Dagselectie 11-04-2025

International audience; Abstract Background Masitinib is an orally administered tyrosine kinase inhibitor that targets activated cells of the neuroimmune system (mast cells and microglia...

Alzheimer's disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins i...

Alzheimer's Disease is an incurable cognitive condition that affects thousands of people globally. While some diagnostic methods exist for Alzheimer's Disease, many of these methods cannot detect Al...

Background A decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in cognitive composite endpoints that are used to de...

Objective: We aimed to develop and validate a novel multimodal framework HiMAL (Hierarchical, Multi-task Auxiliary Learning) framework, for predicting cognitive composite functions as auxiliary task...

Alzheimer's disease is one of the most incisive illnesses among the neurodegenerative ones, and it causes a progressive decline in cognitive abilities that, in the worst cases, becomes severe enough...

More than 10.7% of people aged 65 and older are affected by Alzheimer's disease. Early diagnosis and treatment are crucial as most Alzheimer's patients are unaware of having it until the effects bec...

International audience; Age, sex and APOE-ε4 genotype have been identified as the strongest predictors of the risk of developing Alzheimer's Disease (AD). This work models the pathologic...

CHRFAM7A is a human-specific gene that encodes the nicotinic acetylcholine receptor (nAChR) subunit dupα7. This gene originated after a fusion between a partial duplication of the CHRNA...

Background Solanum lycopersicum Linn. (Tomato, Family Solanaceae) is one of the fruits that are most consumed worldwide. The current research intends to emphasise the possibility of positive and thera...

Introduction Alzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of life. Clinic...

IL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells...

International audience; Amyloid PET imaging has been crucial for detecting the accumulation of amyloid beta (Aβ) deposits in the brain and to study Alzheimer's disease (AD). We performed...

The causal influence of sarcopenia on cardiometabolic disease and Alzheimer's disease and whether and to what extent insulin resistance plays a mediating role therein were unclear. We performed two‐st...

Introduction Alzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of life. Clinic...

BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenera...

Alzheimer's disease is one of the most incisive illnesses among the neurodegenerative ones, and it causes a progressive decline in cognitive abilities that, in the worst cases, becomes severe enough...

Background Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and inflammation. Microglia mainly participate in the inflammat...

Sporadic Alzheimer’s disease (AD) is a complex neurological disorder characterized by many risk loci with potential associations with different traits and diseases. AD, characterized by a progressive ...

An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' inter...

Semantic fluency tests have been widely used as a screening test for dementia of Alzheimer type. However, few studies have explored the application of semantic fluency tests in Mandarin Chinese speake...

Amyloid β protein (Aβ) and tau, the two main proteins implicated in causing Alzheimer's disease (AD), are posited to trigger synaptic dysfunction long before significant synaptic loss occurs in vulner...

Amyotrophic lateral sclerosis (ALS) is a rare, incurable, and fatal neurodegenerative disease with median survival time from onset to death ranging from 20 to 48 months. Breaking bad news about ALS di...

Objective To translate Amyotrophic Lateral Sclerosis-Specific Quality of Life-Short Form (ALSSQOL-SF) and test its reliability and validity, so that explore feasibility in Chinese mainland and make up...

Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive loss of motor neurons. It is a growing and underestimated disease, prompting this epidem...

Background and aim Traditional Chinese medicine (TCM) is widely used by patients with amyotrophic lateral sclerosis (ALS). However, their reasons and experience in using TCM have received insufficient...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axo...

The organization of brain functional connectivity (FC) has been shown to differ between sexes. Amyotrophic lateral sclerosis (ALS) is characterized by sexual dimorphism, showing sex-specific trends in...

Mutations in the gene encoding the ubiquitously expressed free radical scavenging enzyme superoxide dismutase-1 ( SOD1 ) are found in 2–6% of amyotrophic lateral sclerosis patients. The most frequent ...

Introduction Even if electromyography (EMG) is routinely used to confirm the diagnosis of amyotrophic lateral sclerosis (ALS), few studies have analysed the correlation between electrophysiological pa...

Background Magnetic resonance imaging (MRI) of the brain and cervical spinal cord is often performed in diagnostic evaluation of suspected motor neuron disease/amyotrophic lateral sclerosis (MND/ALS)....

Background Interventional trials in amyotrophic lateral sclerosis (ALS) suffer from the heterogeneity of the disease as it considerably reduces statistical power. We asked if blood neurofilament light...

Multiple studies indicate that United States veterans have an increased risk of developing amyotrophic lateral sclerosis (ALS) compared to civilians. However, the responsible etiological factors are u...

Background When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their jeopa...

Background The characterisation of presymptomatic disease-burden patterns in asymptomatic mutation carriers has a dual academic and clinical relevance. The understanding of disease propagation mechani...

Introduction Amyotrophic lateral sclerosis (ALS) is an inevitably fatal condition that leads to a progressive loss of physical functioning, which results in a high psychosocial burden and organization...

Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways h...

Objective The clinical manifestation of amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration, whereas frontotemporal dementia (FTD) patients show alterations of behavior a...

