Document detail
ID
doi:10.1186/s13024-022-00515-1...
Author
Staats, Kim A. Borchelt, David R. Tansey, Malú Gámez Wymer, JamesLangue
enEditor
BioMed Central
Category
Biomedicine
Year
2022
listing date
2/10/2022
Keywords
amyotrophic lateral sclerosis biomarker inflammation cytokines inflammation alsAbstract
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in which many processes are detected including (neuro)inflammation.
Many drugs have been tested for ALS in clinical trials but most have failed to reach their primary endpoints.
The development and inclusion of different types of biomarkers in diagnosis and clinical trials can assist in determining target engagement of a drug, in distinguishing between ALS and other diseases, and in predicting disease progression rate, drug responsiveness, or an adverse event.
Ideally, among other characteristics, a biomarker in ALS correlates highly with a disease process in the central nervous system or with disease progression and is conveniently obtained in a peripheral tissue.
Here, we describe the state of biomarkers of inflammation in ALS by focusing on peripherally detectable and cellular responses from blood cells, and provide new (combinatorial) directions for exploration that are now feasible due to technological advancements.
Staats, Kim A.,Borchelt, David R.,Tansey, Malú Gámez,Wymer, James, 2022, Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis, BioMed Central
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