Document detail
ID
oai:pubmedcentral.nih.gov:7497...
Topic
Research ArticlesAuthor
Irwin, David J. Fedler, Janel Coffey, Christopher S. Caspell‐Garcia, Chelsea Kang, Ju Hee Simuni, Tanya Foroud, Tatiana Toga, Arthur W. Tanner, Caroline M. Kieburtz, Karl Chahine, Lana M. Reimer, Alyssa Hutten, Samantha Weintraub, Daniel Mollenhauer, Brit Galasko, Douglas R. Siderowf, Andrew Marek, Kenneth Trojanowski, John Q. Shaw, Leslie M.Langue
enEditor
John Wiley & Sons, Inc.
Category
Wiley-Blackwell Online Open
Year
2020
listing date
12/1/2023
Keywords
longitudinal parkinson decline < 0 compared t‐tau 03 pg/ml aβ csf 0 disease range median hcs patients 42 biomarkersAbstract
OBJECTIVE: We analyzed the longitudinal profile of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in early Parkinson's disease (PD) compared with healthy controls (HCs) and tested baseline CSF biomarkers for prediction of clinical decline in PD.
METHODS: Amyloid‐β 1 to 42 (Aβ(42)), total tau (t‐tau) and phosphorylated tau (p‐tau) at the threonine 181 position were measured using the high‐precision Roche Elecsys electrochemiluminescence immunoassay in all available CSF samples from longitudinally studied patients with PD (n = 416) and HCs (n = 192) followed for up to 3 years in the Parkinson's Progression Markers Initiative (PPMI).
Longitudinal CSF and clinical data were analyzed with linear‐mixed effects models.
RESULTS: We found patients with PD had lower CSF t‐tau (median = 157.7 pg/mL; range = 80.9–467.0); p‐tau (median = 13.4 pg/mL; range = 8.0–40.1), and Aβ(42) (median = 846.2 pg/mL; range = 238.8–3,707.0) than HCs at baseline (CSF t‐tau median = 173.5 pg/mL; range = 82.0–580.8; p‐tau median = 15.4 pg/mL; range = 8.1–73.6; and Aβ(42) median = 926.5 pg/mL; range = 239.1–3,297.0; p < 0.05–0.001) and a moderate‐to‐strong correlation among these biomarkers in both patients with PD and HCs (Rho = 0.50–0.97; p < 0.001).
Of the patients with PD, 31.5% had pathologically low levels of CSF Aβ(42) at baseline and these patients with PD had lower p‐tau levels (median = 10.8 pg/mL; range = 8.0–32.8) compared with 27.7% of HCs with pathologically low CSF Aβ(42) (CSF p‐tau median = 12.8 pg/mL; range 8.2–73.6; p < 0.03)(.)
In longitudinal CSF analysis, we found patients with PD had greater decline in CSF Aβ(42) (mean difference = −41.83 pg/mL; p = 0.03) and CSF p‐tau (mean difference = −0.38 pg/mL; p = 0.03) at year 3 compared with HCs.
Baseline CSF Aβ(42) values predicted small but measurable decline on cognitive, autonomic, and motor function in early PD.
INTERPRETATION: Our data suggest baseline CSF AD biomarkers may have prognostic value in early PD and that the dynamic change of these markers, although modest over a 3‐year period, suggest biomarker profiles in PD may deviate from healthy aging.
ANN NEUROL 2020;88:574–587
Irwin, David J.,Fedler, Janel,Coffey, Christopher S.,Caspell‐Garcia, Chelsea,Kang, Ju Hee,Simuni, Tanya,Foroud, Tatiana,Toga, Arthur W.,Tanner, Caroline M.,Kieburtz, Karl,Chahine, Lana M.,Reimer, Alyssa,Hutten, Samantha,Weintraub, Daniel,Mollenhauer, Brit,Galasko, Douglas R.,Siderowf, Andrew,Marek, Kenneth,Trojanowski, John Q.,Shaw, Leslie M.,, 2020, Evolution of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Early Parkinson's Disease, John Wiley & Sons, Inc.