Background Major efforts have been made in the last decade to develop and improve therapies for proximal spinal muscular atrophy (SMA). The introduction of Nusinersen/Spinraza™ as an antisense oligonu...

Background Amyotrophic lateral sclerosis (ALS) is characterized by a rapid disease course, with disease severity being associated with declining health-related quality of life (HRQoL) in persons livin...

Background This study evaluated a novel control method for patients unable to independently control powered wheelchairs. Patients with amyotrophic lateral sclerosis often require a wheelchair but stru...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the brain and spinal cord motor neurons. On 25 April 2023, the drug tofersen, an antisense oligonucleotide, received ...

Background As amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) is a fatal progressive neurodegenerative disorder, patients experience severe impairments, with patients and family caregiver...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of both upper and lower motoneurons, leading to motor and non-motor symptoms. Recent evidence...

Focal edema on T2WI of breast MRI indicates stronger tumor invasiveness. Non-luminal breast cancer is more inclined to present focal edema. Breast edema score is a novel and practical tool to guide th...

Chlamydia trachomatis (CT) is the most common sexually transmitted infections globally, and CT infection can enhance HPV persistence. Epidemiological analysis has shown that patients with CT/HPV coinf...

BACKGROUND: Annual screening through low-dose computed tomography (LDCT) is recommended for heavy smokers. However, it is questionable whether all individuals require annual screening given the potent...

INTRODUCTION: Several studies have proved that Polygenic Risk Score (PRS) is a potential candidate for realizing precision screening. The effectiveness of low-dose computed tomography (LDCT) screening...

International audience; Valvular Heart Disease (VHD) is a known late complication of radiotherapy for childhood cancer (CC), and identifying high-risk survivors correctly remains a chall...

Objectives Comparing the long-term tumor control results of partial cystectomy(PC)and radical cystectomy(RC)in the treatment of muscle-invasive bladder cancer, and to explore the feasible method of bl...

Cervical cancer (CC) is the 4th most leading cause of death among women worldwide, and if diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high-risk human p...

Cancer immunotherapy has transformed traditional treatments, with immune checkpoint blockade being particularly prominent. However, immunotherapy has minimal benefit for patients in most types of canc...

Background Prostate cancer (PCa) is one of the most common cancers in men worldwide, and its timely diagnosis and treatment are becoming increasingly important. MRI is in increasing use to diagnose ca...

OBJECTIVE: The aim of this study was to assess the adequacy of cancer-related pain (CRP) management and associated factors among patients with cancer in the Northwest oncology centres of Ethiopia. DES...

In situ vaccination is a desirable strategy for cancer immunotherapy due to its convenience and capacity to target tumor antigens. Here, an in situ nanovaccine based on a cationic peptide with cholest...

Precision medicine fundamentally aims to establish causality between dysregulated biochemical mechanisms and cancer subtypes. Omics-based cancer subtyping has emerged as a revolutionary approach, as...

Streptococcus gallolyticus sp . gallolyticus (SGG) is a gut pathobiont involved in the development of colorectal cancer (CRC). To decipher SGG contribution in tumor initiation and/or ac...

Background To understand how body composition in those with elevated body mass index impacts left ventricular function decline during cancer treatment, we determined the association between baseline b...

Pancreatic ductal adenocarcinoma is a rare but lethal cancer. Recent evidence reveals that pancreatic intraepithelial neoplasms (PanINs), the microscopic precursor lesions in the pancreatic ducts that...

[Image: see text] CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in the biosynthesis of steroid hormones. Therefore, it remains an attractive target in seve...

Thyroid cancer stands out as the most prevalent endocrine cancer, with its incidence on a global rise. While numerous studies have delved into the roles of GSG2 in the progression of various malignanc...

BACKGROUND: The effectiveness of selective COX-2 inhibitors in preventing colorectal cancer recurrence has been demonstrated, however it is unknown how safe and successful they will be over the long t...

Colorectal cancer (CRC) is one of the most fatal cancers in the United States. Although the overall incidence and mortality rates are declining, an alarming rise in early-onset colorectal cancer (EOCR...

Background Prostate cancer is the leading cause of cancer death in Ecuadorian men. However, there is a lack of information regarding the evolution of prostate cancer mortality rates in Ecuador and its...

Background Evidence from observational studies indicates that lung cancer screening (LCS) guidelines with high rates of lung cancer (LC) underdiagnosis, and although current screening guidelines have ...

Anthracycline (ANT)-induced cardiotoxicity (AIC) is a particularly prominent form of cancer therapy-related cardiovascular toxicity leading to the limitations of ANTs in clinical practice. Even though...

Implicit Neural Representations (INRs), as a versatile representation paradigm, have achieved success in various computer vision tasks. Due to the spectral bias of the vanilla multi-layer perceptron...

In this paper, we study learning-augmented algorithms for the Bahncard problem. The Bahncard problem is a generalization of the ski-rental problem, where a traveler needs to irrevocably and repeated...

The ability to reason with and integrate different sensory inputs is the foundation underpinning human intelligence and it is the reason for the growing interest in modelling multi-modal information...

