Document detail
ID
oai:pubmedcentral.nih.gov:1051...
Topic
ArticleAuthor
Creisher, Patrick S. Parish, Maclaine A. Lei, Jun Liu, Jin Perry, Jamie L. Campbell, Ariana D. Sherer, Morgan L. Burd, Irina Klein, Sabra L.Langue
enEditor
Cold Spring Harbor Laboratory
Category
biorxiv
Year
2023
listing date
9/27/2023
Keywords
placental adverse infection outcomes influenza maternal fetalAbstract
Influenza A virus infection during pregnancy can cause adverse maternal and fetal outcomes, but the mechanism responsible remains elusive.
Infection of outbred mice with 2009 H1N1 at embryonic day (E) 10 resulted in significant maternal morbidity, placental tissue damage and inflammation, fetal growth restriction, and developmental delays that lasted through weaning.
Restriction of pulmonary virus replication was not inhibited during pregnancy, but infected dams had suppressed circulating and placental progesterone (P4) concentrations that were caused by H1N1-induced upregulation of pulmonary cyclooxygenase (COX)-1, but not COX-2-, dependent synthesis and secretion of prostaglandin (PG) F2α.
Treatment with 17-α-hydroxyprogesterone caproate (17-OHPC), a synthetic progestin that is safe to use in pregnancy, ameliorated the adverse maternal and fetal outcomes from H1N1 infection and prevented placental cell death and inflammation.
These findings highlight the therapeutic potential of progestin treatments for influenza during pregnancy.
Creisher, Patrick S.,Parish, Maclaine A.,Lei, Jun,Liu, Jin,Perry, Jamie L.,Campbell, Ariana D.,Sherer, Morgan L.,Burd, Irina,Klein, Sabra L., 2023, Suppression of progesterone by influenza A virus causes adverse maternal and fetal outcomes in mice , Cold Spring Harbor Laboratory
Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex
heterogeneity projection-specific
