention prostate qmax ipss 0 tamsulosin volume dose patients bph Mehr lesenPurpose Additive systematic biopsy (SB) contributes to prostate cancer (PCA) detection in MRI-targeted biopsy (TB). However, the reasons for this are not yet clear. We compared the performance of TB, ...
clinically significant prostate ca... biopsy method perifocal saturation biopsy; adjac... systematic biopsy cdr pi-rads detected cspca sb cb tb biopsy Mehr lesenMesothelioma is a rare cancer that generally affects the lining of the lungs. However, in more rare cases, there are extra-pleural involvement of organs that are lined with mesothelial cells, includin...
mesothelioma tunica vaginalis hydrocele orchiectomy testicular tumor rare Mehr lesenBackground Urological complications are not uncommon among people living with HIV and are often the initial clinical manifestation of HIV and AIDS. These complications, when presenting with bothersome...
acquired immunodeficiency syndrome... antiretroviral treatment highly active antiretroviral thera... human immunodeficiency virus international prostate symptom sco... lower urinary tract symptoms quality of life urinary prevalence p = 0 influencing bothersome ipss luts people living hiv symptoms ci 95% Mehr lesenPurpose To predict the post transurethral prostate resection(TURP) urethral stricture probability by applying different machine learning algorithms using the data obtained from preoperative blood para...
urethral stricture transurethral prostate resection machine learning,blood parameters value patients predictive preoperative models 82 urethral stricture accuracy 0 Mehr lesenBackground We aimed to evaluate the role of plasma fibrinogen and D-dimer as prognostic biomarkers in patients with non-muscle invasive bladder cancer (NMIBC). Methods The prospective study included 3...
plasma fibrinogen d-dimer prognostic marker bladder cancer prognostic biomarkers 0 nmibc respectively patients pfs rfs d-dimer fibrinogen follow-up Mehr lesenAim To study the most beneficial coronary revascularization strategy in kidney transplant recipients (KTR). Methods In 16th June 2022 and updated on 26th February 2023, we searched in five databases i...
pci cabg renal transplantation systematic review meta-analysis ktr study 95%ci cabg 0 revascularization pci coronary mortality Mehr lesenBackground Cryptorchid boys with defective mini-puberty and impaired differentiation of Ad spermatogonia (high infertility risk) have altered expression of several genes encoding histone methyltransfe...
cryptorchidism infertility epigenetic chromatin remodeler methyltransferase linc rna gnrha infertilité cryptorchidie épigénétique arn longs non codants chromatine méthyl transférase gnrha differentiation différenciation risk spermatogonia risque garçons histone infertility expression infertilité histones Mehr lesenPurpose The high recurrence rate after traditional transurethral resection of bladder tumor (TURBT) remains a challenge for management of non-muscle invasive bladder tumor (NMIBC). The aim of this stu...
surrounding en bloc resection transurethral resection of bladder... simultaneous intravesical chenmoth... non-muscle invasive bladder cancer... resection tumor data rate recurrence intravesical conventional nmibc bipolar loop electrode chemotherapy simultaneous surrounding bloc turbt bladder Mehr lesenIntroduction and hypothesis Stress urinary incontinence (SUI) is defined as involuntary leakage of urine on physical effort and is prevalent among power- and weightlifters. However, there is scant kno...
female athlete pelvic floor muscle training powerlifter stress urinary incontinence weightlifters women’s health adherence strength power- sui weightlifters study reported change Mehr lesenIntroduction and hypothesis Pelvic organ prolapse quantification by means of upright magnetic resonance imaging (MRI) is a promising research field. This study determines the angle for the pelvic incl...
magnetic resonance imaging pelvic inclination correction syst... pelvic organ prolapse upright magnetic prolapse resonance difference angles upright pics supine position pelvic Mehr lesenBackground On February 6th, 2023, two consecutive earthquakes struck southeastern Türkiye with magnitudes of 7.7 and 7.6, respectively. This study aimed to analyze the clinical and laboratory findings...
acute kidney injury crush syndrome earthquake myoglobin injury victims increase p < 0 001 myoglobin pediatric patients levels [iqr cs vs Mehr lesenPurpose In this study, the feasibility of a no bladder irrigation strategy after transurethral holmium laser enucleation of the prostate (HoLEP) for the treatment of benign prostatic hyperplasia (BPH)...
no bladder irrigation strategy benign prostatic hyperplasia holmium laser enucleation of the prostate surgery ipss qol postoperative complications 05 significant qmax pvr bladder irrigation holep 2021 Mehr lesenObjective To evaluate the proportions of detected prostate cancer (PCa) and clinically significant PCa (csPCa), as well as identify clinical predictors of PCa, in patients with PI-RADS > = 3 lesion a...
