Fatal form of immune reconstitution inflammatory syndrome (IRIS) developed post pneumonia in a solid organ transplant recipient

Hussain, Hussain; Fadel, Aya; Casmartino, Ekaterina; Sullivan, John; Fernandes, Amanda; Garcia, Samantha; Garcia, Efrain

doi:10.1186/s43162-024-00286-9

Fatal form of immune reconstitution inflammatory syndrome (IRIS) developed post pneumonia in a solid organ transplant recipient

Document detail

ID

doi:10.1186/s43162-024-00286-9...

Author

Hussain, Hussain Fadel, Aya Casmartino, Ekaterina Sullivan, John Fernandes, Amanda Garcia, Samantha Garcia, Efrain

Langue

Editor

Springer

Year

2024

listing date

2/14/2024

Keywords

immune reconstitution inflammatory... pneumonia solid organ transplant hiv ... iris

Metrics

Abstract

Background Immune reconstitution inflammatory syndrome (IRIS) is a complex phenomenon commonly diagnosed with human immunodeficiency virus (HIV).

However, rarely, IRIS can develop with other diseases outside of HIV.

We are discussing a rare presentation of IRIS following a pseudomonal infection.

Case presentation We present a 79-year-old Hispanic male who completed a course of cefepime for Pseudomonas aeruginosa hospital-acquired pneumonia.

The patient had a 21-year history of solid organ transplant and immunosuppressive therapy, and he developed a fatal form of IRIS post- Pseudomonas aeruginosa .

Conclusions IRIS may occur in any immunocompromised patient who develops an insidious onset of unexplained clinical and serological deterioration.

Hussain, Hussain,Fadel, Aya,Casmartino, Ekaterina,Sullivan, John,Fernandes, Amanda,Garcia, Samantha,Garcia, Efrain, 2024, Fatal form of immune reconstitution inflammatory syndrome (IRIS) developed post pneumonia in a solid organ transplant recipient, Springer