Document detail
ID
doi:10.1038/s41698-024-00501-4...
Author
Hong, Jiyun Choi, Eunwoo Kim, Dahee Seo, Mi-Kyoung Kang, Hyundeok Park, BeumJin Kim, SangwooLangue
enEditor
Nature
Category
Medicine & Public Health
Year
2024
listing date
1/24/2024
Keywords
sgc characteristics t-cell duct immunological salivary subtyping 001 < 0 cancerAbstract
Gene expression analysis enhances proper cancer subtyping, a better understanding of the molecular characteristics of cancer, and strategies for precision medicine.
However, salivary gland cancer (SGC) subtyping remains largely unexplored because of its rarity and diverse histopathological and immunological characteristics.
This study aimed to determine whether the histological origin and immunological characteristics of SGC subtypes are intrinsic tumor immunity factors.
We performed immune profiling of 94 RNA-seq of SGC tissues and found that the SGCs that originated from the excretory duct (ED), such as the salivary duct and mucoepidermoid carcinomas, exhibit higher immunity than those from the intercalated duct (ID), such as the adenoid cystic and myoepithelial carcinomas, based on the computationally predicted immune score ( p < 0.001), immune cell enrichment in the tumor immune microenvironment (TIME) ( p < 0.001), T-cell receptor diversity ( p < 0.001), and expression of signal I (major histocompatibility complex, MHC, p < 0.001) and signal II (co-stimulatory, p < 0.001 and co-inhibitory, p < 0.001) genes.
Further analysis revealed that tolerogenic dendritic cell-induced dysfunctional T-cell populations and T-cell exclusion in the TIME are the major immune evasive mechanisms of the ED-and ID-derived SGCs, respectively.
Hong, Jiyun,Choi, Eunwoo,Kim, Dahee,Seo, Mi-Kyoung,Kang, Hyundeok,Park, BeumJin,Kim, Sangwoo, 2024, Immunological subtyping of salivary gland cancer identifies histological origin-specific tumor immune microenvironment, Nature
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