Document detail
ID
oai:HAL:hal-03949586v1
Topic
cognitive progression mitochondrial haplogroups Parkinson’s disease [SDV.NEU.NB]Life Sciences [q-bio]/...Author
Liu, Ganqiang Ni, Chunming Zhan, Jiamin Li, Weimin Luo, Junfeng Liao, Zhixiang Locascio, Joseph J. Xian, Wenbiao Chen, Ling Pei, Zhong Corvol, Jean Christophe Maple-Grødem, Jodi Campbell, Meghan C. Elbaz, Alexis Lesage, Suzanne Brice, Alexis Hung, Albert Y. Schwarzschild, Michael A. Hayes, Michael T. Wills, Anne Marie A. Ravina, Bernard Shoulson, Ira Taba, Pille Kõks, Sulev Beach, Thomas Gerald Cormier-Dequaire, Florence Alves, Guido Tysnes, Ole Bj̈orn Perlmutter, Joel S. Heutink, Peter van Hilten, Jacobus Johannes Bob Barker, Roger A. Williams-Gray, Caroline H. Scherzer, Clemens R.Langue
enEditor
HAL CCSD;Oxford University Press (OUP)
Category
CNRS - Centre national de la recherche scientifique
Year
2023
listing date
12/15/2023
Keywords
macro-haplogroup parkinson haplogroups progression cognitive mitochondrial diseaseAbstract
International audience; Mitochondria are a culprit in the onset of Parkinson's disease, but their role during disease progression is unclear.
Here we used Cox proportional hazards models to exam the effect of variation in the mitochondrial genome on longitudinal cognitive and motor progression over time in 4064 patients with Parkinson's disease.
Mitochondrial macro-haplogroup was associated with reduced risk of cognitive disease progression in the discovery and replication population.
In the combined analysis, patients with the super macro-haplogroup J, T, U# had a 41% lower risk of cognitive progression with P = 2.42 × 10-6 compared to those with macro-haplogroup H. Exploratory analysis indicated that the common mitochondrial DNA variant, m.2706A>G, was associated with slower cognitive decline with a hazard ratio of 0.68 (95% confidence interval 0.56-0.81) and P = 2.46 × 10-5.
Mitochondrial haplogroups were not appreciably linked to motor progression.
This initial genetic survival study of the mitochondrial genome suggests that mitochondrial haplogroups may be associated with the pace of cognitive progression in Parkinson's disease over time.
Liu, Ganqiang,Ni, Chunming,Zhan, Jiamin,Li, Weimin,Luo, Junfeng,Liao, Zhixiang,Locascio, Joseph J.,Xian, Wenbiao,Chen, Ling,Pei, Zhong,Corvol, Jean Christophe,Maple-Grødem, Jodi,Campbell, Meghan C.,Elbaz, Alexis,Lesage, Suzanne,Brice, Alexis,Hung, Albert Y.,Schwarzschild, Michael A.,Hayes, Michael T.,Wills, Anne Marie A.,Ravina, Bernard,Shoulson, Ira,Taba, Pille,Kõks, Sulev,Beach, Thomas Gerald,Cormier-Dequaire, Florence,Alves, Guido,Tysnes, Ole Bj̈orn,Perlmutter, Joel S.,Heutink, Peter,van Hilten, Jacobus Johannes Bob,Barker, Roger A.,Williams-Gray, Caroline H.,Scherzer, Clemens R., 2023, Mitochondrial haplogroups and cognitive progression in Parkinson's disease, HAL CCSD;Oxford University Press (OUP)
