Document detail
ID
doi:10.1007/s40487-023-00224-9...
Author
Nunes Filho, Paulo Albuquerque, Caroline Pilon Capella, Mariana Debiasi, MarcioLangue
enEditor
Springer
Category
Medicine & Public Health
Year
2023
listing date
3/15/2023
Keywords
breast neoplasms immune checkpoint inhibitors drug-related side effects and adve... patient care team oncologists cancer breastAbstract
Breast cancer is the most frequently diagnosed malignancy in patients worldwide and the main cause of cancer-related death.
Though still incurable, metastatic breast cancer’s prognosis has been considerably improved in the past 10 years due to the introduction of new targeted agents, such as immune checkpoint inhibitors (ICI).
However, these medications are associated with unique side effects known as immune-mediated adverse events (irAE).
In this paper, we review the clinical evidence for the use of ICIs in breast cancer, in both the metastatic as well as neoadjuvant/adjuvant setting, followed by a review of irAE most commonly seen, and the medications used to treat them.
Our opinion is that any cancer specialist treating patients with breast cancer should be aware of these side effects for early detection and management, and oncologists should be the leaders of the multidisciplinary team that will take care of them.
Nunes Filho, Paulo,Albuquerque, Caroline,Pilon Capella, Mariana,Debiasi, Marcio, 2023, Immune Checkpoint Inhibitors in Breast Cancer: A Narrative Review, Springer
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