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ExplorezIn this study, we employ a transformer encoder model to characterize the significance of longitudinal patient data for forecasting the progression of Alzheimer's Disease (AD). Our model, Longitudina...
alzheimer model forecasting ad longitudinal patient disease data Lire la suiteBackground A decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in cognitive composite endpoints that are used to de...
episodic memory cognition composite scores plasma biomarkers alzheimer disease baseline biomarkers composite decline ptau217 tests included longitudinal recall alzheimer disease plasma memory cognitive paragraph Lire la suiteAlzheimer's disease is a common cognitive disorder in the elderly. Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. At present, re...
loss alzheimer disease Lire la suiteAlzheimer's disease (AD) is a multi-facet pathology, that can be monitored through a variety of data types. This thesis aims to leverage multimodal longitudinal data, especially imaging...
time variety fournir clinical provide biomarqueurs biomarkers fil temps données data variété au grande ma ad progression disease alzheimer maladie Lire la suiteBackground Alzheimer's Disease (AD), the most common type of dementia, is a chronic, progressive, and neurodegenerative brain discomfort that causes the be damage to brain cells. Although there is no ...
aducanumab alzheimer’s disease cost-effectiveness analysis markov model disease alzheimer ad cost-effective $ incremental qaly drug clinical aducanumab soc developed cost cost-effectiveness results treatment Lire la suiteBackground Solanum lycopersicum Linn. (Tomato, Family Solanaceae) is one of the fruits that are most consumed worldwide. The current research intends to emphasise the possibility of positive and thera...
ache alzheimer metabolomics tomato seeds identified vitro disease extract rats levels lycopersicum tests slse alzheimer ache Lire la suiteDeep learning methods have significantly advanced medical image segmentation, yet their success hinges on large volumes of manually annotated data, which require specialized expertise for accurate l...
alzheimer disease segmentation model Lire la suiteAlzheimer's disease (AD) is a leading neurodegenerative condition and the primary cause of dementia, characterized by progressive cognitive decline and memory loss. Its progression, marked by shrink...
weight ad scheme flexi-fuzz-lssvm approach samples flexi-fuzz noise diagnosis alzheimer proposed models imbalance class Lire la suiteAlzheimer's disease (AD) is the leading cause of dementia, and its early detection is crucial for effective intervention, yet current diagnostic methods often fall short in sensitivity and specifici...
features alzheimer disease learning Lire la suiteBackground Mild cognitive impairment (MCI) may evolve into dementia. Early recognition of possible evolution to Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) is of importance, but actua...
lewy body dementia alzheimer dementia mild cognitive decline meta-analysis disease accuracy clinical studies markers Lire la suiteBackground A decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in cognitive composite endpoints that are used to de...
episodic memory cognition composite scores plasma biomarkers alzheimer disease baseline biomarkers composite decline ptau217 tests included longitudinal recall alzheimer disease plasma memory cognitive paragraph Lire la suiteThis research underscores the efficacy of Fourier topological optimization in refining MRI imagery, thereby bolstering the classification precision of Alzheimer's Disease through convolutional neura...
disease mri contrast alzheimer Lire la suiteAutomated diagnosis of Alzheimer Disease(AD) from brain imaging, such as magnetic resonance imaging (MRI), has become increasingly important and has attracted the community to contribute many deep l...
model 2d introduce perspective alzheimer diagnosis adapt 3d Lire la suiteDeep learning, a cutting-edge machine learning approach, outperforms traditional machine learning in identifying intricate structures in complex high-dimensional data, particularly in the domain of ...
imaging machine recall brain disease learning deep alzheimer approach science computer Lire la suiteAlzheimer's disease (AD) is a progressive brain disorder characterized by extracellular amyloid-β (Aβ) plaques, intracellular neurofibrillary tangles formed by hyperphosphorylated Tau p...
alzheimer glucose intolerance disease amyloid-β protein diet app/ps1 hfd neuroinflammation tau resistance insulin inflammation pathology ir Lire la suiteAlzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory and cognitive decline, affecting millions worldwide. Diagnosing AD is challenging due to its heterogeneou...
gnns computer science neuroimaging cognitive brain alzheimer ad layer Lire la suiteAlzheimer disease (AD) is the main form of dementia and is still uncurable. It occurs in 2 forms: the first, the majority (>95% of cases) and non-hereditary, is called “sporadic” (sAD)....
dérivés modèle xénotransplantation derived model humains allowing au adulte souris transplantées permettant chez bmi1 cells transplanted human neurons lv hnpc permis expression adult l’expression gène xenotransplantation cellules study alzheimer sad npc mas pfc neurones Lire la suiteDeep learning, a cutting-edge machine learning approach, outperforms traditional machine learning in identifying intricate structures in complex high-dimensional data, particularly in the domain of ...
imaging machine recall brain disease learning deep alzheimer approach science computer Lire la suiteBackground Working memory capacity impairment is an early sign of Alzheimer's disease, but the underlying mechanisms remain unclear. Clarifying how working memory capacity is affected will help us bet...
alzheimer's disease working memory capacity 5xfad mice fos excitatory neuron results wild-type neurons activation disease alzheimer capacity memory cortex excitatory 5xfad prelimbic Lire la suiteInternational audience; Background Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer's disease (AD), highlighting an intricate i...
c3-positive ad subtypes alzheimer depletion tregs astrocyte disease markers a2-like impact regulatory cells phenotypes reactivity pathology amyloid reactive Lire la suiteBACKGROUND: Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease. M...
levels lps cell-free pha pbmcs secretion stimulated dna alzheimer disease Lire la suiteObjective: We aimed to develop and validate a novel multimodal framework HiMAL (Hierarchical, Multi-task Auxiliary Learning) framework, for predicting cognitive composite functions as auxiliary task...
framework learning alzheimer longitudinal prediction performance multimodal auxiliary multi-task mci himal Lire la suiteBackground Dementia is one of the major causes of disability and dependency among older people worldwide. The formation of an aging population in Iran can be associated with societal problems, includi...
alzheimer dementia prevalence iran systematic review meta-analysis review studies systematic 0 estimated dementia prevalence ci 95% iran Lire la suiteInternational audience; Abstract Background Masitinib is an orally administered tyrosine kinase inhibitor that targets activated cells of the neuroimmune system (mast cells and microglia...