As the number of devices getting connected to the vehicular network grows exponentially, addressing the numerous challenges of effectively allocating spectrum in dynamic vehicular environment become...

We present NodeOP, a novel framework designed to optimize the management of General Node Operators in decentralized networks. By integrating Agent-Based Modeling (ABM) with a Tendermint Byzantine Fa...

This paper tackles the challenging task of maintaining formation among multiple unmanned aerial vehicles (UAVs) while avoiding both static and dynamic obstacles during directed flight. The complexit...

To coordinate the interests of operator and users in a microgrid under complex and changeable operating conditions, this paper proposes a microgrid scheduling model considering the thermal flexibili...

Delirium is an acute confusional state that has been shown to affect up to 31% of patients in the intensive care unit (ICU). Early detection of this condition could lead to more timely interventions...

Complex news events, such as natural disasters and socio-political conflicts, require swift responses from the government and society. Relying on historical events to project the future is insuffici...

A major task for moderators of online spaces is norm-setting, essentially creating shared norms for user behavior in their communities. Platform design principles emphasize the importance of highlig...

Graph Neural Networks (GNNs) traditionally employ a message-passing mechanism that resembles diffusion over undirected graphs, which often leads to homogenization of node features and reduced discri...

For decades, the Bj{\o}ntegaard Delta (BD) has been the metric for evaluating codec Rate-Distortion (R-D) performance. Yet, in most studies, BD is determined using just 4-5 R-D data points, could th...

Speculative decoding is a powerful technique that attempts to circumvent the autoregressive constraint of modern Large Language Models (LLMs). The aim of speculative decoding techniques is to improv...

Robustness towards adversarial attacks is a vital property for classifiers in several applications such as autonomous driving, medical diagnosis, etc. Also, in such scenarios, where the cost of misc...

Training high-quality deep models necessitates vast amounts of data, resulting in overwhelming computational and memory demands. Recently, data pruning, distillation, and coreset selection have been...

Large Language Models (LLMs) have demonstrated remarkable capabilities across various applications, but their performance on long-context tasks is often limited by the computational complexity of at...

In recent years, deep learning has achieved formidable results in creative computing. When it comes to music, one viable model for music generation are Transformer based models. However, while trans...

Fingerprinting large language models (LLMs) is essential for verifying model ownership, ensuring authenticity, and preventing misuse. Traditional fingerprinting methods often require significant com...

Understanding the neurobiology of opioid use disorder (OUD) using resting-state functional magnetic resonance imaging (rs-fMRI) may help inform treatment strategies to improve patient outcomes. Rece...

The development of intelligent Industrial Internet of Things (IIoT) systems promises to revolutionize operational and maintenance practices, driving improvements in operational efficiency. Anomaly d...

This paper introduces a framework for Bayesian Optimization (BO) with metric movement costs, addressing a critical challenge in practical applications where input alterations incur varying costs. Ou...

In the absence of abundant reliable annotations for challenging tasks and contexts, how can we expand the frontier of LLM capabilities with potentially wrong answers? We focus on two research questi...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that long COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if l...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

Chronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...

Chronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

Chronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

Chronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chroni...

Long COVID continues to challenge public health by affecting a significant segment of individuals who have recovered from acute SARS-CoV-2 infection yet endure prolonged and often debilitating sympt...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

We leverage a recently published dataset of Amazon purchase histories, crowdsourced from thousands of US consumers, to study how online purchasing behaviors have changed over time, how changes vary ...

Background Pre-exposure prophylaxis (PrEP) is an effective HIV prevention method and a key component of Philadelphia’s Community Plan to End the HIV Epidemic (EHE). However, significant barriers to ac...

Background High blood pressure (HBP), including hypertension (HTN), is a predictor of cardiovascular events, and is an emerging challenge in young persons. The risk of cardiovascular events may be fur...

BACKGROUND: In Guangdong Province, China, there is lack of information on the HIV epidemic among high-risk groups and the general population, particularly in relation to sexual transmission, which is ...

Background To propose a new mode of HIV test and surveillance among population of men who have sex with men (MSM): Internet-based Self-sampling at home plus Laboratory testing of HIV total nucleic aci...

BACKGROUND: Despite antiretroviral treatment (ART), immune dysfunction persists in children with perinatal HIV infection (HEI). Here we investigated the impact of HIV status on maternal antibody (Ab) ...

Background Female sex workers (FSWs) face an elevated risk of developing mental health disorders and alcohol use disorders (AUD), which in turn increase their vulnerability to HIV and other sexually t...

BACKGROUND: Kenya has a remarkably high burden of oral diseases, especially in vulnerable communities like persons with HIV (PWH). In the last few decades, the National AIDS & STI Control Programme ha...

Background Dolutegravir (DTG)-based antiretroviral therapy (ART) is currently the preferred first-line treatment for persons living with HIV (PLHIV) including children and adolescents in many low- and...

Background: A third of people living with HIV (PLHIV) in Western Africa had an undiagnosed infection in 2020. In 2019-2021, the ATLAS programme has distributed a total of 380 000 HIV se...

Version 2, November 29, 2022.; Abstract Evolutionary convergences are observed at all levels, from phenotype to DNA and protein sequences, and changes at these different levels tend to b...

