3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers

Sjöholm, Erica; Mathiyalagan, Rathna; Rajan Prakash, Dhayakumar; Lindfors, Lisa; Wang, Qingbo; Wang, Xiaoju; Ojala, Samuli; Sandler, Niklas

3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers

Document detail

ID

oai:pubmedcentral.nih.gov:7767...

Topic

Article

Author

Sjöholm, Erica Mathiyalagan, Rathna Rajan Prakash, Dhayakumar Lindfors, Lisa Wang, Qingbo Wang, Xiaoju Ojala, Samuli Sandler, Niklas

Langue

Editor

MDPI

Year

2020

listing date

10/13/2022

Keywords

printers films veterinary

Metrics

Abstract

Currently, the number of approved veterinary medicines are limited, and human medications are used off-label.

These approved human medications are of too high potencies for a cat or a small dog breed.

Therefore, there is a dire demand for smaller doses of veterinary medicines.

This study aims to investigate the use of three semi-solid extrusion 3D printers in a pharmacy or animal clinic setting for the extemporaneous manufacturing of prednisolone containing orodispersible films for veterinary use.

Orodispersible films with adequate content uniformity and acceptance values as defined by the European Pharmacopoeia were produced with one of the studied printers, namely the Allevi 2 bioprinter.

Smooth and flexible films with high mechanical strength, neutral pH, and low moisture content were produced with a high correlation between the prepared design and the obtained drug amount, indicating that the Allevi 2 printer could successfully be used to extemporaneously manufacture personalized doses for animals at the point-of-care.

Sjöholm, Erica,Mathiyalagan, Rathna,Rajan Prakash, Dhayakumar,Lindfors, Lisa,Wang, Qingbo,Wang, Xiaoju,Ojala, Samuli,Sandler, Niklas, 2020, 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers, MDPI