primary alzheimer safety trial kinase tyrosine 5% [−0 respectively versus results microglia ad mast ci cells 95% inhibitor 0 representing mild-to-moderate randomized mg/kg/day mesh alzheimer’s placebo disease Lire la suiteAlzheimer's disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins i...
mutation disease alzheimer amyloid-β peptides connectivity pathology osa synaptic osaka cerebral Lire la suiteIntroduction To capture the patient’s attitude toward remote monitoring of motor neuron disease (MND) in care and clinical trials, and their concerns and preferences regarding the use of digital techn...
motor neuron disease amyotrophic lateral sclerosis digital technology survey patient perspective survey attitude remote mnd patients trials home-monitoring digital technology Lire la suiteThe description of group-level, genotype- and phenotype-associated imaging traits is academically important, but the practical demands of clinical neurology centre on the accurate classification of in...
neuroradiology machine learning amyotrophic lateral sclerosis neuroimaging artificial neural networks diagnostic als matter based controls clinical neural patients classification 0 Lire la suiteDysfunction and degeneration of synapses is a common feature of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene is the...
c9orf72 amyotrophic lateral sclerosis frontotemporal dementia synapsin synapse reduced c9als/ftd hippocampal haploinsufficiency als/ftd excitatory interaction synapsin Lire la suitePurpose Amyotrophic lateral sclerosis (ALS) is a progressive motor impairment leading to early death. Religiousness is one of the factors potentially alleviating the psychological burden of patients. ...
amyotrophic lateral sclerosis religiosity depression quality of life pain culture psychological disease cultural controls functional patients als Lire la suiteBackground In the sporadic form of amyotrophic lateral sclerosis (ALS), the pathogenicity of rare variants in the causative genes characterizing the familial form remains largely unknown. To predict t...
mova missense variant prediction tool amyotrophic lateral sclerosis alphafold2 vcp predicted structural results features method ubqln2 variants mova accuracy pathogenicity fus genes Lire la suiteBackground Given the inevitable relentless progressing nature of amyotrophic lateral sclerosis (ALS), it is essential to identify factors influencing patients’ wellbeing. The study aimed to prospectiv...
amyotrophic lateral sclerosis wellbeing quality of life depression pain functional clinical levels lower factors hcs Lire la suiteBackground Psychiatric presentations similar to that observed in primary psychiatric disorders are well described across the amyotrophic lateral sclerosis–frontotemporal dementia (ALS–FTD) spectrum. D...
frontotemporal dementia amyotrophic lateral sclerosis motor neuron disease schizotypy neuropsychiatry personality disorders als–ftd schizotypy psychiatric traits schizotypal Lire la suiteBackground Uric acid (UA) has emerged as a factor that can modify cognitive function both in the general population and in people with neurodegenerative disorders. Since very few data are available co...
amyotrophic lateral sclerosis cognition frontotemporal dementia uric acid phenotype als-int cognitive levels impairment als-ftd als ua Lire la suiteBackground and aim Traditional Chinese medicine (TCM) is widely used by patients with amyotrophic lateral sclerosis (ALS). However, their reasons and experience in using TCM have received insufficient...
traditional chinese medicine herbal medicine amyotrophic lateral sclerosis mixed method study mixed chinese care-tcm hm als method study interview sclerosis amyotrophic lateral traditional using treatment patients tcm Lire la suiteBackground A single cycle (two repeated treatments) with intrathecal autologous bone marrow-derived mesenchymal stem cells (BM-MSCs, 26-day interval) showed safety and provided therapeutic benefit las...
lenzumestrocel amyotrophic lateral sclerosis bone marrow-derived mesenchymal st... phase iii patients iii randomized phase control single-cycle injections trial protocol efficacy alsummit study safety months Lire la suiteBackground Law 219/2017 was approved in Italy in December 2017, after a years-long debate on the autonomy of healthcare choices. This Law, for the first time in Italian legislation, guarantees the pat...
amyotrophic lateral sclerosis law 219/2017 mechanical ventilation withdrawal end-of-life care palliative care advance care planning survey patients services care health als italy withdrawal italian law Lire la suiteIndividuals with amyotrophic lateral sclerosis (ALS) frequently develop speech and communication problems in the course of their disease. Currently available augmentative and alternative communication...
brain–computer interface implant amyotrophic lateral sclerosis ethics clinical application tracheostomy invasive ventilation technology als implanted people clinical Lire la suiteObjective The Center for Neurologic Study Bulbar Function Scale (CNS-BFS) was specifically designed as a self-reported measure of bulbar function. The purpose of this research was to validate the Chin...
amyotrophic lateral sclerosis center for neurologic study bulbar... als functional rating scale–revise... bulbar function 0 scale patients chinese alsfrs-r < 0 001 als study cns-bfs_c score function total Lire la suiteAmyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in adults with no curative treatment. Neurofilament (NF) level in patient’ fluids have recently emerged as the prime bi...
amyotrophic lateral sclerosis human induced pluripotent stem cel... motoneurons neurofilaments axonal initial segment degeneration pnf-m/h mns ais als axonal nf Lire la suiteThe organization of brain functional connectivity (FC) has been shown to differ between sexes. Amyotrophic lateral sclerosis (ALS) is characterized by sexual dimorphism, showing sex-specific trends in...
amyotrophic lateral sclerosis resting-state functional mri brain networks functional connectivity sex networks brain lateral differences cortex gyrus als affected functional network fc Lire la suiteAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of both upper and lower motor neurons. A defining histopathological feature in ap...
amyotrophic lateral sclerosis als motor neuron disease non-motor symptoms patients clinical neurons non-motor symptoms als Lire la suiteBackground Psychiatric presentations similar to that observed in primary psychiatric disorders are well described across the amyotrophic lateral sclerosis–frontotemporal dementia (ALS–FTD) spectrum. D...
frontotemporal dementia amyotrophic lateral sclerosis motor neuron disease schizotypy neuropsychiatry personality disorders als–ftd schizotypy psychiatric traits schizotypal Lire la suiteBackground Swallowing dysfunction is related to major cause of adverse events and an indicator of shorter survival among patients with neuromuscular disorders (NMD). It is critical to assess the swall...
tongue thickness tongue pressure amyotrophic lateral sclerosis myotonic dystrophy type 1 duchenne muscular dystrophy patients als mean mtp tt dm1 tongue Lire la suiteAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently lacks effective treatments. Mutations in the RNA-binding protein FUS are a common cause of familial ALS, accoun...
