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OntdekkenBACKGROUND: Mild cognitive impairment (MCI), an intermediate stage between normal aging and dementia, has emerged as a prominent research area in geriatric care due to its heightened propensity for pr...
impairment alzheimer bibliometric publication dyssomnias analysis mci disease cognitive clusters Lees verderAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide, necessitating early and accurate diagnosis for optimal patient management. In recent years, advancements in dee...
3d deep computer mri learning accuracy vit-bilstm science disease alzheimer cnn-bilstm models ad video diagnosis Lees verderRecent advancements in generative AI have flourished the development of highly adept Large Language Models (LLMs) that integrate diverse data types to empower decision-making. Among these, Multimoda...
pipeline alzheimer biomedical multimodal Lees verderAlzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory and cognitive decline, affecting millions worldwide. Diagnosing AD is challenging due to its heterogeneou...
gnns computer science neuroimaging cognitive brain alzheimer ad layer Lees verderAlzheimer disease (AD) is the main form of dementia and is still uncurable. It occurs in 2 forms: the first, the majority (>95% of cases) and non-hereditary, is called “sporadic” (sAD)....
dérivés modèle xénotransplantation derived model humains allowing au adulte souris transplantées permettant chez bmi1 cells transplanted human neurons lv hnpc permis expression adult l’expression gène xenotransplantation cellules study alzheimer sad npc mas pfc neurones Lees verderNeurodegeneration as measured through magnetic resonance imaging (MRI) is recognized as a potential biomarker for diagnosing Alzheimer's disease (AD), but is generally considered less specific than ...
dataset alzheimer computer imaging model mri Lees verderBACKGROUND: Mild cognitive impairment (MCI), an intermediate stage between normal aging and dementia, has emerged as a prominent research area in geriatric care due to its heightened propensity for pr...
impairment alzheimer bibliometric publication dyssomnias analysis mci disease cognitive clusters Lees verderBackground Evidence on the relative risk of death across all stages of Alzheimer’s disease (AD) is lacking but greatly needed for the evaluation of new interventions. We used data from the Uniform Dat...
mortality alzheimer mild cognitive impairment prodromal ad predementia comorbidity institution study stage relative severity alzheimer’s participants mortality dementia death risk Lees verderMultimodal medical data (e.g. MR and PET imaging, CSF measurements, clinical assessments) reflect different aspects of Alzheimer's Disease, including early changes in brain structure an...
multimodal ad alzheimer feature stages disease cognitive Lees verderAlzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have sh...
model generalizability dataset disease classification alzheimer Lees verderIntroduction Alzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of life. Clinic...
aducanumab alzheimer’s disease β-amyloid cholinesterase inhibitors dementia cognitive dysfunction early-onset alzheimer’s disease inflammation late-onset alzheimer’s disease n-methyl-d-aspartate neurodegeneration neurofibrillary tangles memory neurocognitive disorders senile plaques tau proteins alzheimer Lees verderInsoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer’s ...
alzheimer tau seeding spreading microglia propagation oligomeric compared seeding tau Lees verderAlzheimer's disease (AD) is a leading neurodegenerative condition and the primary cause of dementia, characterized by progressive cognitive decline and memory loss. Its progression, marked by shrink...
weight ad scheme flexi-fuzz-lssvm approach samples flexi-fuzz noise diagnosis alzheimer proposed models imbalance class Lees verderInsoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer’s ...
alzheimer tau seeding spreading microglia propagation oligomeric compared seeding tau Lees verderAlzheimer's disease (AD) cannot be reversed, but early diagnosis will significantly benefit patients' medical treatment and care. In recent works, AD diagnosis has the primary assumption that all ca...
alzheimer diagnosis ad abnormal pattern Lees verderInternational audience; The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the identification of many diseases. This article aimed to ...
alzheimer diseases biomarker parkinson molecularly imprinted polymers disease biomarkers Lees verderBackgrounds. Deep neural networks have demonstrated high accuracy in classifying Alzheimer's disease (AD). This study aims to enlighten the underlying black-box nature and reveal individual contri...
disease widely alzheimer neural science mri classification computer features texture Lees verderAlzheimer's disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins i...
mutation disease alzheimer amyloid-β peptides connectivity pathology osa synaptic osaka cerebral Lees verderBackground A decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in cognitive composite endpoints that are used to de...
episodic memory cognition composite scores plasma biomarkers alzheimer disease baseline biomarkers composite decline ptau217 tests included longitudinal recall alzheimer disease plasma memory cognitive paragraph Lees verderIL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells...
alzheimer Lees verderIL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells...
alzheimer Lees verderBACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenera...
0 alzheimer disease feature data ad c-swat Lees verderBACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenera...
0 alzheimer disease feature data ad c-swat Lees verderAlzheimer's disease (AD) is a multi-facet pathology, that can be monitored through a variety of data types. This thesis aims to leverage multimodal longitudinal data, especially imaging...
time variety fournir clinical provide biomarqueurs biomarkers fil temps données data variété au grande ma ad progression disease alzheimer maladie Lees verderAlzheimer's Disease is an incurable cognitive condition that affects thousands of people globally. While some diagnostic methods exist for Alzheimer's Disease, many of these methods cannot detect Al...
science disease anns alzheimer Lees verderBackground Fasciculation is an important sign for the diagnosis of amyotrophic lateral sclerosis (ALS). Our study aimed to analyze the difference in fasciculation detected with muscle ultrasonography ...
amyotrophic lateral sclerosis fasciculation ultrasonography peripheral neuropathy diagnosis als non-als mus muscle patients fasciculation Lees verderBackground The present study aimed at determining whether, net of motor confounders, neuropsychological features affect functional independence (FI) in activities of daily living (ADLs) in non-demente...
amyotrophic lateral sclerosis activities of daily living neuropsychology functional independence frontotemporal degeneration scores behavioural fi iadl ecas-language non-demented = 0 features als patients Lees verderBackground Previous studies have yielded inconsistent results about hippocampal involvement in non-demented patients with amyotrophic lateral sclerosis (ALS). We hypothesized that testing of memory-gu...
navigation spatial memory hippocampus amyotrophic lateral sclerosis motor neuron disease spatial test controls memory-guided navigation als mean non-demented memory Lees verderMost neurodegenerative disorders are diseases of protein homeostasis, with misfolded aggregates accumulating. The neurodegenerative process is mediated by numerous metabolic pathways, most of which le...
amyotrophic lateral sclerosis alzheimer’s disease bile acids disease-modifying huntington’s disease neurodegeneration neuroprotection parkinson’s disease ursodeoxycholic acid tauroursodeoxycholic acid als neurodegenerative diseases Lees verderBackground Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting the upper and lower motor neurons, which can lead to death from respiratory failure within 3–5 years after the ...
amyotrophic lateral sclerosis high-calorie therapy nutrition systematic review meta-analysis als performed survival safety 0 meta-analysis 95% ci high-calorie smd = 0 therapy − 0 Lees verderBackground Previous studies have yielded inconsistent results about hippocampal involvement in non-demented patients with amyotrophic lateral sclerosis (ALS). We hypothesized that testing of memory-gu...
navigation spatial memory hippocampus amyotrophic lateral sclerosis motor neuron disease spatial test controls memory-guided navigation als mean non-demented memory Lees verderAmyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disorder in which motor neurons within the brain and spinal cord degenerate. A single infusion of mesenchymal stem cells (MSCs) delays ...
amyotrophic lateral sclerosis mesenchymal stem cells intravenous... multiple doses quality of life deterioration function single als compared motor Lees verderLipids, defined by low solubility in water and high solubility in nonpolar solvents, can be classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols. Lipids not onl...
amyotrophic lateral sclerosis sphingolipids triglycerides phospholipids cholesterol esters fatty acids ceramides arachidonic acid lysophosphatidylcholine eicosanoids als lipids Lees verderIntroduction Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with great heterogeneity. Biological prognostic markers are needed for the patients to plan future supportive tre...
alsfrs-r slope amyotrophic lateral sclerosis median survival time prognostic biomarker disease treatment symptoms test prognostic δfs’ survival Lees verderBackground Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue, expa...
stroke traumatic brain injury sudden cardiac arrest concussion modeling migraine ischemia na/k pump huntington disease alzheimer disease amyotrophic lateral sclerosis ketamine penumbra persistent vegetative state dendritic beading brain swelling spreading brain damage release injury sd excitotoxicity glutamate Lees verderMultiple studies indicate that United States veterans have an increased risk of developing amyotrophic lateral sclerosis (ALS) compared to civilians. However, the responsible etiological factors are u...
amyotrophic lateral sclerosis veterans etiology neurotoxicant persistent exposure civilians factors increased risk Lees verderBackground and objectives Primary lateral sclerosis (PLS) is a motor neuron disease characterised by loss of the upper motor neurons. Most patients present with slowly progressive spasticity of the le...
primary lateral sclerosis amyotrophic lateral sclerosis hereditary spastic paraplegia genetics resulted pathogenic criteria als c9orf72 sclerosis lateral pls variants patients Lees verderBradyarrhythmia can be a life-threatening condition that mandates quick and proper responses and acts from a clinician. Furthermore, bradyarrhythmia management should not stop only in increasing the p...
amyotrophic lateral sclerosis av block bradyarrhythmia wave heart condition performed enmg underlying bradyarrhythmia Lees verderBackground Interventional trials in amyotrophic lateral sclerosis (ALS) suffer from the heterogeneity of the disease as it considerably reduces statistical power. We asked if blood neurofilament light...
neurofilament light prediction model disease progression amyotrophic lateral sclerosis interventional trials statistical power decrease study observational score heterogeneity alsfrs-r als trial onset disease power model Lees verderBackground Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-asso...
spinal cord motor neuron transcription factor amyotrophic lateral sclerosis synthetic mrna mci-186 neurotrophic factor differentiation neuroprotective efficacy mns ipscs disease treatment mimns gdnf effect neurotoxicity signaling neurotrophic edaravone als Lees verderBackground A single cycle (two repeated treatments) with intrathecal autologous bone marrow-derived mesenchymal stem cells (BM-MSCs, 26-day interval) showed safety and provided therapeutic benefit las...
lenzumestrocel amyotrophic lateral sclerosis bone marrow-derived mesenchymal st... phase iii patients iii randomized phase control single-cycle injections trial protocol efficacy alsummit study safety months Lees verderBackground People with amyotrophic lateral sclerosis (ALS) are at high risk for severe outcomes from Covid-19 infection. Researchers exploring ALS and Covid-19 have focused primarily on system respons...
amyotrophic lateral sclerosis covid 19 pandemics emergency planning protective motivation theory patients family caregivers information als participants coping people costs health covid-19 pandemic care Lees verderThe stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis (ALS). While prior studies have fo...
motor neuron disease amyotrophic lateral sclerosis dna damage neuroinflammation sting central neurons immune signaling motor cortical activation neurons Lees verderObjective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive loss of motor neurons. It is a growing and underestimated disease, prompting this epidem...
amyotrophic lateral sclerosis epidemiology registry clinical disease progression egypt median egyptian alsfrs-r iqr als Lees verderThe stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis (ALS). While prior studies have fo...
motor neuron disease amyotrophic lateral sclerosis dna damage neuroinflammation sting central neurons immune signaling motor cortical activation neurons Lees verderAmyotrophic lateral sclerosis (ALS) is the most common subtype of motor neuron disease (MND). The current gold-standard measure of progression is the ALS Functional Rating Scale—Revised (ALS-FRS(R)), ...
amyotrophic lateral sclerosis motor neuron disease devices sensors clinical trials technology function evaluate mnd included motor progression studies Lees verderAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons, leading to paralysis and eventually death. Symptomatic treatments such as i...
amyotrophic lateral sclerosis motor neurons autophagy stem cells gene editing progression therapies als Lees verderBackground Uric acid (UA) has emerged as a factor that can modify cognitive function both in the general population and in people with neurodegenerative disorders. Since very few data are available co...
amyotrophic lateral sclerosis cognition frontotemporal dementia uric acid phenotype als-int cognitive levels impairment als-ftd als ua Lees verderAxonal transport ensures long-range delivery of essential cargoes between proximal and distal compartments, and is needed for neuronal development, function, and survival. Deficits in axonal transport...
axonal transport amyotrophic lateral sclerosis motor neuron bdnf trkb p75 mice fmns vivo als bdnf transport Lees verderBackground Previous studies have yielded inconsistent results about hippocampal involvement in non-demented patients with amyotrophic lateral sclerosis (ALS). We hypothesized that testing of memory-gu...
