Successful desensitization to atezolizumab-induced near-fatal anaphylaxis in patients with hepatocellular carcinoma: A case report and literature review

Oh, Ji Hyun; Seo, Kwang Il; Kim, Hee-Kyoo; Choi, Gil-Soon

Successful desensitization to atezolizumab-induced near-fatal anaphylaxis in patients with hepatocellular carcinoma: A case report and literature review

Dokumentdetails

ID

oai:pubmedcentral.nih.gov:1136...

Thema

Case Report

Autor

Oh, Ji Hyun Seo, Kwang Il Kim, Hee-Kyoo Choi, Gil-Soon

Langue

Editor

Lippincott Williams & Wilkins

Kategorie

Asia Pacific Allergy

Jahr

2024

Auflistungsdatum

04.09.2024

Schlüsselwörter

anaphylaxis atezolizumab report cancer

Metrisch

Zusammenfassung

Atezolizumab, a humanized antiprogrammed death ligand 1 monoclonal immunoglobulin G1 antibody, is a targeted therapeutic drug known as an immune checkpoint inhibitor.

It is currently used to treat various types of cancer, including unresectable hepatocellular carcinoma (HCC), nonsmall cell lung cancer, urothelial cancer, and breast cancer, and is becoming a therapeutic option in the forefront of oncology treatment.

However, it may sometimes lead to undesirable adverse reactions owing to the activation of immune responses in various organs.

Cutaneous adverse reactions to atezolizumab are well known; however, cases of anaphylaxis are very rare.

In this report, we present the first case of HCC who experienced near-fatal anaphylaxis to atezolizumab in South Korea.

Oh, Ji Hyun,Seo, Kwang Il,Kim, Hee-Kyoo,Choi, Gil-Soon, 2024, Successful desensitization to atezolizumab-induced near-fatal anaphylaxis in patients with hepatocellular carcinoma: A case report and literature review, Lippincott Williams & Wilkins