amyotrophic lateral sclerosis pp2a gsk3 kinesin neurons pathogenesis als protein hyperphosphorylation ipsc-smns kinesin-1 gsk3 disease pp2a Lire la suiteBackground Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with not only motor symptoms but also extra-motor features including cognitive impairment. The most common cognitive profile ob...
amyotrophic lateral sclerosis cognitive impairment ecas survival longitudinal decline motor function als time patients Lire la suiteAmyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic eff...
amyotrophic lateral sclerosis als pten bpv akt motor neuron survival = 0 loss mn treatment significantly pic bpv als msod1^g93a Lire la suiteIntroduction Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with great heterogeneity. Biological prognostic markers are needed for the patients to plan future supportive tre...
alsfrs-r slope amyotrophic lateral sclerosis median survival time prognostic biomarker disease treatment symptoms test prognostic δfs’ survival Lire la suiteBackground This article comprises a systematic review of the literature that aims at researching and analyzing the frequently applied guidelines for structuring national databases of epidemiological s...
amyotrophic lateral sclerosis rare disease registries motor neuron disease national databases of epidemiologi... global health systematic research studies registries national data Lire la suiteAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle weakness. Presence of pain in ALS patients is heterogeneously reported in studies, and mostly und...
amyotrophic lateral sclerosis pain pain management medication therapy management pharmacological systematic review trials clinical five efficacy strategies patients als management Lire la suiteBackground Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterised by the loss of upper and lower motor neurons. Increasing evidence indicates that neuroinflamm...
amyotrophic lateral sclerosis microglia tdp-43 inclusions dna damage inflammasome microglia patient cells microglia-like patients monocyte-derived als Lire la suiteBackground In recent years, the role of altered cellular metabolism in tumor progression has attracted widespread attention. Related metabolic enzymes have also been considered as potential cancer the...
shmt2 ec m6a modification c-myc one carbon metabolism cancer progression escape immune experiments related c-myc expression ec modification Lire la suite[Image: see text] To reduce the high mortality rates caused by ovarian cancer, creating high-sensitivity, quick, basic, and inexpensive methods for following cancer antigen 125 (CA-125) levels in bloo...
0 onohs detection ovarian cancer antigen Lire la suiteImmunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells f...
keap1 nsclc cancer pd-l1 Lire la suiteHeat shock protein A1A (HSPA1A) is a molecular chaperone crucial in cell survival. In addition to its cytosolic functions, HSPA1A translocates to heat-shocked and cancer cells’ plasma membrane (PM). I...
crucial cancer hspa1a’s membrane pm ps Lire la suiteCancer is one of the leading causes of deaths worldwide. Survival analysis and prediction of cancer patients is of great significance for their precision medicine. The robustness and interpretability ...
convmixer external robustness interpretability learned activation robust prediction cancer model Lire la suiteBackground Despite effective prevention and control strategies, in countries of the Balkan region, cancers are the second leading cause of mortality, closely following circulatory system diseases. Obj...
forecasted balkan rates breast incidence burden 000 period countries rectum colon cervical cancer 2030 cancers region Lire la suitePLK1 (Polo-like kinase 1) plays a critical role in cancer progression of lung adenocarcinoma (LUAD). Recent studies have demonstrated that targeting PLK1 improves the efficacy of immunotherapy, indica...
microenvironment cancer role immunity tumor Lire la suiteCase series Patients:— Final Diagnosis: Second sentinel lymph node metastasis Symptoms: Breast cancer Clinical Procedure: — Specialty: Oncology OBJECTIVE: Unusual clinical course BACKGROUND: For patie...
spect/ct flow lymph node sentinel axilla cancer breast snb patients Lire la suiteSoumis comme communication à ECC23, 13-16 juin 2023, Bucarest; Mathematical models of cancer growth and evolution of cancer cell characteristics, aka phenotypes, together with optimisati...
cancer cell [math Lire la suiteColorectal cancer (CRC) is a malignancy that is both highly lethal and heterogeneous. Although the correlation between intra-tumoral genetic and functional heterogeneity and cancer clinical prognosis ...
prognostic cancer interactions scrna-seq cell crc model Lire la suiteBackground The effect of cancer diagnosis affects the psychological well-being of the caregivers of cancer patients and results in a risk of psychiatric morbidity. This study aimed to determine the pr...
ethiopia caregivers cancer depression prevalence associated independent results factors cancer patients caregivers prevalence adult primary ci 95% Lire la suiteObjective Research on factors contributing to depressive symptoms in cancer patients at a national level, encompassing a comprehensive set of variables was limited. This study aimed to address this ga...
depression neoplasms cross-sectional studies logistic models status self-rated depression 05 factors < 0 associated patients cancer or = 1 Lire la suiteBackground In 2023 FIGO revised the endometrial cancer staging system after 13 years. There is a lacuna of data regarding the performance and practicality of the revised 2023 FIGO staging schema for e...
endometrial cancer figo 2023 stage shift prognosis lmic 23 patients 2023 cancer 15% system staging endometrial figo stage Lire la suiteThis work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into f...
animal model cancer exercise training immune system prostate promotes rat induced signalome model prostate remodelling pca Lire la suiteBackground Developing trustworthy artificial intelligence (AI) models for clinical applications requires access to clinical and imaging data cohorts. Reusing of publicly available datasets has the pot...
artificial intelligence, breast ne... platform domain • data clinical models dataset access public imaging cancer breast ai Lire la suiteIntroduction The combination of doxorubicin and paclitaxel (AP) is widely used in our country for the neoadjuvant treatment of breast cancer as well as metastatic breast cancer. The AP regimen has sho...
doxorubicin-paclitaxel regimen advanced breast cancer neoadjuvant chemotherapy pathological complete response inoperable regimen iii ap associated achieving hr-negative disease cancer breast neoadjuvant pcr dfs os survival 10-year patients Lire la suiteBackground Supportive end-of-life care plays a significant role for patients with cancer. Significantly, art and aesthetics in nursing are regarded as key components of nursing practice. They may cont...
nurses aesthetic care training end-of-life difference nursing scores nurses mean training care study perceptions cancer patients end-of-life aesthetic experimental Lire la suiteThe extraordinary diversity of T cells and B cells is critical for body maintenance. This diversity has an important role in protecting against tumor formation. In humans, the T-cell receptor (TCR) re...