navigation spatial memory hippocampus amyotrophic lateral sclerosis motor neuron disease spatial test controls memory-guided navigation als mean non-demented memory Lees verderPURPOSE: Oncoplastic breast surgery (OBS) combines breast cancer tumor removal with the cosmetic benefits of plastic surgery at the time of breast-conserving surgery. Potential advantages of OBS inclu...
therapy cancer vs clips >500 oncoplastic adjuvant cm patients radiation obs surgery removed tissue volume lumpectomy Lees verderLines of evidence have demonstrated that the oncogenic miRNAs are pivotal to the progression of breast cancer. In this study, we investigated the biological traits of microRNA-429 (miR-429) in triple-...
tnbc cancer breast Lees verderINTRODUCTION: Screening of cancer is the maximum effort and critical element for providing health related care in order to decrease cancer related dealt because of the disease burden is in its advance...
hospitals amhara -stage burden data analysis study factors cancer time ethiopia 95% patients northwest associated presentation Lees verderBackground Colorectal cancer (CRC) is the third leading cause of cancer and the second cause of cancer-related deaths in the world. Despite the infrastructure and the availability of organized screeni...
cancer colorectal cancer mobile application prevention screening deviation 47 screening average standard history conducted phase randomized users research intervention control evaluation participants mobile age colorectal software colon application cancer Lees verderA fraction of cancer cells are highly dependent on kinesin KIF18A function because of alterations in the ratio of APC/C and spindle assembly checkpoint (SAC) signals. The kinesin KIF18A has emerged as...
anaphase promoting complex (apc/c)... cancer kif18a mitosis spindle assembly checkpoint (sac) metaphase-to-anaphase cell signaling transition dependency spindle checkpoint assembly apc/c cells inhibition sac Lees verderWe investigate different natural language processing (NLP) approaches based on contextualised word representations for the problem of early prediction of lung cancer using free-text patient medical ...
cancer primary using care language lung imbalanced plms models Lees verderTumor-associated macrophage (TAM)-derived IL-6 is involved in small-cell lung cancer (SCLC) progression and chemoresistance via the activation of signal transducer and activator of transcription 3 (ST...
small-cell lung cancer interleukin-6 signal transducer and activator of... tumor-associated macrophage cell–cell interaction cancer il-6 proliferation compounds natural sclc cell–cell ona Lees verderObjective Various systemic inflammation response indexes (SIRI) have repeatedly been described as prognostic factors in ovarian cancer. They have not been validated in prospective trials and published...
ovarian cancer systemic inflammation response ind... neutrophil-to-lymphocyte ratio (nl... platelet-to-lymphocyte ratio (plr)... monocyte-to-lymphocyte ratio (mlr)... red cell distribution width (rdw) mean platelet volume (mpv) cox role = 198 plr > regression diagnosis cancer prognostic patients ovarian Lees verderBackground The benefits of first-line, cisplatin-based chemotherapy for muscle-invasive bladder cancer are limited due to intrinsic or acquired resistance to cisplatin. Increasing evidence has reveale...
bladder cancer cancer stem cell drug resistance ceramide cisplatin sensitivity β-catenin sensitivity resistance assay growth investigate overexpression cancer bladder β-catenin cisplatin lass2 cells Lees verderPurpose Tau/MAPT (microtubule associated protein tau) protein is actively studied for the pathologic consequences of its aberrant proteostasis in central nervous system leading to neurodegenerative di...
prostate cancer docetaxel cancer therapy mitosis cell cycle phosphorylated g2/m phase phosphorylation cancer Lees verderBackground Breast cancer (BC) treatment has recently been revolutionized by the introduction of newer targeted agents, that helped tailoring therapies around the single patient. Along with increased s...
breast cancer multidisciplinary approach tailored oncology cancer prevention oncology and metabolism personalized medicine integrative oncology patients cancer breast care Lees verderBackground: Kinesin family member C1 (KIFC1) is an essential member of the motor protein family, which is critically involved in various cellular events, such as mitosis, meiosis, and macromolecular t...
tumor expression cancer pancreatic Lees verderBackground The role of tumor-draining lymph nodes in the progression of malignant tumors, including stage III colorectal cancer (CRC), is critical. However, the prognostic and predictive value of the ...
examined lymph node colorectal cancer tumor microenvironment restricted cubic spline curves prognosis os tumor crc cancer immune cohorts predictive lymph elns survival iii stage Lees verderAdvanced ovarian cancer remains a leading cause of death from gynecologic malignancy. Surgery and, in most cases, platinum-based chemotherapy with or without maintenance with bevacizumab and/or poly-A...
ovarian cancer Lees verderAim To analyze the clinicopathological features of schistosomal and non-schistosomal colorectal cancer in Central China and compare them with other areas of the Yangtze River Basin. Method The 501 cas...
schistosomiasis colorectal cancer clinicopathological characteristic... central china non-schistosomal schistosomal differences china central crc-s < 0 05 study crc-ns 0 p = clinicopathological schistosomiasis cancer colorectal Lees verderBackground Acquired radio-resistance and the undesired normal tissue radiation injuries seriously discount the therapeutic effect of lung cancer radiotherapy. In this study, we aimed to explore the ro...
lung cancer radiation sensitization radioprotection polydatin immunomodulation tumor microenvironment injuries polydatin effect radiation lung cancer Lees verderBACKGROUND: Cervical cancer stands as one of the most prevalent cancer types among women, despite its preventable nature through early screening and vaccination strategies. The link between being over...
screening cervical women factors cancer ccs 95% Lees verderPurpose The purpose of this study is to determine the incidence and severity of symptoms of patients with cervical cancer within 6 months after radiotherapy and chemotherapy, form a symptom burden rep...
symptom burden symptom clusters cervical cancer radiotherapy chemotherapy exploratory factor analysis burden cluster patients cancer cervical study Lees verderPurpose This study aimed to investigate the impact of tumor size on survival in early-onset colon and rectal cancer. Methods Early-onset colon and rectal cancer patients were identified from the Surve...
colorectal cancer cancer-specific survival early-onset overall survival tumor size worse analysis survival early-onset cancer colon size tumor Lees verderBackground and aim This study aims to examine the mortality rate and trend of gastrointestinal cancers, particularly gastric cancer, as the leading cause of death among cancers in northern Iran over a...
gastrointestinal cancers trends mortality iran cancer study crude iran rates mortality trend gastrointestinal Lees verderBACKGROUND: Current models of post-treatment cancer care rely heavily on hospital-based, medical specialists and do not sufficiently leverage primary care. Many breast cancer survivors face ongoing un...
model consultation post-treatment primary nurse-enabled shared-care cancer care breast trial intervention Lees verderBACKGROUND: Medications are commonly used for symptom control in cancer patients at the end of life. This study aimed to evaluate medication utilization among home care palliative patients with cancer...
analgesics defined 9% medication life home appropriateness care potentially patients cancer medications Lees verderA drug conjugate consists of a cytotoxic drug bound via a linker to a targeted ligand, allowing the targeted delivery of the drug to one or more tumor sites. This approach simultaneously reduces drug ...
drug conjugates lung cancer drug discovery clinical practice lung cancer therapy adcs treatment drug Lees verderBackground In patient assessment for recurrence of neoplasia, a biomarker that shows an elevated serum value before the first treatment is a candidate for follow-up examination. The biomarker squamous...
cervical cancer biomarker scca ca125 lymph nodes biomarker carcinoma cell squamous tissue 125 cancer lymph Lees verderThe Mar Menor, Europe’s largest saltwater lagoon in the Mediterranean basin (Murcia, southeastern Spain), is an ecosystem facing severe pollution, anoxia events, and marine biodiversity loss. This exp...
childhood cancer environmental health leukemia blue spaces epidemiology murcia menor mar health study 95% cancer ci Lees verderDeclarative UI frameworks have gained widespread adoption in mobile app development, offering benefits such as improved code readability and easier maintenance. Despite these advantages, the process...
designs ui rate code declarui Lees verderAutomatic network management strategies have become paramount for meeting the needs of innovative real-time and data-intensive applications, such as in the Internet of Things. However, meeting the e...
resource network Lees verderThe Statistical Classification of Economic Activities in the European Community (NACE) is the standard classification system for the categorization of economic and industrial activities within the E...
classification nace Lees verderWe show that the flip chain for non-crossing spanning trees of $n+1$ points in convex position mixes in time $O(n^8\log n)$. We use connections between Fuss-Catalan structures to construct a compari...
mathematics Lees verderEgocentric videos provide a unique perspective into individuals' daily experiences, yet their unstructured nature presents challenges for perception. In this paper, we introduce AMEGO, a novel appro...
queries egocentric amego Lees verderAccess to quantum computing is steadily increasing each year as the speed advantage of quantum computers solidifies with the growing number of usable qubits. However, the inherent noise encountered ...
systems models quantum circuits Lees verderVisual learning analytics (VLA) is becoming increasingly adopted in educational technologies and learning analytics dashboards to convey critical insights to students and educators. Yet many student...
analytics standalone passive effects agents scaffolding genai learning comprehension Lees verderSpecifying tasks for robotic systems traditionally requires coding expertise, deep domain knowledge, and significant time investment. While learning from demonstration offers a promising alternative...
tasks learning Lees verderIn the context of global energy strategy, accurate natural gas demand forecasting is crucial for ensuring efficient resource allocation and operational planning. Traditional forecasting methods stru...
methods demand natural consumption data gas Lees verderThe people with Major Depressive Disorder (MDD) exhibit the symptoms of tonal variations in their speech compared to the healthy counterparts. However, these tonal variations not only confine to the...
detection sentences depression Lees verderThis paper addresses the optimization of edge-weighted networks by maximizing algebraic connectivity to enhance network robustness. Motivated by the need for precise robot position estimation in coo...
robot control cuts localization cheeger Lees verderSubsynchronous oscillations (SSOs) involving grid-forming converters (GFCs) are in a less familiar territory of power system dynamics. This letter reports a new phenomenon namely cross-area SSOs in ...
ssos Lees verderNon-consensual intimate media (NCIM) presents internet-scale harm to individuals who are depicted. One of the most powerful tools for requesting its removal is the Digital Millennium Copyright Act (...
urls dmca Lees verderPhotometric bundle adjustment (PBA) is widely used in estimating the camera pose and 3D geometry by assuming a Lambertian world. However, the assumption of photometric consistency is often violated ...
computer material illumination photometric Lees verderAir pollution, particularly particulate matter (PM2.5), poses significant risks to public health and the environment, necessitating accurate prediction and continuous monitoring for effective air qu...
pm2 monitoring air data Lees verderMultimodal Large Language Models (MLLMs) have shown promise in a broad range of vision-language tasks with their strong reasoning and generalization capabilities. However, they heavily depend on hig...
high-quality captions data image Lees verderMotor dysfunction is a common sign of neurodegenerative diseases (NDs) such as Parkinson's disease (PD) and Alzheimer's disease (AD), but may be difficult to detect, especially in the early stages. ...
pd ad explainable nds tasks Lees verderMorphologically rich languages are notoriously challenging to process for downstream NLP applications. This paper presents a new pretrained language model, ByT5-Sanskrit, designed for NLP applicatio...
sanskrit morphologically languages rich language nlp tasks Lees verderWe completely determine the second covering radius for binary primitive double-error-correcting BCH codes. As part of this process, we provide a lower bound on the second covering radius for binary ...
binary codes primitive bch covering radius Lees verderRapid advancements in multimodal large language models have enabled the creation of hyper-realistic images from textual descriptions. However, these advancements also raise significant concerns abou...
science computer Lees verderAutoencoders based on Graph Neural Networks (GNNs) have garnered significant attention in recent years for their ability to extract informative latent representations, characterizing the structure o...
graph Lees verderBundle adjustment (BA) is a critical technique in various robotic applications, such as simultaneous localization and mapping (SLAM), augmented reality (AR), and photogrammetry. BA optimizes paramet...
learning efficiency computer deep Lees verderSonar-based indoor mapping systems have been widely employed in robotics for several decades. While such systems are still the mainstream in underwater and pipe inspection settings, the vulnerabilit...
using traditional systems sensors Lees verderModel Predictive Control (MPC) is a common tool for the control of nonlinear, real-world systems, such as legged robots. However, solving MPC quickly enough to enable its use in real-time is often c...
systems algorithm control mpc Lees verderThis paper presents a novel technique for incorporating user input when learning and inferring user preferences. When trying to provide users of black-box machine learning models with actionable rec...
paper learning machine costs feature Lees verderPediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...
conditions pediatric covid Lees verderArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Lees verderThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Lees verderNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Lees verderWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lees verderChronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...
