Document detail
ID
oai:pubmedcentral.nih.gov:1111...
Topic
Research ArticlesAuthor
Guo, Tao Zhou, Lingyan Xiong, Min Xiong, Jing Huang, Juan Li, Yiming Zhang, Guoxin Chen, Guiqin Wang, Zhi‐Hao Xiao, Tingting Hu, Dan Bao, Anyu Zhang, ZhentaoLangue
enEditor
John Wiley and Sons Inc.
Category
Aging Cell
Year
2024
listing date
6/10/2024
Keywords
neuroprotective parkinson disease n‐hcy effect dj‐1Abstract
DJ‐1, also known as Parkinson's disease protein 7 (Park7), is a multifunctional protein that regulates oxidative stress and mitochondrial function.
Dysfunction of DJ‐1 is implicated in the pathogenesis of Parkinson's disease (PD).
Hyperhomocysteinemia is associated with an increased risk of PD.
Here we show that homocysteine thiolactone (HTL), a reactive thioester of homocysteine (Hcy), covalently modifies DJ‐1 on the lysine 182 (K182) residue in an age‐dependent manner.
The N‐homocysteinylation (N‐hcy) of DJ‐1 abolishes its neuroprotective effect against oxidative stress and mitochondrial dysfunction, exacerbating cell toxicity.
Blocking the N‐hcy of DJ‐1 restores its protective effect.
These results indicate that the N‐hcy of DJ‐1 abolishes its neuroprotective effect and promotes the progression of PD.
Inhibiting the N‐hcy of DJ‐1 may exert neuroprotective effect against PD.
Guo, Tao,Zhou, Lingyan,Xiong, Min,Xiong, Jing,Huang, Juan,Li, Yiming,Zhang, Guoxin,Chen, Guiqin,Wang, Zhi‐Hao,Xiao, Tingting,Hu, Dan,Bao, Anyu,Zhang, Zhentao, 2024, N‐homocysteinylation of DJ‐1 promotes neurodegeneration in Parkinson's disease, John Wiley and Sons Inc.
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