Document detail
ID

oai:pubmedcentral.nih.gov:7894...

Topic
Regular Issue Articles
Author
van der Heide, Anouk Meinders, Marjan J. Speckens, Anne E.M. Peerbolte, Tessa F. Bloem, Bastiaan R. Helmich, Rick C.
Langue
en
Editor

John Wiley & Sons, Inc.

Category

Wiley-Blackwell Online Open

Year

2020

listing date

12/1/2023

Keywords
parkinson mindfulness‐based effects interventions disease pd
Metrics

Abstract

Patients with Parkinson's disease (PD) are very vulnerable to the negative effects of psychological distress: neuropsychiatric symptoms, such as anxiety and depression, are highly prevalent in PD; motor symptoms (such as tremor) typically worsen in stressful situations; and dopaminergic medication is less effective.

Furthermore, animal studies of PD suggest that chronic stress may accelerate disease progression.

Adequate self‐management strategies are therefore essential to reduce the detrimental effects of chronic stress on PD.

Mindfulness‐based interventions encourage individuals to independently self‐manage and adapt to the challenges created by their condition.

In PD, emerging clinical evidence suggests that mindfulness‐based interventions may reduce psychological distress and improve clinical symptoms, but insight into the underlying mechanisms is lacking.

In this viewpoint, we provide a systematic overview of existing mindfulness trials in PD.

Furthermore, we discuss the cerebral mechanisms involved in acute and chronic stress, and the impact of mindfulness‐based interventions on these networks.

In addition, we delineate a hypothetical mechanistic framework of how chronic stress may increase the susceptibility for neuropsychiatric symptoms in PD and may potentially even influence disease progression.

We end with offering recommendations for future research.

© 2020 The Authors.

Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

van der Heide, Anouk,Meinders, Marjan J.,Speckens, Anne E.M.,Peerbolte, Tessa F.,Bloem, Bastiaan R.,Helmich, Rick C., 2020, Stress and Mindfulness in Parkinson's Disease: Clinical Effects and Potential Underlying Mechanisms, John Wiley & Sons, Inc.

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