samples tumor system immune t-cell formation cancer tcr oc blood peripheral Lire la suiteObjective To investigate their compliance with postoperative oral nutritional supplementation and nutritional outcomes. Methods A total of 84 patients with colorectal cancer surgery with NRS-2002 risk...
colorectal cancer oral nutritional supplementation goal attainment theory nutrition education health education nutritional status < 0 colorectal cancer postoperatively observation difference scores 7 days 05 surgery significant statistically attainment nutritional oral supplementation Lire la suiteBackground The gold standard treatment for locally advanced colon cancer is curative surgery followed by adjuvant chemotherapy, although this approach is associated with serious concerns, such as high...
locally advanced colon cancer neoadjuvant chemotherapy panitumumab intra-abdominal abscess percutaneous drainage surgery sigmoid abscess frailty tumor resection locally advanced cancer colon followed curative intra-abdominal patient Lire la suiteAim This study aimed to explore the efficacy and safety of endoscopic submucosal dissection/endoscopic mucosal resection (ESD/EMR), laparoscopic-assisted radical gastrectomy (LARG), and open radical g...
early gastric cancer endoscopic submucosal dissection endoscopic mucosal resection laparoscopic-assisted radical gast... open radical gastrectomy compared total early-stage gastrectomy operation risk factors postoperative 05 hospitalization time gastric patients org cancer esd/emr < 0 Lire la suiteBackground Numerous studies over the past four decades have revealed that breast cancer screening (BCS) significantly reduces breast cancer (BC) mortality. However, in BRICS-plus countries, the associ...
breast cancer screening mortality case fatality disability cvd brics-plus sbe/cbe program burden previous study and/or cancer availability brics-plus breast screening mortality bc bcs Lire la suiteGenome maintenance is an enabling characteristic that allows neoplastic cells to tolerate the inherent stresses of tumorigenesis and evade therapy-induced genotoxicity. Neoplastic cells also deploy mi...
gene cells esc cancer endometrial Lire la suiteObjective To construct a prognostic model based on MR features and clinical data to evaluate the progression free survival (PFS), overall survival (OS) and objective response rate (ORR) of pancreatic ...
pancreatic cancer radiomics nomogram survival analysis immunotherapy reached features auc 000 constructed patients predicting chemoimmunotherapy pancreatic cancer hepatic 0 clinical respectively nomogram Lire la suiteCardiovascular complications related to cancer therapies are broad and variable in onset. These complications are the leading cause of non-cancer related morbidity and mortality in childhood cancer su...
childhood cancer survivor cardiovascular cardio-oncology cardiotoxicity survivors childhood cancer cardiovascular cardio-oncology program Lire la suiteLanguage models (LMs) have exhibited impressive abilities in generating codes from natural language requirements. In this work, we highlight the diversity of code generated by LMs as a critical crit...
language similarity functional correctness diversity lms generated Lire la suiteFew-shot classification involves identifying new categories using a limited number of labeled samples. Current few-shot classification methods based on local descriptors primarily leverage underlyin...
fafd-ldwr descriptors local Lire la suiteObject detectors are vulnerable to backdoor attacks. In contrast to classifiers, detectors possess unique characteristics, architecturally and in task execution; often operating in challenging condi...
backdoors detection tasks attacks backdoor object Lire la suiteFully-partitioned fixed-priority scheduling (FP-FPS) multiprocessor systems are widely found in real-time applications, where spin-based protocols are often deployed to manage the mutually exclusive...
existing spin-based analysis spin priority accessing frap resource Lire la suiteWith increasing energy prices, low income households are known to forego or minimize the use of electricity to save on energy costs. If a household is on a prepaid electricity program, it can be aut...
prepaid households energy Lire la suiteIn today's era, where large language models (LLMs) are integrated into numerous real-world applications, ensuring their safety and robustness is crucial for responsible AI usage. Automated red-teami...
mutations rainbow prompt adversarial Lire la suiteThe rapid growth in natural language processing (NLP) over the last couple years has generated student interest and excitement in learning more about the field. In this paper, we present two types o...
skills able Lire la suiteCoupling latent diffusion based image generation with contextual bandits enables the creation of eye-catching personalized product images at scale that was previously either impossible or too expens...
Lire la suiteWe consider a Bayesian budgeted multi-armed bandit problem, in which each arm consumes a different amount of resources when selected and there is a budget constraint on the total amount of resources...
budgeted budget algorithms sampling thompson Lire la suiteAs automated vehicles (AVs) become increasingly popular, the question arises as to how cyclists will interact with such vehicles. This study investigated (1) whether cyclists spontaneously notice if...
instructed vehicles cyclists participants session Lire la suiteIn the last few years, due to the broad applicability of deep learning to downstream tasks and end-to-end training capabilities, increasingly more concerns about potential biases to specific, non-re...
bias deep model biases Lire la suiteRecent studies have demonstrated the vulnerability of recommender systems to data poisoning attacks, where adversaries inject carefully crafted fake user interactions into the training data of recom...
attacks poisoning attack surrogate data gp Lire la suiteThe paper presents a vision-based obstacle avoidance strategy for lightweight self-driving cars that can be run on a CPU-only device using a single RGB-D camera. The method consists of two steps: vi...
visual method Lire la suiteWhile language model (LM)-powered chatbots and generative search engines excel at answering concrete queries, discovering information in the terrain of unknown unknowns remains challenging for users...
language discourse unknown unknowns users user co-storm Lire la suiteIsotropic $\alpha$-stable distributions are central in the theory of heavy-tailed distributions and play a role similar to that of the Gaussian density among finite second-moment laws. Given a seque...