including covid fatigue Lees verderThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Lees verderLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Lees verderArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Lees verderWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lees verderAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Lees verderNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Lees verderAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Lees verderAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Lees verderPediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this expl...
conditions pediatric covid Lees verderAim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...
long covid disease severity veterans’ health covid-19 epidemiology covid positive veterans symptom risk acute developing covid-19 Lees verderThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...
covid 19 potential inhibitors Lees verderLong COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...
research health review covid Lees verderAs a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...
covid Lees verderWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lees verderNearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...
covid structure brain Lees verderWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lees verderWe leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...
crowdsourced retail covid metrics grocery behaviors consumer-level amazon data purchases changes online Lees verderArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Lees verderArid regions, the source of most airborne mineral dusts, comprise a third of the Earth’s land surface, where around two billion people are exposed daily to the fine particles raised by wind. Crossing ...
particulates airborne dust fungi mineral dust haboob dust storm dust source cardiovascular respiratory illness valley fever coccidioidomycosis covid asthma human health health risks climate epidemiology disease surveillance airborne environmental Lees verderAcquired Immune Deficiency Syndrome (AIDS) is a highly dangerous infectious disease caused by the Human Immunodeficiency Virus (HIV), a virus that attacks the human immune system. To explore the corre...
hiv aids intestinal fungi its inflammatory factors relative positively candida abundance significantly healthy intestinal factors correlated immune fungal plwha Lees verderBackground Ciswomen constitute a disproportionately low percentage of pre-exposure prophylaxis for HIV prevention (PrEP) users compared to men. Despite PrEP’s effectiveness, women are 5.25 times less ...
pre-exposure prophylaxis women hiv data sources hiv prevention ciswomen missed opportunities identified sti identifying emr evaluation prevention multiple data hiv prep medical participants women factors Lees verderBACKGROUND: HIV Pre-Exposure Prophylaxis (HIV PrEP) may help reduce the rate of HIV infection among women in sub-Saharan Africa (SSA). This study aimed to assess women’s knowledge and attitudes toward...
tanzania kenya countries health model study prevention women’s survey using community level media exposure anc five hiv aor = 1 95% ci attitudes prep knowledge 0 women Lees verderBACKGROUND: While South Africa’s national HIV program is the largest in the world, it has yet to reach the UNAIDS 95–95-95 targets. To reach these targets, the expansion of the HIV treatment program m...
services conducted results hiv sector delivery models vl treatment private primary health outcomes similar Lees verderBackground To propose a new mode of HIV test and surveillance among population of men who have sex with men (MSM): Internet-based Self-sampling at home plus Laboratory testing of HIV total nucleic aci...
internet plus self-sampling dbs hiv total nucleic acid sentinel surveillance online sentinel results test surveillance dbs isl hiv Lees verderBackground Treatment of latent tuberculosis infection (LTBI) is effective in preventing progression to TB disease. This study aimed to synthesize available evidence on the efficacy, adherence, and saf...
systematic review network meta-analysis tuberculosis preventive therapy contact ltbi included 3hp tpt incidence efficacy safety 6h 3rh hiv followed review treatment tb Lees verderBACKGROUND: Urinary tract infections, a prevalent global infectious disease, are clinical issues not well studied in HIV-positive individuals. UTIs have become a global drug resistance issue, but the ...
tigray utis-causing prevalence patterns identified isolates hiv utis agar resistant bacterial patients using hospital Lees verderWe piloted a Motivational Interviewing (MI) training program for lay counsellors in South Africa (SA) to assess its impact on retention and viral suppression among newly diagnosed individuals living w...
plhiv lay 3% participants clinics vs suppression viral rr 95%ci hiv 0 intervention months 95% Lees verderINTRODUCTION: The role of religion and spirituality as social determinants of health has been widely discussed. Studies among people living with HIV describe positive and negative influences of religi...
struggles living research measures mental hiv people zimbabwe common disorder viral spirituality religion health Lees verderLe Buanec et al. compared distribution and frequency of cell markers associated with immune dysfunction between HIV elite controllers (EC) and untreated non-EC. They demonstrate that untreated HIV-inf...
individuals elite controllers patients infection serum elevated key hiv non-ec cure ecs cell ifnα subsets immune Lees verderBackground Women with HIV have a higher risk of getting cervical cancer due to induced immunosuppression. Though this burden could be avoided through early identification and appropriate management, t...
cervical cancer cancer screening hiv factors utilization uganda study referral hospital regional 001 < 0 cancer cervical lira adjusted screening 95% pr factors services associated women ccs ci utilization hiv-positive 0 Lees verderBackground Pre-exposure prophylaxis (PrEP) is an effective HIV prevention method and a key component of Philadelphia’s Community Plan to End the HIV Epidemic (EHE). However, significant barriers to ac...
pre-exposure prophylaxis hiv prevention consolidated framework for impleme... implementation strategies sexual health prevention philadelphia strategies sexual 2022 staff barriers delivery health hiv clinics low-threshold Lees verderINTRODUCTION: Nigeria has a low uptake of early infant diagnosis (EID) of HIV despite its high pediatric HIV infection rate. Efforts to increase the EID of HIV have been limited by many factors. This ...
study follow-up primary uptake nigeria diagnosis infection centers services research lagos sample results eid hiv phcs infant Lees verderBackground Injection Drug use is associated with increased HIV risk behaviour that may result in the transmission of HIV and poor access to HIV prevention and treatment. In 2020, Uganda introduced the...
retention people who inject drugs medication for opioid-use disorder... uganda programme 12-month hiv methadone uganda pwid enrolled drugs people 5 km inject months associated participants Lees verderBackground Title X-funded family planning clinics have been identified as optimal sites for delivery of pre-exposure prophylaxis (PrEP) for HIV prevention to U.S. women. However, PrEP has not been wid...
pre-exposure prophylaxis (prep) hiv family planning configurational comparative method... implementation low engagement successful title strategies leadership qualitative planning family led clinics pathways Lees verderBackground The Joint United Nations Programme on HIV/AIDS launched the 90-90-90 initiative. Failure to meet the target reflects the difficulties in successfully implementing HIV treatment policy. Ther...
influencing stakeholders environmental individual availability hiv implementation ghana training policy treatment Lees verderBackground Chlamydia genital infections continue to be a serious health concern globally. Previous studies have reported that Chlamydia trachomatis infection alters the vaginal microbiota of infected ...
vaginal microbiota pregnant women hiv pregnant study chlamydia south microbiome microbiota uninfected -infected infection women vaginal Lees verderScientific reports on the association between human immunodeficiency virus (HIV) in patients with COVID-19 and mortality have not been in agreement. In this nationwide study, we described and analyzed...
covid.19 mortality hiv population-based hospitalized included risk due covid-19 patients mortality Lees verderBackground Tuberculosis (TB) has a high morbidity and mortality rate, and its prevention and treatment focus is on impoverished areas. The Liangshan Yi Autonomous Prefecture is a typical impoverished ...
sputum smear positive pulmonary tuberculosis impoverished area comorbidity drug-resistant 01 cough weeks prefecture drug-resistant hiv autonomous tb patients p < 0 ci 95% yi drug resistance Lees verderThe use of traditional, complementary, and alternative medicine (TCAM) can lead to delays and interruptions in the HIV continuum of care. This study explores reasons for TCAM use in people living with...
eswatini hiv interrupted care tcam test-and-treat antiretroviral therapy art hiv continuum of care. study factors users reasons using care interrupted tcam Lees verderINTRODUCTION: Guidelines in high-income countries recommend women living with human immunodeficiency virus (HIV) to formula feed their newborns, because the possibility of mother-to-child-transmission...
likert data scale monitoring additional expressed breastfeed participants hiv living breastfeeding women Lees verderIntroduction Cervical cancer is the fourth most diagnosed cancer among women globally, with much of the burden being carried by women in limited-resource settings often worsened by the high prevalence...
hiv management haart adherence pap smear covid-19 cervical cancer screening study average nigeria sought apin viral load settings routine hiv care women cancer significantly screening cervical covid-19 pandemic Lees verderBackground The ambitious goal to eliminate new pediatric HIV infections by 2030 requires accelerated prevention strategies in high-risk settings such as South Africa. One approach could be pre-exposur...
hiv broadly neutralizing antibody vertical transmission of hiv-1 vertical transmission breastfeeding pre-exposure prophylaxis long-acting drugs safety infant exposed to hiv paediatric trial subcutaneous administration evaluate step arms trial pk profile doses hiv safety Lees verderIntroduction China has implemented Basic Public Health Service (BPHS) in 2009, aiming to improve the health status of the people, and the content of service includes implying health education for resi...
bphs china migrant population hiv health education hiv health education rate china study receive migrants education Lees verderBackground Black cisgender and transgender women are disproportionately affected by the HIV epidemic compared to women of other racial and ethnic identities. Twelve demonstration sites across the Unit...
implementation science hiv black women health equity intervention improve client care outcomes women implementation Lees verderINTRODUCTION: Infection with SARS-CoV-2 is typically compared with influenza to contextualize its health risks. SARS-CoV-2 has been linked with coagulation disturbances including arterial thrombosis, ...
sars-cov-2 venous cohort risks hr risk influenza covid-19 0 compared 95% ci thromboembolic thrombosis Lees verderSIMPLE SUMMARY: During 2020–2021, highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 were spreading rapidly, and two genetically distinct lineages were detected in Europe, the Middle Eas...
virus avian influenza pathogenic recently egypt hpai viruses Lees verderBACKGROUND: The SARS-CoV-2 virus can bind to angiotensin-converting enzyme 2 receptors on host renal cells and may cause acute kidney injury (AKI). The comparative risks of AKI in patients severely il...
total admission special significantly model analyses hospital comorbidity ratio china project region administrative acute kidney program patients influenza covid-19 research 0 lower icu risk aki Lees verderINTRODUCTION: Maternal vaccination is a promising strategy to reduce the burden of vaccine-preventable diseases for mothers and infants. We aimed to provide an up-to-date overview of the efficacy and ...
reduce disease outcomes maternal rr event ci 95% vs rate 0 influenza safety vaccines rct infants laboratory-confirmed confirmed clinically mothers =0% Lees verderINTRODUCTION: Active and passive surveillance studies have found that a greater proportion of females report adverse events (AE) following receipt of either the COVID-19 or seasonal influenza vaccine ...
active reporting recipients research aes covid-19 vaccine ⇒ vaccination workers p=0 women healthcare following influenza sex gender Lees verderInternational audience; Background: Lung reactivations of Herpesviridae, herpes simplex virus (HSV) and cytomegalovirus (CMV) have been reported in COVID-19 patients. Whether or not thos...
virus respectively similar patients severe lung influenza pneumonia reactivations hsv covid-19 Lees verderThe surface protein hemagglutinin (HA) of the influenza virus plays a pivotal role in facilitating viral infection by binding to sialic acid receptors on host cells. Its conformational state is pH-sen...
non-protonated ha2 helices systems dynamics conformational ha protein protonated influenza Lees verderInfluenza antivirals are important tools in our fight against annual influenza epidemics and future influenza pandemics. Combinations of antivirals may reduce the likelihood of drug resistance and imp...
virus ferrets resistant wt influenza transmission Lees verderOBJECTIVE: The 2022 Australian winter was the first time that COVID-19, influenza and respiratory syncytial virus (RSV) were circulating in the population together, after two winters of physical dista...
testing-based sentinel results incidence programme surveillance covid-19 influenza participants Lees verderBackground Influenza spreads from schools to the rest of society. Thus, we conducted questionnaire surveys of influenza vaccination in elementary and middle schools in a district for 10 years to deter...
follow-up studies surveys and questionnaires influenza vaccines immunization infection influenza infection vaccinated morbidity Lees verderAging is a major risk factor associated with increased morbidity and mortality rates observed during respiratory infections. In this study, we investigated the role of influenza virus infections in th...
premature replication influenza viral increased senescent senescence cells cellular Lees verderIndirect transmission of influenza A virus (IAV) contributes to virus spread in pigs. To identify farm management activities with the ability to contaminate farmworkers’ hands and clothing that then c...
influenza a virus pigs breeding herds internal biosecurity management practices influenza vaccination spread samples collected weaning virus contamination activities Lees verderInternational audience; Introduction: The objective of our study was to assess, in an at-risk population, perception and knowledge about influenza and pneumococcal vaccinations. Methods:...
sciences coverage recommended declared [sdv perception vaccines vaccine covid-19 pandemic influenza patients vaccination Lees verderBACKGROUND: COVID 19 infection represents a global threat and now a frequent cause of hospitalization in pediatrics. COVID 19, as well as Influenza virus could have a severe course. There are few stud...
