Document detail
ID
oai:www.zora.uzh.ch:225967
Topic
Institute of Evolutionary Medicine... Evolution in Action: From Genomes ... 610 Medicine & health General Physics and Astronomy, Gen...Author
Patrono, Livia V Vrancken, Bram https://orcid.org/0000-0001-6547-5283 Budt, Matthias et al Schuenemann, Verena J https://orcid.org/0000-0002-8593-3672 Urban, ChristianLangue
engEditor
Nature Publishing Group
Category
Subjects = 04 Faculty of Medicine
Year
2022
listing date
10/12/2023
Keywords
influenza genomic 1918 iavAbstract
The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV).
Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak.
1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events.
Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans.
Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.
Patrono, Livia V,Vrancken, Bram, https://orcid.org/0000-0001-6547-5283,Budt, Matthias,et al,Schuenemann, Verena J, https://orcid.org/0000-0002-8593-3672,Urban, Christian, 2022, Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic, Nature Publishing Group
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