The potential role of hydrogen sulfide in cancer cell apoptosis

Gao, Wei; Liu, Ya-Fang; Zhang, Yan-Xia; Wang, Yan; Jin, Yu-Qing; Yuan, Hang; Liang, Xiao-Yi; Ji, Xin-Ying; Jiang, Qi-Ying; Wu, Dong-Dong

doi:10.1038/s41420-024-01868-w

The potential role of hydrogen sulfide in cancer cell apoptosis

Document detail

ID

doi:10.1038/s41420-024-01868-w...

Author

Gao, Wei Liu, Ya-Fang Zhang, Yan-Xia Wang, Yan Jin, Yu-Qing Yuan, Hang Liang, Xiao-Yi Ji, Xin-Ying Jiang, Qi-Ying Wu, Dong-Dong

Langue

Editor

Nature

Year

2024

listing date

3/13/2024

Keywords

signaling cancer

Metrics

Abstract

For a long time, hydrogen sulfide (H_2S) has been considered a toxic compound, but recent studies have found that H_2S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions.

Currently, a large number of studies have shown that H_2S mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways.

Therefore, the regulation of the production and metabolism of H_2S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment.

In this review, the role and mechanism of H_2S in cancer cell apoptosis in mammals are summarized.

Gao, Wei,Liu, Ya-Fang,Zhang, Yan-Xia,Wang, Yan,Jin, Yu-Qing,Yuan, Hang,Liang, Xiao-Yi,Ji, Xin-Ying,Jiang, Qi-Ying,Wu, Dong-Dong, 2024, The potential role of hydrogen sulfide in cancer cell apoptosis, Nature