Lire la suiteSince SLAs specify the contractual terms that are formally used between consumers and providers, there is a need to aggregate QoS requirements from the perspectives of Clouds, networks, and devices ...
qos science computer iot Lire la suiteReinforcement Learning (RL) is increasingly adopted to train agents that can deal with complex sequential tasks, such as driving an autonomous vehicle or controlling a humanoid robot. Correspondingl...
rl muprl Lire la suiteReal-time speech enhancement has began to rise in performance, and the Demucs Denoiser model has recently demonstrated strong performance in multiple-speech-source scenarios when accompanied by a lo...
proposed real-time doa quality Lire la suiteWe introduce Synthetic Playground (SynPlay), a new synthetic human dataset that aims to bring out the diversity of human appearance in the real world. We focus on two factors to achieve a level of d...
diversity motions dataset synplay Lire la suiteThe Segment Anything Model (SAM), introduced to the computer vision community by Meta in April 2023, is a groundbreaking tool that allows automated segmentation of objects in images based on prompts...
vision computer Lire la suiteThis research investigates the performance and efficiency of Unmanned Surface Vehicles (USVs) in multi-target tracking scenarios using the Adaptive Particle Swarm Optimization with k-Nearest Neighbo...
usvs environments Lire la suiteManually annotating instruction data for large language models is difficult, costly, and hard to scale. Meanwhile, current automatic annotation methods typically rely on distilling synthetic data fr...
data reinstruct Lire la suiteBiomedical data is inherently multimodal, consisting of electronic health records, medical imaging, digital pathology, genome sequencing, wearable sensors, and more. The application of artificial in...
data biomedical tasks modalities multimed medical science computer Lire la suiteCurrent parking area perception algorithms primarily focus on detecting vacant slots within a limited range, relying on error-prone homographic projection for both labeling and inference. However, r...
fisheye computer vehicles mt perception slots f-cvt Lire la suiteNeural Radiance Fields (NeRFs) have become a powerful tool for modeling 3D scenes from multiple images. However, NeRFs remain difficult to segment into semantically meaningful regions. Previous appr...
3d computer scenes masks nerfs Lire la suiteThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Lire la suiteAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Lire la suiteIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Lire la suiteAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Lire la suiteChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Lire la suitePediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...
conditions pediatric covid Lire la suiteWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lire la suiteAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Lire la suiteWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lire la suiteChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Lire la suitePediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...
conditions pediatric covid Lire la suiteWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lire la suiteWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lire la suiteLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Lire la suiteChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Lire la suiteWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lire la suiteChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Lire la suitePediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...
conditions pediatric covid Lire la suiteChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Lire la suiteChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Lire la suiteChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Lire la suitePediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...
conditions pediatric covid Lire la suiteIMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...
diagnosis confirmed meta-analysis systematic healthcare primary objective regions estimated ci 95% positive covid-19 review symptoms meta-analyzed data covid prevalence population subtypes studies study global risk follow-up Lire la suiteThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Lire la suiteBACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...
36 reduce week covid covid-19 outcome placebo amubarvimab/romlusevimab Lire la suitePre-exposure prophylaxis (PrEP) availability through the Pharmaceutical Benefits Scheme provides real potential for the elimination of HIV transmission in Australia, as evidenced by a rapid decline in...
hiv prevention cisgender women pre-exposure prophylaxis prep review conducted elimination hiv prep cisgender australia Lire la suiteBACKGROUND: Diagnosis of tuberculous meningitis (TBM) is hampered by the lack of a gold standard. Current microbiological tests lack sensitivity and clinical diagnostic approaches are subjective. We t...
test latent class tests mycobacterial lack hiv results meningitis models tuberculous simplified developed diagnostic tbm 0% Lire la suiteBackground Globally, young gay, bisexual and other men who have sex with men (YMSM) experience a disproportionate burden of disease compared to young heterosexual men and older MSM. However, YMSM expe...
andersen’s model healthcare providers hiv mental health sexually transmitted infections stigma and discrimination telehealth young men who have sex with men experiences digital engagement interventions seeking experience ymsm participants healthcare services health Lire la suiteBackground Histones posttranslational modification represent an epigenetic mechanism that regulate gene expression and other cellular processes. Quantitative mass spectrometry used for the absolute qu...
hiv methamphetamine histone h3 lysine 14 acetylation (... proteomics mass spectrometry absolute quantification liquid chromatography lysine unmodified hmdm samples acetylated absolute peptides quantification h3 0 assay h3k14ac stoichiometry Lire la suiteBackground Maternal HIV infection and antiretroviral drugs (ARVs) are associated with increased risks of adverse perinatal outcomes. The vast majority of pregnant women living with HIV (WLHIV) reside ...
conduct monotherapy determine arvs preconception outcomes perinatal adverse receiving cart hiv pregnant babies sub-saharan africa birth risk women 2020 attributable Lire la suiteBackground Prevention of vertical (mother to child) transmission of HIV is one of the key strategies towards HIV epidemic control. Despite considerable progress over the past decade in Zambia, the cou...
hiv vertical transmission unmet need family planning women zambia integration survey trends women transmission vertical study zambia hiv Lire la suiteObjectives To make clear the roles of social interaction and social support in HIV infection among elderly men who visit female sex workers (FSW). Methods We conducted a case-control study: 106 newly ...
social support hiv elderly men client of female sex workers case-control study material interaction hrhe protective partner life experiences social fsw sexual controls hiv visiting Lire la suiteSexual minority men (SMM) are disproportionately affected by HIV. Although pre-exposure prophylaxis (PrEP) is an effective way of reducing HIV incidence, PrEP use has remained relatively low. Social s...
hiv pre-exposure prophylaxis sexual minority men social support review datos para study findings una hiv las esta estudio hallazgos el social prep support se apoyo estudios eran los association smm uso Lire la suiteBackground The global campaign for “Undetectable equals Untransmittable” (U = U) seeks to spread awareness of HIV treatment as prevention, aiming to enhance psychological well-being and diminish stigm...
intervention mapping u = u treatment-as-prevention intervention south africa south develop hiv u = u intervention Lire la suiteBackground Following reports of anti-retroviral therapy (ART) experienced Ugandan people living with HIV (PLHIV) presenting with diabetic ketoacidosis weeks to months following a switch to dolutegravi...
hiv type 2 diabetes mellitus dolutegravir hiv incidence integrase inhibitors diabetes naïve patients dolutegravir 48 baseline art 2hbg week ugandan 36 plhiv blood fbg glucose dtg incidence t2dm Lire la suiteBackground There is increasing interest in the use of electronic health records (EHRs) to improve the efficiency and cost-effectiveness of clinical trials, including the capture of outcome measures. M...
electronic health records routinely collected health-care da... primary outcome hiv outcome capture uk prevention linkage ukhsa trials Lire la suiteBackground The Middle East and North Africa (MENA) region continues to have the lowest prevalence of HIV (human immunodeficiency virus) in the world, less than 0.1%, yet new transmissions are increasi...
