detalle del documento
IDENTIFICACIÓN
doi:10.1007/s10072-024-07508-6...
Autor
Kubat, Gokhan Burcin Picone, PasqualeLangue
enEditor
Springer
Categoría
Medicine & Public Health
Año
2024
fecha de cotización
1/5/2024
Palabras clave
amyotrophic lateral sclerosis mitochondria skeletal muscle dysfunction mitochondrial transplantation mitochondrial therapeutic cellsResumen
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease that results in the loss of motor neurons and severe skeletal muscle atrophy.
The etiology of ALS is linked to skeletal muscle, which can activate a retrograde signaling cascade that destroys motor neurons.
This is why satellite cells and mitochondria play a crucial role in the health and performance of skeletal muscles.
This review presents current knowledge on the involvement of mitochondrial dysfunction, skeletal muscle atrophy, muscle satellite cells, and neuromuscular junction (NMJ) in ALS.
It also discusses current therapeutic strategies, including exercise, drugs, stem cells, gene therapy, and the prospective use of mitochondrial transplantation as a viable therapeutic strategy.
Kubat, Gokhan Burcin,Picone, Pasquale, 2024, Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approaches, Springer
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