Background HIV remains a critical global public health challenge. In 2022, it was estimated that approximately 39.0 million people worldwide were living with HIV, and of these, around 29.8 million wer...

Background In 2020, 14% of diagnosed persons living with HIV (PLWH) in Kenya were not taking antiretroviral therapy (ART), and 19% of those on ART had unsuppressed viral loads. Long-acting antiretrovi...

Background Community-based HIV-prevention services are a key approach to prevent HIV transmission among key population representatives. Transgender people have multiple specific needs and it is crucia...

BACKGROUND: Although community health worker (CHW) programs focus on improving access to healthcare, some individuals may not receive the intended quality or quantity of an intervention. The objective...

Background World Health Organization (WHO) HEARTS packages are increasingly used to control hypertension. However, their feasibility in persons living with HIV (PLHIV) is unknown. We studied the effec...

Background In French Guiana (population 294,000) the prevalence of type 2 diabetes (10%) and of HIV(1.1%) are very high. Our objective was to determine the prevalence of diabetes and its complications...

Background HIV testing is crucial for finding the remaining cases in a declining HIV epidemic in The Netherlands; providing HIV testing in non-traditional settings may be warranted. We conducted a pil...

Approximately one-quarter of people with HIV (PWH) in the U.S. receive coverage through the Medicare program; however, no prior real-world study has examined antiretroviral therapy (ART) gaps and adhe...

Background To examine COVID-19 vaccination and HIV transmission among persons who inject drugs (PWID) during the COVID-19 pandemic (2020–2022) in New York City (NYC). Methods Two hundred and seventy f...

BACKGROUND: The introduction of dolutegravir (DTG) in treating HIV has shown enhanced efficacy and tolerability. This study examined changes in weight gain and body mass index (BMI) at 6- and 12-month...

Background Female sex workers (FSW) in sub-Saharan Africa are disproportionately affected by HIV and remain a key target population for efforts to reduce transmission. While HIV prevention tools such ...

Background Infant post-natal prophylaxis (PNP) is used to prevent HIV transmission through breastfeeding. The WHO edited recommendations but so far there is no consensus on the duration...

Background Influenza is an acute respiratory infection caused by influenza virus. Maxing Shigan Decoction (MXSGD) is a commonly used traditional Chinese medicine prescription for the prevention and tr...

Sialic acid that presents on the surface of lung epithelial cells is considered as one of the main binding targets for many respiratory viruses, including influenza and the current coronavirus (SARS-C...

BACKGROUND: Influenza is responsible for more than 5 million severe cases and 290,000 to 650,000 deaths every year worldwide. Developing countries account for 99% of influenza deaths in children under...

Background Seasonal influenza epidemics have a substantial public health and economic burden, which can be alleviated through vaccination. The World Health Organization (WHO) recommends a 75% vaccinat...

BACKGROUND: The SARS-CoV-2 virus can bind to angiotensin-converting enzyme 2 receptors on host renal cells and may cause acute kidney injury (AKI). The comparative risks of AKI in patients severely il...

BACKGROUND: To compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. METHODS: Retrospective cohort study ...

BACKGROUND: Pregnancy and early infancy are increased risk periods for severe adverse effects of respiratory infections. Aboriginal and/or Torres Strait Islander (respectfully referred to as First Nat...

International audience; Sub-Saharan Africa was historically considered an animal influenza cold spot, with only sporadic highly pathogenic H5 outbreaks detected over the last 20 years. H...

INTRODUCTION: Influenza virus infection is associated with high morbidity and mortality, and so additional therapeutic strategies to reduce the burden for healthcare systems are needed. Statins, by vi...

International audience; Highly Pathogenic Avian Influenza Viruses (HPAIV) evolve from Low Pathogenic Avian Influenza Viruses (LPAIV) of the H5 and H7 subtypes. This evolution is characte...

Background Evidence on the effectiveness of influenza vaccination in the elderly is limited, and results are controversial. There are also few reports from China. Methods We conducted a test-negative ...

Seasonal influenza kills hundreds of thousands every year, with multiple constantly-changing strains in circulation at any given time. A high mutation rate enables the influenza virus to evade recog...

Background Lung reactivations of Herpesviridae , herpes simplex virus (HSV) and cytomegalovirus (CMV) have been reported in COVID-19 patients. Whether or not those viral reactivations are more frequen...

BACKGROUND: Influenza A virus (IAV) infection is a continual threat to the health of animals and humans globally. Consumption of the conventional drugs has shown several side effects and drug resistan...

The Influenza virus can be considered as one of the most severe viruses that can infect multiple species with often fatal consequences to the hosts. The Hemagglutinin (HA) gene of the virus can be a...

International audience; In August 2021, we detected highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses in poultry in southern Benin. The isolates were genetically similar t...

Influenza virus infection can cause severe respiratory disease and is estimated to cause millions of illnesses annually. Studies of the contribution of the innate immune response to influenza A virus ...

BACKGROUND: Increasing severe morbidity and mortality by simultaneous or sequential infections with SARS-CoV-2 and influenza A viruses (IAV), especially in the elderly and obese patients, highlight th...

