Sélection du jour 04/04/2025

Early detection of Alzheimer's disease's precursor stages is imperative for significantly enhancing patient outcomes and quality of life. This challenge is tackled through a semi-supervised multi-mo...

Alzheimer's Disease is a global health challenge that requires early and accurate detection to improve patient outcomes. Magnetic Resonance Imaging (MRI) holds significant diagnostic potential, but ...

Recent advancements in generative AI have flourished the development of highly adept Large Language Models (LLMs) that integrate diverse data types to empower decision-making. Among these, Multimoda...

Brain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a comm...

The causal influence of sarcopenia on cardiometabolic disease and Alzheimer's disease and whether and to what extent insulin resistance plays a mediating role therein were unclear. We performed two‐st...

Prolonged exposure to glucocorticoids, the main stress hormones, damages the brain and is a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid-related neurotoxicit...

The activation of the Wnt signaling pathway is implicated in a neuroprotective mechanism against the Alzheimer disease. When this pathway is blocked, it activates GSK3 beta, leading to tau hyperphosph...

The landscape of RNA isoforms in human cortex is revealed by deep long-read RNA sequencing. Determining whether the RNA isoforms from medically relevant genes have distinct functions could facilitate ...

Background Dementia is one of the major causes of disability and dependency among older people worldwide. The formation of an aging population in Iran can be associated with societal problems, includi...

International audience; The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the identification of many diseases. This article aimed to ...

Background A positive effect of the effect of a 3-month oral spermidine intake on memory performance has already been demonstrated. The continuation of this study aimed to examine whether there could ...

Alzheimer's disease (AD) cannot be reversed, but early diagnosis will significantly benefit patients' medical treatment and care. In recent works, AD diagnosis has the primary assumption that all ca...

Background Research into the neurobiological underpinnings of learning and memory has demonstrated the cognitive-enhancing effects associated with diverse classes of phosphodiesterase (PDE) inhibitors...

Alzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have sh...

International audience; Amyloid PET imaging has been crucial for detecting the accumulation of amyloid beta (Aβ) deposits in the brain and to study Alzheimer's disease (AD). We performed...

Nearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent “neurologica...

Background Research into the neurobiological underpinnings of learning and memory has demonstrated the cognitive-enhancing effects associated with diverse classes of phosphodiesterase (PDE) inhibitors...

APOE ^ ε4 is the major genetic risk factor for sporadic Alzheimer’s disease (AD). Although APOE ^ ε4 is known to promote Aβ pathology, recent data also support an effect of  APOE  polymorphism on phos...

Background Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and inflammation. Microglia mainly participate in the inflammat...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with increasing prevalence among the aging population, necessitating early and accurate diagnosis for effective disease managemen...

Disinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism rem...

Sporadic Alzheimer’s disease (AD) is a complex neurological disorder characterized by many risk loci with potential associations with different traits and diseases. AD, characterized by a progressive ...

Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmission. However, high levels of glutamatergic input elicit exci...

Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and management implications. The objective of this study is the longitudinal evaluation of a large panel imagi...

Introduction The absence of nigrosome 1 on brain MRI and the hyperechogenicity of substantia nigra (SNh) by transcranial sonography are two useful biomarkers in the diagnosis of parkinsonisms. We aime...

Objective To employ Artificial Intelligence to model, predict and simulate the amyotrophic lateral sclerosis (ALS) progression over time in terms of variable interactions, functional impairments, and ...

Introduction In this work, we describe a new case of association between SCA2 and MND. Case Report A 58-year-old man who was diagnosed with spinocerebellar ataxia type 2 presented dysphagia and a sign...

Background The rationale for this paper is a description of a patient from Southeast Europe with genetically confirmed Huntington’s disease (HD), coexisting with sporadic, bulbar-onset amyotrophic lat...

Frontotemporal lobar degeneration (FTLD) is a clinically, genetically, and neuropathologically heterogeneous group of neurodegenerative syndromes, leading to progressive cognitive dysfunction and fron...

ALCAR (Acetyl-L-carnitine) is a donor of acetyl groups and increases the intracellular levels of carnitine, the primary transporter of fatty acids across the mitochondrial membranes. In vivo studies s...

Introduction Even if electromyography (EMG) is routinely used to confirm the diagnosis of amyotrophic lateral sclerosis (ALS), few studies have analysed the correlation between electrophysiological pa...

Background Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with not only motor symptoms but also extra-motor features including cognitive impairment. The most common cognitive profile ob...

Introduction Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with great heterogeneity. Biological prognostic markers are needed for the patients to plan future supportive tre...

Objective There is increasing evidence that amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting large-scale brain networks. However, it is still unclear which stru...

Background Neuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS) indicates that neurodegeneration may spread corticofugally. Methods We conducted an observational study to define the...

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with progressive motor system impairment, and recent evidence has identified the extra-motor involvement. Small fib...

Background Respite care provides caregiving support to people with amyotrophic lateral sclerosis (ALS) and their care partners by providing the care partner with temporary relief from their caregiving...

