The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer

Chuang, Liu; Qifeng, Ju; Shaolei, Yu

doi:10.1007/s12672-024-01117-7

The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer

Document detail

ID

doi:10.1007/s12672-024-01117-7...

Author

Chuang, Liu Qifeng, Ju Shaolei, Yu

Langue

Editor

Springer

Year

2024

listing date

6/26/2024

Keywords

colorectal cancer tumor immune microenvironment t cell monoclonal antibody car-t tumor cancer colorectal

Metrics

Abstract

The tumor microenvironment includes a complex network of immune T-cell subsets that play important roles in colorectal cancer (CRC) progression and are key elements of CRC immunotherapy.

T cells develop and migrate within tumors, recognizing tumor-specific antigens to regulate immune surveillance.

Current immunotherapies are divided into the following main categories based on the regulatory role of T-cell subsets in the tumor immune microenvironment (TIME): cytokines, monoclonal antibodies, peptide vaccines, CAR-T cells and more.

This review describes the composition of the tumor immune microenvironment in colorectal cancer and the involvement of T cells in the pathogenesis and progression of CRC as well as current T-cell-related immunotherapies.

Further studies on CRC-specific tumor antigens, the gene regulation of T cells, and the regulation of immune activity are needed.

Chuang, Liu,Qifeng, Ju,Shaolei, Yu, 2024, The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer, Springer