Document detail
ID

doi:10.1186/s40792-023-01774-w...

Author
Dejima, Akira Seyama, Yasuji Nakano, Daisuke Takao, Misato Natsume, Soichiro Takao, Mikiya Nakamori, Sakiko Kanai, Tatsuya Horiguchi, Shinichiro Kawai, Kazushige
Langue
en
Editor

Springer

Category

Medicine & Public Health

Year

2023

listing date

11/22/2023

Keywords
peliosis hepatis metastatic liver tumor oxaliplatin oxaliplatin associated cancer metastatic tumor liver hepatis peliosis
Metrics

Abstract

Background Oxaliplatin-based regimens are commonly used as adjuvant chemotherapy following surgery for colorectal cancer.

Adverse events associated with oxaliplatin include blue liver, which is caused by sinusoidal dilation and diffuse peliosis hepatis.

We report herein a case of localized peliosis hepatis closely resembling a metastatic liver tumor.

Case presentation The patient, a 50-year-old male, underwent a robotically assisted colectomy for rectosigmoid colon cancer, which was discovered when hematochezia occurred.

The patient received a diagnosis of pStage IIIb and was treated with four courses of CAPOX as adjuvant chemotherapy starting at postoperative month 1.

At postoperative month 4, contrast-enhanced computed tomography (CT) of the abdomen revealed a 20-mm, low-density area with heterogeneous internal structure in S6/7 of the liver.

Abdominal ultrasound and gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI) findings led to a diagnosis of metastatic liver tumor, for which a laparoscopic partial hepatectomy was performed.

The resected lesion was a dark reddish-brown nodule with indistinct margins that appeared to be continuous with the surrounding area.

Histopathological analysis revealed severe, localized dilatation of the sinusoids and congestion consistent with the gross nodule.

Based on these findings, localized peliosis hepatis associated with oxaliplatin-induced sinusoidal damage was diagnosed.

Conclusions Localized peliosis hepatis associated with oxaliplatin use can be difficult to distinguish from a metastatic liver tumor on imaging studies.

Dejima, Akira,Seyama, Yasuji,Nakano, Daisuke,Takao, Misato,Natsume, Soichiro,Takao, Mikiya,Nakamori, Sakiko,Kanai, Tatsuya,Horiguchi, Shinichiro,Kawai, Kazushige, 2023, A rare case of localized peliosis hepatis during adjuvant chemotherapy including oxaliplatin mimicking a liver metastasis of colon cancer, Springer

Document

Open

Share

Source

Articles recommended by ES/IODE AI

The role of VI-RADS scoring criteria for predicting oncological outcomes in bladder cancer
bladder cancer multiparametric magnetic resonance... recurrence bladder cancer staging 96 0 recurrent cancer bca primary bladder tumors vi-rads mibc