Document detail
ID
doi:10.1007/s00702-021-02431-y...
Author
Hommen, Franziska Bilican, Saygın Vilchez, DavidLangue
enEditor
Springer
Category
Neurology
Year
2022
listing date
12/8/2022
Keywords
proteostasis proteasome autophagy alzheimer’s disease huntington’s disease parkinson’s disease amyotrophic lateral sclerosis aging cancer proteinAbstract
Protein homeostasis, or proteostasis, is essential for cell function and viability.
Unwanted, damaged, misfolded and aggregated proteins are degraded by the ubiquitin–proteasome system (UPS) and the autophagy-lysosome pathway.
Growing evidence indicates that alterations in these major proteolytic mechanisms lead to a demise in proteostasis, contributing to the onset and development of distinct diseases.
Indeed, dysregulation of the UPS or autophagy is linked to several neurodegenerative, infectious and inflammatory disorders as well as cancer.
Thus, modulation of protein clearance pathways is a promising approach for therapeutics.
In this review, we discuss recent findings and open questions on how targeting proteolytic mechanisms could be applied for disease intervention.
Hommen, Franziska,Bilican, Saygın,Vilchez, David, 2022, Protein clearance strategies for disease intervention, Springer
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