congresses msd p=0 virus infection participation lower 7% vs pfizer support received influenza patients 19 covid Lees verderBackground Abnormal behavior after oseltamivir administration has been reported in the media; in 2007, the package insert for oseltamivir phosphate was revised to restrict its administration to indivi...
reports prescriptions 2019/2020 2016/2017 pediatric outpatients prescription oseltamivir drug season aged influenza package insert Lees verderBACKGROUND: Observational studies of influenza vaccination are criticized as flawed due to unmeasured confounding. The goal of this cohort study was to explore the value and role of secondary claims d...
patients study hr hospitalizations models health season influenza Lees verderBackground. Respiratory tract infections are a leading cause of hospital visits in the paediatric population and carry significant associated morbidity and mortality in this population. The introducti...
mycoplasma testing analysed population organisms medications influenza respiratory hospital management patients results Lees verderBackground Influenza is an acute respiratory infection caused by influenza virus. Maxing Shigan Decoction (MXSGD) is a commonly used traditional Chinese medicine prescription for the prevention and tr...
maxing shigan decoction influenza virus influenza a transcriptomics metabonomics microbiology transcriptomics microbiome results influenza virus lung pneumonia mxsgd Lees verderInternational audience; The 2020-2021 avian influenza epidemic with a total of 3,777 reported highly pathogenic avian influenza (HPAI) detections and approximately 22,900,000 affected po...
detections low human virus wild hpai europe due countries bird birds poultry avian influenza viruses Lees verderBACKGROUND: Increasing severe morbidity and mortality by simultaneous or sequential infections with SARS-CoV-2 and influenza A viruses (IAV), especially in the elderly and obese patients, highlight th...
mice binding candidate sars-cov-2 ha1-trimer rbd-trimer influenza Lees verderInfluenza viruses cause a common respiratory disease known as influenza. In humans, seasonal influenza viruses can lead to epidemics, with avian influenza viruses of particular concern because they ca...
disease monovalent multivalent adjuvanted influenza cobra cgamp antibody mps viruses responses titers Lees verderThe generation time, representing the interval between infections in primary and secondary cases, is essential for understanding and predicting the transmission dynamics of seasonal influenza, includi...
incubation influenza time period transmission data Lees verderBACKGROUND: Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months of age from influenza infection. However, it is unknow...
data in-hospital infection impact death vaccination mortality influenza-related maternal influenza global children countries Lees verderThe global spread of avian influenza A viruses in domestic birds is causing increasing socioeconomic devastation. Various mechanistic models have been developed to better understand avian influenza tr...
avian influenza modeling systematic review control strategies disease transmission poultry simulations dynamics virus articles overall parameters models transmission strategies mechanistic review avian influenza control Lees verderBacillus Calmette-Guerin (BCG) and the cell wall skeleton (CWS) derived from BCG are known to enhance nonspecific immune activation and anti-cancer immunity; however, their roles as a vaccine adjuvant...
bcg vaccine protective responses adjuvant immune influenza Lees verderBackground Bacteria in nature live together in communities called biofilms, where they produce a matrix that protects them from hostile environments. The components of this matrix vary among species, ...
biofilm typhimur... matrix antimicrobial stress cellulose curli biofilms specialists cellulose curli stress biofilm produces generalist components Lees verderBackground Chrysomycin A (CA) is a promising antibiotic for treatment of Gram-positive bacterial infections and cancers. In order to enhance CA yield, optimization of fermentation conditions and mediu...
chrysomycin marine fermentation optimization single-factor experiment response surface methodology yield strain 891-b6 conditions ca fermentation Lees verderBackground Colorectal cancer (CRC) is a prevalent malignant malignancy affecting the gastrointestinal tract that is usually treated clinically with chemotherapeutic agents, whereas chemotherapeutic ag...
colorectal cancer irinotecan intestinal microbiota gastrointestinal toxicity agents chemotherapeutic signaling effect pathway vs effects gastrointestinal crc sx-1326 longum Lees verderAlthough there is a continuous increase in available molecular data, not all sequence identities in public databases are always properly verified and managed. Here, the sequences available in GenBank ...
annotation five new taxa its molecular identification five phylogeny sequences fuscoporia species Lees verderBackground Pseudomonas aeruginosa is a notorious pathogen. Its multidrug resistant strains are listed among priority pathogens against whom discovery of novel antibacterial agents and, elucidation of ...
amr (antimicrobial resistance); ... silver transcriptome nitrosative stress iron homeostasis pseudomonas resistant aeruginosa Lees verderBackground Anaerobes are normal flora of the human body. However, they can cause serious infections in humans. Anaerobic bacteria are known to cause respiratory infections like pneumonia and acute exa...
anaerobic bacteria respiratory infections antimicrobial resistance genera anaerobic infections isolates patients respiratory Lees verderBackground The in-depth understanding of the role of lateral genetic transfer (LGT) in phage-prophage interactions is essential to rationalizing phage applications for human and animal therapy, as wel...
bacteriophage phage prophage genetic recombination lateral genetic transfer intergeneric recombination campylobacter phage staphylococcus listeria escherichia salmonella encoding interactions virulent genes industrial potential recombination genetic hosts Lees verderBackground Surfactin produced by microbial fermentation has attracted increasing attention because of its low toxicity and excellent antibacterial activity. However, its application is greatly limited...
. yps-32... surfactin plackett-burman box-behnken landy medium yield 8 h mgso_4 optimization medium production surfactin 42 subtilis yps-32 strain 0 optimal fermentation landy Lees verderBackground Undernutrition (UN) is a critical public health issue that threatens the lives of children under five in developing countries. While evidence indicates the crucial role of the gut microbiom...
strain-level analysis childhood undernutrition gut microbiome gm complex network nutrient absorption complex analysis hc children species undernutrition strain-level co-occurrence level copri strain Lees verderBiofilms produced by Candida albicans present a challenge in treatment with antifungal drug. Enhancing the sensitivity to fluconazole (FLC) is a reasonable method for treating FLC-resistant species. M...
biofilm berberine fluconazole ergosterol fluconazole candida drug albicans combination study bbr genes metabolic gene flc expression treatment Lees verderOnychomycosis, a nail infection caused by dermatophytes, yeast, and molds makes up roughly half of all onychopathies and is the most prevalent nail condition in the world. Clinically, nail psoriasis a...
psoriasis oychomycosis mycology dermoscopy histopathology nail prevalent study patients psoriasis onychomycosis Lees verderThe microbiota that colonize the human gut and other tissues are dynamic, varying both in composition and functional state between individuals and over time. Gene expression measurements can provide i...
next-generation sequencing microbiome metatranscriptomics rrna depletion depletion human rrna Lees verderObesity is a metabolic disorder closely associated with profound alterations in gut microbial composition. However, the dynamics of species composition and functional changes in the gut microbiome in ...
obesity gut microbiota metagenomics microbiome virome ruminococcus eubacterium species obesity gut Lees verderBackground Plant-based diets offer more beneficial microbes and can modulate gut microbiomes to improve human health. We evaluated the effects of the plant-based OsomeFood Clean Label meal range (‘AWE...
metagenomic microbiota nutrition intervention plant-based gut status health osomefood microbiome diversity Lees verderBackground Belonging to the Actinobacteria phylum, members of the Rhodococcus genus thrive in soil, water, and even intracellularly. While most species are non-pathogenic, several cause respiratory di...
phage wc1 transcriptome rna-seq gene genus host rhodococcus expression wc1 genes species Lees verderHuman fungus infections are a serious public health issue that needs a prompt and correct diagnosis to cure effectively. Human fungal infections have historically been treated with in-person consultat...
deep learning encoder flattened patches mycology neural networks transformer yeasts vision research diagnosis Lees verderBackground Urinary tract infections, a prevalent global infectious disease, are clinical issues not well studied in HIV-positive individuals. UTIs have become a global drug resistance issue, but the p...
antimicrobial susceptibility patte... bacterial isolates hiv patients utis prevalence identified utis-causing tigray patterns isolates hiv utis agar resistant bacterial using hospital Lees verderBackground Acanthamoeba castellanii is a free-living protist that feeds on diverse bacteria. A. castellanii has frequently been utilized in studies on microbial interactions. Grazing bacteria also exh...
amino acids metabolomic coculture exposed medium presence cellular composition effects bacteria amino acid acids Lees verderThe human-pathogenic Enterobacter species are widely distributed in diverse environmental conditions, however, the understanding of the virulence factors and genetic variations within the genus is ver...
comparative genomics pan-genomics type vi secretion system t6ss-c suggesting genetic diversity gene species t6ss enterobacter Lees verderBackground This study was aimed to evaluate the prevalence and molecular characteristics of ciprofloxacin resistance among 346 Escherichia coli isolates collected from clinical specimens ( n = 82), h...
ciprofloxacin qrdr antibiotic resistance pmqr patients healthy carriers wastewater respectively pmqr iran identified 03% ciprofloxacin resistance wastewater genes ciprofloxacin-resistant isolates Lees verderPurpose The biodegradation of skatole was used as a starting point in this study, and existing strains of degrading NH_3 and H_2S in the laboratory were combined to create a composite deodorant. The d...
skatole human feces composite deodorant metabolic analysis microbial community odor rate effect indole agent nh_3 liquid h_2s human feces composite bacteria microbial Lees verderWith almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the world. Transmitted by ticks...
lyme disease tick diagnostic culture pcr serology detection, direct and ind... lb detection Lees verderBackground Selenium nanoparticles (SeNPs) are increasingly gaining attention due to its characteristics of low toxicity, high activity, and stability. Additionally, Bacillus licheniformis , as a probi...
sodium selenite senps rsm f1 senps Lees verderBackground The yeast Komagataella phaffii ( Pichia pastoris ) is routinely used for heterologous protein expression and is suggested as a model organism for yeast. Despite its importance and applicati...
rt-qpcr relative transcript analysis transcriptomics housekeeping genes results genes Lees verderObjectives Methicillin-resistant Staphylococcus aureus (MRSA) is a challenging global health threat, resulting in significant morbidity and mortality worldwide. This study aims to determine the molecu...
methicillin-resistant (mrsa) st5-scc ii-t311 bloodstream infections (bsis) antimicrobial susceptibility virulence genes typing non-st5-ii-t311 aureus mec china east st5-ii-t311 mrsa clone Lees verderTo maintain stable posture of the head and body during our everyday activities, the brain integrates information across multiple sensory systems. Here, we examined how the primate vestibular system, i...
sensorimotor postural everyday activities autonomic dynamic self-motion posture control responses motion vestibular motor head Lees verderBACKGROUND AND PURPOSE: An increased number of pathogenic variants have been described in mitochondrial encephalomyopathy lactic acidosis and strokelike episodes (MELAS). Different imaging presentatio...
presentations mitochondrial strokelike patients variability phenotype clinical melas Lees verderBACKGROUND AND OBJECTIVE: Fibromyalgia syndrome (FMS) is a chronic disease characterized by widespread, persistent musculoskeletal pain in association with impaired health-related quality of life. Rep...
significant following stimulation fms treatment Lees verderBACKGROUND: Sialidosis is a rare disorder caused by mutations in the NEU1 gene located on chromosome 6p21.3, constituting a group of autosomal recessive diseases. Enzyme activity analysis, electron mi...
spots report disease cherry-red genetic testing Lees verderBACKGROUND: Several phosphodiesterase 4 (PDE4) inhibitors have emerged as potential therapeutics for central nervous system (CNS) diseases. This study investigated the pharmacological effects of two s...
inhibitors pde4 brain effects roflumilast Lees verderElectroencephalogram (EEG) microstate analysis entails finding dynamics of quasi-stable and generally recurrent discrete states in multichannel EEG time series data and relating properties of the esti...
reliability test–retest dynamics eeg fmri microstate Lees verderPrevious research has shown that ocular dominance can be biased by prolonged attention to one eye. The ocular-opponency-neuron model of binocular rivalry has been proposed as a candidate account for t...
adaptation ocular Lees verderOBJECTIVE: The goal of this study was to determine the base rates of failing proposed embedded validity indicators (EVIs) for the National Institutes of Health Toolbox Cognition Battery (NIHTB-CB) in ...
crystallized data false-positive failure tests scores age-adjusted validity standard using evi failures multivariable nihtb-cb cognition rates sd Lees verderBACKGROUND: Myelin oligodendrocyte glycoprotein-associated disorders (MOGAD) is an autoimmune central nervous system disease. Antigen-specific immune tolerance using nanoparticles such as Polylactic-c...
conjugated using affiliation score autoimmune tolerance immune administration eae Lees verderBACKGROUND AND PURPOSE: Endovascular treatment of acute ischemic stroke is now performed more frequently in the late window in radiologically selected patients. However, little is known about whether ...
