Document detail
ID

oai:HAL:hal-02635143v1

Topic
emotional Prosody Subthalamic nucleus Striatum Parkinson's disease Deep brain stimulation Asymmetry (18)FDG-PET [SDV.IB]Life Sciences [q-bio]/Bioe... [SDV.MHEP.PSM]Life Sciences [q-bio...
Author
Voruz, Philippe Le Jeune, Florence Haegelen, Claire N'Diaye, Karim Houvenaghel, Jean-François Sauleau, Paul Drapier, Sophie Drapier, Dominique Grandjean, Didier Vérin, Marc Péron, Julie
Langue
en
Editor

HAL CCSD;Elsevier

Category

CNRS - Centre national de la recherche scientifique

Year

2020

listing date

12/15/2023

Keywords
deep stimulation subthalamic nucleus metabolic asymmetry condition right-sided correlated motor patients disease parkinson brain symptoms
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Abstract

International audience; The objective of this study was to explore the brain modifications associated with vocal emotion (i.e., emotional prosody) processing deficits in patients with Parkinson's disease after deep brain stimulation of the subthalamic nucleus, and the impact of motor asymmetry on these deficits.

We therefore conducted 18-fluorodeoxyglucose positron emission tomography scans of 29 patients with left- or right-sided motor symptoms of Parkinson's disease before and after surgery, and correlated changes in their glucose metabolism with modified performances on the recognition of emotional prosody.

Results were also compared with those of a matched healthy control group.

Patients with more left-sided motor symptoms exhibited a deficit in vocal emotion recognition for neutral, anger, happiness and sadness in the preoperative condition that was normalized postoperatively.

Patients with more right-sided motor symptoms performed comparably to controls in the preoperative condition, but differed significantly on fear postoperatively.

At the metabolic level, the improvement observed among patients with left-sided motor symptoms was correlated with metabolic modifications in a right-lateralized network known to be involved in emotional prosody, while the behavioral worsening observed among patients with right-sided motor symptoms was correlated with metabolic modifications in the left parahippocampal gyrus and right cerebellum.

We suggest that surgery has a differential impact on emotional processing according to motor symptom lateralization, and interpret these results as reflecting the (de)synchronization of the limbic loop in the postoperative condition.

Voruz, Philippe,Le Jeune, Florence,Haegelen, Claire,N'Diaye, Karim,Houvenaghel, Jean-François,Sauleau, Paul,Drapier, Sophie,Drapier, Dominique,Grandjean, Didier,Vérin, Marc,Péron, Julie, 2020, Motor symptom asymmetry in Parkinson's disease predicts emotional outcome following subthalamic nucleus deep brain stimulation, HAL CCSD;Elsevier

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