Kidney transplants from elderly donors: what we have learned 20 years after the Crystal City consensus criteria meeting

Mella, Alberto; Calvetti, Ruggero; Barreca, Antonella; Congiu, Giovanni; Biancone, Luigi

doi:10.1007/s40620-024-01888-w

Kidney transplants from elderly donors: what we have learned 20 years after the Crystal City consensus criteria meeting

Document detail

ID

doi:10.1007/s40620-024-01888-w...

Author

Mella, Alberto Calvetti, Ruggero Barreca, Antonella Congiu, Giovanni Biancone, Luigi

Langue

Editor

Springer

Year

2024

listing date

3/13/2024

Keywords

expanded criteria donors kidney transplantation senescence discard rate machine perfusion elderly extended

Metrics

Abstract

Based on the current projection of the general population and the combined increase in end-stage kidney disease with age, the number of elderly donors and recipients is increasing, raising crucial questions about how to minimize the discard rate of organs from elderly donors and improve graft and patient outcomes.

In 2002, extended criteria donors were the focus of a meeting in Crystal City (VA, USA), with a goal of maximizing the use of organs from deceased donors.

Since then, extended criteria donors have progressively contributed to a large number of transplanted grafts worldwide, posing specific issues for allocation systems, recipient management, and therapeutic approaches.

This review analyzes what we have learned in the last 20 years about extended criteria donor utilization, the promising innovations in immunosuppressive management, and the molecular pathways involved in the aging process, which constitute potential targets for novel therapies.

Graphical abstract

Mella, Alberto,Calvetti, Ruggero,Barreca, Antonella,Congiu, Giovanni,Biancone, Luigi, 2024, Kidney transplants from elderly donors: what we have learned 20 years after the Crystal City consensus criteria meeting, Springer