receiving late adjusted acute versus similar stroke complications ischemic endovascular treatment patients Lees verderBACKGROUND: Large language models such as ChatGPT have demonstrated potential as innovative tools for medical education and practice, with studies showing their ability to perform at or near the passi...
education models examination ai medical specialty questions Lees verderStroke-like migraine attacks after radiation therapy (SMART) syndrome is a delayed complication of cranial irradiation, with subacute onset of stroke-like symptoms including seizures, visual disturban...
features imaging clinical Lees verderOBJECTIVE: Diabetic peripheral neuropathy (DPN), a complication of diabetes, is detected only in later stages. Medial plantar nerve (MPL) can identify earlier stages of neuropathy. We evaluated the co...
performed studies mean subjects 0 mpl using nerve neuropathy tcns snap Lees verderBACKGROUND: Ischemic stroke is a serious disease leading to significant disability in humans worldwide. Increasing evidence suggests that some microRNAs (miRNAs) participate in the pathophysiology of ...
imaging stroke treatment ischemic Lees verderIntroduction: Lumbosacral transitional vertebra (LSTV) is the most common congenital anomaly of the lumbosacral junction and is a frequent cause of back pain in young patients with a prevalence of 4.6...
lordosis lumbar study patients ache compared low lstv parameters lumbosacral pelvic vertebra transitional Lees verderFemales increase aggression for mating opportunities and for acquiring reproductive resources. Although the close relationship between female aggression and mating status is widely appreciated, whethe...
cues mating drosophila neural circuit mating-related females virgin neurons Lees verderMild cognitive impairment (MCI) is often considered a precursor to Alzheimer's disease (AD) and early diagnosis may help improve treatment effectiveness. To identify accurate MCI biomarkers, researche...
review research mci Lees verderCSF-venous fistulas are an increasingly recognized type of CSF leak that can be particularly challenging to detect, even with recently improved imaging techniques. Currently, most institutions use dec...
imaging photon-counting myelography Lees verderINTRODUCTION: Fibrocartilaginous embolism (FCE) is a rare spinal cord infarction due to embolism of fibrocartilaginous material with consecutive arterial infarction of the anterior spinal artery. Phys...
recovery due fibrocartilaginous mountain embolism cycling fce clinical spinal Lees verderBACKGROUND: Nationally representative studies evaluating the impact of the COVID-19 pandemic on haemorrhagic stroke outcomes are lacking. METHODS: In this pooled cross-sectional analysis, we identifie...
00 month p<0 0 patients outcomes ich Lees verderIntroduction: Lumbosacral transitional vertebra (LSTV) is the most common congenital anomaly of the lumbosacral junction and is a frequent cause of back pain in young patients with a prevalence of 4.6...
lordosis lumbar study patients ache compared low lstv parameters lumbosacral pelvic vertebra transitional Lees verderErdheim-Chester disease is a rare non-Langerhans cell histiocytosis. The disease is widely variable in its severity, ranging from incidental findings in asymptomatic patients to a fatal multisystem il...
imaging disease erdheim-chester Lees verderBACKGROUND: Spontaneous intracranial hypotension is an important cause of treatable secondary headaches. Evidence on the efficacy of epidural blood patching and surgery for spontaneous intracranial hy...
surgery using epidural data blood patching efficacy Lees verderBACKGROUND: The beneficial effects of gardening as a form of physical activity have garnered growing interest in recent years. Existing research suggests that physical activity enhances brain function...
literature function reviewers studies protocol review systematic physical activity search Lees verderBACKGROUND AND OBJECTIVE: Fibromyalgia syndrome (FMS) is a chronic disease characterized by widespread, persistent musculoskeletal pain in association with impaired health-related quality of life. Rep...
significant following stimulation fms treatment Lees verderInternational audience; BackgroundExcessive daytime sleepiness (EDS) is a frequent and disabling symptom of Parkinson's disease (PD) without approved treatment. THN102 is a novel combina...
modafinil eds trial disease pd efficacy flecainide parkinson thn102 Lees verderα‐Synuclein aggregation is a hallmark of Parkinson's disease and a promising biomarker for early detection and assessment of disease progression. The prospect of a molecular test for Parkinson's disea...
amplification methods α‐synuclein patients parkinson detection disease Lees verderBACKGROUND: Dementia greatly contributes to poor prognosis in patients with Parkinson's disease (PD). We previously reported that severe olfactory dysfunction may be a good predictor of Parkinson's di...
hyposmia study trial severe disease placebo parkinson dementia patients pdd pd Lees verderDecline of protein quality control in neurons contributes to age-related neurodegenerative disorders caused by misfolded proteins. 4E-BP1 is a key node in the regulation of protein synthesis, as activ...
control parkinson quality activation proteins primary protein 4e-bp1 stress misfolded 4e-bp1-overexpressing mitochondrial unfolded response neurons disease Lees verderParkinson's disease (PD) has a large impact on patients' physical and mental health, which also greatly affects their family caregivers. Deep brain stimulation (DBS) has emerged as an effective treatm...
family study person caregivers dbs patients impact parkinson disease Lees verderBACKGROUND: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. OBJEC...
gwass international prostate prs cancer pd 0 parkinson [0 disease associated cancers consortium ovarian genetic association Lees verderInternational audience; Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerat...
parkinson µg/m3 disease study european associations exposure 0 air pollution long-term pm2 pd no2 mortality Lees verderDeep Brain Stimulation (DBS) is a successful and encouraging way of treating abnormal movement diseases, such as Parkinson’s Disease (PD). The success of the surgical procedure depends ...
decision procedure sciences proposons deep disease apprentissage learning brain parkinson stimulation mesh Lees verderParkinson's disease (PD), the second most prevalent neurodegenerative disorder worldwide, frequently presents with early-stage speech impairments. Recent advancements in Artificial Intelligence (AI)...
systematic parkinson speech classification disease tl dl pd science deep speech-based learning computer e2e Lees verderOBJECTIVES: To investigate potential risk factors for Parkinson’s disease (PD) in elderly individuals rural living in Turkey. METHODS: In total, 72 consecutive elderly Parkinson disease patients refer...
elderly turkey living iğdır parkinson disease patients water consumption Lees verderBACKGROUND: The neurophysiological correlates of gastrointestinal symptoms (GISs) in Parkinson's disease (PD) are not well understood. It has been proposed that in patients with a gastrointestinal ori...
dopaminergic parkinson defect dat predominant gastrointestinal giss pd Lees verderInternational audience; Goal: Impulse control disorders (ICDs) are frequent non-motor symptoms occurring during the course of Parkinson's disease (PD). The objective of this study was to...
visit roc recurrent neural network science sciences [info auc trivial machine control impulse genetic disorders parkinson disease using model 0 ppmi digpd data pd [0 Lees verderObjective There are two major issues in the MRI image diagnosis task for Parkinson's disease. Firstly, there are slight differences in MRI images between healthy individuals and Parkinson's patients, ...
parkinson’s disease yolov5 coordinate attention dynamic full dimensional convoluti... decoupling joint detection based results features parkinson mri diagnosis disease images Lees verderThe aim of this prospective study was to investigate autonomic function in Parkinson’s disease with a multidimensional approach including clinical evaluation tools, head-up tilt test and morphological...
function orthostatic significantly vagal parasympathetic patients frequency tilt parkinson Lees verderInternational audience; Mitochondria are a culprit in the onset of Parkinson's disease, but their role during disease progression is unclear. Here we used Cox proportional hazards models...
macro-haplogroup parkinson haplogroups progression cognitive mitochondrial disease Lees verderLimited accessibility to neurological care leads to underdiagnosed Parkinson's Disease (PD), preventing early intervention. Existing AI-based PD detection methods primarily focus on unimodal analysi...
disease analysis science ufnet accuracy pd computer Lees verderCell-to-cell transmission of α-synuclein (α-syn) pathology is considered to underlie the spread of neurodegeneration in Parkinson's disease (PD). Previous studies have demonstrated that α-syn is secre...
pd abc parkinson disease aggregates formation detergent-insoluble intracellular monoamine oxidase-b α-synuclein mao-b aggregation secretion rat inhibition α-syn Lees verderGenetic testing for persons with Parkinson's disease is becoming increasingly common. Significant gains have been made regarding genetic testing methods, and testing is becoming more readily available...
parkinson gaps controversies testing genetic Lees verderSubject: In this article, convolutional networks of one, two, and three dimensions are compared with respect to their ability to distinguish between the drawing tests produced by Parkinson's disease...
cnn parkinson disease convolutional two- one- three-dimensional models Lees verderInternational audience; Pathophysiology of idiopathic Parkinson's disease (iPD) is complex and still misunderstood. At a time when treatments with disease-modifying potential are being d...
sn parkinson [sdv atrophy neurodegeneration concentration ± 0 mri sciences vs disease Lees verderObjective: We present the PaHaW Parkinson's disease handwriting database, consisting of handwriting samples from Parkinson's disease (PD) patients and healthy controls. Our goal is to show that kine...
diagnosis writing disease parkinson pacc controls handwriting patients healthy Lees verderParkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like th...
computer datscan machine parkinson disease Lees verderBackground Parkinson’s disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α-synuclein, chronic neuroinfl...
parkinson’s disease p38 nlrp3 chaperone-mediated autophagy tfeb nlrp3 signaling α-synuclein microglial via promote model disease p38 p38-tfeb microglia inhibiting activation autophagy pathways parkinson degradation cma-mediated Lees verderThe aim of this prospective study was to investigate autonomic function in Parkinson’s disease with a multidimensional approach including clinical evaluation tools, head-up tilt test and morphological...
function orthostatic significantly vagal parasympathetic patients frequency tilt parkinson Lees verderBackground Sex hormones affect the pathogenesis of Parkinson patients and it has been suggested that gender is the most important factor in the development and progression of Parkinson’s disease. Stud...
2d:4d parkinson disease sexual dimorphism handgrip strength sex hormones healthy significant results parkinson hgs left elderly respectively strength ratio p = 0 disease 4d 2d Lees verderIn this paper we present three different applications, based on deep learning methodologies, that we are developing to support the scientific analysis conducted within the ASKAP-EMU and MeerKAT radi...
sources Lees verderGeophysical and astrophysical fluid flows are typically buoyantly driven and are strongly constrained by planetary rotation at large scales. Rapidly rotating Rayleigh-B\'enard convection (RRRBC) pro...
$\rm physics rotation Lees verderDuring the fourth observing run, the LIGO-Virgo-KAGRA Collaboration reported the detection of a coalescing compact binary (GW230529$_{-}$181500) with component masses estimated at $2.5-4.5\, M_\odot...
bhns lmg $\chi_{\rm astrophysics ns black 0 binary bh spin bh} Lees verderThe paper is devoted to the analysis of the influence of the galactic bar on the nature of the orbital motion (chaotic or regular) of globular clusters in the central region of the Galaxy with a rad...
regular dynamics globular clusters chaotic bar influence Lees verderRelic galaxies, the oldest ultra-compact massive galaxies (UCMGs), contain almost exclusively "pristine" stars formed during an intense star formation (SF) burst at high redshift. As such, they allo...
cluster sf relics catalogue galaxy clusters galaxies Lees verderTo understand the evolution of global accretion disk structure in the ``rebrightening'' phase of MAXI J1820$+$070, we perform a comprehensive analysis of its near infrared/optical/UV to X-ray spectr...
g}$ sed period phase periods accretion optical/uv x-ray flux Lees verderWe present 22 GHz imaging of regions of massive star formation within the Local Wolf-Rayet Galaxy Sample (LWRGS), a NSF's Karl G. Jansky Very Large Array (VLA) survey of 30 local galaxies showing sp...
wolf-rayet local star galaxies formation sscs regions Lees verderIn this paper we explore independently for the first time three chemical potentials (baryon $\mu_B$, charged $\mu_Q$, and strange $\mu_S$) in the Chiral mean-field (CMF) model. We designed and imple...
potentials model chemical phases quark \texttt{cmf++} hadronic phase Lees verderWe present results of high-resolution spectroscopic observations of detached eclipsing binaries (DEBs) with total eclipses, for which UVES spectra were obtained during the phase of totality. With th...
debs spectroscopic astrophysics spectra high-resolution binaries parameters obtained Lees verderThe pattern of nucleosynthesis during the explosion of a low-mass neutron star formed in a close binary system in the stripping scenario is considered. In the scenario considered the shock arising d...
explosion neutron star astrophysics shock matter Lees verderWe present and discuss two catalogues of UV-selected (NUV $< 22.8$ mag) galaxies that lie within a 200 deg$^2$ area of sky covered by the ASKAP FLASH survey and have an impact parameter of less than...