International audience; Detailed information are lacking on influenza transmissibility in hospital although clusters are regularly reported. In this pilot study, our goal was to estimate...

INTRODUCTION: This study aimed to assess if the frequency of the Italian general public searches for influenza, using the Wikipedia web-page, are aligned with Istituto Superiore di Sanità (ISS) influe...

Influenza poses a significant threat to public health, particularly among the elderly, young children, and people with underlying dis-eases. The manifestation of severe conditions, such as pneumonia...

Background Previous studies have typically explored the daily lagged relations between influenza and meteorology, but few have explored seasonally the monthly lagged relationship, interaction and mult...

Background Plant growth-promoting endophytic fungi (PGPEF) that are associated with halophytes have the potential to boost crop salinity tolerance and productivity. This in turn has the potential of e...

Background Enterocytozoon bieneusi is the most common species found in humans. Although E. bieneusi has been investigated in humans, genotype profile of E. bieneusi is not known in Türkiye. Methods In...

In South Africa, basic healthcare centres treat sexually transmitted infections (STIs) using a syndromic approach. In line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRIS...

Background Gut microbiota play a key role in the nutrition of many marine herbivorous fishes through hindgut fermentation of seaweed. Gut microbiota composition in the herbivorous fish Kyphosus sydney...

Objective The association between heart failure (HF) and intestinal inflammation caused by a disturbed intestinal microbiota in infants with congenital heart disease (CHD) was investigated. Methods Tw...

Background Methicillin-resistant Staphylococcus aureus (MRSA) infections are considered a major public health problem, as the treatment options are restricted. Biofilm formation and the quorum sensing...

Background Late-onset sepsis (LOS) and pneumonia are common infectious diseases, with high morbidity and mortality in neonates. This study aimed to investigate the differences in the gut microbiota am...

Background Although the spread of antimicrobial resistance (AMR) through food and its production poses a significant concern, there is limited research on the prevalence of AMR bacteria in various agr...

(1) The EXS2600 platform demonstrated superior capability in distinguishing between Fusarium species. (2) The data demonstrated that EXS2600 platform provided comparable results and was suitable for f...

Background The main natural reservoir for Campylobacter jejuni is the avian intestinal tract. There, C. jejuni multiplies optimally at 42 °C – the avian body temperature. After infecting humans throug...

Background ESBL-producing Escherichia coli pose a growing health risk in community and healthcare settings. We investigated the resistome, virulome, mobilome, and genetic relatedness of multidrug-resi...

Due to specific bacterial microbiota, raw milk cheeses have appreciated sensory properties. However, they may pose a threat to consumer safety due to potential pathogens presence. This study evaluated...

Background Little is known about susceptibility of Staphylococcus lugdunensis to antiseptics. The objective of this study was to evaluate, at the molecular and phenotypic level, the susceptibility of ...

Background Pediatric chronic intestinal pseudo-obstruction (PIPO) is a rare disease characterized by symptoms and radiological signs suggestive of intestinal obstruction, in the absence of lumen-occlu...

Background The impact of probiotic strains on host health is widely known. The available studies on the interaction between bacteria and the host are focused on the changes induced by bacteria in the ...

Background Cobweb disease is a fungal disease that commonly affects the cultivation and production of edible mushrooms, leading to serious yield and economic losses. It is considered a major fungal di...

Background Pseudomonas aeruginosa is a common cause of nosocomial infections. However, the emergence of multidrug-resistant strains has complicated the treatment of P. aeruginosa infections. While pol...

Background Endophytic fungi are very rich sources of natural antibacterial and antifungal compounds. The main aim of this study is to isolate the fungal endophytes from the medicinal plant Corchorus o...

Background Klebsiella pneumoniae is one of the main pathogens of clinical isolation and nosocomial infections, as K. pneumoniae show broad-spectrum resistance to β-lactam and carbapenem antibiotics. I...

Background Patients with diabetic feet are prone to be infected due to the impaired immune system. However, the prognostic outcome of different microbial infections remains controversial. Identificati...

Plants absorb mineral nutrients for growth and development from the soil though their roots; nutrient acquisition is therefore limited by their root area. To improve it, especially in nutrient-poor co...

Background The ascomycetous heterothallic yeast Wickerhamomyces anomalus (WA) has received considerable attention and has been widely reported in the winemaking industry for its distinctive physiologi...

BACKGROUND AND PURPOSE: Endovascular treatment of acute ischemic stroke is now performed more frequently in the late window in radiologically selected patients. However, little is known about whether ...

In this narrative review, we examine biological processes linking psychological stress and cognition, with a focus on how psychological stress can activate multiple neurobiological mechanisms that dri...

BACKGROUND: Acute ischaemic stroke (AIS) is a leading cause of disability and mortality worldwide. Determining subgroups and outcomes of AIS may lead to better treatment. We aimed to investigate the r...

Numerosity, the set size of a group of items, helps guide human and animals' behavior and decisions. Numerosity perception is thought to be a precursor of symbolic numerical cognition. Previously, we ...

