Document detail
ID
oai:pubmedcentral.nih.gov:7756...
Topic
Research ArticlesAuthor
Murueta‐Goyena, Ane Del Pino, Rocío Galdós, Marta Arana, Begoña Acera, Marian Carmona‐Abellán, Mar Fernández‐Valle, Tamara Tijero, Beatriz Lucas‐Jiménez, Olaia Ojeda, Natalia Ibarretxe‐Bilbao, Naroa Peña, Javier Cortes, Jesus Ayala, Unai Barrenechea, Maitane Gómez‐Esteban, Juan Carlos Gabilondo, IñigoLangue
enEditor
John Wiley & Sons, Inc.
Category
Wiley-Blackwell Online Open
Year
2020
listing date
12/1/2023
Keywords
parkinson parafoveal prnfl retinal disease 0 thickness ipd patients gciplAbstract
OBJECTIVE: This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD).
METHODS: Patients with Lewy body diseases were enrolled and prospectively evaluated at 3 years, including patients with iPD (n = 42), dementia with Lewy bodies (n = 4), E46K‐SNCA mutation carriers (n = 4), and controls (n = 17).
All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment, and Unified Parkinson's Disease Rating Scale score was obtained in patients.
Macular ganglion cell–inner plexiform layer complex (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness reduction rates were estimated with linear mixed models.
Risk ratios were calculated to evaluate the association between baseline GCIPL and pRNFL thicknesses and the risk of subsequent cognitive and motor worsening, using clinically meaningful cutoffs.
RESULTS: GCIPL thickness in the parafoveal region (1‐ to 3‐mm ring) presented the largest reduction rate.
The annualized atrophy rate was 0.63μm in iPD patients and 0.23μm in controls (p < 0.0001).
iPD patients with lower parafoveal GCIPL and pRNFL thickness at baseline presented an increased risk of cognitive decline at 3 years (relative risk [RR] = 3.49, 95% confidence interval [CI] = 1.10–11.1, p = 0.03 and RR = 3.28, 95% CI = 1.03–10.45, p = 0.045, respectively).
We did not identify significant associations between retinal thickness and motor deterioration.
INTERPRETATION: Our results provide evidence of the potential use of optical coherence tomography–measured parafoveal GCIPL thickness to monitor neurodegeneration and to predict the risk of cognitive worsening over time in iPD.
ANN NEUROL 2021;89:165–176
Murueta‐Goyena, Ane,Del Pino, Rocío,Galdós, Marta,Arana, Begoña,Acera, Marian,Carmona‐Abellán, Mar,Fernández‐Valle, Tamara,Tijero, Beatriz,Lucas‐Jiménez, Olaia,Ojeda, Natalia,Ibarretxe‐Bilbao, Naroa,Peña, Javier,Cortes, Jesus,Ayala, Unai,Barrenechea, Maitane,Gómez‐Esteban, Juan Carlos,Gabilondo, Iñigo, 2020, Retinal Thickness Predicts the Risk of Cognitive Decline in Parkinson Disease, John Wiley & Sons, Inc.
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