Document detail
ID
oai:HAL:hal-03213105v1
Topic
Africa Influenza virus antigenic cartography one health phylogeny [SDV]Life Sciences [q-bio]Author
Fusade-Boyer, Maxime Djegui, Fidélia Batawui, Komla Byuragaba, Denis, K. Jones, Jeremy, C. Wabwire-Mangeni, Fred Erima, Bernard Atim, Gladys Ukuli, Qouilazoni, A. Tugume, Titus Dogno, Koffi Adjabli, Komlan Nzuzi, Mvibudulu Adjin, Rachidatou Jeevan, Trushar Rubrum, Adam Go-Maro, Wolali Kayali, Ghazi Mckenzie, Pamela Webby, Richard, J. Ducatez, MarietteLangue
enEditor
HAL CCSD;Earliest : Springer-Nature ; Latest : Taylor & Francis
Category
sciences: life sciences
Year
2021
listing date
12/8/2023
Keywords
sub-saharan h9n2 pathogenic uganda togo benin antigenic viruses influenzaAbstract
International audience; Sub-Saharan Africa was historically considered an animal influenza cold spot, with only sporadic highly pathogenic H5 outbreaks detected over the last 20 years.
However, in 2017, low pathogenic avian influenza A(H9N2) viruses were detected in poultry in Sub-Saharan Africa.
Molecular, phylogenetic, and antigenic characterization of isolates from Benin, Togo, and Uganda showed that they belonged to the G1 lineage.
Isolates from Benin and Togo clustered with viruses previously described in Western Africa, whereas viruses from Uganda were genetically distant and clustered with viruses from the Middle East.
Viruses from Benin exhibited decreased cross-reactivity with those from Togo and Uganda, suggesting antigenic drift associated with reduced replication in Calu-3 cells.
The viruses exhibited mammalian adaptation markers similar to those of the human strain A/Senegal/0243/2019 (H9N2).
Therefore, viral genetic and antigenic surveillance in Africa is of paramount importance to detect further evolution or emergence of new zoonotic strains.
Fusade-Boyer, Maxime,Djegui, Fidélia,Batawui, Komla,Byuragaba, Denis, K.,Jones, Jeremy, C.,Wabwire-Mangeni, Fred,Erima, Bernard,Atim, Gladys,Ukuli, Qouilazoni, A.,Tugume, Titus,Dogno, Koffi,Adjabli, Komlan,Nzuzi, Mvibudulu,Adjin, Rachidatou,Jeevan, Trushar,Rubrum, Adam,Go-Maro, Wolali,Kayali, Ghazi,Mckenzie, Pamela,Webby, Richard, J.,Ducatez, Mariette, 2021, Antigenic and molecular characterization of low pathogenic avian influenza A(H9N2) viruses in sub-Saharan Africa from 2017 through 2019, HAL CCSD;Earliest : Springer-Nature ; Latest : Taylor & Francis
VR-Splatting: Foveated Radiance Field Rendering via 3D Gaussian Splatting and Neural Points
computer demands rendering neural
Attractor-Like Dynamics Extracted from Human Electrocorticographic Recordings Underlie Computational Principles of Auditory Bistable Perception
low-dimensional ecog subjects neural features dynamics perception
