Document detail
ID

doi:10.1007/s00702-021-02431-y...

Author
Hommen, Franziska Bilican, Saygın Vilchez, David
Langue
en
Editor

Springer

Category

Neurology

Year

2022

listing date

12/8/2022

Keywords
proteostasis proteasome autophagy alzheimer’s disease huntington’s disease parkinson’s disease amyotrophic lateral sclerosis aging cancer protein
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Abstract

Protein homeostasis, or proteostasis, is essential for cell function and viability.

Unwanted, damaged, misfolded and aggregated proteins are degraded by the ubiquitin–proteasome system (UPS) and the autophagy-lysosome pathway.

Growing evidence indicates that alterations in these major proteolytic mechanisms lead to a demise in proteostasis, contributing to the onset and development of distinct diseases.

Indeed, dysregulation of the UPS or autophagy is linked to several neurodegenerative, infectious and inflammatory disorders as well as cancer.

Thus, modulation of protein clearance pathways is a promising approach for therapeutics.

In this review, we discuss recent findings and open questions on how targeting proteolytic mechanisms could be applied for disease intervention.

Hommen, Franziska,Bilican, Saygın,Vilchez, David, 2022, Protein clearance strategies for disease intervention, Springer

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