Détail du document
Identifiant
doi:10.1007/s10072-023-07262-1...
Auteur
Katerelos, Adamantios Alexopoulos, Panagiotis Economou, Polychronis Polychronopoulos, Panagiotis Chroni, ElisabethLangue
enEditeur
Springer
Catégorie
Medicine & Public Health
Année
2023
Date de référencement
20/12/2023
Mots clés
amyotrophic lateral sclerosis als cognitive impairment fab moca individuals cognitive alsRésumé
Background Amyotrophic lateral sclerosis (ALS) can present with either bulbar or spinal symptoms, and in some cases, both types of symptoms may be present.
In addition, cognitive impairment has been observed in ALS.
The study aimed to evaluate the frontal and general cognitive performance in ALS not only cross-sectionally but also longitudinally.
Methods and materials The Frontal Assessment Battery (FAB) and the Montreal Cognitive Assessment (MoCA) were employed to assess cognitive function in 52 adults with ALS and 52 cognitively healthy individuals.
The statistical analyses encompassed the Pearson Chi square test, the Skillings-Mack test, the Spearman’s rank correlation coefficient, and the Proportional Odds Logistic Regression Model (POLR).
Results Cross-sectionally, lower cognitive performance was associated with ALS diagnosis, older age, and motor functional decline.
The cognitive impairment of individuals with bulbar and spinal-bulbar symptoms showed faster deterioration compared to those with spinal symptoms.
The spinal subgroup consistently performed worst in delayed recall and attention, while the spinal-bulbar and bulbar subgroups exhibited inferior scores in delayed recall, attention, visuospatial skills, orientation, and verbal fluency.
Conclusion The incorporation of cognitive screening in the diagnostic workup of ALS may be beneficial, as early detection can enhance symptom management and improve the quality of life for both individuals with ALS and their care partners.
Katerelos, Adamantios,Alexopoulos, Panagiotis,Economou, Polychronis,Polychronopoulos, Panagiotis,Chroni, Elisabeth, 2023, Cognitive function in amyotrophic lateral sclerosis: a cross-sectional and prospective pragmatic clinical study with review of the literature, Springer
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