Détail du document
Identifiant
oai:pubmedcentral.nih.gov:1033...
Sujet
Research ArticlesAuteur
Sugier, Pierre‐Emmanuel Lucotte, Elise A. Domenighetti, Cloé Law, Matthew H. Iles, Mark M. Brown, Kevin Amos, Christopher McKay, James D. Hung, Rayjean J. Karimi, Mojgan Bacq‐Daian, Delphine Boland‐Augé, Anne Olaso, Robert Deleuze, Jean‐françois Lesueur, Fabienne Ostroumova, Evgenia Kesminiene, Ausrele de Vathaire, Florent Guénel, Pascal Sreelatha, Ashwin Ashok Kumar Schulte, Claudia Grover, Sandeep May, Patrick Bobbili, Dheeraj R. Radivojkov‐Blagojevic, Milena Lichtner, Peter Singleton, Andrew B. Hernandez, Dena G. Edsall, Connor Mellick, George D. Zimprich, Alexander Pirker, Walter Rogaeva, Ekaterina Lang, Anthony E. Koks, Sulev Taba, Pille Lesage, Suzanne Brice, Alexis Corvol, Jean‐Christophe Chartier‐Harlin, Marie‐Christine Mutez, Eugénie Brockmann, Kathrin Deutschländer, Angela B. Hadjigeorgiou, Georges M. Dardiotis, Efthimios Stefanis, Leonidas Simitsi, Athina Maria Valente, Enza Maria Petrucci, Simona Straniero, Letizia Zecchinelli, Anna Pezzoli, Gianni Brighina, Laura Ferrarese, Carlo Annesi, Grazia Quattrone, Andrea Gagliardi, Monica Matsuo, Hirotaka Nakayama, Akiyoshi Hattori, Nobutaka Nishioka, Kenya Chung, Sun Ju Kim, Yun Joong Kolber, Pierre van de Warrenburg, Bart P.C. Bloem, Bastiaan R. Aasly, Jan Toft, Mathias Pihlstrøm, Lasse Guedes, Leonor Correia Ferreira, Joaquim J. Bardien, Soraya Carr, Jonathan Tolosa, Eduardo Ezquerra, Mario Pastor, Pau Diez‐Fairen, Monica Wirdefeldt, Karin Pedersen, Nancy Ran, Caroline Belin, Andrea C. Puschmann, Andreas Rödström, Emil Ygland Clarke, Carl E. Morrison, Karen E. Tan, Manuela Krainc, Dimitri Burbulla, Lena F. Farrer, Matt J. Kruger, Rejko Gasser, Thomas Sharma, Manu Truong, Thérèse Elbaz, AlexisLangue
enEditeur
John Wiley & Sons, Inc.
Catégorie
Wiley-Blackwell Online Open
Année
2023
Date de référencement
11/06/2024
Mots clés
gwass international prostate prs cancer pd 0 parkinson [0 disease associated cancers consortium ovarian genetic associationRésumé
BACKGROUND: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties.
OBJECTIVE: We used results from genome‐wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors.
METHODS: We used individual data for participants of European ancestry from the Courage‐PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta‐Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs).
We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression.
We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross‐phenotypes polygenic risk score (PRS) analyses.
RESULTS: We confirmed a previously reported positive genetic correlation of PD with melanoma (G(corr) = 0.16 [0.04; 0.28]) and reported an additional significant positive correlation of PD with prostate cancer (G(corr) = 0.11 [0.03; 0.19]).
There was a significant inverse association between the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89 [0.84; 0.94]).
Conversely, the PRS of PD was positively associated with breast cancer (OR = 1.08 [1.06; 1.10]) and inversely associated with ovarian cancer (OR = 0.95 [0.91; 0.99]).
The association between PD and ovarian cancer was mostly driven by rs183211 located in an intron of the NSF gene (17q21.31).
CONCLUSIONS: We show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers.
© 2023 The Authors.
Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Sugier, Pierre‐Emmanuel,Lucotte, Elise A.,Domenighetti, Cloé,Law, Matthew H.,Iles, Mark M.,Brown, Kevin,Amos, Christopher,McKay, James D.,Hung, Rayjean J.,Karimi, Mojgan,Bacq‐Daian, Delphine,Boland‐Augé, Anne,Olaso, Robert,Deleuze, Jean‐françois,Lesueur, Fabienne,Ostroumova, Evgenia,Kesminiene, Ausrele,de Vathaire, Florent,Guénel, Pascal,,Sreelatha, Ashwin Ashok Kumar,Schulte, Claudia,Grover, Sandeep,May, Patrick,Bobbili, Dheeraj R.,Radivojkov‐Blagojevic, Milena,Lichtner, Peter,Singleton, Andrew B.,Hernandez, Dena G.,Edsall, Connor,Mellick, George D.,Zimprich, Alexander,Pirker, Walter,Rogaeva, Ekaterina,Lang, Anthony E.,Koks, Sulev,Taba, Pille,Lesage, Suzanne,Brice, Alexis,Corvol, Jean‐Christophe,Chartier‐Harlin, Marie‐Christine,Mutez, Eugénie,Brockmann, Kathrin,Deutschländer, Angela B.,Hadjigeorgiou, Georges M.,Dardiotis, Efthimios,Stefanis, Leonidas,Simitsi, Athina Maria,Valente, Enza Maria,Petrucci, Simona,Straniero, Letizia,Zecchinelli, Anna,Pezzoli, Gianni,Brighina, Laura,Ferrarese, Carlo,Annesi, Grazia,Quattrone, Andrea,Gagliardi, Monica,Matsuo, Hirotaka,Nakayama, Akiyoshi,Hattori, Nobutaka,Nishioka, Kenya,Chung, Sun Ju,Kim, Yun Joong,Kolber, Pierre,van de Warrenburg, Bart P.C.,Bloem, Bastiaan R.,Aasly, Jan,Toft, Mathias,Pihlstrøm, Lasse,Guedes, Leonor Correia,Ferreira, Joaquim J.,Bardien, Soraya,Carr, Jonathan,Tolosa, Eduardo,Ezquerra, Mario,Pastor, Pau,Diez‐Fairen, Monica,Wirdefeldt, Karin,Pedersen, Nancy,Ran, Caroline,Belin, Andrea C.,Puschmann, Andreas,Rödström, Emil Ygland,Clarke, Carl E.,Morrison, Karen E.,Tan, Manuela,Krainc, Dimitri,Burbulla, Lena F.,Farrer, Matt J.,Kruger, Rejko,Gasser, Thomas,Sharma, Manu,Truong, Thérèse,Elbaz, Alexis, 2023, Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers, John Wiley & Sons, Inc.
Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex
heterogeneity projection-specific