mena hiv condoms prevention region review mena Lire la suiteBackground Option B + offers lifelong ART to pregnant or breastfeeding mothers, but postpartum loss to HIV care, partially driven by perinatal depression (PND), threatens the impact of this policy. Th...
perinatal depression hiv mental health malawi living fgds results depression study using care hiv perinatal pnd support engagement women Lire la suiteMale HIV serodiscordant couples have diverse relationship agreements regarding sex outside the relationship. We examined the relationship agreements as described by 343 male HIV-negative partners in H...
serodiscordant couples homosexual gay men men who have sex with men hiv prevention risk reduction strategies sexual behavior relationships male partners agreement hiv serodiscordant relationship hiv-negative Lire la suite[Image: see text] Human immunodeficiency virus (HIV) causing acquired immune deficiency syndrome (AIDS) is still a global issue. Long-term drug treatment and nonadherence to medication increase the sp...
pr c-sa hiv-1 hiv biosensor Lire la suiteBACKGROUND: Adequate sexual and reproductive health literacy (SRHL) among young people has been linked to informed sexual behaviours. Studies on SRHL have largely been conducted among the general adol...
using odds study clinic access ci 5% times prevalence factors srh ylhiv literate srhl issues youth 0 95% literacy hiv health associated Lire la suiteDentistry involves the use of many instruments that are sharp and deal with blood and saliva that may be contaminated with either HBV, HCV, or HIV. Professional exposure of healthcare workers (as dent...
hbv hcv hiv knowledge attitude risk perception transmission respectively perception knowledge dental ii infection students risk attitude study Lire la suiteBackground As oral PrEP scales up in Nigeria, information about uptake, use pattern and client preference in a real-world, implementation setting is invaluable to guide refining service provision and ...
prep pre-exposure prophylaxis hiv prevention prep discontinuation sero-discordant relationship nigeria services initiated programs oral nigeria 95% aor hiv clients prep discontinuation Lire la suiteBackground Adolescent girls and young women (AGYW) account for 29% of new HIV infections in Uganda despite representing just 10% of the population. Peer support improves AGYW linkage to HIV care and m...
young women oral prep hiv self-testing peer delivery participants support intervention six feasibility acceptability uganda hiv adherence peer prep delivery women hivst Lire la suiteTo better understand the impact of Uganda’s initial COVID-19 lockdown on alcohol use, we conducted a cross-sectional survey (August 2020-September 2021) among persons with HIV (PWH) with unhealthy alc...
coronavirus disease-19 (covid-19) hiv tb lockdown unhealthy alcohol use bar-based lockdown alcohol Lire la suiteInternational audience; BackgroundHIV testing is a central element of the strategy to end AIDS epidemic, as status awareness is the entry point to HIV care. In West Africa, only 68% of p...
departments assess status reported practice côte hiv participants females hivst testing males conventional d’ivoire atlas Lire la suiteBackground In May 2022, a multi-national mpox outbreak was reported in several non-endemic countries. The only licensed treatment for mpox in the European Union is the orally available small molecule ...
mpox germany tecovirimat hiv msm germany severe mpox patients Lire la suiteINTRODUCTION: Black gay and bisexual men are overburdened by HIV in the USA. While the socioecological model has been applied to understand potential mechanisms of HIV acquisition among black gay and ...
racism homophobia published conducted hiv bisexual gay review Lire la suiteWith a 676% growth rate in HIV incidence between 2010 and 2021, the HIV/AIDS epidemic in the Philippines is the one that is spreading the quickest in the western Pacific. Although the full effects o...
nation hiv Lire la suiteBackground Chronic HIV infection significantly elevates the risk of brain pathology, precipitating neurocognitive impairment (NCI) among people living with HIV (PLWH). The diagnosis of NCI in PLWH hin...
study controls hiv neurocognitive systematic plwh review mohe Lire la suiteBackground With increased attention to the importance of integrating the One Health approach into zoonotic disease surveillance and response, a greater understanding of the mechanisms to support effec...
public health information dissemination agriculture disease outbreak zoonoses health services veterinarians information sectors influenza approach effective human communication channels animal stakeholders swine Lire la suiteSecondary infection with Streptococcus pneumoniae has contributed significantly to morbidity and mortality during multiple influenza virus pandemics and remains a common threat today. During a concurr...
ferrets infection co-infected spn environmental persistence impact microbial h1n1pdm09 virus influenza pneumoniae stability Lire la suiteThe head domain of influenza hemagglutinin (HA) elicits potently neutralizing yet mostly strain-specific antibodies during infection and vaccination. Here we evaluated a series of immunogens that comb...
influenza neutralizing responses antibody hyperglycosylated Lire la suiteBackground Previous observational studies have indicated a correlation between the gut microbiota and influenza; however, the exact nature of the bidirectional causal connection remains uncertain. Met...
two-sample mendelian randomization... influenza pneumonia gwas connection causal bacterial infection egger association gut microbiota pneumonia ivw influenza bidirectional Lire la suiteInternational audience; Live bird markets (LBMs) have been identified as key factors in the spread, persistence and evolution of avian influenza viruses (AIVs). In addition, these settin...
air influenza workers samplers exposure bird live aiv period circulation Lire la suiteIn the past, cats were considered resistant to influenza. Today, we know that they are susceptible to some influenza A viruses (IAVs) originating in other species. Usually, the outcome is only subclin...
feline infection clinical disease influenza cats iav Lire la suiteBackground The protective effect of T cell-mediated immunity against influenza virus infections in natural settings remains unclear, especially in seasonal epidemics. Methods To explore the potential ...
influenza susceptibility t cell-mediated immunity titer odds h3n2 8% lower infection response hai epidemics pre-existing protection cell associated cd4 95% ci Lire la suiteInternational audience; In late 2015, an epizootic of Highly Pathogenic Avian Influenza (H5Nx) was registered in Southwestern France, including more than 70 outbreaks in commercial poult...
guinea influenza duck infected glycan-binding france pathogenic highly affinity rha h5 Lire la suiteIntroduction For pregnant women, vaccination with inactivated influenza vaccine (IIV) and tetanus, diphtheria, acellular pertussis vaccine (Tdap) is recommended. In Peru, uptake is nonetheless low. A ...