impact star-forming wigglez objects arcsec hi absorption catalogues Lees verderWe present an improved method for vetoing candidates of continuous gravitational-wave sources during all-sky searches utilizing the Frequency Hough pipeline. This approach leverages linear correlati...
candidates frequency analysis hough Lees verderStellar-mass black holes (BHs) embedded in active galactic nuclei (AGN) may be major sources of astrophysical gravitational waves (GWs), contributing both to the observed LIGO-Virgo-KAGRA population...
bhs Lees verderThe super star cluster NGC1569-B has recently been observed to have an extremely high [Ba/Fe]. We consider that the observed high [Ba/Fe] ($\sim$ 1.3) is due to the chemical enrichment of giant mole...
dwarf 0 $\pm$ chemical enrichment star collapsars cluster Lees verderArchean atmospheric evolution is the transition from an abiological atmosphere, to an atmosphere for which the composition and therefore climate is highly altered by life. We review the key processe...
evolution Lees verderHow much cosmological information can we reliably extract from existing and upcoming large-scale structure observations? Many summary statistics fall short in describing the non-Gaussian nature of t...
existing models simulation Lees verderA primary goal of characterizing exoplanet atmospheres is to constrain planetary bulk properties, such as their metallicity, C/O ratio, and intrinsic heat. However, there are significant uncertainti...
upper cold planetary interiors eq}$ c/o $t_{\rm planets Lees verderAstronomy is entering an unprecedented era of Big Data science, driven by missions like the ESA's Gaia telescope, which aims to map the Milky Way in three dimensions. Gaia's vast dataset presents a ...
data methods mean error 0 deep learning Lees verderGravitational waves (GWs) from binary neutron stars (BNSs) offer valuable understanding of the nature of compact objects and hadronic matter. However, their analysis requires substantial computation...
astrophysics bns Lees verderOver the Nullarbor Plain in South Australia, the Desert Fireball Network detected a fireball on the night of 1 June 2019 (7:30 pm local time), and six weeks later recovered a single meteorite (42 g)...
fireball h5 16 0 +- arpu kuilpu meteorite Lees verderWe use the Monte Carlo For AGN (active galactic nucleus) Channel Testing and Simulation (McFACTS, https://www.github.com/mcfacts/mcfacts) code to study the effect of AGN disk and nuclear star cluste...
astrophysics preferred agn disk Lees verderWe model the power spectrum of galaxies in the IllustrisTNG simulation when they are weighted by their star formation rate. Such a weighting is relevant in the context of line-intensity mapping (LIM...
satellite haloes model term astrophysics Lees verderThe discovery of phosphine in Venus' atmosphere provides lessons for the search for life. The detection has survived all challenges and has acquired independent support from archival data from PVP. ...
lessons venus discovery life Lees verderWe study the deflection of light rays in a cold, non-magnetized plasma using the worldline framework. Starting from Synge's Hamiltonian formalism, we construct a position-space action and use it per...
light bending Lees verderSST-1M is a prototype of a single-mirror Small Size Telescope developed by a consortium of institutes from Poland, Switzerland and the Czech Republic. With a wide field of view of 9 degrees, SST-1Ms...
astrophysics Lees verderBACKGROUND: Isthmic spondylolisthesis (IS) is a common clinical disease with a high incidence rate. However, most current researches explain the clear pathogenesis from a single perspective. The aim o...
incidence level factors l4-l5 tropism spondylolisthesis study isthmic cranial fja p = 0 Lees verderIn this paper, we study the motion of test particles around two exact charged black-hole solutions in Einstein-{\AE}ther theory. Specifically, we first consider the quasi-periodic oscillations (QPOs...
theory circular study qpos particles orbits Lees verderOBJECTIVE: In this study, we aimed to explore the relationship between five selected proinflammatory and immune-mediated genes (TNF rs1800629G>A, rs361525G>A, rs1799964T>C, LTA rs1800683G>A, rs909253A...
associated population overall g>a genotype patients study Lees verderInternational audience; (1) Background: Oxaliplatin is among the most neurotoxic anticancer drugs. Little data are available on the long-term prevalence and consequences of chemotherapy-...
quality neuropathy life colorectal study oxaliplatin peripheral patients prevalence cipn cancer Lees verderBACKGROUND Caesarean section with extraction of a deeply impacted fetal head is technically challenging and is associated with serious maternal and neonatal complications. The purpose of the study ...
study labour neonatal extraction caesarean section method advanced head maternal fetal Lees verderThe existence of the COVID-19 pandemic has affected the tourism industry, including the purchase of hotel and restaurant services. This study aims to determine the level of consumer confidence in purc...
services sample decisions products tourism restaurant hotel study level purchase Lees verderThis manuscript deals with the study of low dimensional cuprates, namely, the spin chains systems SrCuO₂ and Sr₂CuO₃. These two compounds exhibit highly anisotropic thermal conduction p...
doped magnetic l’étude thermiques inelastic propriétés neutron scattering conduction thermal phonons spinon composés transport cuprates study Lees verderBACKGROUND: Participation in social activities has positive health effects among older adults; however, few studies have investigated the association between social activity and depressive symptoms am...
studies china associated inversely weekly urban-rural differences daily social activities or = 0 association urban 0 95%ci participation study rural Lees verderBACKGROUND AND AIMS: Retrospective measures of alcohol intake are becoming increasingly popular; however, the reliability of such measures remains uncertain. This study assessed the reliability of a r...
drinking consumption study age single life‐course decade‐based retrospective administered alcohol reliability Lees verderBackground Psychosocial interventions are needed to enhance patient engagement and retention in medication treatment within opioid treatment programs. Measurement-based care (MBC), an evidence-based i...
measurement-based care opioid use disorder opioid treatment programs mixed methods protocol outcomes inform enhance methods treatment mbc evaluate implementation clinical trial study rapice opioid Lees verderBackground Mental health problems among adolescents is a global challenge. During the transition to adolescence, physiological, psychological, and social changes occur, leading to increased vulnerabil...
adolescence boys experience empowerment help-seeking mental health literacy qualitative school nurse experiences adolescents interviews qualitative health study adolescent Lees verderBACKGROUND: Residual kidney function (RKF) may provide many benefits to patients on permanent renal replacement therapy that are reflected in better control of biochemical parameters. In hemodialysis ...
patients significant study life score moca pcs function rkf hemodialysis cognitive Lees verderIntroduction There is a substantial unmet need for effective therapies to treat patients with refractory dry eye disease (DED). The goal of this open-label pilot study was to investigate the efficacy ...
acthar gel clinical trial ded ocular inflammation rci lesions dry eye moderate staining spk scores ded = 0 study rci Lees verderOBJECTIVE: The purpose of this study was to compare the efficacy and tolerability of continued olanzapine (OLA) versus amisulpride (AMI) augmentation in schizophrenic patients with poor response to OL...
response scale subscale study schizophrenia patients Lees verderSpeaker localization for binaural microphone arrays has been widely studied for applications such as speech communication, video conferencing, and robot audition. Many methods developed for this tas...
binaural proposed doa study Lees verderSIMPLE SUMMARY: Garlic oil and cinnamaldehyde are plant-derived bioactive compounds with antimicrobial activity, which might contribute to improving the efficiency of rumen fermentation. However, an a...
mg/l 180 rusitec p2 increased bacterial compounds study production 0 p1 garlic oil cinnamaldehyde populations fermentation fermenters rumen Lees verderPoor knowledge about mental health disorders and their treatment likely contributes to the large treatment gap reported for mental health problems. Therefore, we studied the association between mental...
mental health literacy active help-seeking behaviour mental health problems/disorders longitudinal community study study vignette analyses health mental community problems/disorders baseline Lees verderBACKGROUND: The aim of this multicenter, randomized phase II study was to analyze the feasibility and safety of alternate-day S-1, an oral fluoropyrimidine, for adjuvant chemotherapy in patients with ...
lung alternate-day stage registration 4% p = 0 rate cancer grade study chemotherapy adjuvant patients Lees verderAs a result of digitalization, the shift to an experience economy reshaping customer behavior, and increased market dynamism that threaten their survival, established companies seek to ...
l’organisation components composantes dynamiques study company se organizational d’un d’une construction capacité capability integration building organization transformation capabilities model modèle Lees verder[Context]} Natural language processing (NLP) techniques have been widely applied in the requirements engineering (RE) field to support tasks such as classification and ambiguity detection. Despite i...
engineering tasks nlp re replication Lees verderBACKGROUND: Studies examining post-race emotional experiences in the context of endurance races among recreational athletes are scarce. The purpose of this study was to describe how recreational athle...
interviews recreational study goals completed selection post-race emotions endurance Lees verderInternational audience; Background Repeated rotation of empiric antibiotic treatment strategies is hypothesized to reduce antibiotic resistance. Clinical rotation studies failed to chang...
piperacillin-tazobactam rotation sciences [sdv 0 effects antibiotic individual cluster-randomized crossover study arb mixing carriage cycling Lees verderInternational audience; In this study, we consider a production planning and resource allocation problem of a Reconfigurable Manufacturing System (RMS). Four general scenarios are consid...
reconfigurable study system manufacturing optimization model simulation Lees verderSIMPLE SUMMARY: Recent clinical trials have demonstrated the capability of safely delivering prostate radiotherapy with a simultaneous focal boost. These studies have also indicated limitations to ach...
prostate radiotherapy study imaging resonance targeted magnetic focal approach plans hypoxia dose boost Lees verderInternational audience; Agroecology represents one of the main alternatives to production models generated by the green revolution, both in Uruguay and other countries. It appears as a r...
study practices processes farmers uruguay agroecological Lees verderPurpose The aim of this prospective study was to investigate the diagnostic performance of shear wave elastography (SWE) in differentiating benign and malignant thyroid nodules and their correlation w...
thyroid nodules acr ti-rads shear wave elastography virtual touch tissue imaging and q... ultrasonography fine needle aspiration biopsy cytopathology/histopathology study differentiating ti-rads value nodules thyroid benign Lees verderIntroduction Thyroid swellings are prevalent in 4 to 7% of the Indian population and are commonly present in females. Thyroid swelling has been attributed to various causes, such as ingestion of goitr...
thyroid neoplasms fine needle aspiration bethesda classification histopathology papillary thyroid cancer diagnostic imaging thyroid nodule follicular thyroid cancer thyroid content benign environmental category patients radiation Lees verderINTRODUCTION: Pheochromocytomas can present as a diagnostic challenge, given their diverse clinical manifestations. Though classically taught as presenting with headaches, palpitations and paroxysmal ...
infarction non-obstructive erratic patients blood pressure thyroid myocardial pheochromocytoma minoca Lees verderBackground Cancer progression can be promoted by chronic inflammation. Local immune response may be associated with favourable or unfavourable prognosis of Papillary Thyroid Carcinoma (PTC). Regulator...
il-17a papillary thyroid carcinoma disease progression foxp3 thyroid foxp3 cytokines il-17 a cells progression expression tumor lt Lees verderMultiple endocrine neoplasia type 2B is a rare autosomal dominant disease characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, Marfan-like fatigue, a peculiar face with thic...
multiple endocrine neoplasia type ... constipation megacolon volvulus ganglioneuromatosis thyroid medullary carcinoma intestinal Lees verderBACKGROUND: The higher prevalence of thyroid dysfunction in type 1 diabetes patients has been well established, whereas it is a matter of debate whether that is also observed in type 2 diabetes patien...
ft4 prevalence tsh basal ft3/ft4 diabetes patients thyroid levels function Lees verderAnaplastic thyroid cancer (ATC) is a clinically aggressive malignancy with a dismal prognosis. Combined BRAF/MEK inhibition offers significant therapeutic benefit in patients with BRAF (V600E) -mutant...
thyroid cancer macrophages atc tet2 inhibition atcs -mutant Lees verderBackground Parathyroid glands are important endocrine glands, and the identification of normal parathyroid glands is crucial for their protection. The aim of this study is to explore the sonographic c...
parathyroid glands ultrasound shear wave elastography (swe) contrast-enhanced ultrasonography ... affecting factors echogenicity ultrasound characteristics glands parathyroid display normal thyroid Lees verderBackground The family of perfluoroalkyl and polyfluoroalkyl substances (PFAS) raised concern for their proven bioaccumulation and persistence in the environment and animals as well as for their hazard...
pfoa pfos endocrine disruptor thyroid pfos compounds similar function structure pfoa thyroid pfas Lees verderBackground Evidence regarding adverse pregnancy outcomes in patients with thyroid cancer has been conflicting, and the effect of thyroid dysfunction caused by thyroid hormone suppression therapy in te...
