Détail du document
Identifiant
doi:10.1007/s00415-024-12388-z...
Auteur
Lehto, Annaliis Schumacher, Julia Kasper, Elisabeth Teipel, Stefan Hermann, Andreas Kurth, Jens Krause, Bernd Joachim Prudlo, JohannesLangue
enEditeur
Springer
Catégorie
Medicine & Public Health
Année
2024
Date de référencement
12/06/2024
Mots clés
amyotrophic lateral sclerosis cerebral glucose metabolism fdg-pet cognition grey matter volume cognitively patients results behaviourally cerebral als metabolism impaired alsni alsci alscbi glucoseRésumé
Objective Half of ALS patients are cognitively and/or behaviourally impaired.
As cognition/behaviour and cerebral glucose metabolism can be correlated by means of ^18F-Fluorodeoxyglucose positron emission tomography (FDG-PET), we aimed to utilise FDG-PET, first, to replicate group-level differences in glucose metabolism between non-demented ALS patients separated into non-impaired (ALSni), cognitively impaired (ALSci), behaviourally impaired (ALSbi), and cognitively and behaviourally impaired (ALScbi) groups; second, to investigate glucose metabolism and performance in various cognitive domains; and third, to examine the impact of partial volume effects correction (PVEC) of the FDG-PET data on the results.
Methods We analysed neuropsychological, clinical, and imaging data from 67 ALS patients (30 ALSni, 21 ALSci, 5 ALSbi, and 11 ALScbi).
Cognition was assessed with the Edinburgh Cognitive and Behavioural ALS Screen, and two social cognition tests.
FDG-PET and structural MRI scans were acquired for each patient.
Voxel-based statistical analyses were undertaken on grey matter volume (GMV) and non-corrected vs. PVE-corrected FDG-PET scans.
Results ALSci and ALScbi had lower cognitive scores than ALSni.
In contrast to both ALSni and ALSci, ALScbi showed widespread hypometabolism in the superior- and middle-frontal gyri in addition to the right temporal pole.
Correlations were observed between the GMV, the FDG-PET signal, and various cognitive scores.
The FDG-PET results were largely unaffected by PVEC.
Interpretation Our study identified widespread differences in hypometabolism in the ALScbi-ni but not in the ALSci-ni group comparison, raising the possibility that cerebral metabolism may be more closely related to the presence of behavioural changes than to mild cognitive deficits.
Lehto, Annaliis,Schumacher, Julia,Kasper, Elisabeth,Teipel, Stefan,Hermann, Andreas,Kurth, Jens,Krause, Bernd Joachim,Prudlo, Johannes, 2024, Cerebral glucose metabolic correlates of cognitive and behavioural impairments in amyotrophic lateral sclerosis, Springer
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