Purpose The identification of prognostic tools in amyotrophic lateral sclerosis (ALS) would improve the design of clinical trials, the management of patients, and life planning. We aimed to evaluate t...

Background Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons...

Amyotrophic lateral sclerosis (ALS) is a rare, incurable, and fatal neurodegenerative disease with median survival time from onset to death ranging from 20 to 48 months. Breaking bad news about ALS di...

Background We investigated the risk of ischemic stroke in ALS and analyzed the effect of ALS-related physical disability using the Korean National Health Insurance Service database. Methods A total of...

Background A single cycle (two repeated treatments) with intrathecal autologous bone marrow-derived mesenchymal stem cells (BM-MSCs, 26-day interval) showed safety and provided therapeutic benefit las...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motor neurons (MNs). Since the identification of the first ALS mutation in 1993, more than 40 genes h...

Background Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-asso...

OBJECTIVE: Ovarian cancer is one of the most common cancers with a high mortality rate worldwide. Despite optimal surgical therapy and chemotherapy, recurrence is still common. Cancer stem cells expre...

PURPOSE: Deep learning methods for classifying prostate cancer (PCa) in ultrasound images typically employ convolutional networks (CNNs) to detect cancer in small regions of interest (ROI) along a n...

Objectives To better understand the type of care offered to Italian patients with advanced breast cancer at the End-of-Life (EoL), we conducted a retrospective observational study. EoL was defined as ...

Background Microsatellite instability (MSI) is an important prognosticator for colorectal cancer (CRC). The present study aimed to assess the impact of MSI status on the characteristics and outcomes o...

Purpose Theory-based interventions aimed at promoting health behavior change in cancer survivors seem to be effective but remain scarce. More information on intervention features is also needed. This ...

This study investigates molecular changes in the response of NSCLC patients to ICI using spatial transcriptomics. Activation of B cellassociated pathways correlates with improved prognosis and guides ...

BACKGROUND: Patients with major depressive disorder (MDD) have an increased risk of breast cancer (BC), implying that these two diseases share similar pathological mechanisms. This study aimed to iden...

To identify mechanisms underlying the growth of ductal carcinoma in situ (DCIS) and properties that lead to progression to invasive cancer, we performed single-cell RNA-sequencing (scRNA-seq) on DCIS ...

Artificial Intelligence (AI) has emerged as a valuable tool for assisting radiologists in breast cancer detection and diagnosis. However, the success of AI applications in this domain is restricted ...

Background New persistent opioid use (NPOU) after surgery has been identified as a common complication. This study sought to assess the long-term health outcomes among patients who experienced NPOU af...

Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Hedgehog Interacting Protein (HHIP) is evolutionarily conserved protein, which are important morphogens for a wide range of...

Background An estimated 119,300 new cases of cervical cancer occur annually in China, accounting for 372,00 deaths. Cutaneous metastasis from cervical cancer is a rare event, with an incidence of 0.1–...

Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, an important fraction of the patients progresses to castr...

OBJECTIVES: Mono(ADP-ribosyl)ation (MARylation), a post translational modification of proteins, is emerging as an important regulator of the biology of cancer cells. PARP7 (TiPARP), a mono (ADP-ribosy...

The use of machine learning (ML) for cancer staging through medical image analysis has gained substantial interest across medical disciplines. When accompanied by the innovative federated learning (...

Background Human ABO blood group type and the antigenic secretor status are hypothesized to associate with oral diseases including oral cancer. Secretor status is the ability of individuals to secrete...

Background Existing methods to detect tumor signal in liquid biopsy have focused on the analysis of nuclear cell-free DNA (cfDNA). However, non-nuclear cfDNA and in particular mitochondrial DNA (mtDNA...

Background Liver cancer remains a significant burden in Hong Kong. We sought to examine trends in liver cancer incidence using 30 years of cancer registry data in Hong Kong. Additionally, we aimed to ...

BACKGROUND: Although oncological palliative care is increasingly being offered by multidisciplinary teams, there is still a lack of data about some symptoms handled by these teams, such as dysphagia, ...

BACKGROUND AND SIGNIFICANCE: Fibroblast growth factor receptor 2b (FGFR2b), a splice isoform of FGFR2, is found to overexpress across multiple cancers types and promotes dysregulated tyrosine kinase a...

Background Cervical cancer (CC) is a danger to women’s health, especially in many developing countries. Metabolomics can make the connection between genotypes and phenotypes. It provides a wide spectr...

Background Men who have sex with men (MSM) face many challenges and biases in healthcare. Within urology there is a need to better understand how prostate cancer impacts MSM given the unique ways in w...

Pixel-based language models have emerged as a compelling alternative to subword-based language modelling, particularly because they can represent virtually any script. PIXEL, a canonical example of ...

A control system structure for the underwater docking procedure of an Autonomous Underwater Helicopter (AUH) is proposed in this paper, which utilizes acoustic-inertial-optical guidance. Unlike conv...

This paper introduces a novel method to enhance the connectivity of multi-reconfigurable intelligent surface-assisted device-to-device networks, referred to as multi-RIS-assisted D2D networks, throu...

