Document detail
ID
doi:10.1038/s41598-025-89080-3...
Author
Peters, Tracy L. Qiu, Weihong Yang, Haomin Huang, Wuqing Hu, Yizhen Zou, Zhangyu Ye, WeiminLangue
enEditor
Nature
Category
Epidemiology
Year
2025
listing date
2/12/2025
Keywords
amyotrophic lateral sclerosis epidemiology frailty cachexia study associationsAbstract
In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area.
In this prospective study, we extracted cachexia and frailty status from the UK Biobank cohort to study the associations of these conditions (as determined via international classification of disease-10 codes) with amyotrophic lateral sclerosis.
There was a greater risk of developing amyotrophic lateral sclerosis among individuals with cachexia and frailty status after adjusting for age, sex, income (pounds), body mass index, UK Biobank centers and smoking status.
Among individuals with frailty status: a grip strength of < 21 kg, a slow walking speed, and exhaustion (more than half the days or nearly every day) increase the risk of developing amyotrophic lateral sclerosis.
We believe that studying cachexia and frailty status can be used to help define and treat amyotrophic lateral sclerosis.
Peters, Tracy L.,Qiu, Weihong,Yang, Haomin,Huang, Wuqing,Hu, Yizhen,Zou, Zhangyu,Ye, Weimin, 2025, Associations of cachexia and frailty with amyotrophic lateral sclerosis, Nature
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