Document detail
ID
oai:pubmedcentral.nih.gov:1060...
Topic
ReviewAuthor
Li, Yang Zeng, Peng-Ming Wu, Jian Luo, Zhen-GeLangue
enEditor
Springer Nature Singapore
Category
Neuroscience Bulletin
Year
2023
listing date
11/1/2023
Keywords
diseases brainAbstract
Understanding the fundamental processes of human brain development and diseases is of great importance for our health.
However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.
Over the past years, an emerging model, the “brain organoid” integrated from human pluripotent stem cells, has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent, making it possible to better understand the complex structures and functions of the human brain.
In this review, we summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors.
Finally, we also discuss current limitations and the potential of brain organoids.
Li, Yang,Zeng, Peng-Ming,Wu, Jian,Luo, Zhen-Ge, 2023, Advances and Applications of Brain Organoids, Springer Nature Singapore