Standard decoding approaches for convolutional codes, such as the Viterbi and BCJR algorithms, entail significant complexity when correcting synchronization errors. The situation worsens when multip...

Collaborative filtering generates recommendations based on user-item similarities through rating data, which may involve numerous unrated items. To predict scores for unrated items, matrix factoriza...

Fine-tuning has become a popular approach to adapting large foundational models to specific tasks. As the size of models and datasets grows, parameter-efficient fine-tuning techniques are increasing...

Retrieval-Augmented Generation (RAG) aims to enhance large language models (LLMs) to generate more accurate and reliable answers with the help of the retrieved context from external knowledge source...

Data-serialization libraries are essential tools in software development, responsible for converting between programmable data structures and data persistence formats. Among them, JSON is the most p...

Recent advances in diffusion-based Large Restoration Models (LRMs) have significantly improved photo-realistic image restoration by leveraging the internal knowledge embedded within model weights. H...

How can individual agents coordinate their actions to achieve a shared objective in distributed systems? This challenge spans economic, technical, and sociological domains, each confronting scalabil...

The effect of surprisal on processing difficulty has been a central topic of investigation in psycholinguistics. Here, we use eyetracking data to examine three language processing regimes that are c...

Recent advancements in Radiance Fields have significantly improved novel-view synthesis. However, in many real-world applications, the more advanced challenge lies in inverse rendering, which seeks ...

We study fair division of indivisible mixed manna when agents have unequal entitlements, with weighted envy-freeness up to one item (WEF1) as our primary notion of fairness. We identify several shor...

Dynamic concepts in time series are crucial for understanding complex systems such as financial markets, healthcare, and online activity logs. These concepts help reveal structures and behaviors in ...

In this work, we present a comprehensive analysis of causal image modeling and introduce the Adventurer series models where we treat images as sequences of patch tokens and employ uni-directional la...

Research of adversarial attacks is important for AI security because it shows the vulnerability of deep learning models and helps to build more robust models. Adversarial attacks on images are most ...

Background: Humor is a fundamental part of human communication, with prior work linking positive humor in the workplace to positive outcomes, such as improved performance and job satisfaction. Aims:...

Despite their immense success, deep neural networks (CNNs) are costly to train, while modern architectures can retain hundreds of convolutional layers in network depth. Standard convolutional operat...

The generation of high-quality 3D car assets is essential for various applications, including video games, autonomous driving, and virtual reality. Current 3D generation methods utilizing NeRF or 3D...

Scene sketching is to convert a scene into a simplified, abstract representation that captures the essential elements and composition of the original scene. It requires semantic understanding of the...

Abstraction-based control design is a promising approach for ensuring safety-critical control of complex cyber-physical systems. A key aspect of this methodology is the relation between the original...

We propose an advancement in cardinality estimation by augmenting autoregressive models with a traditional grid structure. The novel hybrid estimator addresses the limitations of autoregressive mode...

Long COVID continues to challenge public health by affecting a considerable number of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

IMPORTANCE: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographic...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

Arid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

Background Zambian adolescent girls and young women (AGYW) have high HIV incidence and face barriers to the use of pre-exposure prophylaxis (PrEP). Parental support improves PrEP use and adherence in ...

Background Adolescents and young adults account for over 21% of new HIV infections in the U.S. with most new cases among young men. As an important information source for this group, social media can ...

Low- and middle-income countries are facing a growing burden of noncommunicable diseases (NCDs). Providing HIV treatment may provide opportunities to increase access to NCD services in under-resourced...

Background In Peru, HIV cases are highly concentrated among men who have sex with men (MSM). Despite the availability of anti-retroviral therapy, people living with HIV (PWH) have higher levels of ora...

Introduction In 2022, the WHO reported that 29.8 million people around the world were living with HIV (PLHIV) and receiving antiretroviral treatment (ART), including 25‌ 375 people in Gabon (54% of al...

Introduction Intracranial fungal infections’ (IcFIs) varying clinical manifestations lead to difficulties in diagnosis and treatment. African populations are disproportionately affected by the high bu...

Introduction Infants who are born from mothers with HIV (infants who are HIV exposed but uninfected; iHEU) are at higher risk of morbidity and display multiple immune alterations compared to infants w...

Background Long-acting injectable antiretroviral therapy (LAI-ART) represents the next innovation in HIV therapy. Pre-implementation research is needed to develop effective strategies to ensure equita...

Transmigration of circulating monocytes from the bloodstream to tissues represents an early hallmark of inflammation. This process plays a pivotal role during viral neuroinvasion, encephalitis, and HI...

Background Registered nurses working in the mobile health clinics (MHCs) play an important role in enabling HIV care access to populations in remote areas through Nurse Initiated Antiretroviral Therap...

Tuberculosis (TB) is the leading infectious killer worldwide, with 10.6 million cases and 1.6 million deaths in 2021 alone. One in 5 incident TB cases were attributable to malnutrition, more than doub...