prostate cancer diagnosis prostate mri negative biopsy target prostate biopsy targeted biopsy systematic predictors patients presence pca cspca Mehr lesenBackground Donors bravely donate their kidneys because they expect that living donor kidney transplantation (LKT) confers benefits to recipients. However, the magnitude of the survival benefit of LKT ...
hemodialysis kidney transplantation living kidney donor kidney transplantation expectancy life benefit patients recipients main model 0 survival hd lkt Mehr lesenIntroduction and aims Pelvic floor dysfunction (PFD) is a collection of signs, symptoms and conditions affecting the pelvic floor and urinary incontinence (UI) is the most common type of PFD. Recent s...
elite athletes/sportswomen experiences pelvic floor dysfunction floor pelvic systematic impact pfd studies Mehr lesenContexte Des anomalies structurelles ainsi que des variations mineures du chromosome Y peuvent provoquer des troubles de la différenciation sexuelle ou, plus fréquemment, une azoospermie. Cette étude ...
azoospermia y chromosome loss 45,x/46,xy mosaicism y microdeletion y chromosome azoospermie perte du chromosome y mosaïque 45,x/46,xy microdélétions y chromosome y région azoospermia found chez caryotype karyotype structural loss microdeletions microdélétions mosaïque Mehr lesenBackground Retroperitoneal liposarcoma (RPLPS), a rare tumor, is often treated using surgical procedures as the first choice for treatment. However, there is no consensus on the scope of surgical rese...
recurrence metastasis dedifferentiated liposarcoma combined organ resection targeted therapy lps dedifferentiated tumors left surgical tumor rplps retroperitoneal Mehr lesenInternational audience; This article focuses on the development of the French veterinary profession in the twentieth century and on the importance of sera and vaccines production and use...
french article national medicine diseases disease archives veterinarians veterinary Mehr lesenBACKGROUND: Animals are a reservoir for ESBL/pAmpC-producing Escherichia coli/Klebsiella pneumoniae (ESBL-E/K). We investigated the association between occupational contact with different types of ani...
factors positive workers months coli esbl prevalence animals veterinary healthcare Mehr lesenInternational audience; This article focuses on the development of veterinary medicine in the industrial pig and poultry production sector. In the current context of controversies over t...
medicine production antimicrobial preventive resistance expertise professional poultry pig veterinary Mehr lesenThe COVID-19 pandemic has resulted in the global recognition for greater inter-disciplinary and multi-disciplinary working, and the need for systematic approaches which recognise the interconnectednes...
medicine systematic approach veterinary Mehr lesenSIMPLE SUMMARY: Entrepreneurship and intrapreneurship (entrepreneurial behaviour of employees) foster business innovation and growth and support wealth creation and employment in both privately owned ...
sector businesses entrants employment corporate intentions veterinary entrepreneurship students respondents intrapreneurial business Mehr lesenInternational audience; Veterinary autopsy requires a high level of expertise and skills that not all veterinarians necessarily master, especially in the context of the desertification o...
necropsy process tool diagnosis veterinary ivan support Mehr lesenBACKGROUND: The FAIR (Findable, Accessible, Interoperable, Reusable) principles were proposed in 2016 to set a path towards reusability of research datasets. In this systematic review, we assessed the...
veterinary articles research principles data fair epidemiology available Mehr lesenInternational audience; Dr. Peter Rossdale (1927-2021) practiced all his life in Newmarket, England. Founder of the most important equine clinic in Europe, he is also one of the major co...
médecine profession sa vétérinaire medicine veterinary Mehr lesenSIMPLE SUMMARY: Measuring left atrial size has important prognostic and therapeutic consequences in cardiac diseases. An enlarged left atrium indicates that the cardiac disease is severe. Though cardi...
enlarged atrium veterinary determining disease standardized size x-rays left cardiac method Mehr lesenInternational audience; This article focuses on the development of the French veterinary profession in the twentieth century and on the importance of sera and vaccines production and use...
french article national medicine diseases disease archives veterinarians veterinary Mehr lesenIntroductionCranial and upper-airway anatomy of short-nosed, flat-faced brachycephalic dogs predisposes them to brachycephalic obstructive airway syndrome (BOAS). Periodic apnoea increased inspiratory...
parameters lower objective plasma veterinary significantly bc dogs nc boas compared blood brachycephalic Mehr lesenBACKGROUND: Despite extensive research, many questions remain unanswered about common problems that impact dog welfare, particularly where there are multiple contributing factors that can occur months...
welfare research veterinary life collection generation pup protocol study canine puppies factors data health behaviour Mehr lesenInternational audience; Materia Medica is a Latin term, relating to the history of pharmacy. It describes the sources (vegetable, animal and mineral), nature, preparation, and properties...
medicine review medica materia veterinary Mehr lesenOBJECTIVES: In veterinary settings, high exposures to animal allergens and microbial agents can be expected. However, occupational exposure levels are largely unknown. The objective of this study was ...