BACKGROUND AND OBJECTIVES: ChatGPT has shown promise in healthcare. To assess the utility of this novel tool in healthcare education, we evaluated ChatGPT’s performance in answering neurology board ex...

OBJECTIVES: Wiedemann–Steiner syndrome (WSS) is a neurogenetic disorder caused by heterozygous variants in KMT2A. Recent investigations suggest increased anxiety and behavior regulation challenges amo...

Erdheim-Chester disease is a rare non-Langerhans cell histiocytosis. The disease is widely variable in its severity, ranging from incidental findings in asymptomatic patients to a fatal multisystem il...

BACKGROUND: In Australia, tixagevimab/cilgavimab 150 mg/150 mg was a government-funded pre-exposure prophylaxis for COVID-19 people with multiple sclerosis (pwMS) and other neuroimmunological conditio...

BACKGROUND AND PURPOSE: Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety and efficacy of the 2 treatments in a ...

Metabotropic glutamate receptor 2 (GRM2) is highly expressed in hippocampal dentate granule cells (DGCs), regulating synaptic transmission and hippocampal functions. Newborn DGCs are continuously gene...

The current project was funded by the Global Engagement Seed Grant from the International Brain Research Organisation (IBRO) as part of the IBRO-led Global Engagement Initiative. The project was focus...

BACKGROUND: Gut microbiomes play a role in developing and regulating autoimmune diseases such as multiple sclerosis (MS). We designed this systematic review to summarize the evidence of the effect of ...

The detection of environmental temperatures is critical for survival, yet inappropriate responses to thermal stimuli can have a negative impact on overall health. The physiological effect of cold is d...

BACKGROUND AND OBJECTIVES: Spontaneous spinal cord infarction (SCInf) is a rare condition resulting in acute neurological impairment. Consensus on diagnostic criteria is lacking, which may present a c...

The prefrontal cortex and hippocampus may support sequential working memory beyond episodic memory and spatial navigation. This stereoelectroencephalography (SEEG) study investigated how the dorsolate...

Temporal lobe epilepsy (TLE) is the most prevalent form of epilepsy, through the neuronal mechanisms of this syndrome remain elusive. In addition to the temporal lobe structures, it was found that the...

Temporal orienting of attention plays an important role in our day-to-day lives and can use timing information from exogenous or endogenous sources. Yet, it is unclear what neural mechanisms give rise...

Introduction: Lumbosacral transitional vertebra (LSTV) is the most common congenital anomaly of the lumbosacral junction and is a frequent cause of back pain in young patients with a prevalence of 4.6...

Retrograde adeno-associated viruses (AAVs) are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural networks. ...

In this narrative review, we examine biological processes linking psychological stress and cognition, with a focus on how psychological stress can activate multiple neurobiological mechanisms that dri...

The meaning of words in natural language depends crucially on context. However, most neuroimaging studies of word meaning use isolated words and isolated sentences with little context. Because the bra...

BACKGROUND: Acute ischaemic stroke (AIS) is a leading cause of disability and mortality worldwide. Determining subgroups and outcomes of AIS may lead to better treatment. We aimed to investigate the r...

International audience; Background: Hypomimia is a symptom of Parkinson's disease (PD), characterized by a decrease in facial movements and loss of face emotional expressions. This study...

Background Accumulating data have suggested that vitamin D receptor (VDR) gene is a pretender gene for vulnerability to Parkinson disease (PD). This study aimed to assess the relationship of VDR gene ...

International audience; α-synucleinopathies, encompassing Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are devastating neurodegenerative diseases for whic...

The aim of this prospective study was to investigate autonomic function in Parkinson’s disease with a multidimensional approach including clinical evaluation tools, head-up tilt test and morphological...

International audience; In this paper, we study the problem of detecting early signs of Parkinson's disease during an indirect human-computer interaction via a computer mouse activated b...

OBJECTIVE: We analyzed the longitudinal profile of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in early Parkinson's disease (PD) compared with healthy controls (HCs) and tested basel...

BACKGROUND: Pathogenic variants in the LRRK2 gene are a common monogenic cause of Parkinson's disease. However, only seven variants have been confirmed to be pathogenic. OBJECTIVES: We identified two ...

Parkinson's disease (PD) is the most common neurodegenerative movement disorder in humans. Despite intense investigations, effective therapies are not yet available to halt the progression of PD. Gemf...

International audience; In Parkinson's disease, nigrostriatal dopamine (DA) degeneration is commonly associated with motor symptomatology. However, non-motor symptoms affecting cognitive...

OBJECTIVES: This study aimed to assess the efficacy of DA‐9701 on gastrointestinal symptom‐related quality of life in patients with Parkinson's disease on stable dopaminergic medications. METHODS: Thi...

Parkinson's disease (PD) and Multiple System Atrophy (MSA) are progressive neurodegenerative diseases with overlap of symptoms in early stages of disease. No reliable biomarker exists a...

BACKGROUND: Both Parkinson's disease (PD) and multiple system atrophy (MSA) exhibit degeneration of brainstem serotoninergic nuclei, affecting multiple subcortical and cortical serotoninergic projecti...

