Document detail
ID
doi:10.1038/s41416-024-02762-z...
Author
Pujana-Vaquerizo, Mikel Bozal-Basterra, Laura Carracedo, ArkaitzLangue
enEditor
Nature
Category
Epidemiology
Year
2024
listing date
7/10/2024
Keywords
adaptations metabolic cancerAbstract
Prostate cancer is one of the most commonly diagnosed cancers in men and is a major cause of cancer-related deaths worldwide.
Among the molecular processes that contribute to this disease, the weight of metabolism has been placed under the limelight in recent years.
Tumours exhibit metabolic adaptations to comply with their biosynthetic needs.
However, metabolites also play an important role in supporting cell survival in challenging environments or remodelling the tumour microenvironment, thus being recognized as a hallmark in cancer.
Prostate cancer is uniquely driven by androgen receptor signalling, and this knowledge has also influenced the paths of cancer metabolism research.
This review provides a comprehensive perspective on the metabolic adaptations that support prostate cancer progression beyond androgen signalling, with a particular focus on tumour cell intrinsic and extrinsic pathways.
Pujana-Vaquerizo, Mikel,Bozal-Basterra, Laura,Carracedo, Arkaitz, 2024, Metabolic adaptations in prostate cancer, Nature
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