thyroid cancer pregnancy outcome neonatal thyroid function pregnancies = 0 outcomes study vs adverse pregnancy tsh 001 effect < 0 function thyroid neonatal control cancer Lees verderBackground Rheumatoid Arthritis (RA) and autoimmune thyroid disease (AITD) are the two most prevalent coexisting autoimmune diseases due to their similar pathogenesis. Considering the potential effect...
rheumatoid arthritis thyroid dysfunction anti-thyroid autoantibody autoimmune thyroid disease disease activity disease severity autoimmune severity anti-tpo positivity ra patients aitd severe disease thyroid dysfunction remission Lees verderFollicular thyroid carcinoma (FTC) is recognized by its ability to invade the tumor capsule and blood vessels, although the exact molecular signals orchestrating this phenotype remain elusive. In this...
ftc invasion spatial transcriptomics phylogenetics, extracellular matri... core spatial thyroid follicular ftc tumor Lees verderPurpose Dosimetry is rarely performed for the treatment of differentiated thyroid cancer patients with Na[^131I]I (radioiodine), and information regarding absorbed doses delivered is limited. Collecti...
multicentre study dosimetry nai thyroid cancer administered performed multi-centre data median differentiated whole-body respectively dosimetry na[^131i]i cancer 0 thyroid absorbed doses Lees verderBackground Rheumatoid Arthritis (RA) and autoimmune thyroid disease (AITD) are the two most prevalent coexisting autoimmune diseases due to their similar pathogenesis. Considering the potential effect...
rheumatoid arthritis thyroid dysfunction anti-thyroid autoantibody autoimmune thyroid disease disease activity disease severity autoimmune severity anti-tpo positivity ra patients aitd severe disease thyroid dysfunction remission Lees verderPapillary thyroid carcinoma (PTC) is considered an indolent neoplasm but it may demonstrate aggressive behavior. We aimed to identify clinical and pathological characteristics and molecular signatures...
papillary thyroid carcinoma prognosis gene expression profiling nanostring patients thyroid presence non-aggressive parameters disease-free clinical ptc aggressive Lees verderPURPOSE: As thyroid cancer patients are experiencing longer disease-free survival periods, evaluating their quality of life after surgery has become crucial. However, studies on this topic have primar...
results korean thyroidectomy quality life thyroid cancer surgery Lees verderParathyroid carcinoma (PC) is a rare malignant endocrine tumor. It can be divided into functional and non-functional types according to the tumor’s ability to secrete parathyroid hormone. Herein, we p...
parathyroid carcinoma pathological characteristics diagnosis operation lobe prognosis pc patient surgery thyroid functional parathyroid Lees verderBackground Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is characterized by immune system dysregulation after exposure to adjuvants, such as aluminum. Although cases of autoimmune thyr...
graves’ disease covid-19 vaccine autoimmune/inflammatory syndrome i... exposure graves’ asia thyroid sars-cov-2 disease Lees verderBACKGROUND: The introduction of new targeted therapies for RET-altered lung and thyroid cancers (LC/TC) has impacted pathologists’ practice by making genomic testing more relevant. Variations in healt...
thyroid lung reported lc/tc care challenges testing uk ret tests ret-altered pathologists japan Lees verderSIMPLE SUMMARY: The ingestion of excessive nitrate can affect the thyroid gland and cause thyroid dysfunction in humans. In the present study, amphibian embryos were exposed to nitrate, thyroxine and ...
morphogenesis embryonic nitrate -n thyroid n100 gargarizans embryos development mmi Lees verderAims A few studies have evaluated the performance of the American College of Radiology Thyroid Imaging Reporting And Data System (ACR-TIRADS) in pediatric and elderly patients and found differences be...
thyroid tirads fnac age young elderly rate patients fnac acr-tirads performance age Lees verderObjectives To study the relationship between the ablation range and applied energy of laser ablation (LA) and microwave ablation (MWA) in papillary thyroid microcarcinoma (PTMC). Methods A total of 20...
papillary thyroid microcarcinoma ultrasonography microwaves laser therapy ablation techniques ht laser microwave diameter • ablation 0 r_av/e ptmc papillary thyroid microcarcinoma mwa Lees verderBackground Gender differences in patients with major depressive disorder (MDD) are commonly reported; however, gender differences in first-episode and drug-naïve (FEDN) MDD patients with comorbid suic...
gender abnormal thyroid function major depressive disorder suicide blood scale score tpoab hamd dbp clinical attempts suicide differences mdd prevalence thyroid male glucose comorbid female symptoms patients psychotic study Lees verderBackground The incidental finding of thyroid inclusions in lymph nodes of neck dissections of non-thyroid cancer patients is an unusual event. It is still controversial for pathologists about whether ...
incidental finding papillary thyroid cancer neck dissections metastasis metastatic nodules v600e clinicopathological incidentally patients cancer braf non-thyroid thyroid Lees verderPurpose We undertook a multicenter epidemiological survey among hospitalized patients with chronic kidney disease (CKD), aiming to reveal the characteristics of elderly CKD by comparing it with non-el...
chronic kidney disease elderly etiology comorbidities in-hospital outcomes hospitalized characteristics patients kidney chronic non-elderly Lees verderIn the past decade, scientific research in the area of Nephrology has focused on evaluating the clinical utility and performance of various biomarkers for diagnosis, risk stratification and prognosis....
area under the curve diagnostic test, discriminatory ability receiver operator characteristic c... sensitivity specificity performance biomarker nephrology Lees verderObjective To report the experience of partial inferior pubicectomy in the treatment of complex posterior urethral stricture after trauma. Methods A total of 46 patients with post-traumatic posterior u...
urethroplasty inferior partial pubicectomy complex posterior urethral strictu... postoperative surgical inferior repair operation urethral stricture pubicectomy partial posterior Lees verderBackground In the primary analysis of the PREDICT trial, a higher hemoglobin target (11–13 g/dl) with darbepoetin alfa did not improve renal outcomes compared with a lower hemoglobin target (9–11 g/dl...
renal anemia ckd kidney egfr slope proteinuria advanced trial 0 proteinuria diabetes per-protocol egfr renal outcomes kidney hemoglobin set Lees verderBackground To suppress the incidence of end-stage kidney disease, we need to identify chronic kidney disease (CKD) patients with a high risk of rapid decline in the estimated glomerular filtration rat...
chronic kidney disease egfr slope risk factor proteinuria health checkup japanese japanese kidney disease levels subjects examinees slope rapid egfr decline Lees verderBackground Diabetic nephropathy may begin in childhood, but clinical kidney disease ascribable to this is uncommon in children with type 1 (insulin dependent) diabetes mellitus. Methods We reviewed ou...
diabetes mellitus kidney biopsy diabetic nephropathy kidney mellitus biopsies diabetes children nephropathy Lees verderBackground The parasitic disease known as the cystic echinococcosis (CE) is brought on by cysts made up of the larval forms (metacestodes) of Echinococcus tapeworms. In North Africa, it is greater in ...
cystic echinococcosis pelvic position bladder detrusor muscle total cystectomy child echinococcosis abdominal cystic Lees verderEarly research suggested that compulsive sexual behavior (CSB) and paraphilic interests (PI) are more prevalent in adults with primary tic disorders compared to the general population. However, recent...
primary adults prevalence tic disorders pi Lees verderBackground We compare the outcome of microsurgical subinguinal varicocelectomy (MSV) using the pulling technique (P-MSV) compared to the standard technique (S-MSV). Methods A total of 60 patients were...
varicocele pulling technique microsurgical subinguinal fertility semen analysis scrotal pain technique microsurgical randomized statistical difference compared s-msv p-msv pulling Lees verderWhile partial nephrectomy offers oncologic efficacy and preserves renal function for T1 renal tumors, renal artery pseudoaneurysm (RAP) remains a rare but potentially life-threatening complication. Th...
angiography laparoscopic partial nephrectomy open partial nephrectomy postoperative pseudoaneurysm renal artery robotic partial nephrectomy selective embolization associated patients significantly long-term = 0 partial compared embolization Lees verderNo studies have reported on the impact at team level of the Medtronic Hugo^™ RAS system. We described the work patterns and learning curves of an experienced robotic nurse team adapting to the new rob...
robotic surgery nurses team learning curve hugo ras team nurse iqr time nurses system robotic Lees verderBackground Stress urinary incontinence (SUI) is a common condition that requires proper evaluation to select a personalized therapy. Vaginal Tactile Imaging (VTI) is a novel method to assess the biome...
stress urinary incontinence pelvic floor biomechanical parameters of the pe... questionnaires disease severity severity refers severe pgi-s 16 maximum pelvic parameter biomechanical mild floor pressure score index = 0 Lees verderPurpose False penile fractures (FPF) represent a rare sexual emergency characterized by blunt trauma of penis in the absence of albuginea’s injury, with or without lesion of dorsal penile vein. Their ...
penis trauma penis rupture false penile fractures penis diagnosis absence false deviation item patients fractures presentation detumescence clinical fpf penile Lees verderPurpose Battle-related trauma is common in modern warfare and can lead to genitourinary injuries. In Western countries, urogenital injuries are rare in the civilian environment. The main objective of ...
genitourinary injury battle-related injury urological surgery reconstructive surgery laparotomy deployment 2% procedures urological non-bri external genitalia performed bri interventions Lees verderPurpose of Review Granulomatous prostatitis is a rare inflammatory disease of the prostate. It is challenging for the clinician because it mimics prostate cancer and cannot be distinguished from prost...
granulomatous prostatitis prostate cancer histopathology prostate Lees verderIntroduction and hypothesis Pelvic floor dysfunction (PFD) affects many women and participation in elite sport and high-impact exercise has been reported as a potential risk. However, few studies have...
female athlete pelvic floor incontinence pelvic organ prolapse prevalence exercising ai reported recreational incontinence exercise pfd women Lees verderBackground Classic bladder exstrophy is a complex, multi-system congenital malformation affecting formation of the genitourinary system, pelvis, and abdominal wall. Main body Historically children wit...
bladder exstrophy transitional urology congenitalism diagnosis disorder life quality Lees verderBackground Accurate volume status assessment and dry weight achievement are the most challenging goals for a nephrologist. We aimed to evaluate the role of ultrasonographic parameters including lung u...
hemodialysis pediatrics fluid overload bioimpedance spectroscopy lung ultrasonography inferior vena cava children b-line fluid assessment pediatric volume patients status ivc Lees verderBackground IgG4-related disease (IgG4-RD) is a newly discovered systemic disease that can affect any organ or tissue in the body. IgG4-related kidney disease (IgG4-RKD) is relatively rare but essentia...
igg4-rd,ureter mass hydronephrosis hormone therapy mass therapy igg4-related disease ureter igg4-rd Lees verderBackground Streptococcus pneumoniae -associated hemolytic uremic syndrome (P-HUS) is a rare and severe disease. Only a few reports have been published about eculizumab use in P-HUS. Methods We analyze...
hemolytic uremic syndrome eculizumab chronic kidney disease dialysis outcomes respectively patients eculizumab = 0 p-hus Lees verderPurpose To evaluate our experience with different surgical techniques and to find clinical factors that affect the outcome of treatment in cases of redo-hypospadias. Methods We have retrospectively ev...
hypospadias hypospadias surgery cripple hypospadias pediatric urology 1% 32 underwent 25 17 meatal surgery technique 9% surgical = 0 Lees verderThe role of robotics has grown exponentially. There is an active interest amongst practitioners in the transferability of the potential benefits into plastic and reconstructive surgery; however, many ...
robotic robotic assisted plastic and reconstructive surgery... articles reconstructive review systematic robotics surgery Lees verderIn primary hyperoxaluria type 1 excessive endogenous production of oxalate and glycolate leads to increased urinary excretion of these metabolites. Although genetic testing is the most definitive and ...
primary hyperoxaluria type 1 glycolate glyoxylate recombinant glycolate oxidase ortho-aminobenzaldehyde primary hyperoxaluria method Lees verderBackground A high level of PD-L1 expression is the most relevant predictive parameter for response to immune checkpoint inhibitor (CPI) therapy in urinary bladder cancer. Existing data on the relation...
pd-l1 urothelial bladder carcinomas tissue microarray immunohistochemistry checkpoint carcinomas prognosis bladder immune urothelial linked inflammatory favorable = 0 expression 0001 tumor pd-l1 positivity Lees verderRobotics facilitates the realization of intra-corporeal anastomosis during right hemicolectomy and allows extracting the operative specimen through a C-section, offering potential benefits in terms of...