BACKGROUND: GBA mutations are the commonest genetic risk factor for Parkinson's disease (PD) and also impact disease progression. OBJECTIVE: The objective of this study was to define a biochemical pro...

OBJECTIVE: To examine specific symptom progression patterns and possible disease staging in Parkinson disease clinical subtypes. METHODS: We recently identified Parkinson disease clinical subtypes bas...

Advanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device‐aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG),...

BACKGROUND: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. OBJEC...

BACKGROUND: Type 2 diabetes (T2DM) is an established risk factor for developing Parkinson's disease (PD), but its effect on disease progression is not well understood. OBJECTIVE: The aim of this study...

BACKGROUND: The most common genetic risk factor for Parkinson's disease known is a damaging variant in the GBA1 gene. The entire GBA1 gene has rarely been studied in a large cohort from a single popul...

BACKGROUND: Solriamfetol is approved (US and EU) for excessive daytime sleepiness (EDS) in narcolepsy and obstructive sleep apnea. OBJECTIVES: Evaluate solriamfetol safety/efficacy for EDS in Parkinso...

Parkinson's disease is a common neurological disease, entailing a multitude of motor deficiency symptoms. In this project, we developed a device with an uploaded edge machine learning algorithm that...

International audience; Background: High consumption of Annona muricata fruit has been previously identified as a risk factor for atypical parkinsonism in the French Caribbean islands.Ob...

OBJECTIVES: Excessive daytime sleepiness (EDS) affects a large percentage of Parkinson's disease (PD) patients, and it is enhanced by dopamine agonist drugs. Currently, there is no treatment of choice...

Nuclear structure properties and weak interaction rates of neutron rich even even iron (Fe) isotopes (A = 50 70) are investigated using the Interacting Boson Model1 (IBM1) and the proton neutron Qua...

Context. Solar energetic particles (SEPs) are detected in interplanetary space in association with solar flares and coronal mass ejections (CMEs). The magnetic connection between the observing space...

X-ray polarization is a unique new probe of the particle acceleration in astrophysical jets made possible through the Imaging X-ray Polarimetry Explorer. Here we report on the first dense X-ray pola...

We investigate the production of dark radiation (DR) from axions and axion-like particles (ALPs) as potential origins of dark matter. Focusing on the dark matter misalignment mechanism, we examine n...

In recent years, numerical simulations have become indispensable for addressing complex astrophysical problems. The MagnetoHydroDynamics (MHD) framework represents a key tool for investigating the d...

An avenue for understanding cosmological galaxy formation is to compare morphometric parameters in observations and simulations of galaxy assembly. In this second paper of the ASymba: Asymmetries of...

We present a catalog of 34 new candidate (13 high confidence) isolated, young stellar systems within the Virgo galaxy cluster identified through a citizen science search of public optical and ultrav...

We focus on a sample of 42 sources in the vicinity of the bow-shock source IRS 1W (N-sources), located at the distance of $6.05''$ north-east of the supermassive black hole (SMBH) Sagittarius A* (Sg...

The effect of the returning radiation has long been ignored in the analysis of the reflection spectra of Galactic black holes and active galactic nuclei and only recently has been implemented in the...

GWtuna is a fast gravitational-wave search prototype built on Optuna (optimisation software library) and JAX (accelerator-orientated array computation library) [1, 2]. Using Optuna, we introduce bla...

Isolated neutron stars are thought to receive a natal kick velocity at birth nearly aligned with their spin axis. Direct observational confirmation of this alignment has been limited to a single sou...

Richardson-Lucy deconvolution is widely used to restore images from degradation caused by the broadening effects of a point spread function and corruption by photon shot noise, in order to recover a...

As globular clusters (GCs) orbit the Milky Way, their stars are tidally stripped forming tidal tails that follow the orbit of the clusters around the Galaxy. The morphology of these tails is complex...

Recent observations by Mistele et al. show that the circular velocity curves of isolated galaxies remain flat out to the largest radii probed so far, i.e. $\approx 1$ Mpc. The velocity decline beyon...

In Adil et al. 2023, we reported an increasing trend in $S_8$ with effective redshift $z_{\textrm{eff}}$ based on $f \sigma_8(z)$ constraints over the redshift range $0 \lesssim z \lesssim 2$, and p...

We have studied the accreting black hole binary GX 339--4 using two highly accurate broad-band X-ray data sets in very soft spectral states from simultaneous NICER and NuSTAR observations. Joint fit...

We describe the software package $\texttt{ESpRESSO}$ - [E]xtragalactic [Sp]ectroscopic [R]oman [E]mulator and [S]imulator of [S]ynthetic [O]bjects, created to emulate the slitless spectroscopic obse...

This paper presents Taylor expansions for the imaging and timing characteristics of spherical optical systems with infinitesimal mirror facets, sometimes referred to as ''modified Davies-Cotton'' te...

We present three separate void catalogs created using a volume-limited sample of the DESI Year 1 Bright Galaxy Survey. We use the algorithms VoidFinder and V2 to construct void catalogs out to a red...