In Côte d’Ivoire, female sex workers (FSW) continue to have an unmet need for sexual and reproductive health (SRH) and HIV prevention services. The disproportionate burden of HIV/STIs is driven by sev...

Background HIV seroprevalence in Nigeria is increasing among men who have sex with men (MSM) from 14% to 2007 to 23% in 2014, threatening progress towards ending the epidemic in the country. Expanding...

INTRODUCTION: Adolescents living with HIV are at an increased risk of experiencing mental health challenges, which may impact their overall well-being and adherence to treatment. Evidence-based interv...

Background With improved access to anti-retroviral drugs, persons living with HIV/AIDS (PLWHA) are living longer but with attendant increased risks of non-communicable diseases (NCDs). The increasing ...

Background Preliminary evidence suggests that people who inject drugs (PWID) may be at an increased risk of developing infective endocarditis (IE), hepatitis C virus (HCV) infection, and/or human immu...

BACKGROUND: Human immunodeficiency virus (HIV) drug prophylaxis, including post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP), has not yet been generally recognized and accepted by th...

BACKGROUND: Despite effective antiretroviral therapy (ART) coverage in other groups living with human immunodeficiency virus (HIV) in Tanzania, virologic suppression among HIV-positive children receiv...

Background Title X-funded family planning clinics have been identified as optimal sites for delivery of pre-exposure prophylaxis (PrEP) for HIV prevention to U.S. women. However, PrEP has not been wid...

BACKGROUND: Despite successful antiretroviral therapy (ART), frequencies and immunological functions of memory CCR6(+) Th17-polarised CD4(+) T-cells are not fully restored in people with HIV (PWH). Mo...

BACKGROUND: Mental health and substance use disorders disproportionately affect people with HIV (PWH), and may have been exacerbated during COVID-19. The Promoting Access to Care Engagement (PACE) tri...

OBJECTIVE: Assess whether biomarkers of systemic inflammation are associated with HIV acquisition or with the timing of ART initiation (“immediate”, at diagnosis, versus “deferred”, at 24 weeks postdi...

Background The impact of coronavirus diseases 2019 (COVID-19) related non-pharmaceutical interventions (NPIs) on influenza activity in the presence of other known seasonal driving factors is unclear, ...

BACKGROUND: Health-care workers (HCWs) are at a higher occupational risk of contracting and transmitting influenza. Annual vaccination is an essential tool to prevent seasonal influenza infection. How...

Highly pathogenic avian influenza viruses (HPAIV) have been responsible for causing several severe outbreaks across the world. To protect poultry farms and to prevent the possible spread of new influe...

BACKGROUND: Radix Scutellariae (RS) has been used to treat influenza for thousands of years in China. However, its mechanisms of action remain unclear. The aim of the present study was to use a networ...

Adult females of reproductive ages develop greater antibody responses to inactivated influenza vaccine (IIV) than males. How sex, age, and sex steroid changes impact B cells and durability of IIV-indu...

OBJECTIVE: To compare facility-level influenza vaccination rates in long-term care (LTC) homes from four countries and to identify factors associated with influenza vaccination among residents. DESIGN...

Intracellular pathogens interact with host factors, exploiting those that enhance replication while countering those that suppress it. Genetic screens have begun to define the host:pathogen interface ...

Sialic acid that presents on the surface of lung epithelial cells is considered as one of the main binding targets for many respiratory viruses, including influenza and the current coronavirus (SARS-C...

International audience; Detailed information are lacking on influenza transmissibility in hospital although clusters are regularly reported. In this pilot study, our goal was to estimate...

Introduction Influenza is a respiratory infection associated with a significant clinical burden globally. Adults aged ≥ 65 years are at increased risk of severe influenza-related symptoms and complica...

Background We aimed to investigate the clinical characteristics of severe influenza virus-associated pneumonia complicated with bacterial infection in children. Methods We retrospectively analysed dat...

BACKGROUND: To protect hospitalized patients, who are more susceptible to complications of influenza, seasonal influenza vaccination of healthcare workers (HCW) has been recommended internationally. H...

Between 16 September and 8 December 2021, 867 highly pathogenic avian influenza (HPAI) virus detections were reported in 27 EU/EEA countries and the UK in poultry (316), in wild (523) and in captive b...

International audience; Bovine respiratory disease (BRD) is a major disease of young cattle whose etiology lies in complex interactions between pathogens and environmental and host facto...

BACKGROUND: Demonstration of influenza vaccine effectiveness (VE) against hospitalized illness in addition to milder outpatient illness may strengthen vaccination messaging. Our objective was to compa...

The surface protein hemagglutinin (HA) of the influenza virus plays a pivotal role in facilitating viral infection by binding to sialic acid receptors on host cells. Its conformational state is pH-sen...

OBJECTIVES: Pregnant women are among the priority groups to receive influenza vaccines in the Czech Republic since 2011, data on vaccination coverage are not yet available. The aim of the study was to...

Patient: Female, 57-year-old Final Diagnosis: Acquired thrombocytopenic purpura • influenza A virus infection Symptoms: Hypoxemia Medication:— Clinical Procedure: Plasma exchange Specialty: Critical C...

