Rapid response to dupilumab in an adult patient with eosinophilic esophagitis and allergic asthma

Klein, Benjamin; Treudler, Regina

Rapid response to dupilumab in an adult patient with eosinophilic esophagitis and allergic asthma

Document detail

ID

oai:pubmedcentral.nih.gov:1100...

Topic

Case Report

Author

Klein, Benjamin Treudler, Regina

Langue

Editor

Dustri-Verlag Dr. Karl Feistle

Year

2024

listing date

6/10/2024

Keywords

eosinophilic dupilumab

Metrics

Abstract

Abstract.

Background: Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus that belongs to the spectrum of Th2-mediated diseases.

It is often associated with atopic comorbidities such as allergic asthma (AA) and poses a therapeutic challenge.

Case report: We report on a 43-year-old patient with EoE and AA who did not show sufficient therapeutic control despite standard therapy.

We started treatment with dupilumab, whereupon both EoE and AA rapidly improved and complete symptom resolution could be documented.

The response to dupilumab was assessed by laboratory monitoring and gastroscopy, which showed a reduction of markers of type II inflammation and eosinophilic infiltrates in the esophagus.

Summary: Our report emphasizes the effective and safe use of dupilumab as a treatment option for EoE with concomitant beneficial effects on AA.

Klein, Benjamin,Treudler, Regina, 2024, Rapid response to dupilumab in an adult patient with eosinophilic esophagitis and allergic asthma, Dustri-Verlag Dr. Karl Feistle