Détail du document
Identifiant
oai:HAL:hal-03313375v1
Sujet
Parkinson's disease Multiple system atrophy Dysarthria Pathological speech processing Consonant distortion [INFO]Computer Science [cs]Auteur
Daoudi, Khalid Das, Biswajit Milhé de Saint Victor, Solange Foubert-Samier, Alexandra Pavy-Le Traon, Anne Rascol, Olivier Meissner, Wassilios, G Woisard, VirginieLangue
enEditeur
HAL CCSD
Catégorie
INRIA - Institut National de Recherche en Informatique et en Automatique
Année
2021
Date de référencement
09/10/2023
Mots clés
parkinson multiple atrophy system voiced disease differential diagnosisRésumé
International audience; Parkinson's disease (PD) and the parkinsonian variant of Multiple System Atrophy (MSA-P) are two neurodegenerative diseases which share similar clinical features, particularly in early disease stages.
The differential diagnosis can be thus very challenging.
Dysarthria is known to be a frequent and early clinical feature of PD and MSA.
It can be thus used as a vehicle to provide a vocal biomarker which could help in the differential diagnosis.
In particular, distortion of consonants is known to be a frequent impairment in these diseases.
The aim of this study is to investigate distinctive patterns in the distortion of voiced obstruents (plosives and fricatives).
It is the first study which attempts to examine such distortions in the French language for the purpose of the differential diagnosis between PD and MSA-P (and among the very few studies if we consider all languages).
We carry out a perceptual and objective analysis of voiced obstruents extracted from isolated pseudo-words initials.
We first show that devoicing is a significant impairment which predominates in MSA-P.
We then show that voice onset time (VOT) of voiced plosives (prevoicing duration) can be a complementary feature to improve the accuracy in discrimination between PD and MSA-P.
Daoudi, Khalid,Das, Biswajit,Milhé de Saint Victor, Solange,Foubert-Samier, Alexandra,Pavy-Le Traon, Anne,Rascol, Olivier,Meissner, Wassilios, G,Woisard, Virginie, 2021, Distortion of voiced obstruents for differential diagnosis between parkinson's disease and multiple system atrophy, HAL CCSD
Configurable Safety Tuning of Language Models with Synthetic Preference Data
data preference cst dpo configurable language safety
Affective flexibility as a developmental building block of cognitive reappraisal: An fMRI study
cognitive success affective flexibility
