Dokumentdetails
ID
oai:pubmedcentral.nih.gov:1114...
Thema
Review ArticleAutor
Karpischenko, Sergey Jung, Yong Gi Kim, Dae-Woo Spriggs, Kymble Tsang, Raymond King-Yin Yeh, Te-HueiLangue
enEditor
Lippincott Williams & Wilkins
Kategorie
Asia Pacific Allergy
Jahr
2024
Auflistungsdatum
11.06.2024
Schlüsselwörter
disease patients ess treatment management chronic polyps crswnp nasalZusammenfassung
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition of the nasal and paranasal tissues, characterized by the presence of bilateral nasal polyps.
An expert panel of specialists from the Asian-Pacific region and Russia was convened to develop regional guidance on the management of CRSwNP through a consensus approach.
The present article presents the chief observations and recommendations from this panel to provide guidance for clinicians in these areas.
Etiology and pathogenetic mechanisms in CRSwNP are heterogeneous and complex.
In many patients, CRSwNP is primarily driven by type 2 inflammation, although this may be less important in Asian populations.
Frequent comorbidities include asthma and other inflammatory diseases such as non-steroidal anti-inflammatory drug (NSAID)/aspirin-exacerbated respiratory disease or atopic dermatitis.
Clinical management of CRSwNP is challenging, and a multidisciplinary approach to evaluation and treatment is recommended.
While many patients respond to medical treatment (topical irrigation and intranasal corticosteroids, and adjunctive short-term use of systemic corticosteroids), those with more severe/uncontrolled disease usually require endoscopic sinus surgery (ESS), although outcomes can be unsatisfactory, requiring revision surgery.
Biological therapies targeting underlying type 2 inflammation offer additional, effective treatment options in uncontrolled disease, either as an alternative to ESS or for those patients with persistent symptoms despite ESS.
Karpischenko, Sergey,Jung, Yong Gi,Kim, Dae-Woo,Spriggs, Kymble,Tsang, Raymond King-Yin,Yeh, Te-Huei, 2024, Management of chronic rhinosinusitis with nasal polyps in the Asia-Pacific region and Russia: Recommendations from an expert working group, Lippincott Williams & Wilkins
Configurable Safety Tuning of Language Models with Synthetic Preference Data
data preference cst dpo configurable language safety
Affective flexibility as a developmental building block of cognitive reappraisal: An fMRI study
cognitive success affective flexibility
