doi:10.1186/s12933-023-01740-8...
BioMed Central
Medicine & Public Health
2023
2/1/2023
Background Although a great deal of scientific evidence on the epidemiological risk factors for diabetes and prediabetes has been accumulated, there is still insufficient evidence to explore sex-related differences.
The aim of this study was to examine sex-specific differences in the effect of the atherogenic index of plasma (AIP) on prediabetes and diabetes.
Methods This cross-sectional study included data from 10099 American adults.
The exposure variable was the AIP, which was defined as log10 (triglycerides/high-density lipoprotein cholesterol).
The outcome variables included prediabetes and diabetes defined by the 2013 American Diabetes Association guidelines.
Results The median age (mean ± SD) was 48.51 ± 18.42 years, and the average value (SD) of the AIP was − 0.09 (0.34).
The prevalence of prediabetes was 40.24%, and that of diabetes was 21.32%.
Overall, there was a significant positive association between the AIP and prediabetes and diabetes (per 1-unit increment in the AIP: OR, 2.49; 95% CI 1.75, 3.54).
The multivariate logistic regression model demonstrated that for each unit increment in the AIP, the prediabetes and diabetes prevalence increased 4.96-fold among female participants (OR 4.96, 95% CI 2.68, 9.18) but not among male participants.
We found that the AIP was not related to the prevalence of prediabetes or diabetes (OR 1.41; 95% CI 0.87, 2.29) among males.
There was an interaction between sex and the AIP (P for interaction < 0.0001).
Conclusions This study showed that a higher AIP was significantly associated with an increased prevalence of prediabetes and diabetes, and the above relationships occurred only among women and not men.
Shi, Yumeng,Wen, Minghua, 2023, Sex-specific differences in the effect of the atherogenic index of plasma on prediabetes and diabetes in the NHANES 2011–2018 population, BioMed Central