BACKGROUND: Common air pollutants such as ozone (O(3)), sulfur dioxide (SO(2)), nitrogen dioxide (NO(2)), and particulate matter play significant roles as influential factors in influenza-like illness...

International audience; Seasonal influenza viruses repeatedly infect humans in part because they rapidly change their antigenic properties and evade host immune responses, necessitating ...

Objectives The concurrent impact of COVID-19 and influenza on disease burden is a topic of great concern. This discussion delves into the epidemiological characteristics of seasonal influenza activity...

Background Data on ventilator associated pneumonia (VAP) in COVID-19 and influenza patients admitted to intensive care units (ICU) are scarce. This study aimed to estimate day-60 mortality related to ...

Background Candida glabrata is an important cause of invasive candidiasis. Echinocandins are the first-line treatment of invasive candidiasis caused by C. glabrata . The epidemiological echinocandin s...

Background Hyaluronic acid (HA) has gained significant attention due to its unique physical, chemical, and biological properties, making it widely used in various industries. This study aimed to scree...

Resistance mechanisms are a shelter for Acinetobacter baumannii to adapt to our environment which causes difficulty for the infections to be treated and WHO declares this organism on the top of pathog...

Extracellular vesicles (EVs) are a heterogeneous group of lipid membrane-enclosed compartments that contain different biomolecules and are released by almost all living cells, including fungal genera....

Background Unbalanced gut microbiota is considered as a pivotal etiological factor in colitis. Nevertheless, the precise influence of the endogenous gut microbiota composition on the therapeutic effic...

Background Data about the prevalence of plasmid-mediated quinolone resistance (PMQR) and extended-spectrum beta-lactamase (ESBL) production in P . aeruginosa compared to the Enterobacteriaceae family ...

Background Antibiotic-associated diarrhea (AAD) refers to symptoms of diarrhea that cannot be explained by other causes after the use of antibiotics. AAD is thought to be caused by a disruption of int...

Background Carbapenem-resistant gram-negative bacilli (CR-GNB) have been increasingly reported in China. However, dynamic monitoring data on molecular epidemiology of CR-GNB are limited in pediatric p...

Introduction Probiotic lactobacilli are generally recognized as safe (GRAS) and are being used in several food and pharma formulations. However, growing concern of antibiotic resistance in bacterial s...

Background and objectives Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible and multi-components nanocomposite...

Background Angelica polysaccharides (AP) have numerous benefits in relieving type 2 diabetes (T2D). However, the underlying mechanisms have yet to be fully understood. Recent many reports have suggest...

The microbial colonization on ancient murals attracts more and more attention since the threaten by microorganisms was first reported in Lascaux, Spain. However, the biodeterioration or biodegradation...

Molecular studies of fungi within the order Laboulbeniales ( Ascomycota , Pezizomycotina ) have been hampered for years because of their minute size, inability to grow in axenic culture, and lack of r...

Background Members of the fungal kingdom are heterotrophic eukaryotes encased in a chitin containing cell wall. This polymer is vital for cell wall stiffness and, ultimately, cell shape. Most fungal g...

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by an elevated level of blood glucose due to the absence of insulin secretion, ineffectiveness, or lack of uptake of secreted insul...

(1) We screened and identified a chitosanase producing strain from the soil as Fusarium oxysporum D18 with an accession number OL343607. (2) The enzyme activity of chitosanase was greatly improved by ...

Background Candida glabrata is an important cause of invasive candidiasis. Echinocandins are the first-line treatment of invasive candidiasis caused by C. glabrata . The epidemiological echinocandin s...

Background Severe infections caused by β- lactamase producers, hypervirulent Klebsiella pneumoniae (BhvKp) with K2 serotype, highlight emergency need for new therapeutic strategies against this pathog...

Sugarcane ( Saccharum officinarum , Poaceae ) is cultivated on a large scale in (sub)tropical regions such as Brazil and has considerable economic value for sugar and biofuel production. The plant is ...

Sphaerellopsis species are putative hyperparasites of rust fungi and may be promising biological control agents (BCA) of rust diseases. However, few detailed studies limit potential BCA development in...

Background The study aims to investigate the effect of combining silver nanoparticles (AGNPs) with different antibiotics on multi-drug resistant (MDR) and extensively drug resistant (XDR) isolates of ...

INTRODUCTION: Cerebrovascular disease and neurodegeneration are causes of cognitive decline and dementia, for which primary prevention options are currently lacking. Statins are well-tolerated and wid...

BACKGROUND AND PURPOSE: The fetal subarachnoid space size serves as an indicator of normal brain development. The subarachnoid space is commonly measured by an ultrasound examination. Introduction of ...

INTRODUCTION: Parkinson’s disease is a movement disorder that also manifests non-motor symptoms (NMS). Physical exercise is a prominent strategy that can have an impact on NMS; however, the evidence i...

The organizational principles of the object space represented in the human ventral visual cortex are debated. Here we contrast two prominent proposals that, in addition to an organization in terms of ...