Context. Current implementations of mass loss for hot, massive stars in stellar evolution models include a sharp increase in mass loss when blue supergiants become cooler than Teff 20-22kK. This dra...

The three-dimensional velocity structure of the shock-heated Si-reach and S-reach ejecta were reconstructed in Tycho supernova remnant from Doppler-shifted lines. The vector components along the lin...

In this catalog, we present the results of a systematic study of 199 short gamma-ray bursts (GRBs) detected by Konus-Wind between 2011 January 1 and 2021 August 31. The catalog extends the Second Ca...

Background Work-related stress (WRS) is a growing problem around the world that affects the health and well-being of employees. However, evidence of work-related stress in Ethiopia, particularly among...

Background Changes in Swedish university students’ lifestyle behaviors during the COVID-19 pandemic are unknown. This study aimed to assess physical activity, sitting time, meal frequency and risk sub...

BACKGROUND: Femtosecond laser–assisted LASIK (FS-LASIK) can make ultra-thin corneal flap accurately. MEL 90 excimer laser provides Triple-A ablation mode, which significantly reduces the amount of cor...

BACKGROUND: Despite the rapid increase in knowledge about coronavirus disease 2019 (COVID-19), there is limited data on vertical transmission, viral loads in mother-neonate pairs, and health outcomes....

BACKGROUND: The psychological distress of fathers in the postpartum period can have adverse effects on the well-being of the family and the newborn’s development in particular. However, fathers’ menta...

BACKGROUND: Bullous pemphigoid is the most common bullous chronic autoimmune skin disease. Recent studies have suggested dipeptidyl-peptidase 4 inhibitors as possible predisposing agents of bullous pe...

SIMPLE SUMMARY: Although atezolizumab plus bevacizumab combination therapy was approved in September 2020 as the first immune-combined therapy for hepatocellular carcinoma, the efficacy and safety of ...

SIMPLE SUMMARY: The histopathological characteristics and prognostic effects of intratumoral necrosis in pancreatic ductal adenocarcinoma (PDAC) observed on computed tomography (CT) or magnetic resona...

Background The viral G-protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein–Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected ce...

We present the results of the first X-ray study of a sample of 16 young radio sources classified as Compact Symmetric Objects (CSOs). We observed six of them for the first time in X-rays using {\it ...

Background The co-administration of drugs known to interact greatly impacts morbidity, mortality, and health economics. This study aims to examine the drug–drug interaction (DDI) phenomenon with a lar...

International audience; This study focuses on the thermal maturity assessment of Silurian-Devonian sediments from the Ghadamis Basin, North Africa, comparing optical and geochemical anal...

OBJECTIVE: To explore the contribution of a mindfulness-based intervention as an adjuvant to outpatient substance use disorder treatment. Outcomes included substance use behavior, depression and anxie...

INTRODUCTION: The dipeptidyl peptidase-4 (DPP-4) enzyme significantly influences carcinogenic pathways in the skin. The objective of this study was to determine whether DPP-4 inhibitors are associated...

Background Low birth weight is associated with an increased risk of developing chronic diseases in adulthood, with a particularly high incidence in Japan among developed countries. Maternal undernutri...

Purpose This study investigated pancreatic enzyme replacement therapy (PERT) use in people diagnosed with pancreatic cancer in New Zealand (NZ) and Australia (AU). Methods A cross-sectional survey stu...

Background Arts therapies are widely but inconsistently provided in community mental health. Whilst they are appealing to patients, evidence for their effectiveness is mixed. Trials to date have been ...

ML models can be used in all parts of medical treatments. With good features, it would be useful in the prediction of surgical pathologies. ML models are strong predictors of the severity of acute app...

BACKGROUND: Open cardiac surgical patients may experience severe acute poststernotomy pain. The ultrasound-guided Pecto-intercostal Fascial Block (PIFB) can cover anterior branches of intercostal nerv...

Introduction There is a substantial unmet need for effective therapies to treat patients with refractory dry eye disease (DED). The goal of this open-label pilot study was to investigate the efficacy ...

OBJECTIVES: The specific aims of the study are to assess whether the amount of time a cytology learner spends reviewing slides correlates with increased diagnostic competency and to determine whether ...

Background Cognitive bias modification for interpretation (CBM-I) trainings have shown positive effects on interpretation bias in both active interpretation bias training conditions and structurally s...

Objectives Previous studies have shown that there may be a positive correlation between serum uric acid levels and hyperthyroidism. However, the relationship between thyroid function and serum uric ac...

Background Thyroid storm is a state of circulating thyroid hormone excess leading to multiorgan dysfunction and systemic decompensation. It typically occurs in the setting of poorly controlled hyperth...

Background Whether prophylactic central lymph node dissection is necessary for patients with clinically node-negative (cN0) papillary thyroid microcarcinoma (PTMC) remains controversial. Herein, we ai...

Background The association between breast cancer (BC) and thyroid cancer (TC) has been studied in several epidemiological studies. However, the underlying causal relationship between them is not yet c...

Background The early diagnosis of medullary thyroid carcinoma (MTC) is still a challenge in clinical practice. Based on ultrasound features, many MTC cases without suspicious characteristics are not c...