robotic surgery mis rhc colorectal cancer colon cancer hemicolectomy underwent 7% centre robotic robrhc post-operative patients Lees verderInternational audience; Despite sustained agricultural production and a growing animal health market, support in terms of animal health management is waning, in particular due to veterin...
surveillance support production veterinary animal health vétérinaire animale santé Lees verderSIMPLE SUMMARY: Research suggests that half of all veterinary clients fail to adhere to veterinarians’ dietary recommendations, which can lead to serious consequences for pet health. However, little i...
clients study health proposals changes clients’ veterinary resistance Lees verderInternational audience; Veterinary autopsy requires a high level of expertise and skills that not all veterinarians necessarily master, especially in the context of the desertification o...
necropsy process tool diagnosis veterinary ivan support Lees verderSIMPLE SUMMARY: Inappropriate use of regular anthelmintic drugs has led to the development of anthelmintic resistance in sheep gastrointestinal nematodes (GINs) and consequently caused huge economic l...
vivo veterinary test egg gins efficacy practice vulgare count sheep reduction control Lees verderSIMPLE SUMMARY: During the COVID-19 pandemic, many veterinary practices have been required to move to a low or no-contact consultation model to minimise the risk of SARS-CoV-2. Utilising data from a g...
clients no-contact euthanasia pandemic covid-19 veterinary Lees verderSIMPLE SUMMARY: Cats are the most popular companion animals in New Zealand. Many owners form close relationships with their cats and these relationships, along with other factors in cat owners’ lives,...
veterinarians veterinary cats cat end-of-life themes decisions owners Lees verderBACKGROUND: Animals are a reservoir for ESBL/pAmpC-producing Escherichia coli/Klebsiella pneumoniae (ESBL-E/K). We investigated the association between occupational contact with different types of ani...
factors positive workers months coli esbl prevalence animals veterinary healthcare Lees verderAntimicrobial resistance (AMR) is a profound threat to human and animal health. Antimicrobial prescribing behaviours are influenced by psychological factors such as knowledge, beliefs, and emotions. A...
stewardship abr veterinary resistance responsibility behaviors vet beliefs amr knowledge Lees verderBackground Previous studies have demonstrated that fidaxomicin, a macrocyclic lactone antibiotic used to treat recurrent Clostridioides difficile -associated diarrhea, also displays potent in vitro ba...
antibiotic combination cat dog fidaxomicin combinations veterinary data vitro perfringens strains Lees verderLarge language models (LLMs) can extract information from veterinary electronic health records (EHRs), but performance differences between models, the effect of temperature settings, and the influen...
ehrs extraction 9% 81 4% 96 iqr information veterinary performance temperature Lees verderProfessor Gerhard Sand (1861–1921) was the first professor of veterinary obstetrics at the Royal Veterinary and Agricultural University, Copenhagen, Denmark. He began teaching the theory and practice ...
horses dystocia cattle veterinary sand illustrations Lees verderOBJECTIVE: To provide a systematic assessment of the efficacy of preoperative skin asepsis using chlorhexidine versus povidone‐iodine based protocols for surgical site infection (SSI) prevention in ve...
veterinary search surgery bacterial colonization systematic Lees verderBackground Zoonotic infections are a recognised risk for the veterinary community. Veterinary students are at risk, due to the range of activities they participate with on training coupled with their ...
zoonosis veterinary work-place infection uk farm particularly placements risk infection survey veterinary zoonotic infections Lees verderBackground Electrocardiography is a method widely applied in diagnosing abnormalities in the functioning of the heart muscle in veterinary medicine. It is a non-invasive and easy to perform test helpf...
body position ecg pig heart cardiology veterinary examination widely results significant animal anesthesia performed body position Lees verderBackground Electrocardiography is a method widely applied in diagnosing abnormalities in the functioning of the heart muscle in veterinary medicine. It is a non-invasive and easy to perform test helpf...
body position ecg pig heart cardiology veterinary examination widely results significant animal anesthesia performed body position Lees verderBACKGROUND: Animals are a reservoir for ESBL/pAmpC-producing Escherichia coli/Klebsiella pneumoniae (ESBL-E/K). We investigated the association between occupational contact with different types of ani...
factors positive workers months coli esbl prevalence animals veterinary healthcare Lees verderBackground Quality of life (QoL) provides a comprehensive concept underpinning veterinary decision-making that encompasses factors beyond physical health. It becomes particularly pertinent when seekin...
horse welfare quality of life end-of-life decisions euthanasia veterinary care decisions a good life owners study assess discussions challenges regarding horse ill chronically differences veterinary assessments life stakeholders Lees verderIntroductionCranial and upper-airway anatomy of short-nosed, flat-faced brachycephalic dogs predisposes them to brachycephalic obstructive airway syndrome (BOAS). Periodic apnoea increased inspiratory...
parameters lower objective plasma veterinary significantly bc dogs nc boas compared blood brachycephalic Lees verderPugs have become phenomenally popular in the UK over recent decades. The breed has a flat-faced look (brachycephalic) that many humans find highly attractive and ‘cute’ but this flat face is also link...
vetcompass electronic patient record epr breed dog epidemiology primary-care veterinary pedigree purebred pug iqr adjusted health non-pugs 0 odds dogs 95% risk uk ci pugs included × 0 common disorders Lees verderLarge language models (LLMs) can extract information from veterinary electronic health records (EHRs), but performance differences between models, the effect of temperature settings, and the influen...
ehrs extraction 9% 81 4% 96 iqr information veterinary performance temperature Lees verderBACKGROUND: Dental disease is very common in dogs and veterinary professional dental cleaning and examination, together with daily dental home care, is the foundation for good dental health. To our kn...
radiography anesthesia routines respondents access equipment dental performed vn swedish veterinarians nurses veterinary cleaning Lees verderThe Boxer is a medium-large sized, active dog with a short coat and a moderately flat-faced (brachycephalic) skull shape. Despite many decades of popularity in the UK, there is limited published evide...
vetcompass electronic patient record epr breed dog epidemiology primary-care veterinary pedigree purebred ear average evidence female male non-white boxer disorder health disorders study white recorded breed Lees verderThe present study highlights challenges in the veterinary microbiology diagnostic laboratory in the identification of bacteria responsible for infections in veterinary settings, particularly when evid...
laboratory acinetobacter conjunctivitis unilateral microbiology diagnostic veterinary Lees verderBackground Previous studies have demonstrated that fidaxomicin, a macrocyclic lactone antibiotic used to treat recurrent Clostridioides difficile -associated diarrhea, also displays potent in vitro ba...
antibiotic combination cat dog fidaxomicin combinations veterinary data vitro perfringens strains Lees verderThis paper explores the innovative use of simulation environments to enhance data acquisition and diagnostics in veterinary medicine, focusing specifically on gait analysis in dogs. The study harnes...
acquisition medicine veterinary Lees verderINTRODUCTION: Inflammation is crucial in the pathogenesis of chronic spontaneous urticaria (CSU). Investigating the correlation between levels of serum inflammatory cytokines (SICs) and the severity o...
pruritus disease correlations 05 0 inflammatory il-17 il-4 csu il-31 levels patients Lees verderBACKGROUND: Histones have been associated with human diseases. However, the implication of extranuclear histone proteins and their potential mechanism in the pathophysiology of chronic rhinosinusitis ...
crs cell histone expression Lees verderBACKGROUND: The prevalence of allergic diseases has increased significantly in China over the last few decades, and there have been very few reports of allergic diseases in certain occupational specia...
study 00% china ragweed workers 20% urban allergic prevalence rates sanitation diseases Lees verderBACKGROUND: With ongoing COVID-19 vaccination schedules and the popularity of cosmetic fillers, it is important to examine and record associated adverse reactions to a more general audience of health ...
diagnosis reactions treatment vaccination reaction Lees verderBACKGROUND: There are some adverse effects with coronavirus disease 2019 (COVID-19) vaccines, but the impact of COVID-19 vaccination on attacks in hereditary angioedema (HAE) is not well defined. OBJE...
0 ± attack vaccination hae attacks doses covid-19 Lees verderBACKGROUND: Mastocytosis is a rare neoplastic disease of the bone marrow associated with the proliferation and accumulation of mast cells in various internal organs, including the gastrointestinal tra...
content mineral symptoms microbiota bmi low sequencing using study Lees verderINTRODUCTION: In allergy diagnostics, component-resolved diagnostics (CRD) allows the clinician to assess the presence of specific IgE (sIgE) to allergenic proteins. Molecular diagnostics has improved...
panallergen georgian diagnostics population 0% nsltp patients plant ige sensitization pr-10 allergic 0 Lees verderHypersensitivity pneumonitis (HP) is a rare, mostly occupational allergic disease of the lungs. There are many inhalable antigens that can cause HP. Most are organic dusts, rarely chemicals. A clinica...
occupational hp anhydride phthalic Lees verderThe prevalence of food allergy (FA) among children is increasing, affecting nearly 8% of children, and FA is the most common cause of anaphylaxis and anaphylaxis-related emergency department visits in...
fa omics children multi-omics Lees verderBACKGROUND: Food ladders are tools designed to facilitate home-based dietary advancement in children with food allergies through stepwise exposures to increasingly allergenic forms of milk and egg. Se...
using allergies reactions surveys safety food participants milk ladder egg ladders Lees verderFurry pets are beloved companion animals; horse riding is a popular leisure activity. So-called hypoallergenic animals have gained high interest as sensitization to animal dander and allergy to furry ...
animals hypoallergenic Lees verderIntroduction: Treatment effects in allergen immunotherapy (AIT) studies are based on symptomatic improvement, and evaluations of naturally exposed patients do often show weak efficacy. Allergen challe...
tests allergen challenge ait Lees verderPURPOSE: The identification of risk factors associated with uncontrolled moderate-to-severe asthma is important to improve asthma outcomes. Aim of this study was to identify risk factors for uncontrol...
significantly 0 ehr patients study index moderate-to-severe uncontrolled hr risk asthma associated Lees verderChronic urticarial rash, mostly due to chronic spontaneous urticaria (CSU), is seen in up to 1 – 4% of the general population. Urticarial vasculitis (UV) and autoinflammatory syndromes, i.e., cryopyri...
symptoms rash urticarial uv Lees verderAllergen immunotherapy (AIT) has been performed for 112 years. In this article we summarize regulatory standards and challenges based on scientific evidence on AIT. Most crucial and timely aspects con...
ait Lees verderChronic urticarial rash, mostly due to chronic spontaneous urticaria (CSU), is seen in up to 1 – 4% of the general population. Urticarial vasculitis (UV) and autoinflammatory syndromes, i.e., cryopyri...
symptoms rash urticarial uv Lees verderAcute and chronic cough are common symptoms in patients with severe allergic asthma. Although asthma-related cough can be controlled by asthma-specific medications, both prescription and over-the-coun...
controlled analysis moderate-to-severe antitussives asthma placebo omalizumab Lees verderAsthma is an important health concern in Latin America (LA) where it is associated with variable prevalence and disease burden between countries. High prevalence and morbidity have been observed in so...
poor health environmental disease asthma factors research Lees verderBACKGROUND: Over the last few decades, there was observed an increase of asthma and allergic rhinitis cases caused by allergy to pets. OBJECTIVE: This study aimed to analyze molecular sensitization pa...
lithuanian allergens – sensitized components molecular sensitization cat fel dog Lees verderBACKGROUND: To investigate the role of combined impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) in the diagnosis of cough variant asthma (CVA) in preschool children. METHODS: A t...
diagnosis value chronic preschool asthma variant trial 0 children x5 ios cva cough feno Lees verderPURPOSE: Fruits have been identified as the primary triggers of anaphylaxis in older children in the Chinese population, especially among individuals with pollen sensitization. To date, no allergies h...
report blueberry anaphylaxis chinese kua/l Lees verderINTRODUCTION: Recent studies have indicated the significance of the peripheral airways in asthma control. Methods estimating airway resistance, air trapping, and ventilation inhomogeneity are useful f...
auc controlled function asthma 0 airway sensitivity specificity diagnostic accuracy Lees verderPURPOSE: Numerous genes have been associated with allergic diseases (asthma, allergic rhinitis, and eczema), but they explain only part of their heritability. This is partly because most previous stud...
allergic eczema diseases tns1 exposure ets Lees verderNon-adherence to medications has many deleterious effects including poor treatment outcomes, increased economic burden, increased morbidity, hospitalization rate, health care utilization, productivity...
heterogeneity performed africa Lees verderINTRODUCTION: Bullous scabies (BS) is an infrequent and atypical presentation of scabies, with a predilection for elderly males. The mechanism of BS is not fully understood; superinfection, friction d...
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