In the human brain, aversive and appetitive processing have been studied with controlled stimuli in rather static settings. In addition, the extent to which aversive-related and appetitive-related pro...

OBJECTIVE: Previous research has suggested that neurodevelopmental conditions may be associated with distinctive cognitive profiles on the Wechsler intelligence tests (of which the most recent edition...

BACKGROUND: Imaging of in vitro neuronal differentiation and measurements of cell morphologies have led to novel insights into neuronal development. Live-cell imaging techniques and large datasets of ...

BACKGROUND: Deep cerebral venous thrombosis (DCVT) can have long-term functional and cognitive sequelae. Although literature exists on cognitive impairment after arterial stroke, cognitive sequelae af...

INTRODUCTION: Isolated infarction of the fornix is a relatively rare stroke syndrome frequently associated with amnesia. The long-term cognitive outcome in cases of acute fornix infarction is poorly u...

BACKGROUND: Most neurodevelopmental tests used to assess child development in sub-Saharan Africa were developed in western or high-income countries, raising the question of their usefulness with Afric...

Mitochondria exert powerful control over cellular physiology, contributing to ion homeostasis, energy production, and metabolite biosynthesis. The trafficking and function of these organelles are part...

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a delayed complication of cranial irradiation, with subacute onset of stroke-like symptoms including seizures, visual disturban...

Microglia, the resident immune cells of the CNS, sense the activity of neurons and regulate physiological brain functions. They have been implicated in the pathology of brain diseases associated with ...

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a delayed complication of cranial irradiation, with subacute onset of stroke-like symptoms including seizures, visual disturban...

BACKGROUND AND OBJECTIVES: Spontaneous spinal cord infarction (SCInf) is a rare condition resulting in acute neurological impairment. Consensus on diagnostic criteria is lacking, which may present a c...

OBJECTIVE: Allelic variation in the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been shown to moderate rates of cognitive decline in preclinical sporadic Alzheimer’s disease (AD...

BACKGROUND AND PURPOSE: We conducted a systematic review and meta-analysis to assess the incidence of acute kidney injury (AKI) in patients undergoing CT angiography (CTA) and CT perfusion (CTP) for a...

Parvalbumin interneurons belong to the major types of GABAergic interneurons. Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied, the dis...

BACKGROUND AND PURPOSE: Vein of Galen malformation is a rare congenital cerebrovascular malformation. In affected patients, increased cerebral venous pressure constitutes an important etiologic factor...

Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes, where proteins, lipids, and organelles are degraded and recycled. According to the way the cytoplasmic componen...

BACKGROUND: Internet is an integral part of the daily life of everyone. Internet addiction (IA) is one of the major concerns, specifically among young adults. The association between IA, depression, a...

Opioid use disorder (OUD) has become a considerable global public health challenge; however, potential medications for the management of OUD that are effective, safe, and nonaddictive are not availabl...

Cell-to-cell transmission of α-synuclein (α-syn) pathology is considered to underlie the spread of neurodegeneration in Parkinson's disease (PD). Previous studies have demonstrated that α-syn is secre...

International audience; Autosomal recessive early-onset parkinsonism is clinically and genetically heterogeneous. Mutations of three genes, PRKN, PINK1, and DJ-1 cause pure phenotypes us...

International audience; The subthalamic nucleus (STN) is involved in different aspects of emotional processes and more specifically in emotional prosody recognition. Recent studies on th...

Parkinson disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain. The majority of early onset forms of Parkinson disease are a result of ...

OBJECTIVES: This study aimed to assess the efficacy of DA‐9701 on gastrointestinal symptom‐related quality of life in patients with Parkinson's disease on stable dopaminergic medications. METHODS: Thi...

Participation in supervised, laboratory‐based aerobic exercise protocols holds promise in slowing the progression of Parkinson's disease (PD). Gaps remain regarding exercise adherence and effectivenes...

International audience; BackgroundExcessive daytime sleepiness (EDS) is a frequent and disabling symptom of Parkinson's disease (PD) without approved treatment. THN102 is a novel combina...

Neuronal action potential firing patterns are key components of healthy brain function. Importantly, restoring dysregulated neuronal firing patterns has the potential to be a promising strategy in the...

International audience; Background: Results regarding the association between hormonal exposure and risk of Parkinson's disease (PD) are heterogeneous. Objectives: To investigate the ass...

AIMS: Neuropsychiatric symptoms including depression, apathy and psychosis are experienced by the majority of patients with Parkinson's disease. A subgroup of patients develop cognitive impairment, wh...

BACKGROUND: The gut microbiome and its metabolites can impact brain health and are altered in Parkinson's disease (PD) patients. It has been recently demonstrated that PD patients have reduced fecal l...

BACKGROUND: The neurophysiological correlates of gastrointestinal symptoms (GISs) in Parkinson's disease (PD) are not well understood. It has been proposed that in patients with a gastrointestinal ori...

Flexible Endoscopic Evaluation of Swallowing (FEES) is one of two diagnostic gold standards for pharyngeal dysphagia in Parkinson's disease (PD), however, validated global outcome measures at the pati...

