Document detail
ID
doi:10.1007/s10157-023-02384-4...
Author
Kimura, Tomonori Sakai, Shinsuke Isaka, YoshitakaLangue
enEditor
Springer
Category
Urology
Year
2023
listing date
8/2/2023
Keywords
-serine glomerular filtration rate chronic kidney disease kidney transplantation -serine clea... diabetes -asparagine glomerular filtration rate function serine kidneyAbstract
d -Serine, a rare enantiomer of serine, is a biomarker of kidney disease and function.
The level of d- serine in the human body is precisely regulated through the urinary clearance of the kidney, and its clearance serves as a new measure of glomerular filtration rate with a lower bias than creatinine clearance.
d-S erine also has a direct effect on the kidneys and mediates the cellular proliferation of tubular cells via mTOR signaling and induces kidney remodeling as a compensatory reaction to the loss of kidney mass.
In living kidney donors, the removal of the kidney results in an increase in blood d- serine level, which in turn accelerates kidney remodeling and augments kidney clearance, thus reducing blood levels of d- serine.
This feedback system strictly controls d -serine levels in the body.
The function of d- serine as a biomarker and modulator of kidney function will be the basis of precision medicine for kidney diseases.
Kimura, Tomonori,Sakai, Shinsuke,Isaka, Yoshitaka, 2023, d-Serine as a sensor and effector of the kidney, Springer
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