coverage knowledge maternal immunization influenza pertussis tetanus peru vaccine tdap pregnant health conducted practices attitudes immunization recommended peru women knowledge vaccination pregnant/postpartum Lire la suiteThe genome data were generated and shared via GISAID (Supplementary Data 2). All anonymized data, code, and analysis files are available in the GitHub repository (https://github.com/vjlab/episodic-h5)...
influenza avian spread genomic domestic pathogenic h5n1 wild virus birds Lire la suiteBackground Influenza viruses cause pneumonia in approximately one-third of cases, and pneumonia is an important cause of death. The aim was to identify risk factors associated with severity and those ...
influenza risk factors coinfection influenza vaccination crp infection disease admitted severe 8% confusion patients 001 < 0 0 vs influenza pneumonia Lire la suiteThe surface protein hemagglutinin (HA) of the influenza virus plays a pivotal role in facilitating viral infection by binding to sialic acid receptors on host cells. Its conformational state is pH-sen...
non-protonated ha2 helices systems dynamics conformational ha protein protonated influenza Lire la suiteBACKGROUND: The highly pathogenic avian influenza A/H5N1 virus is one of the causative agents of acute lung injury (ALI) with high mortality rate. Studies on therapeutic administration of bone marrow-...
influenza a/h5n1 highly pathogenic avian cell ali mortality balb/c injury bone caused alveolar mscs Lire la suiteBACKGROUND: The 2009 H1N1 influenza pandemic (influenza A(H1N1)pdm09) disproportionately impacted Indigenous peoples. Indigenous Australians are also affected by a health gap in chronic disease preval...
australian ratios rate population conditions disease influenza health chronic amongst severity prevalence non-indigenous Lire la suiteINTRODUCTION: Influenza virus infection is associated with high morbidity and mortality, and so additional therapeutic strategies to reduce the burden for healthcare systems are needed. Statins, by vi...
statin studies meta-analysis 0 95% ci statins influenza patients virus mortality Lire la suiteHost lipid composition influences many stages of the influenza A virus (IAV) entry process, including initial binding of IAV to sialylated glycans, fusion between the viral envelope and the host membr...
host virus influenza efficiency membrane cholesterol lipid mixing target fusion Lire la suiteIGHV1-69 is frequently utilized by broadly neutralizing influenza antibodies to the hemagglutinin (HA) stem. These IGHV1-69 HA stem antibodies have diverse complementarity-determining region (CDR) H3 ...
sequence light broadly neutralizing influenza antibodies Lire la suiteThe occurrence of human infections caused by avian H9N2 influenza viruses has raised concerns regarding the potential for human epidemics and pandemics. The molecular basis of viral adaptation to a ne...
h9n2 cross-host infection mouse adaptation pathogenicity polymerase mice avian adaptation mammalian mutations pb2 influenza Lire la suiteBACKGROUND: We investigated whether we could use influenza data to develop prediction models for COVID-19 to increase the speed at which prediction models can reliably be developed and validated early...
flu-like symptoms prediction risk model patients models disease validations cover develop scores using data influenza Lire la suiteBackground The school-located influenza vaccinations (SLIV) can increase influenza vaccination and reduce influenza infections among school-aged children. However, the vaccination rate has remained lo...
school-located influenza vaccinati... consolidated framework for impleme... expert recommendations for impleme... china implementing facilitators influenza barriers implementation Lire la suiteIntroduction: Influenza A virus (IAV) is responsible for epidemics and, every 10-15 years, for pandemics. Secondary bacterial infections (pneumococcus) can develop in the aftermath of i...
réduit susceptibility secondary traitement susceptibilité scfas surinfection bacterial microbiota iav infections au bactériennes souris gut cours microbiote agcc aux bactérienne grippale influenza infection intestinal superinfection Lire la suiteBackground Influenza can have a domino effect, triggering severe conditions and leading to hospitalization or even death. Since influenza testing is not routinely performed, statistical modeling techn...
influenza burden excess mortality hospitalization cardiovascular respiratory portugal estimated 000 deaths severe 100 million study people influenza mean population icd-10 annual icd-9 Lire la suiteBACKGROUND: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), influenza A, and respiratory syncytial virus (RSV) infections have similar modes of transmission and clinical symptoms. Th...
ratio mpv/plt exhibited study values significantly lymphocyte routine sars-cov-2 compared lym*plt platelet count lmr infections 05 plt p < 0 diagnostic blood rsv patients children influenza value 0 Lire la suiteBackground Influenza surveillance aims to determine onset, duration and intensity of the seasonal Influence-like Illness (ILI); data collection begins in the week 42 of a year and ends in the week 17 ...
influenza year-round surveillance pediatric influenza-like illness seasonality out-of-season circulation previous hospital pandemic surveillance circulation influenza respiratory flu weeks detected Lire la suiteBACKGROUND: The 2009 H1N1 influenza pandemic (influenza A(H1N1)pdm09) disproportionately impacted Indigenous peoples. Indigenous Australians are also affected by a health gap in chronic disease preval...
australian ratios rate population conditions disease influenza health chronic amongst severity prevalence non-indigenous Lire la suiteThe most prevalent microorganism association in terrestrial plants is the symbiosis between arbuscular mycorrhizal fungi (AMF) and plant roots. This implies that the genetic background for establishin...
arbuscule mycorrhizal fungi mycorrhizal symbiosis common symbiotic pathway ca signaling pathway strigolactones phosphate acquisition plant immune response pathways plant symbiosis Lire la suiteBackground As antibiotics and chemotherapeutics are no longer as efficient as they once were, multidrug resistant (MDR) pathogens and cancer are presently considered as two of the most dangerous threa...
biosynthesized selenium nanopartic... selenium/chitosan-nanoconjugate antimicrobial enzymes anticancer parvulus streptomyces mar4 cell nch biosynthesized anticancer cytotoxicity antimicrobial Lire la suiteBackground As probiotics protect host cells, they are used to treat bacterial infections. It has been indicated that probiotics may prevent or reduce the attachment of pathogens to host cells. In this...
broad spectrum antagonistic adhesion inhibition results 0 d19^t bile strain 16-hbe adhesion Lire la suiteBackground The safety of milk production in terms of foodborne infections is a worldwide issue, particularly in developing countries where production is often unhygienic. A cross-sectional study was c...