Background Sex hormones affect the pathogenesis of Parkinson patients and it has been suggested that gender is the most important factor in the development and progression of Parkinson’s disease. Stud...

A 59-year-old man with advanced Parkinson's disease treated using levodopa-carbidopa intestinal gel (LCIG) presented with leg edema, hypoalbuminemia, and proteinuria at 1 year after the treatment. He ...

One of the most catastrophic neurological disorders worldwide is Parkinson's Disease. Along with it, the treatment is complicated and abundantly expensive. The only effective action to control the p...

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease perceived as a motor disorder. It is most commonly associated with autonomic dysfunction, affecting multiple systems. This altered a...

Advanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device‐aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG),...

BACKGROUND: Individuals with Parkinson's disease present arm swing alterations that can adversely affect their locomotion. OBJECTIVE: To identify differences in arm swing asymmetry (ASA) between indiv...

Parkinson's disease (PD) has a large impact on patients' physical and mental health, which also greatly affects their family caregivers. Deep brain stimulation (DBS) has emerged as an effective treatm...

International audience; Parkinson's disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein (αSyn) aggregation and associated with abnormalities in lipid metabolism...

Nearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent “neurologica...

The extreme environments of transiting close-in exoplanets in highly-eccentric orbits are ideal for testing exo-climate physics. Spectroscopically resolved phase curves not only allow for the charac...

Recent observations of planetary atmospheres in HAT-P-32 b and HAT-P-67 b reveal extensive outflows reaching up to hundreds of planetary radii. The helium 1083 nm light curves for these planets, cap...

Investigating line-locked phenomena within quasars is crucial for understanding the dynamics of quasar outflows, the role of radiation pressure in astrophysical flows, and the star formation history...

We investigated the pulsating behavior of KIC 10855535 using Kepler 4-year long cadence data. Two independent frequencies were detected: a pulsation frequency F0 = 17.733260(5)d-1 and a low frequenc...

Galaxy cluster masses estimated from parametric modeling of weak lensing shear observations are known to be biased by inaccuracies in observationally determined centers. It has recently been shown t...

We present an investigation into the rotation and stellar activity of four fully convective M dwarf `twin' wide binaries. Components in each pair have (1) astrometry confirming they are common-prope...

Tests of general relativity (GR) can be systematically biased when our waveform models are inaccurate. We here study systematic biases in tests of general relativity induced by neglecting lensing ef...

Context. Relativistic jets from Active Galactic Nuclei are observed to be collimated on the parsec scale. When the pressure between the jet and the ambient medium is mismatched, recollimation shocks...

The Pleiades is the most prominent open star cluster visible from Earth and an important benchmark for simple stellar populations, unified by common origin, age, and distance. Binary stars are its e...

This paper investigates scalar perturbations and quasinormal modes (QNMs) associated with cylindrical black holes constructed within the frameworks of $f(\mathcal{R})$-gravity and Ricci-Inverse ($\m...

We employ an efficient method for identifying gamma-ray sources across the entire sky, leveraging advanced algorithms from Fermi p y, and cleverly utilizing the Galactic diffuse background emission ...

The detection of various molecular species, including complex organic molecules relevant to biochemical and geochemical processes, in astronomical settings such as the interstellar medium or the out...

We performed a chemical analysis of the asteroid-bearing white dwarf WD 1145+017 using optical and ultraviolet spectroscopic data from 25 epochs between 2015 and 2023. We present an updated gas disk...

This document compiles results obtained from the test campaign of the European Moon Rover System (EMRS) project. The test campaign, conducted at the Planetary Exploration Lab of DLR in Wessling, aim...

An accurate estimation of the continuum excess emission from accretion spots and inner circumstellar disk regions is crucial for a proper derivation of fundamental stellar parameters in accreting sy...

The plasma opacity in stars depends mainly on the local state of matter (the density, temperature, and chemical composition at the point of interest), but in supernova ejecta it also depends on the ...

We introduce a new method designed for Bayesian inference of the angular power spectrum of the Gravitational Wave Background (GWB) anisotropy. This scheme works with time-series data and can optiona...

A gaseous counter-rotating galaxy is a galaxy containing a gas component with opposite angular momentum to the main stellar disk. The counter-rotating gas provides direct evidence for the accretion ...

Evolved cool stars have three distinct evolutionary status: shell Hydrogen-burning (RGB), core Helium and shell Hydrogen burning (RC), and double shell burning (AGB). Asteroseismology can distinguis...

We present capivara, a fast and scalable multi-decomposition package designed to study astrophysical properties within distinct structural components of galaxies. Our spectro-decomposition code for ...

Transit timing variations (TTVs) are observed for exoplanets at a range of amplitudes and periods, yielding an ostensibly degenerate forest of possible explanations. We offer some clarity in this fo...

The ability to differentiate between different models of inflation through the imprint of primordial non-Gaussianity (PNG) requires a tight constraint on the local PNG parameter $f_{\text{NL}}^{\tex...