β- -glucan significantly equ veterinary using animal exposure allergens endotoxin practices homes Mehr lesenBACKGROUND: The Old world Alphavirus, Middelburg virus (MIDV), is not well known and although a few cases associated with animal illness have previously been described from Southern Africa, there has ...
manifestations ad veterinary hoc illness edta africa patients sample middelburg study genome nhls virus samples csf neurological Mehr lesenBACKGROUND: Retractions are a key proxy for recognizing errors in research and publication and for reconciling misconduct in the scientific literature. The underlying factors associated with retractio...
animal 2% available published retractions retraction misconduct health journal articles veterinary Mehr lesenBACKGROUND: The aim of our study was to analyse the influence of air temperature and implemented veterinary measures on salmonellosis incidence in the Czech Republic (CZ). METHODS: We conducted a desc...
1998–2017 czech annual cz influence significant veterinary measures salmonellosis Mehr lesenChatGPT, the most accessible generative artificial intelligence (AI) tool, offers considerable potential for veterinary medicine, yet a dedicated review of its specific applications is lacking. This...
potential generative specific medicine veterinary chatgpt Mehr lesenSIMPLE SUMMARY: Nowadays, animal welfare is seen as a ‘common good’ and a societal expectation. Veterinarians are expected to promote and ensure the welfare of animals under their care by using their ...
2013 day-1 eaeve evolution european animal veterinary teaching europe Mehr lesenSIMPLE SUMMARY: Veterinary students are required to determine an animal’s heart rate and diagnose heart murmurs and arrhythmias by the time of graduation. Accurate assessment of the heart sounds of ho...
understanding access analysis 0 analyzed cardiac teaching veterinary heart fifth-year murmurs results sounds auscultation survey horses Mehr lesenSIMPLE SUMMARY: Canine mast cell tumors are cutaneous and subcutaneous tumors that spread through the lymphatic system and lead to high mortality rates. Lymph node mapping, crucial for pinpointing the...
lymphography sln animals oncology critical tumors mast cell mapping mcts node lymph technique veterinary detection treatment Mehr lesenThe indiscriminate usage and overuse of antimicrobials in pets or companion animals are underlying causes of antimicrobial resistance (AMR). Despite the multi-faceted global challenge presented by ant...
clean veterinary surgical resistance amr reported antimicrobial pet Mehr lesenBackground Quality of life (QoL) provides a comprehensive concept underpinning veterinary decision-making that encompasses factors beyond physical health. It becomes particularly pertinent when seekin...
horse welfare quality of life end-of-life decisions euthanasia veterinary care decisions a good life owners study assess discussions challenges regarding horse ill chronically differences veterinary assessments life stakeholders Mehr lesenSIMPLE SUMMARY: The occurrence of traumatic injuries was assessed in cattle, sheep, goats and pigs reared and slaughtered in the Czech Republic. For the purposes of the study, the results of veterinar...
slaughterhouses kids lambs reared occurrence veterinary slaughtered found sheep goats difference transport animals limbs 0 01 welfare postmortem detected trauma findings body cattle pigs cows slaughterhouse traumatic Mehr lesenSIMPLE SUMMARY: Gut health has been a main topic in veterinary medicine research after the ban on the use of antimicrobial growth promoters. Gut health has been defined as absence/prevention/avoidance...
research analysis bibliometric veterinary gut health Mehr lesenBACKGROUND: Oral food challenge (OFC) is useful for diagnosing food allergies and assessing tolerance, but severe reactions may occur during the procedure. OBJECTIVE: To characterize the frequency and...
challenge tests patients ige-mediated anaphylaxis oral food ofc milk cm Mehr lesenBACKGROUND: Sputum eosinophilia is a treatable trait for chronic cough. It is currently not clear whether the blood eosinophil counts could be used to identify sputum eosinophilia in patients with chr...
identifying auc tige diagnostic eosinophils cough chronic [0 0 patients feno sputum blood Mehr lesenPURPOSE: A subset of asthmatics suffers from persistent airflow limitation, known as remodeled asthma, despite optimal treatment. Typical quantitative scoring methods to evaluate structural changes of...
