Document detail
ID
oai:pubmedcentral.nih.gov:8524...
Topic
ResearchAuthor
Meijs, Anouk P. Gijsbers, Esther F. Hengeveld, Paul D. Dierikx, Cindy M. de Greeff, Sabine C. van Duijkeren, EngelineLangue
enEditor
BioMed Central
Category
Antimicrobial Resistance and Infection Control
Year
2021
listing date
10/21/2023
Keywords
factors positive workers months coli esbl prevalence animals veterinary healthcareAbstract
BACKGROUND: Animals are a reservoir for ESBL/pAmpC-producing Escherichia coli/Klebsiella pneumoniae (ESBL-E/K).
We investigated the association between occupational contact with different types of animals and the prevalence of ESBL-E/K carriage among veterinary healthcare workers, assessed molecular characteristics of ESBL-E/K, and followed-up on the ESBL-E/K carriage status of participants and their household members.
METHODS: Participants completed a questionnaire about their contact with animals at work and at home, health status, travel behaviour and hygiene, and sent in a faecal sample which was tested for the presence of ESBL-E/K. Resistance genes were typed using PCR and sequencing.
ESBL-E/K positive participants and their household members were followed up after 6 months.
Risk factors were analysed using multivariable logistic regression methods.
RESULTS: The prevalence of ESBL-E/K carriage was 9.8% (47/482; 95%CI 7.4–12.7).
The most frequently occurring ESBL genes were bla(CTX-M-15), bla(CTX-M-14) and bla(DHA-1).
The predominant sequence type was ST131.
None of the occupation related factors, such as contact with specific animal species, were significantly associated with ESBL-E/K carriage, whereas travel to Africa, Asia or Latin America in the past 6 months (OR 4.4), and stomach/bowel complaints in the past 4 weeks (OR 2.2) were.
Sixteen of 33 initially ESBL-E/K positive participants (48.5%) tested positive again 6 months later, in 14 persons the same ESBL gene and E. coli ST was found.
Four of 23 (17.4%) household members carried ESBL-E/K, in three persons this was the same ESBL gene and E. coli ST as in the veterinary healthcare worker.
CONCLUSIONS: Despite the absence of specific occupation related risk factors, ESBL-E/K carriage in veterinary healthcare workers was high compared to the prevalence in the general Dutch population (5%).
This indicates that occupational contact with animals is a potential source of ESBL-E/K for the population at large.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13756-021-01012-8.
Meijs, Anouk P.,Gijsbers, Esther F.,Hengeveld, Paul D.,Dierikx, Cindy M.,de Greeff, Sabine C.,van Duijkeren, Engeline, 2021, ESBL/pAmpC-producing Escherichia coli and Klebsiella pneumoniae carriage among veterinary healthcare workers in the Netherlands, BioMed Central
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