Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges

Document detail
ID

doi:10.1007/s00018-022-04225-1...

Author
Han, Jinming Chitu, Violeta Stanley, E. Richard Wszolek, Zbigniew K. Karrenbauer, Virginija Danylaité Harris, Robert A.
Langue
en
Editor

Springer

Category

Life Sciences

Year

2022

listing date

4/6/2022

Keywords
colony stimulating factor-1 recept... alzheimer’s disease parkinson’s disease huntington’s disease amyotrophic lateral sclerosis multiple sclerosis diseases inhibitors csf-1r
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Abstract

Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states.

Persistent neuroinflammation is considered a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson's disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS) and primary progressive multiple sclerosis (MS).

Colony stimulating factor 1-receptor (CSF-1R) is predominantly expressed on microglia and its expression is significantly increased in neurodegenerative diseases.

Cumulative findings have indicated that CSF-1R inhibitors can have beneficial effects in preclinical neurodegenerative disease models.

Research using CSF-1R inhibitors has now been extended into non-human primates and humans.

This review article summarizes the most recent advances using CSF-1R inhibitors in different neurodegenerative conditions including AD, PD, HD, ALS and MS. Potential challenges for translating these findings into clinical practice are presented.

Han, Jinming,Chitu, Violeta,Stanley, E. Richard,Wszolek, Zbigniew K.,Karrenbauer, Virginija Danylaité,Harris, Robert A., 2022, Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges, Springer

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