hygiene staphylococcus aureus antimicrobial resistance raw milk meta ethiopia hygiene raw cow mastitis 95%ci smallholder dairy 8% study susceptibility milk assess aureus Lire la suiteBackground Legionella pneumophila is a Gram-negative intracellular bacillus and is the causative agent of a severe form of pneumonia called Legionnaires’ disease which accounts for 2-9% of cases of co...
rtx family lapd lapg type 1 secretion system virulence virulence embedded legionella rtxa role protein Lire la suiteBackground Two important virulence factors, urease and cagA, play an important role in Helicobacter pylori ( H. pylori ) gastric cancer. Aim of this study was to investigate the expression level and f...
ureb caga sirna caga sirna ureb Lire la suiteBackground Enteroccocus spp. are human opportunistic pathogens causing a variety of serious and life-threating infections in humans, including urinary tract infection, endocarditis, skin infection and...
spp. antibiotic resistance vre mic values biofilm formation pig farms resistant total 5% farm infections cm^2 log cfu vre antimicrobial analysis respectively identified strains resistance efm enterococcus efa Lire la suiteBackground The dinucleotide alarmone diadenosine tetraphosphate (Ap4A), which is found in cells, has been shown to affect the survival of bacteria under stress. Results Here, we labeled Ap4A with biot...
kanamycin diadenosine tetraphosphate biofilm quorum sensing treated strain bacteria kanamycin Lire la suiteBackground Sahiwal cattle is an indigenous cattle breed of Pakistan and mastitis is one of the major problems faced by Sahiwal cattle which hinders its production potential. The study was designed to ...
sahiwal cattle milk microbiota 16s rrna metagenomics cattle diversity muciniphila akkermansia compared microbiota sahiwal clinical milk subclinical dominant Lire la suiteEndophytic fungi, particularly from higher plants have proven to be a rich source of antimicrobial secondary metabolites. The purpose of this study is to examine the antimicrobial potential of three e...
endophytes metabolomics antimicrobial molecular docking metabolites atcc Lire la suiteObjective The purpose of this study is to investigate the connection of pre-competition anxiety with gut microbiota and metabolites in wrestlers with different sports performances. Methods One week pr...
wrestlers pre-competition anxiety brain-gut axis gut microbiota untargeted metabonomics performances competition differential metabolites wrestlers cp pre-competition cnp anxiety Lire la suiteMicrobial skin infections, antibiotic resistance, and poor wound healing are major problems, and new treatments are needed. Our study targeted solving this problem with Nigella sativa (NS) oil and pho...
anti-coronavirus (229e) antibacterial activity gas chromatography low-intensity laser therapy photodynamic therapy transmission electron microscope activity photodynamic treatment methylene mb-pdt + ns blue based healing oil wound Lire la suiteBackground Swine production expanded in the last decades. Efforts have been made to improve meat production and to understand its relationship to pig gut microbiota. Copper (Cu) is a usual supplement ...
16s rrna gene microbiota swine copper feed supplement animal nutrition fed bacteria pen source supplementation production copper piglets Lire la suiteThe objective of the study was to evaluate the frequency and genetic characteristics of ESBL-producing Escherichia coli and Klebsiella spp. and the risk factors associated with a high total bacterial ...
bulk tank milk total bacterial count antimicrobial resistance esbl milking spp coli isolates milk klebsiella Lire la suiteMulti-drug-resistant Staphylococcus aureus infections necessitate novel antibiotic development. D-3263, a transient receptor potential melastatin member 8 (TRPM8) agonist, has potential antineoplastic...
antibacterial activity biofilm d-3263 phospholipids concentrations membrane antibacterial aureus Lire la suiteBackground The increase in the resistance of bacterial strains to antibiotics has led to research into the bactericidal potential of non-antibiotic compounds. This study aimed to evaluate in vitro ant...
nanoparticles antimicrobial activity antibiofilm nisin selenium thiolated chitosan n/se@tcsnps ≤ 0 0001 pg/ml atcc Lire la suiteBackground Chronic stress induces cognitive deficits. There is a well-established connection between the enteric and central nervous systems through the microbiota-gut-brain (MGB) axis. However, the e...
gut microbiota chronic restraint stress cognitive deficits mice stress stress-induced muricomes < 0 crs-cd results cognitive deficits crs-ncd gut microbiota vs Lire la suiteBackground Hospital infections such as ventilator-associated pneumonia (VAP) due to multidrug-resistant Klebsiella pneumoniae (MDR-KP) strains have increased worldwide. In addition, biofilm production...
combination therapy synergism synergistic effect colistin carbapenem-resistant ... multidrug resistant pathogen biofilm checkerboard method fractional inhibitory concentratio... planktonic pneumonia combination amikacin amoxicillin/clavulanate colistin meropenem combinations isolates biofilm Lire la suiteBackground Sequencing of the human skin microbiome revealed that Corynebacterium is an ubiquitous and abundant bacterial genus on human skin. Shotgun sequencing further highlighted the microbial “dark...
skin microbiome antimicrobial resistance pan-genome found resistance strains strain skin human Lire la suiteIntroduction : Lactic acid bacteria (LAB) are a cluster of microbes distributed in a variety of environments and have potential probiotic activity to improve human well-being. This study was aimed at ...
derashe konso lactic acid bacteria probiotic starter culture study fermented isolated pseudomesenteroides potential weissella paramesenteroides cheka probiotic leuconostoc isolates lab Lire la suiteBackground In Ethiopia, milk production and handling practices often lack proper hygiene measures, leading to the potential contamination of milk and milk products with Staphylococcus aureus ( S. aure...
antimicrobial resistance cottage cheese milk and gen... yogurt cottage using cheese highlands arsi yogurt raw strains aureus isolates products antimicrobial Lire la suiteNon-homologous end joining (NHEJ) and homology-directed repair (HDR) are two mechanisms in filamentous fungi to repair DNA damages. NHEJ is the dominant response pathway to rapidly join DNA double-str...
dna repair crispr/cas9-mediated genome editin... dna modification homology-directed repair non-homologous end joining self-replicating plasmid palindrome nhej dna repair Lire la suiteBackground Escherichia coli (E. coli) is one of the most frequent causes of fatal bacterial infections affecting both humans and animals. The resistance to Carbapenems is mainly associated with enzyme...
carbapenem resistance sewage national mulago study hospital referral meropenem detected markers sewage isolates gene genes carbapenem-resistant Lire la suite