Document detail
ID
oai:www.zora.uzh.ch:203492
Topic
Institute of Medical Virology Clinic and Policlinic for Internal... Clinic for Radiation Oncology Rheumatology Clinic and Institute ... Clinic for Cardiology Clinic for Infectious Diseases Clinic for Reconstructive Surgery Department of Aging Medicine Clinic for Oncology and Hematology... 610 Medicine & healthAuthor
Tamò, Raphaël https://orcid.org/0000-0002-2098-9392 Turk, Teja https://orcid.org/0000-0003-3065-8578 Böni, Jürg https://orcid.org/0000-0001-7925-4852 Kouyos, Roger D https://orcid.org/0000-0002-9220-8348 Schmutz, Stefan https://orcid.org/0000-0002-1955-7007 Huber, Michael https://orcid.org/0000-0002-0384-0000 Shah, Cyril Bischoff-Ferrari, Heike A Distler, Oliver https://orcid.org/0000-0002-0546-8310 Battegay, Edouard https://orcid.org/0000-0001-9202-5034 Giovanoli, Pietro Guckenberger, Matthias https://orcid.org/0000-0002-7146-9071 Kohler, Malcolm https://orcid.org/0000-0003-1800-8003 Müller, Rouven Petry, Heidi https://orcid.org/0000-0001-5220-4273 Ruschitzka, Frank https://orcid.org/0000-0001-5972-0596 McGeer, Allison Sax, Hugo https://orcid.org/0000-0002-1532-2198 Weber, Rainer Trkola, Alexandra https://orcid.org/0000-0003-1013-876X Kuster, Stefan P https://orcid.org/0000-0002-0525-6529Langue
engEditor
Cambridge University Press
Category
Subjects = 04 Faculty of Medicine
Year
2022
listing date
10/12/2023
Keywords
symptoms swabs individuals influenza-positive secondary attack hcws days study clinic participants symptomatic medicine inpatients transmission 5% asymptomatic influenzaAbstract
OBJECTIVE: Nosocomial transmission of influenza is a major concern for infection control.
We aimed to dissect transmission dynamics of influenza, including asymptomatic transmission events, in acute care.
DESIGN: Prospective surveillance study during 2 influenza seasons.
SETTING: Tertiary-care hospital.
PARTICIPANTS: Volunteer sample of inpatients on medical wards and healthcare workers (HCWs).
METHODS: Participants provided daily illness diaries and nasal swabs for influenza A and B detection and whole-genome sequencing for phylogenetic analyses.
Contacts between study participants were tracked.
Secondary influenza attack rates were calculated based on spatial and temporal proximity and phylogenetic evidence for transmission.
RESULTS: In total, 152 HCWs and 542 inpatients were included; 16 HCWs (10.5%) and 19 inpatients (3.5%) tested positive for influenza on 109 study days.
Study participants had symptoms of disease on most of the days they tested positive for influenza (83.1% and 91.9% for HCWs and inpatients, respectively).
Also, 11(15.5%) of 71 influenza-positive swabs among HCWs and 3 (7.9%) of 38 influenza-positive swabs among inpatients were collected on days without symptoms; 2 (12.5%) of 16 HCWs and 2 (10.5%) of 19 inpatients remained fully asymptomatic.
The secondary attack rate was low: we recorded 1 transmission event over 159 contact days (0.6%) that originated from a symptomatic case.
No transmission event occurred in 61 monitored days of contacts with asymptomatic influenza-positive individuals.
CONCLUSIONS: Influenza in acute care is common, and individuals regularly shed influenza virus without harboring symptoms.
Nevertheless, both symptomatic and asymptomatic transmission events proved rare.
We suggest that healthcare-associated influenza prevention strategies that are based on preseason vaccination and barrier precautions for symptomatic individuals seem to be effective.
Tamò, Raphaël, https://orcid.org/0000-0002-2098-9392,Turk, Teja, https://orcid.org/0000-0003-3065-8578,Böni, Jürg, https://orcid.org/0000-0001-7925-4852,Kouyos, Roger D, https://orcid.org/0000-0002-9220-8348,Schmutz, Stefan, https://orcid.org/0000-0002-1955-7007,Huber, Michael, https://orcid.org/0000-0002-0384-0000,Shah, Cyril,Bischoff-Ferrari, Heike A,Distler, Oliver, https://orcid.org/0000-0002-0546-8310,Battegay, Edouard, https://orcid.org/0000-0001-9202-5034,Giovanoli, Pietro,Guckenberger, Matthias, https://orcid.org/0000-0002-7146-9071,Kohler, Malcolm, https://orcid.org/0000-0003-1800-8003,Müller, Rouven,Petry, Heidi, https://orcid.org/0000-0001-5220-4273,Ruschitzka, Frank, https://orcid.org/0000-0001-5972-0596,McGeer, Allison,Sax, Hugo, https://orcid.org/0000-0002-1532-2198,Weber, Rainer,Trkola, Alexandra, https://orcid.org/0000-0003-1013-876X,Kuster, Stefan P, https://orcid.org/0000-0002-0525-6529, 2022, Secondary attack rates from asymptomatic and symptomatic influenza virus shedders in hospitals: Results from the TransFLUas influenza transmission study, Cambridge University Press
Machine learning and EEG can classify passive viewing of discrete categories of visual stimuli but not the observation of pain
eeg classify neutral ml participants non-pain expressions images scenes pain
