The influence of modern living conditions on the human microbiome and potential therapeutic opportunities for allergy prevention

Modern living conditions and the recent surge in global urbanization have transformed the human microbiome.

This transformation is believed to be a significant factor in the recent spike of common chronic inflammatory diseases like asthma and allergies worldwide, evident in both developed and developing nations.

Immigrants from less developed regions who settle in highly urbanized and affluent areas present an ideal demographic for research.

Investigating immigrant populations can yield valuable insights, particularly when studying microbiome changes that occur as individuals transition from areas with low asthma prevalence to regions with a high prevalence of the condition.

The application of prebiotics and probiotics as potential treatments for asthma and allergies faces challenges.

This is due to the complex interplay of numerous factors that contribute to their aetiology.

Exploring the interaction between the human microbiome and potential epigenetic changes in specific populations, such as immigrants adapting to new, urbanized environments, may offer crucial insights.

Such research could underscore the role of prebiotics and probiotics in preventing allergic conditions.

Recognizing the changes in the human microbiome in the context of a Western/modern environment might be essential in addressing the increasing prevalence of allergic diseases.

Persistent research in this domain is pivotal for devising effective interventions such as dietary supplementation with prebiotics and probiotics.