0 methods tr5 scores persistent bwt asthmatics hrct bd-fev1 Mehr lesenIgE-mediated atopic diseases such as allergic rhinitis and rhinoconjunctivitis are common chronic diseases in the western world. Allergen immunotherapy (AIT) plays a fundamental role in the treatment ...
treatment allergic Mehr lesenBACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy that has a cumulative incidence of 0.015 to 0.7% in infants [1]. The most common allergens causing FP...
food fpies Mehr lesenBACKGROUND: Physician awareness and adherence to guidelines varies among countries and between types of physician practice. Identifying the needs of the physician and patient is essential to improve p...
intermittent asthma persistent respondents examination physical history patient immunotherapy practices reasons ar choice diagnosis management physician guidelines Mehr lesenThe majority of viral rashes occurring during an antibiotic therapy are considered as a drug hypersensitivity reaction (DHR). Differentiating a viral rash versus a DHR is difficult or even impossible....
viral drug Mehr lesenBACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has been associated with a dramatic increase in postviral olfactory dysfunction (PVOD) among patients who are infected. A contemporary evid...
recommendations systematic current studies pvod outcomes olfactory review treatment Mehr lesenBACKGROUND: The mainstay of treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is systemic corticosteroid therapy; some patients also receive intravenous immunoglobulins, other immunos...
egpa dose responders eosinophil daily bvas rates p < 0 01 lower patients visit super-responders mepolizumab relapse treatment Mehr lesenBACKGROUND: The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in a...
2% common allergens concomitant fel asthma patterns molecular cat Mehr lesenChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition of the nasal and paranasal tissues, characterized by the presence of bilateral nasal polyps. An expert panel of sp...
disease patients ess treatment management chronic polyps crswnp nasal Mehr lesenBACKGROUND: Role of complement fraction 5a (C5a), interleukin (IL)-9, and apolipoprotein (apo) A-IV as biomarkers of disease severity and antihistamine response in chronic spontaneous urticaria (CSU) ...
nonresponders responders significantly anti-tpo baseline study antihistamine response 0 levels patients urticaria il-9 a-iv apo disease serum severity biomarkers Mehr lesenPURPOSE: Humulus japonicus (HJ) is one of the most important causes of weed pollinosis in East Asia. The 10 kDa protein with pI 10 in 2-dimensional gel has been recognized as the representative major ...
ige hum major Mehr lesenBackground: On the occasion of the 110(th) anniversary of allergen-specific immunotherapy (AIT), the question arises of “how do patients feel about AIT?”. Materials and methods: Informed by questions ...
survey Mehr lesenBACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy that has a cumulative incidence of 0.015 to 0.7% in infants [1]. The most common allergens causing FP...
food fpies Mehr lesenPURPOSE: Eosinophils have pivotal roles in the development of allergic rhinitis (AR) through the release of cytotoxic substances. Apolipoprotein A-I (Apo-AI) exhibits a strong inhibitory effect on eos...
rhinitis inhibitory allergic ar eosinophils Mehr lesenINTRODUCTION: Recently, the literature has promoted the use of patient‐reported outcome measures (PROMs) in clinical practice as a means to foster patient engagement. However, conditions necessary to ...
french‐speaking study belgium interviews patient asthma engagement centers hps proms Mehr lesenPrognostic models hold great potential for predicting asthma exacerbations, providing opportunities for early intervention, and are a popular area of current research. However, it is unclear how model...
practice review implementation asthma models Mehr lesenINTRODUCTION: Our previous study showed that the severity of atopic dermatitis (AD) in children significantly correlates with the quality of life and perceived stress in their mothers. AIM: To compare...
study scale children strategies stress ad quality Mehr lesenBACKGROUND: Significant morbidity and mortality are associated with poor asthma control. The aim of this study was to determine factors associated with poor control and referral to specialist secondar...
poorly controlled asthma referral associated factors poor Mehr lesenBACKGROUND: Eosinophilic gastritis (EoG) has rarely been reported in conjunction with gluten-sensitive enteropathy (GSE). When this does occur, patients typically present with gastrointestinal symptom...
report omalizumab eog hypoproteinemia Mehr lesenINTRODUCTION: The integrated care pathways for atopic dermatitis (AD‐ICPs) aim to bridge the gap between existing AD treatment evidence‐based guidelines and expert opinion based on daily practice by o...
icps management treatment care Mehr lesenBACKGROUND: To validate case definitions for eczema using primary care Electronic Medical Record (EMR) data from the Canadian Primary Care Sentential Surveillance Network (CPCSSN). METHODS: This study...
8% medical using eczema care ppv se sp primary definition Mehr lesenBACKGROUND: Immunoglobulin E (IgE) and immunoglobulin G4 (IgG4) to peanut and its components may influence the clinical reactivity to peanut. Allergen‐specific immunotherapy is known for modifying bot...
components trial participants placebo dbpcfc specific immunotherapy levels screening exit ige peanut ptah Mehr lesenBACKGROUND: There are gaps in our understanding of the epidemiology of atopic dermatitis (AD) in adults. OBJECTIVE: To evaluate the prevalence and severity of AD in adults from countries/regions withi...
range 4% survey – adults disease Mehr lesenWir verwenden Cookies und andere ähnliche Technologien, um :
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