Document detail
ID
doi:10.1186/s12964-023-01199-w...
Author
Mao, Mingwen Chen, Weina Huang, Xingbiao Ye, DongLangue
enEditor
BioMed Central
Category
Life Sciences
Year
2023
listing date
7/26/2023
Keywords
tsrnas malignant tumour trna-derived fragments diagnosis treatment malignant trna tumours tsrnas cancerAbstract
Malignant tumours area leading cause of death globally, accounting for approximately 13% of all deaths.
A detailed understanding of the mechanism(s) of the occurrence and development of malignant tumours and identification of relevant therapeutic targets are therefore key to tumour treatment.
tsRNAs(tRNA-derived small RNAs)—also known as TRFs (tRNA-derived fragments), tiRNAs (tRNA-derived stress-induced RNAs), tRNA halves, etc.—are a recently identified class of small noncoding RNAs that are generated from mature tRNA or tRNA precursors through cleavage by enzymes such as angiogenin, Dicer, RNase Z, and RNase P. Several studies have confirmed that dysregulation of tsRNAs is closely related to the tumorigenesis of breast cancer, nasopharyngeal cancer, lung cancer, and so on.
Furthermore, research indicates that tsRNAs can be used as clinical diagnostic markers and therapeutic targets for cancer.
In our review, we summarized the recent research progress on the role and clinical application of tsRNAs in tumorigenesis and progression.
Video Abstract
Mao, Mingwen,Chen, Weina,Huang, Xingbiao,Ye, Dong, 2023, Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours, BioMed Central
Evaluating Image Hallucination in Text-to-Image Generation with Question-Answering
evaluation computer dataset images tti generation i-halla
Role of Repetitive Transcranial Magnetic Stimulation in Treatment of Fibromyalgia: A Randomized Controlled Trial
significant following stimulation fms treatment