INTRODUCTION: Drug-resistant tuberculosis (TB) is a global concern. The proper diagnosis and management of drug-resistant TB are critical for improving treatment outcome. Molecular-based genotypic dru...

The high-risk dynamic environments management (transports, nuclear industry, medicine etc.) increases every day in our societies. A good management of these environments requires the re...

Purpose The fragmentation of polyps affects complete resection confirmation. The primary aim of this study was to assess the feasibility of a novel polyp retrieval bag for reducing the fragmentation r...

BACKGROUND: As the number of cancer survivors is increasing, the importance of their healthcare management is becoming emphasized. For this purpose, appropriate recognition of the importance of body w...

Objective The aim of this study was to investigate risk factors for the severity of breast abscess during lactation. Methods A cross-sectional study was conducted using data from the Questionnaire sur...

[Image: see text] The efficient selectivity of heavy metal ions from wastewater is still challenging but gains great public attention in water treatment on a world scale. In this study, the novel disu...

STUDY QUESTION: Does immune response to COVID-19 vaccination affect the clinical outcome in fully vaccinated infertile women undergoing IVF/ICSI cycles? SUMMARY ANSWER: COVID-19 IgG antibodies are pre...

OBJECTIVES: Current evidence shows a variable rate of emergency action plan (EAP) implementation and a low rate of compliance to EAP guidelines in United States secondary schools. There is limited dat...

Background The Health Extension Program (HEP) is Ethiopia’s flagship community health program, launched in 2003. Health Extension Workers (HEWs) are key vehicles for the delivery of the HEP. While it ...

Background There has been a noticeable relative increase in psychiatric comorbidities among smokers as opposed to the general population. This is likely due to comparatively slower decrease in smoking...

BACKGROUND: An optimal position for strength testing of the hip musculature has not been identified. However, sagittal plane hip position during testing has been shown to influence hip external rotati...

During development, embryos undergo a complex sequence of morphogenetic shape changes powered by cellular contractile forces which allow the embryo to correctly form tissues and organs....

Among the 3000 exoplanets detected at this time, about 50 have been observed by direct imaging. The benefit of direct imaging is to give access to exoplanet light, paving the way for sp...

BACKGROUND: Children regularly consume foods from quick-service restaurants (QSR), but little is known about the foods that children order, the calories and nutrients consumed, the accuracy of stated ...

In this paper, we explore the design and use of conversational telepresence robots to help homebound older adults interact with the external world. An initial needfinding study (N=8) using video vig...

AIM: Heat‐related illness is common, but its epidemiology and pathological mechanism remain unclear. The aim of this study was to report current clinical characteristics, prognostic factors, and outco...

Background Clinical competency is the ability to integrate knowledge, skills, attitudes and values into a clinical situation and it is very important in nursing education, clinical settings, nursing m...

This study aimed to investigate the causal relationship between bone mineral density (BMD) and intervertebral disk degeneration (IVDD) using a two-sample bidirectional Mendelian randomization analysis...

International audience; Objective: To understand the perceptions and attitudes of general practitioners (GPs) regarding children with an Autism Spectrum Disorder (ASD).Design: Phenomenol...

Background Acute hypoxemic respiratory failure (AHRF) is a leading concern in critically ill patients. Experimental and clinical data suggest that early sedation with volatile anesthestics may improve...

The rapid growth and development in the first 1,000 days of life makes monitoring children's growth and development very important at this age. Monitoring growth and development is expected to always ...

Background Enterocutaneous fistula after removal of the jejunostomy tube leads to multiple problems, such as cosmetic problems, decreased quality of life, electrolyte imbalances, infectious complicati...

BACKGROUND: This study investigates the effects of intranasal dantrolene nanoparticles on inflammation and programmed cell death by pyroptosis in 5XFAD Alzheimer’s Disease (AD) mice. METHODS: 5XFAD an...

Background Anti-programmed cell death-1 (ligand-1) antibody [PD-(L)1-Ab] can cause destructive thyroiditis and/or hypothyroidism. In addition, tyrosine kinase inhibitors (TKIs) frequently induce hypot...

Thyroid surgery rates have tripled over the past three decades, making it one of the most frequently performed procedures within general surgery. Thyroid surgery is associated with the possibility of ...

INTRODUCTION: In recent years, the incidence of thyroid cancer has increased manyfold and young adults, who have a greater financial burden and occupational stress, comprise a large number. Previous s...

BACKGROUND: Thyroid dysfunction is the leading endocrine disorder worldwide. Iodine deficiency disorders, which were once the major etiology of thyroid dysfunctions, now have been succeeded by autoimm...

Background Radioactive iodine 131 (I-131) is used in the treatment of differentiated thyroid cancer after thyroidectomy; however, its accumulation in non-thyroidal regions may give false positive resu...

Purpose The vertical level of carotid bifurcation (CB) is commonly indicated at the superior margin of the thyroid cartilage. Few studies observed the CB vertical topography. It was aimed at studying ...

SIMPLE SUMMARY: The lambing trait is an important production trait in sheep, and the FecB gene is one of the major genes affecting sheep reproduction. In order to explore the molecular regulatory mech...